{"id":"https://openalex.org/W4387939611","doi":"https://doi.org/10.3389/fimmu.2023.1276852","title":"Enhancement of prostaglandin D2-D prostanoid 1 signaling reduces intestinal permeability by stimulating mucus secretion","display_name":"Enhancement of prostaglandin D2-D prostanoid 1 signaling reduces intestinal permeability by stimulating mucus secretion","publication_year":2023,"publication_date":"2023-10-24","ids":{"openalex":"https://openalex.org/W4387939611","doi":"https://doi.org/10.3389/fimmu.2023.1276852","pmid":"https://pubmed.ncbi.nlm.nih.gov/37942331","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10628818"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2023.1276852","doi":"https://doi.org/10.3389/fimmu.2023.1276852","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1276852","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1276852/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1276852/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103279276","display_name":"Akane Hayashi","orcid":"https://orcid.org/0000-0003-3174-6836","observed_orcids":["https://orcid.org/0000-0003-3174-6836"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akane Hayashi","raw_affiliation_strings":["Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Naoaki Sakamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoaki Sakamoto","raw_affiliation_strings":["Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088855764","display_name":"Koji Kobayashi","orcid":"https://orcid.org/0000-0001-7223-607X","observed_orcids":["https://orcid.org/0000-0001-7223-607X"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koji Kobayashi","raw_affiliation_strings":["Food and Animal Systemics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Food and Animal Systemics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023789798","display_name":"Takahisa Murata","orcid":"https://orcid.org/0000-0002-3328-0796","observed_orcids":["https://orcid.org/0000-0002-3328-0796"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takahisa Murata","raw_affiliation_strings":["Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan","Food and Animal Systemics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan","Veterinary Pharmacology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Food and Animal Systemics, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Veterinary Pharmacology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023789798"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.8778,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.70738405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"14","issue":null,"first_page":"1276852","last_page":"1276852"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.7304999828338623,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.7304999828338623,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.15360000729560852,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.05079999938607216,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-d2","display_name":"prostaglandin D2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/dp1-receptor","display_name":"DP1 receptor","score":0.8370000123977661},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.8960000276565552},{"id":"https://openalex.org/keywords/intestinal-barrier","display_name":"intestinal barrier","score":0.8550000190734863},{"id":"https://openalex.org/keywords/mucus-secretion","display_name":"mucus secretion","score":0.9959999918937683},{"id":"https://openalex.org/keywords/goblet-cells","display_name":"goblet cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tight-junctions","display_name":"tight junctions","score":0.8690000176429749},{"id":"https://openalex.org/keywords/bw245c","display_name":"BW245C","score":0.9309999942779541},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.8349999785423279},{"id":"https://openalex.org/keywords/mucolytic-activity","display_name":"mucolytic activity","score":0.546999990940094},{"id":"https://openalex.org/keywords/colitis","display_name":"colitis","score":0.6000000238418579},{"id":"https://openalex.org/keywords/food-allergy","display_name":"food allergy","score":0.9819999933242798}],"concepts":[{"id":"https://openalex.org/C2777361909","wikidata":"https://www.wikidata.org/wiki/Q419750","display_name":"Prostaglandin D2","level":3,"score":0.5231127142906189},{"id":"https://openalex.org/C2777312293","wikidata":"https://www.wikidata.org/wiki/Q3649349","display_name":"Mucus","level":2,"score":0.48670056462287903},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4841945469379425},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.47939634323120117},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.475488543510437},{"id":"https://openalex.org/C2781071285","wikidata":"https://www.wikidata.org/wiki/Q17141320","display_name":"Intestinal permeability","level":2,"score":0.4736700654029846},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.4533485770225525},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.447780042886734},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41953927278518677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3692753314971924},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36436113715171814},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26848191022872925},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.19969305396080017},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19968420267105103},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1956140398979187},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009093","descriptor_name":"Mucus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015230","descriptor_name":"Prostaglandin D2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018938","descriptor_name":"Caco-2 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2023.1276852","doi":"https://doi.org/10.3389/fimmu.2023.1276852","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1276852","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1276852/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10628818","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10628818","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10628818/pdf/fimmu-14-1276852.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:37942331","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37942331","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:46744883366443d4b92664c899ab2e9f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/46744883366443d4b92664c899ab2e9f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 14 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2023.1276852","doi":"https://doi.org/10.3389/fimmu.2023.1276852","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1276852","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1276852/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3776669352","display_name":"Investigation of intestinal lipid metabolism in food allergy","funder_award_id":"20H05678","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7224738145","display_name":null,"funder_award_id":"JPMJTR22UF","funder_id":"https://openalex.org/F4320320907","funder_display_name":"Japan Science and Technology Corporation"}],"funders":[{"id":"https://openalex.org/F4320320907","display_name":"Japan Science and Technology Corporation","ror":"https://ror.org/00097mb19"},{"id":"https://openalex.org/F4320325290","display_name":"Terumo Foundation for Life Sciences and Arts","ror":"https://ror.org/02kbe5v55"},{"id":"https://openalex.org/F4320327426","display_name":"Sekisui Chemical","ror":"https://ror.org/05hessd06"},{"id":"https://openalex.org/F4320333054","display_name":"Asahi Group Foundation","ror":"https://ror.org/014aeyd41"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387939611.pdf","grobid_xml":"https://content.openalex.org/works/W4387939611.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W810159654","https://openalex.org/W1558263145","https://openalex.org/W1992152055","https://openalex.org/W2018297739","https://openalex.org/W2028950494","https://openalex.org/W2044627132","https://openalex.org/W2055847901","https://openalex.org/W2058405570","https://openalex.org/W2064873678","https://openalex.org/W2074913692","https://openalex.org/W2100723130","https://openalex.org/W2103310685","https://openalex.org/W2105100736","https://openalex.org/W2108636884","https://openalex.org/W2109383966","https://openalex.org/W2121960517","https://openalex.org/W2142781849","https://openalex.org/W2157699210","https://openalex.org/W2272764162","https://openalex.org/W2279877516","https://openalex.org/W2414478455","https://openalex.org/W2460600979","https://openalex.org/W2535078809","https://openalex.org/W2885093728","https://openalex.org/W2924455969","https://openalex.org/W3032914467","https://openalex.org/W3107076968","https://openalex.org/W3161117753","https://openalex.org/W3164786685","https://openalex.org/W4315797293"],"related_works":["https://openalex.org/W7125096742","https://openalex.org/W2030900467","https://openalex.org/W2800058620","https://openalex.org/W2113204284","https://openalex.org/W2157699210","https://openalex.org/W4389028521","https://openalex.org/W772368646","https://openalex.org/W2002085613","https://openalex.org/W4411293701","https://openalex.org/W1943588667"],"abstract_inverted_index":{"Introduction":[0],"The":[1,66,109,123],"intestinal":[2,64,78,124,152,165,172,222,236],"barrier":[3,79],"plays":[4],"a":[5,214],"crucial":[6],"role":[7],"in":[8,53,93,140,149,175,202],"distinguishing":[9],"foods":[10],"from":[11,23,208],"toxins.":[12],"Prostaglandin":[13],"D2":[14],"(PGD2)":[15],"is":[16],"one":[17],"of":[18,34,44,74,99,192,221],"the":[19,42,63,72,83,97,107,129,144,150,189,193,219],"lipid-derived":[20],"autacoids":[21],"synthesized":[22],"cell":[24,154],"membrane-derived":[25],"arachidonic":[26],"acid.":[27],"We":[28],"previously":[29],"reported":[30],"that":[31,59,183,231],"pharmacological":[32,232],"stimulation":[33,61,76,170,197,234],"PGD2":[35],"receptor,":[36],"D":[37],"prostanoid":[38],"1":[39],"(DP1)":[40],"attenuated":[41],"symptoms":[43],"azoxymethane/dextran":[45],"sodium":[46],"sulfate-induced":[47],"colitis":[48],"and":[49,81,87,177],"ovalbumin-induced":[50],"food":[51],"allergy":[52],"mouse":[54],"models.":[55],"These":[56,228],"observations":[57,229],"suggested":[58],"DP1":[60,75,110,169,184,196,225,233],"protects":[62],"barrier.":[65],"present":[67],"study":[68],"aimed":[69],"to":[70,120],"uncover":[71],"effects":[73],"on":[77,188],"function":[80],"elucidate":[82],"underlying":[84],"mechanisms.":[85],"Materials":[86],"methods":[88],"Intestinal":[89],"permeability":[90,125,173,223,237],"was":[91,115,126,138,159,185],"assessed":[92,160],"mice":[94],"by":[95,142,161,213,224,238],"measuring":[96,143],"transfer":[98],"orally":[100],"administered":[101,116],"fluorescein":[102],"isothiocyanate-dextran":[103],"(40":[104],"kDa)":[105],"into":[106],"blood.":[108],"agonist":[111],"BW245C":[112],"(1":[113],"mg/kg)":[114],"10":[117],"min":[118],"prior":[119],"dextran":[121],"administration.":[122],"confirmed":[127],"using":[128],"ex":[130,178],"vivo":[131,176],"everted":[132],"sac":[133],"method.":[134],"Tight":[135],"junction":[136],"integrity":[137],"evaluated":[139],"vitro":[141,203],"transepithelial":[145],"electrical":[146],"resistance":[147],"(TER)":[148],"human":[151],"epithelial":[153,194],"line":[155],"Caco-2.":[156],"Mucus":[157,211],"secretion":[158,207],"observing":[162],"Alcian":[163],"Blue-stained":[164],"sections.":[166],"Results":[167],"Pharmacological":[168],"reduced":[171],"both":[174],"vivo.":[179],"Immunohistochemical":[180],"staining":[181],"showed":[182],"strongly":[186],"expressed":[187],"apical":[190],"side":[191],"cells.":[195,210],"did":[198],"not":[199],"affect":[200],"TER":[201],"but":[204],"induced":[205],"mucus":[206,240],"goblet":[209],"removal":[212],"mucolytic":[215],"agent":[216],"N-acetyl-l-cysteine":[217],"canceled":[218],"inhibition":[220],"stimulation.":[226],"Conclusion":[227],"suggest":[230],"decreases":[235],"stimulating":[239],"secretion.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-26T00:00:00"}