{"id":"https://openalex.org/W4387936076","doi":"https://doi.org/10.5455/annalsmedres.2023.08.196","title":"The Evaluation of Dynamic Thiol/Disulfide Homeostasis in Papillary Thyroid Carcinoma","display_name":"The Evaluation of Dynamic Thiol/Disulfide Homeostasis in Papillary Thyroid Carcinoma","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4387936076","doi":"https://doi.org/10.5455/annalsmedres.2023.08.196"},"language":"en","primary_location":{"id":"doi:10.5455/annalsmedres.2023.08.196","doi":"https://doi.org/10.5455/annalsmedres.2023.08.196","is_oa":true,"landing_page_url":"https://doi.org/10.5455/annalsmedres.2023.08.196","pdf_url":null,"source":{"id":"https://openalex.org/S4210239751","display_name":"Annals of Medical Research","issn_l":"1300-1744","issn":["1300-1744","2636-7688"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4360969463","host_organization_name":"Inonu University Faculty of Medicine","host_organization_lineage":["https://openalex.org/P4360969463"],"host_organization_lineage_names":["Inonu University Faculty of Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Medical Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.5455/annalsmedres.2023.08.196","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093124227","display_name":"P Akhanl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Akhanl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113030955","display_name":"Sema en","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sema en","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114093852","display_name":"Hakan er","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hakan er","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Muhammed l","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muhammed l","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111062625","display_name":"Salim lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salim lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063751184","display_name":"zcan Erel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"zcan Erel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5016730314","display_name":"Erman akal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erman akal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.24206077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"30","issue":"10","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.04830000177025795,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.8970000147819519},{"id":"https://openalex.org/keywords/thiol-disulfide-homeostasis","display_name":"thiol/disulfide homeostasis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/native-thiol","display_name":"native thiol","score":0.796999990940094},{"id":"https://openalex.org/keywords/total-thiol","display_name":"total thiol","score":0.9139999747276306},{"id":"https://openalex.org/keywords/disulfides","display_name":"disulfides","score":0.925000011920929},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5070000290870667},{"id":"https://openalex.org/keywords/thyroid-nodules","display_name":"thyroid nodules","score":0.7720000147819519},{"id":"https://openalex.org/keywords/lymphovascular-invasion","display_name":"lymphovascular invasion","score":0.7409999966621399},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6370000243186951},{"id":"https://openalex.org/keywords/tumor-subtypes","display_name":"tumor subtypes","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6760067343711853},{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.6641440987586975},{"id":"https://openalex.org/C2777195454","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Euthyroid","level":3,"score":0.6152806282043457},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.5770233869552612},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.5347503423690796},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5242300629615784},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4945199191570282},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.45698264241218567},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.42289280891418457},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34896641969680786},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32944273948669434},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14784282445907593},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14123153686523438}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5455/annalsmedres.2023.08.196","doi":"https://doi.org/10.5455/annalsmedres.2023.08.196","is_oa":true,"landing_page_url":"https://doi.org/10.5455/annalsmedres.2023.08.196","pdf_url":null,"source":{"id":"https://openalex.org/S4210239751","display_name":"Annals of Medical Research","issn_l":"1300-1744","issn":["1300-1744","2636-7688"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4360969463","host_organization_name":"Inonu University Faculty of Medicine","host_organization_lineage":["https://openalex.org/P4360969463"],"host_organization_lineage_names":["Inonu University Faculty of Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Medical Research","raw_type":"journal-article"},{"id":"pmh:35b02d67-c2bd-432a-be66-8fe4eb935f68","doi":null,"is_oa":false,"landing_page_url":"https://avesis.aybu.edu.tr/publication/details/35b02d67-c2bd-432a-be66-8fe4eb935f68/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055213","display_name":"AYBU AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.5455/annalsmedres.2023.08.196","doi":"https://doi.org/10.5455/annalsmedres.2023.08.196","is_oa":true,"landing_page_url":"https://doi.org/10.5455/annalsmedres.2023.08.196","pdf_url":null,"source":{"id":"https://openalex.org/S4210239751","display_name":"Annals of Medical Research","issn_l":"1300-1744","issn":["1300-1744","2636-7688"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","tr-dizin"],"host_organization":"https://openalex.org/P4360969463","host_organization_name":"Inonu University Faculty of Medicine","host_organization_lineage":["https://openalex.org/P4360969463"],"host_organization_lineage_names":["Inonu University Faculty of Medicine"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Medical Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4239183065","https://openalex.org/W2887570461","https://openalex.org/W2516124013","https://openalex.org/W1993656194","https://openalex.org/W4384277467","https://openalex.org/W4313039433","https://openalex.org/W3210014905","https://openalex.org/W2994439410","https://openalex.org/W4288716074","https://openalex.org/W7167908832"],"abstract_inverted_index":{"Objectives:":[0],"Aim":[1],"of":[2,25,30,77,98,193,197,203,210,232,236,241],"this":[3,82],"study":[4],"is":[5],"to":[6,20,46,50,65,112,131,160],"analyze":[7],"the":[8,22,28,42,66,75,101,113,135,164,174,188,191,195,201,208,214,227,230,234],"correlation":[9],"between":[10],"thiol/disulfide":[11],"homeostasis":[12],"(TDH)":[13],"and":[14,19,33,54,92,103,108,122,152,200,212,239],"papillary":[15],"thyroid":[16,90,93],"carcinoma":[17],"(PTCA)":[18],"reveal":[21],"possible":[23],"impact":[24],"TDH":[26,182],"on":[27],"development":[29],"PTCA.":[31],"Material":[32],"Methods:":[34],"Preoperative":[35],"venous":[36],"blood":[37],"sampling":[38],"was":[39,106],"obtained":[40],"from":[41],"patients":[43,175],"having":[44],"applied":[45],"our":[47],"hospital":[48],"due":[49],"euthyroid":[51],"nodular":[52],"goiter":[53],"detected":[55,159],"with":[56,138,167,176,187,247],"suspected":[57],"malignancy":[58],"or":[59],"malignant":[60],"cytology":[61],"in":[62,81,100,134,163],"FNAB,":[63],"according":[64],"BETHESDA":[67],"system.":[68],"Those":[69],"whose":[70],"postoperative":[71,222],"histopathological":[72,223],"results":[73,215],"proved":[74],"presence":[76,196,202,235,240],"PTCA":[78,177,189,211,228],"were":[79,87,129,143,158,178,184,216,244],"involved":[80],"study.":[83],"Healthy":[84],"volunteers":[85],"who":[86],"without":[88],"any":[89],"nodules":[91],"dysfunction.":[94],"Results:":[95],"The":[96],"number":[97,192,231],"participants":[99],"patient":[102,136,165],"control":[104,114],"groups":[105],"34":[107],"101,":[109],"respectively.":[110],"Compared":[111],"group,":[115],"native":[116,123],"thiol":[117,120,125,149,154],"(\u03bcmol/L),":[118,121],"total":[119],"thiol/total":[124],"\u00d7":[126,150,155],"100":[127,156],"values":[128,142,157],"ascertained":[130],"be":[132,161],"lower":[133,162],"group":[137,166],"PTCA;":[139],"however,":[140],"these":[141],"not":[144,170,185,217,245],"statistically":[145,171,218],"significant.":[146,172,219],"Disulfide,":[147],"disulfide/native":[148],"100,":[151],"disulfide/total":[153],"PTCA,":[168],"but":[169],"When":[173],"assessed":[179],"within":[180],"themselves,":[181],"parameters":[183,209],"associated":[186],"subtype,":[190,229],"foci,":[194,233],"lymphovascular":[198,237],"invasion,":[199,238],"metastatic":[204,242],"lap.":[205],"Conclusion:":[206],"Considering":[207],"TDH,":[213],"And":[220],"besides":[221],"findings":[224],"such":[225],"as":[226],"lap":[243],"correlated":[246],"THD":[248],"parameters.":[249]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-10-26T00:00:00"}