{"id":"https://openalex.org/W4387937031","doi":"https://doi.org/10.3390/ijms242115581","title":"Novel Substituted Azoloazines with Anticoagulant Activity","display_name":"Novel Substituted Azoloazines with Anticoagulant Activity","publication_year":2023,"publication_date":"2023-10-25","ids":{"openalex":"https://openalex.org/W4387937031","doi":"https://doi.org/10.3390/ijms242115581","pmid":"https://pubmed.ncbi.nlm.nih.gov/37958560","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10648877"},"language":"en","primary_location":{"id":"doi:10.3390/ijms242115581","doi":"https://doi.org/10.3390/ijms242115581","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms242115581","pdf_url":"https://www.mdpi.com/1422-0067/24/21/15581/pdf?version=1698235588","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/24/21/15581/pdf?version=1698235588","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081710389","display_name":"\u0410. \u0410. \u0421\u043f\u0430\u0441\u043e\u0432","orcid":"https://orcid.org/0000-0002-7185-4826","observed_orcids":["https://orcid.org/0000-0002-7185-4826"]},"institutions":[{"id":"https://openalex.org/I155623535","display_name":"Volgograd State Medical University","ror":"https://ror.org/04q6a0352","country_code":"RU","type":"education","lineage":["https://openalex.org/I155623535"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Alexander A. Spasov","raw_affiliation_strings":["Department of Pharmacology & Bioinformatics, Scientific Center for Innovative Drugs, Volgograd State Medical University, Volgograd 400131, Russia"],"raw_orcid":"https://orcid.org/0000-0002-7185-4826","affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Bioinformatics, Scientific Center for Innovative Drugs, Volgograd State Medical University, Volgograd 400131, Russia","institution_ids":["https://openalex.org/I155623535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014944442","display_name":"Olga V. Fedorova","orcid":"https://orcid.org/0000-0001-9355-283X","observed_orcids":["https://orcid.org/0000-0001-9355-283X"]},"institutions":[{"id":"https://openalex.org/I4210104350","display_name":"Institute of Organic Synthesis","ror":"https://ror.org/019tvvb70","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104350","https://openalex.org/I4210145551"]},{"id":"https://openalex.org/I4210119369","display_name":"Ural Branch of the Russian Academy of Sciences","ror":"https://ror.org/02s4h3z39","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210119369"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Olga V. Fedorova","raw_affiliation_strings":["I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia","institution_ids":["https://openalex.org/I4210104350","https://openalex.org/I4210119369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063848915","display_name":"Nikolay A. Rasputin","orcid":"https://orcid.org/0000-0002-4610-3617","observed_orcids":["https://orcid.org/0000-0002-4610-3617"]},"institutions":[{"id":"https://openalex.org/I4210104350","display_name":"Institute of Organic Synthesis","ror":"https://ror.org/019tvvb70","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104350","https://openalex.org/I4210145551"]},{"id":"https://openalex.org/I4210119369","display_name":"Ural Branch of the Russian Academy of Sciences","ror":"https://ror.org/02s4h3z39","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210119369"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Nikolay A. Rasputin","raw_affiliation_strings":["I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia","institution_ids":["https://openalex.org/I4210104350","https://openalex.org/I4210119369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077373902","display_name":"I.G. Ovchinnikova","orcid":"https://orcid.org/0000-0002-3304-6553","observed_orcids":["https://orcid.org/0000-0002-3304-6553"]},"institutions":[{"id":"https://openalex.org/I4210104350","display_name":"Institute of Organic Synthesis","ror":"https://ror.org/019tvvb70","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104350","https://openalex.org/I4210145551"]},{"id":"https://openalex.org/I4210119369","display_name":"Ural Branch of the Russian Academy of Sciences","ror":"https://ror.org/02s4h3z39","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210119369"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Irina G. Ovchinnikova","raw_affiliation_strings":["I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia"],"raw_orcid":"https://orcid.org/0000-0002-3304-6553","affiliations":[{"raw_affiliation_string":"I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia","institution_ids":["https://openalex.org/I4210104350","https://openalex.org/I4210119369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030334966","display_name":"\u0420\u0430\u0448\u0438\u0434\u0430 \u0418\u0440\u0448\u043e\u0442\u043e\u0432\u043d\u0430 \u0418\u0448\u043c\u0435\u0442\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0003-1007-1921","observed_orcids":["https://orcid.org/0000-0003-1007-1921"]},"institutions":[{"id":"https://openalex.org/I4210104350","display_name":"Institute of Organic Synthesis","ror":"https://ror.org/019tvvb70","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104350","https://openalex.org/I4210145551"]},{"id":"https://openalex.org/I4210119369","display_name":"Ural Branch of the Russian Academy of Sciences","ror":"https://ror.org/02s4h3z39","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210119369"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Rashida I. Ishmetova","raw_affiliation_strings":["I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia","institution_ids":["https://openalex.org/I4210104350","https://openalex.org/I4210119369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069588515","display_name":"\u041d\u0438\u043d\u0430 \u041a\u043e\u043d\u0441\u0442\u0430\u043d\u0442\u0438\u043d\u043e\u0432\u043d\u0430 \u0418\u0433\u043d\u0430\u0442\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0003-2362-4556","observed_orcids":["https://orcid.org/0000-0003-2362-4556"]},"institutions":[{"id":"https://openalex.org/I4210104350","display_name":"Institute of Organic Synthesis","ror":"https://ror.org/019tvvb70","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104350","https://openalex.org/I4210145551"]},{"id":"https://openalex.org/I4210119369","display_name":"Ural Branch of the Russian Academy of Sciences","ror":"https://ror.org/02s4h3z39","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210119369"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Nina K. Ignatenko","raw_affiliation_strings":["I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia","institution_ids":["https://openalex.org/I4210104350","https://openalex.org/I4210119369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064175209","display_name":"Evgeny B. Gorbunov","orcid":"https://orcid.org/0000-0003-0740-3358","observed_orcids":["https://orcid.org/0000-0003-0740-3358"]},"institutions":[{"id":"https://openalex.org/I4210104350","display_name":"Institute of Organic Synthesis","ror":"https://ror.org/019tvvb70","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104350","https://openalex.org/I4210145551"]},{"id":"https://openalex.org/I4210119369","display_name":"Ural Branch of the Russian Academy of Sciences","ror":"https://ror.org/02s4h3z39","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210119369"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Evgeny B. Gorbunov","raw_affiliation_strings":["I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia","institution_ids":["https://openalex.org/I4210104350","https://openalex.org/I4210119369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085485665","display_name":"Gusein A. o. Sadykhov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130823665","display_name":"Ural Federal University","ror":"https://ror.org/00hs7dr46","country_code":"RU","type":"education","lineage":["https://openalex.org/I130823665"]},{"id":"https://openalex.org/I4210104350","display_name":"Institute of Organic Synthesis","ror":"https://ror.org/019tvvb70","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104350","https://openalex.org/I4210145551"]},{"id":"https://openalex.org/I4210119369","display_name":"Ural Branch of the Russian Academy of Sciences","ror":"https://ror.org/02s4h3z39","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210119369"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Gusein A. o. Sadykhov","raw_affiliation_strings":["Department of Organic and Biomolecular Chemistry, Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg 620002, Russia","I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Organic and Biomolecular Chemistry, Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg 620002, Russia","institution_ids":["https://openalex.org/I130823665"]},{"raw_affiliation_string":"I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia","institution_ids":["https://openalex.org/I4210104350","https://openalex.org/I4210119369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026787498","display_name":"Aida F. Kucheryavenko","orcid":"https://orcid.org/0000-0003-1406-6919","observed_orcids":["https://orcid.org/0000-0003-1406-6919"]},"institutions":[{"id":"https://openalex.org/I155623535","display_name":"Volgograd State Medical University","ror":"https://ror.org/04q6a0352","country_code":"RU","type":"education","lineage":["https://openalex.org/I155623535"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Aida F. Kucheryavenko","raw_affiliation_strings":["Department of Pharmacology & Bioinformatics, Scientific Center for Innovative Drugs, Volgograd State Medical University, Volgograd 400131, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Bioinformatics, Scientific Center for Innovative Drugs, Volgograd State Medical University, Volgograd 400131, Russia","institution_ids":["https://openalex.org/I155623535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083499825","display_name":"\u041a\u0441\u0435\u043d\u0438\u044f \u0410\u043d\u0434\u0440\u0435\u0435\u0432\u043d\u0430 \u0413\u0430\u0439\u0434\u0443\u043a\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0003-4376-6332","observed_orcids":["https://orcid.org/0000-0003-4376-6332"]},"institutions":[{"id":"https://openalex.org/I155623535","display_name":"Volgograd State Medical University","ror":"https://ror.org/04q6a0352","country_code":"RU","type":"education","lineage":["https://openalex.org/I155623535"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Kseniia A. Gaidukova","raw_affiliation_strings":["Department of Pharmacology & Bioinformatics, Scientific Center for Innovative Drugs, Volgograd State Medical University, Volgograd 400131, Russia"],"raw_orcid":"https://orcid.org/0000-0003-4376-6332","affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Bioinformatics, Scientific Center for Innovative Drugs, Volgograd State Medical University, Volgograd 400131, Russia","institution_ids":["https://openalex.org/I155623535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085774239","display_name":"\u0412. \u0421. \u0421\u0438\u0440\u043e\u0442\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0003-2249-020X","observed_orcids":["https://orcid.org/0000-0003-2249-020X"]},"institutions":[{"id":"https://openalex.org/I155623535","display_name":"Volgograd State Medical University","ror":"https://ror.org/04q6a0352","country_code":"RU","type":"education","lineage":["https://openalex.org/I155623535"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Victor S. Sirotenko","raw_affiliation_strings":["Department of Pharmacology & Bioinformatics, Scientific Center for Innovative Drugs, Volgograd State Medical University, Volgograd 400131, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Bioinformatics, Scientific Center for Innovative Drugs, Volgograd State Medical University, Volgograd 400131, Russia","institution_ids":["https://openalex.org/I155623535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048726096","display_name":"Gennady Leonidovich Rusinov","orcid":"https://orcid.org/0000-0001-8567-9435","observed_orcids":["https://orcid.org/0000-0001-8567-9435"]},"institutions":[{"id":"https://openalex.org/I130823665","display_name":"Ural Federal University","ror":"https://ror.org/00hs7dr46","country_code":"RU","type":"education","lineage":["https://openalex.org/I130823665"]},{"id":"https://openalex.org/I4210104350","display_name":"Institute of Organic Synthesis","ror":"https://ror.org/019tvvb70","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104350","https://openalex.org/I4210145551"]},{"id":"https://openalex.org/I4210119369","display_name":"Ural Branch of the Russian Academy of Sciences","ror":"https://ror.org/02s4h3z39","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210119369"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Gennady L. Rusinov","raw_affiliation_strings":["Department of Technology & Organic Synthesis, Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg 620002, Russia","I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Technology & Organic Synthesis, Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg 620002, Russia","institution_ids":["https://openalex.org/I130823665"]},{"raw_affiliation_string":"I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia","institution_ids":["https://openalex.org/I4210104350","https://openalex.org/I4210119369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044324082","display_name":"Egor Vladimirovich Verbitskiy","orcid":"https://orcid.org/0000-0002-9613-8738","observed_orcids":["https://orcid.org/0000-0002-9613-8738","https://orcid.org/0000-0002-1482-206X"]},"institutions":[{"id":"https://openalex.org/I130823665","display_name":"Ural Federal University","ror":"https://ror.org/00hs7dr46","country_code":"RU","type":"education","lineage":["https://openalex.org/I130823665"]},{"id":"https://openalex.org/I4210104350","display_name":"Institute of Organic Synthesis","ror":"https://ror.org/019tvvb70","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104350","https://openalex.org/I4210145551"]},{"id":"https://openalex.org/I4210119369","display_name":"Ural Branch of the Russian Academy of Sciences","ror":"https://ror.org/02s4h3z39","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210119369"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Egor V. Verbitskiy","raw_affiliation_strings":["Department of Organic and Biomolecular Chemistry, Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg 620002, Russia","I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia"],"raw_orcid":"https://orcid.org/0000-0002-1482-206X","affiliations":[{"raw_affiliation_string":"Department of Organic and Biomolecular Chemistry, Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg 620002, Russia","institution_ids":["https://openalex.org/I130823665"]},{"raw_affiliation_string":"I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia","institution_ids":["https://openalex.org/I4210104350","https://openalex.org/I4210119369"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019631216","display_name":"\u0412\u0430\u043b\u0435\u0440\u0438\u0439 \u041d\u0438\u043a\u043e\u043b\u0430\u0435\u0432\u0438\u0447 \u0427\u0430\u0440\u0443\u0448\u0438\u043d","orcid":"https://orcid.org/0000-0002-9140-358X","observed_orcids":["https://orcid.org/0000-0002-9140-358X"]},"institutions":[{"id":"https://openalex.org/I130823665","display_name":"Ural Federal University","ror":"https://ror.org/00hs7dr46","country_code":"RU","type":"education","lineage":["https://openalex.org/I130823665"]},{"id":"https://openalex.org/I4210104350","display_name":"Institute of Organic Synthesis","ror":"https://ror.org/019tvvb70","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210104350","https://openalex.org/I4210145551"]},{"id":"https://openalex.org/I4210119369","display_name":"Ural Branch of the Russian Academy of Sciences","ror":"https://ror.org/02s4h3z39","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210119369"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Valery N. Charushin","raw_affiliation_strings":["Department of Organic and Biomolecular Chemistry, Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg 620002, Russia","I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia"],"raw_orcid":"https://orcid.org/0000-0002-9140-358X","affiliations":[{"raw_affiliation_string":"Department of Organic and Biomolecular Chemistry, Ural Federal University Named after the First President of Russia B. N. Yeltsin, Ekaterinburg 620002, Russia","institution_ids":["https://openalex.org/I130823665"]},{"raw_affiliation_string":"I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg 620108, Russia","institution_ids":["https://openalex.org/I4210104350","https://openalex.org/I4210119369"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5063848915","https://openalex.org/A5081710389"],"corresponding_institution_ids":["https://openalex.org/I155623535","https://openalex.org/I4210104350","https://openalex.org/I4210119369"],"apc_list":{"value":2500,"currency":"CHF","value_usd":2780},"apc_paid":{"value":2500,"currency":"CHF","value_usd":2780},"fwci":1.0704,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.69592409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"24","issue":"21","first_page":"15581","last_page":"15581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.42820000648498535,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.42820000648498535,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.3529999852180481,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.14499999582767487,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anticoagulant-activity","display_name":"anticoagulant activity","score":0.8939999938011169},{"id":"https://openalex.org/keywords/1-2-4-triazolo-1-5-a-pyrimidines","display_name":"1,2,4-triazolo[1,5-a]pyrimidines","score":0.9800000190734863},{"id":"https://openalex.org/keywords/thrombin-inhibition","display_name":"thrombin inhibition","score":0.7649999856948853},{"id":"https://openalex.org/keywords/thrombin-time","display_name":"thrombin time","score":0.8190000057220459},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8299999833106995},{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.9120000004768372},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.8840000033378601},{"id":"https://openalex.org/keywords/dabigatran-etexilate","display_name":"dabigatran etexilate","score":0.8240000009536743},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.7099999785423279},{"id":"https://openalex.org/keywords/antidiabetic-activity","display_name":"antidiabetic activity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.8088714480400085},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.5754843354225159},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5406507849693298},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.539894700050354},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.511989176273346},{"id":"https://openalex.org/C2911117829","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant drug","level":3,"score":0.5006260871887207},{"id":"https://openalex.org/C2778810321","wikidata":"https://www.wikidata.org/wiki/Q419345","display_name":"Dabigatran","level":4,"score":0.46219995617866516},{"id":"https://openalex.org/C2779321679","wikidata":"https://www.wikidata.org/wiki/Q207722","display_name":"Pyrimidine","level":2,"score":0.44175955653190613},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4372006356716156},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.4239605665206909},{"id":"https://openalex.org/C2993316766","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant therapy","level":2,"score":0.4217136800289154},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33939963579177856},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21660500764846802},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17864811420440674},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.16833534836769104},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.10329636931419373},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069604","descriptor_name":"Dabigatran","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms242115581","doi":"https://doi.org/10.3390/ijms242115581","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms242115581","pdf_url":"https://www.mdpi.com/1422-0067/24/21/15581/pdf?version=1698235588","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10648877","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10648877","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:37958560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37958560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:elar.urfu.ru:10995/130943","doi":null,"is_oa":true,"landing_page_url":"https://www.scopus.com/inward/record.uri?eid=2-s2.0-85176322723&doi=10.3390%2fijms242115581&partnerID=40&md5=57c29372a6ef5a898df667f5a2fd5e50","pdf_url":null,"source":{"id":"https://openalex.org/S4406922546","display_name":"Electronic Archive of Ural Federal University (ELAR UrFU)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/ijms242115581","doi":"https://doi.org/10.3390/ijms242115581","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms242115581","pdf_url":"https://www.mdpi.com/1422-0067/24/21/15581/pdf?version=1698235588","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G417126629","display_name":null,"funder_award_id":"\u2116 075-15-2020-777","funder_id":"https://openalex.org/F4320327494","funder_display_name":"Ministry of Science and Higher Education of the Russian Federation"}],"funders":[{"id":"https://openalex.org/F4320323859","display_name":"Ural Branch, Russian Academy of Sciences","ror":"https://ror.org/02s4h3z39"},{"id":"https://openalex.org/F4320327494","display_name":"Ministry of Science and Higher Education of the Russian Federation","ror":null},{"id":"https://openalex.org/F4320334801","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25"},{"id":"https://openalex.org/F4320336123","display_name":"Postovsky Institute of Organic Synthesis","ror":"https://ror.org/019tvvb70"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387937031.pdf","grobid_xml":"https://content.openalex.org/works/W4387937031.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1511701404","https://openalex.org/W1977559293","https://openalex.org/W1993716579","https://openalex.org/W2010215929","https://openalex.org/W2037541016","https://openalex.org/W2053437895","https://openalex.org/W2064808863","https://openalex.org/W2093482680","https://openalex.org/W2094158785","https://openalex.org/W2104450299","https://openalex.org/W2162595073","https://openalex.org/W2188301483","https://openalex.org/W2510904187","https://openalex.org/W2582439522","https://openalex.org/W2588710889","https://openalex.org/W2734243548","https://openalex.org/W2740606342","https://openalex.org/W2741515752","https://openalex.org/W2772527093","https://openalex.org/W2804833713","https://openalex.org/W2901601846","https://openalex.org/W2907062897","https://openalex.org/W2910001605","https://openalex.org/W2911093128","https://openalex.org/W2921761665","https://openalex.org/W2945557774","https://openalex.org/W2950230241","https://openalex.org/W2971494618","https://openalex.org/W2972839082","https://openalex.org/W2981665100","https://openalex.org/W3007986137","https://openalex.org/W3009600499","https://openalex.org/W3015622053","https://openalex.org/W3017661324","https://openalex.org/W3018691837","https://openalex.org/W3043135743","https://openalex.org/W3046714277","https://openalex.org/W3081101292","https://openalex.org/W3105285173","https://openalex.org/W3139360498","https://openalex.org/W3195915980","https://openalex.org/W3201570839","https://openalex.org/W4229451036","https://openalex.org/W4322485561"],"related_works":["https://openalex.org/W4226225991","https://openalex.org/W4405276877","https://openalex.org/W4283779845","https://openalex.org/W4213083592","https://openalex.org/W2003173649","https://openalex.org/W4367836480","https://openalex.org/W2952445938","https://openalex.org/W4393358520","https://openalex.org/W2137088071","https://openalex.org/W3007465164"],"abstract_inverted_index":{"Hypercytokinemia,":[0],"or":[1,68,90,134],"cytokine":[2],"storm,":[3],"often":[4],"complicates":[5],"the":[6,17,22,30,42,57,75,122,144,150,155,174,181,190],"treatment":[7,31,76],"of":[8,19,24,32,44,77,97,102,124,140,176,184,192],"viral":[9],"and":[10,53,116],"bacterial":[11],"infections,":[12],"including":[13],"COVID-19,":[14],"leading":[15],"to":[16,38,153],"risk":[18],"thrombosis.":[20],"However,":[21],"use":[23],"currently":[25],"available":[26],"direct":[27],"anticoagulants":[28,46],"for":[29,51],"COVID-19":[33,78],"patients":[34],"is":[35],"limited":[36],"due":[37],"safety":[39],"reasons.":[40],"Therefore,":[41],"development":[43],"new":[45,60],"remains":[47],"an":[48],"urgent":[49],"task":[50],"organic":[52],"medicinal":[54],"chemistry.":[55],"At":[56],"same":[58],"time,":[59,157],"drugs":[61],"that":[62,139],"combine":[63],"anticoagulant":[64,117,128,170,182],"properties":[65],"with":[66,110,138,173],"antiviral":[67],"antidiabetic":[69],"activity":[70,129,171],"could":[71],"be":[72],"helpfull":[73],"in":[74],"patients,":[79],"especially":[80],"those":[81],"suffering":[82],"from":[83,121],"such":[84],"concomitant":[85],"diseases":[86],"as":[87,108,143],"arterial":[88],"hypertension":[89],"diabetes.":[91],"We":[92],"have":[93,104,126],"synthesized":[94],"a":[95,131,193],"number":[96],"novel":[98],"substituted":[99],"azoloazines,":[100],"some":[101],"which":[103],"previously":[105],"been":[106],"identified":[107],"compounds":[109,120],"pronounced":[111],"antiviral,":[112],"antibacterial,":[113],"antidiabetic,":[114],"antiaggregant,":[115],"activity.":[118],"Two":[119],"family":[123],"1,2,4-triazolo[1,5-a]pyrimidines":[125],"demonstrated":[127],"at":[130,135],"level":[132],"exceeding":[133],"least":[136],"comparable":[137],"dabigatran":[141],"etexilate":[142],"reference":[145,160],"compound.":[146],"7,5-Di(2-thienyl)-4,5-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine":[147],"has":[148,167],"shown":[149],"highest":[151],"ability":[152],"prolong":[154],"thrombin":[156,177],"surpassing":[158],"this":[159,185],"drug":[161],"by":[162],"2.2":[163],"times.":[164],"This":[165],"compound":[166],"also":[168],"exhibited":[169],"associated":[172],"inhibition":[175],"(factor":[178],"IIa).":[179],"Moreover,":[180],"effect":[183],"substance":[186],"becomes":[187],"enhanced":[188],"under":[189],"conditions":[191],"systemic":[194],"inflammatory":[195],"reaction.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-26T00:00:00"}