{"id":"https://openalex.org/W4387935706","doi":"https://doi.org/10.3390/idr15060061","title":"Oral Molnupiravir and Nirmatrelvir/Ritonavir for the Treatment of COVID-19: A Literature Review with a Focus on Real-World Evidence","display_name":"Oral Molnupiravir and Nirmatrelvir/Ritonavir for the Treatment of COVID-19: A Literature Review with a Focus on Real-World Evidence","publication_year":2023,"publication_date":"2023-10-25","ids":{"openalex":"https://openalex.org/W4387935706","doi":"https://doi.org/10.3390/idr15060061","pmid":"https://pubmed.ncbi.nlm.nih.gov/37987399","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10660858"},"language":"en","primary_location":{"id":"doi:10.3390/idr15060061","doi":"https://doi.org/10.3390/idr15060061","is_oa":true,"landing_page_url":"https://doi.org/10.3390/idr15060061","pdf_url":"https://www.mdpi.com/2036-7449/15/6/61/pdf?version=1698228877","source":{"id":"https://openalex.org/S59274399","display_name":"Infectious Disease Reports","issn_l":"2036-7449","issn":["2036-7449","2036-7430"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious Disease Reports","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2036-7449/15/6/61/pdf?version=1698228877","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085335793","display_name":"Ioannis Karniadakis","orcid":"https://orcid.org/0000-0001-9924-0044","observed_orcids":["https://orcid.org/0000-0001-9924-0044"]},"institutions":[{"id":"https://openalex.org/I1299209451","display_name":"Cardiff and Vale University Health Board","ror":"https://ror.org/0489f6q08","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1299209451","https://openalex.org/I4210144625"]},{"id":"https://openalex.org/I2800861664","display_name":"University Hospital of Wales","ror":"https://ror.org/04fgpet95","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1299209451","https://openalex.org/I2800861664","https://openalex.org/I4210144625"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ioannis Karniadakis","raw_affiliation_strings":["Cardiff Transplant Unit, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff CF14 4XW, UK"],"raw_orcid":"https://orcid.org/0000-0001-9924-0044","affiliations":[{"raw_affiliation_string":"Cardiff Transplant Unit, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff CF14 4XW, UK","institution_ids":["https://openalex.org/I1299209451","https://openalex.org/I2800861664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038739037","display_name":"Nikolaos Mazonakis","orcid":"https://orcid.org/0000-0001-8114-9066","observed_orcids":["https://orcid.org/0000-0001-8114-9066"]},"institutions":[{"id":"https://openalex.org/I4210166756","display_name":"Sotiria General Hospital","ror":"https://ror.org/05gbdc474","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166756"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nikolaos Mazonakis","raw_affiliation_strings":["Internal Medicine Department, Thoracic Diseases General Hospital Sotiria, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Department, Thoracic Diseases General Hospital Sotiria, 11527 Athens, Greece","institution_ids":["https://openalex.org/I4210166756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088348112","display_name":"Constantinos Tsioutis","orcid":"https://orcid.org/0000-0002-7865-8529","observed_orcids":["https://orcid.org/0000-0002-7865-8529"]},"institutions":[{"id":"https://openalex.org/I201118511","display_name":"European University Cyprus","ror":"https://ror.org/04xp48827","country_code":"CY","type":"education","lineage":["https://openalex.org/I201118511"]}],"countries":["CY"],"is_corresponding":true,"raw_author_name":"Constantinos Tsioutis","raw_affiliation_strings":["School of Medicine, European University Cyprus, 6 Diogenis St., Nicosia 2404, Cyprus"],"raw_orcid":"https://orcid.org/0000-0002-7865-8529","affiliations":[{"raw_affiliation_string":"School of Medicine, European University Cyprus, 6 Diogenis St., Nicosia 2404, Cyprus","institution_ids":["https://openalex.org/I201118511"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michail Papadakis","orcid":"https://orcid.org/0000-0003-4069-3086","observed_orcids":["https://orcid.org/0000-0003-4069-3086"]},"institutions":[{"id":"https://openalex.org/I4210140769","display_name":"General Hospital of Nikea","ror":"https://ror.org/043eknq26","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210140769"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Michail Papadakis","raw_affiliation_strings":["3rd Internal Medicine Department & Diabetes Center, General Hospital of Nikaia Piraeus \u201cAgios Panteleimon\u201d, 18454 Piraeus, Greece"],"raw_orcid":"https://orcid.org/0000-0003-4069-3086","affiliations":[{"raw_affiliation_string":"3rd Internal Medicine Department & Diabetes Center, General Hospital of Nikaia Piraeus \u201cAgios Panteleimon\u201d, 18454 Piraeus, Greece","institution_ids":["https://openalex.org/I4210140769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078719303","display_name":"Ioulia Markaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166756","display_name":"Sotiria General Hospital","ror":"https://ror.org/05gbdc474","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166756"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Ioulia Markaki","raw_affiliation_strings":["Internal Medicine Department, Thoracic Diseases General Hospital Sotiria, 11527 Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Internal Medicine Department, Thoracic Diseases General Hospital Sotiria, 11527 Athens, Greece","institution_ids":["https://openalex.org/I4210166756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005610081","display_name":"Nikolaos A. Spernovasilis","orcid":"https://orcid.org/0000-0002-6981-8535","observed_orcids":["https://orcid.org/0000-0002-6981-8535"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nikolaos Spernovasilis","raw_affiliation_strings":["Department of Infectious Diseases, German Oncology Center, Agios Athanasios, Limassol 4108, Cyprus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Diseases, German Oncology Center, Agios Athanasios, Limassol 4108, Cyprus","institution_ids":["https://openalex.org/I17937529"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5088348112"],"corresponding_institution_ids":["https://openalex.org/I201118511"],"apc_list":{"value":1400,"currency":"CHF","value_usd":1557},"apc_paid":{"value":1400,"currency":"CHF","value_usd":1557},"fwci":0.5747,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.53403361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"15","issue":"6","first_page":"662","last_page":"678"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.8859999775886536},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9490000009536743},{"id":"https://openalex.org/keywords/molnupiravir","display_name":"molnupiravir","score":0.9670000076293945},{"id":"https://openalex.org/keywords/nirmatrelvir-ritonavir","display_name":"nirmatrelvir/ritonavir","score":0.9879999756813049},{"id":"https://openalex.org/keywords/oral-antiviral-therapy","display_name":"oral antiviral therapy","score":0.8949999809265137},{"id":"https://openalex.org/keywords/real-world-evidence","display_name":"real-world evidence","score":0.9039999842643738},{"id":"https://openalex.org/keywords/clinical-trial-efficacy","display_name":"clinical trial efficacy","score":0.5870000123977661},{"id":"https://openalex.org/keywords/high-risk-patients","display_name":"high-risk patients","score":0.8040000200271606},{"id":"https://openalex.org/keywords/immunocompromised-patients","display_name":"immunocompromised patients","score":0.9449999928474426},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.6759999990463257},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.6299999952316284},{"id":"https://openalex.org/keywords/pediatric-use","display_name":"pediatric use","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9483765363693237},{"id":"https://openalex.org/C2779298103","wikidata":"https://www.wikidata.org/wiki/Q422618","display_name":"Ritonavir","level":5,"score":0.6379495859146118},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6342411637306213},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.629200279712677},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6003210544586182},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5744581818580627},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5624436140060425},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.4441049098968506},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.354079008102417},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.32126742601394653},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1959669291973114},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.07403019070625305},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/idr15060061","doi":"https://doi.org/10.3390/idr15060061","is_oa":true,"landing_page_url":"https://doi.org/10.3390/idr15060061","pdf_url":"https://www.mdpi.com/2036-7449/15/6/61/pdf?version=1698228877","source":{"id":"https://openalex.org/S59274399","display_name":"Infectious Disease Reports","issn_l":"2036-7449","issn":["2036-7449","2036-7430"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious Disease Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10660858","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10660858","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10660858/pdf/idr-15-00061.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infect Dis Rep","raw_type":"Text"},{"id":"pmid:37987399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37987399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious disease reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6eef809229184d91999a7e33b39c75d3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6eef809229184d91999a7e33b39c75d3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Infectious Disease Reports, Vol 15, Iss 6, Pp 662-678 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/idr15060061","doi":"https://doi.org/10.3390/idr15060061","is_oa":true,"landing_page_url":"https://doi.org/10.3390/idr15060061","pdf_url":"https://www.mdpi.com/2036-7449/15/6/61/pdf?version=1698228877","source":{"id":"https://openalex.org/S59274399","display_name":"Infectious Disease Reports","issn_l":"2036-7449","issn":["2036-7449","2036-7430"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Infectious Disease Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387935706.pdf","grobid_xml":"https://content.openalex.org/works/W4387935706.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W138334773","https://openalex.org/W1948326274","https://openalex.org/W1994542643","https://openalex.org/W1997844736","https://openalex.org/W2009987166","https://openalex.org/W2025152688","https://openalex.org/W2189487392","https://openalex.org/W2582590404","https://openalex.org/W2807193652","https://openalex.org/W2972279236","https://openalex.org/W2979108578","https://openalex.org/W2996962570","https://openalex.org/W3020300207","https://openalex.org/W3046843764","https://openalex.org/W3082489976","https://openalex.org/W3096967708","https://openalex.org/W3110209099","https://openalex.org/W3126546961","https://openalex.org/W3156751139","https://openalex.org/W3157786842","https://openalex.org/W3157878567","https://openalex.org/W3166200642","https://openalex.org/W3189646261","https://openalex.org/W3192713004","https://openalex.org/W3196045004","https://openalex.org/W3212101057","https://openalex.org/W3215329385","https://openalex.org/W3217268039","https://openalex.org/W4200051875","https://openalex.org/W4200200825","https://openalex.org/W4200243339","https://openalex.org/W4205709855","https://openalex.org/W4206545113","https://openalex.org/W4212904481","https://openalex.org/W4214687508","https://openalex.org/W4221018380","https://openalex.org/W4225422621","https://openalex.org/W4229334584","https://openalex.org/W4249009625","https://openalex.org/W4280596105","https://openalex.org/W4281988270","https://openalex.org/W4283261856","https://openalex.org/W4283646787","https://openalex.org/W4283769677","https://openalex.org/W4284989411","https://openalex.org/W4285029348","https://openalex.org/W4285501387","https://openalex.org/W4292549392","https://openalex.org/W4293198902","https://openalex.org/W4301393853","https://openalex.org/W4312072294","https://openalex.org/W4312134853","https://openalex.org/W4313473013","https://openalex.org/W4316927629","https://openalex.org/W4318754872","https://openalex.org/W4319322444","https://openalex.org/W4319870639","https://openalex.org/W4320483261","https://openalex.org/W4322496518","https://openalex.org/W4323355832","https://openalex.org/W4323664498","https://openalex.org/W4324026749","https://openalex.org/W4324332959","https://openalex.org/W4360600280","https://openalex.org/W4360600770","https://openalex.org/W4362518589","https://openalex.org/W4364381800","https://openalex.org/W4365519893","https://openalex.org/W4366983740","https://openalex.org/W4366989300","https://openalex.org/W4367557031","https://openalex.org/W4376225374","https://openalex.org/W4376612479","https://openalex.org/W4377091878","https://openalex.org/W4378193844","https://openalex.org/W4378375265","https://openalex.org/W4378515324","https://openalex.org/W4378976426","https://openalex.org/W4380577369","https://openalex.org/W4380884877","https://openalex.org/W4381953230","https://openalex.org/W4382240409","https://openalex.org/W4384008044","https://openalex.org/W4384344133","https://openalex.org/W4384664918","https://openalex.org/W4385752246","https://openalex.org/W4385790300","https://openalex.org/W4387035676","https://openalex.org/W6771955912","https://openalex.org/W6803715815","https://openalex.org/W6804275040","https://openalex.org/W6805935023","https://openalex.org/W6810636493","https://openalex.org/W6850359194","https://openalex.org/W6851742765","https://openalex.org/W6852234836","https://openalex.org/W6853665893"],"related_works":["https://openalex.org/W4319880050","https://openalex.org/W4391329253","https://openalex.org/W4303423592","https://openalex.org/W4385751207","https://openalex.org/W4379016937","https://openalex.org/W4311633829","https://openalex.org/W4229334584","https://openalex.org/W4309604538","https://openalex.org/W4389178750","https://openalex.org/W4324026749"],"abstract_inverted_index":{"Vaccines":[0],"remain":[1],"the":[2,13,27,31,45,66,73,86],"cornerstone":[3],"of":[4,15,29,75,88,120],"medical":[5],"prevention":[6],"and":[7,18,38,69,81,94,145],"are":[8,116],"highly":[9],"effective":[10,47],"in":[11,91,97,108,131],"reducing":[12,92],"risk":[14,119],"severe":[16,51,122,140],"disease":[17,23],"death":[19,95],"due":[20],"to":[21,112],"coronavirus":[22,55],"2019":[24],"(COVID-19).":[25],"In":[26,58],"context":[28],"expanding":[30],"therapeutic":[32],"armamentarium":[33],"against":[34,50],"COVID-19,":[35],"molnupiravir":[36],"(Lagevrio)":[37],"ritonavir-boosted":[39],"nirmatrelvir":[40],"(Paxlovid)":[41],"were":[42],"developed,":[43],"constituting":[44],"first":[46],"oral":[48],"treatments":[49],"acute":[52],"respiratory":[53],"syndrome":[54],"2":[56],"(SARS-CoV-2).":[57],"this":[59],"narrative":[60],"review,":[61],"we":[62],"retrospectively":[63],"inquired":[64],"into":[65],"clinical":[67,79],"trials":[68,80],"real-world":[70,82],"studies":[71,83],"investigating":[72],"efficacy":[74,87,130],"these":[76],"agents.":[77],"Overall,":[78],"have":[84],"demonstrated":[85],"both":[89],"agents":[90],"hospitalization":[93],"rates":[96],"COVID-19":[98],"patients.":[99],"As":[100],"per":[101],"current":[102],"recommendations,":[103],"their":[104,129],"use":[105],"is":[106],"suggested":[107],"patients":[109],"with":[110,139],"mild":[111],"moderate":[113],"symptoms":[114],"who":[115],"at":[117],"high":[118],"developing":[121],"disease.":[123],"Nevertheless,":[124],"limited":[125],"data":[126],"exist":[127],"regarding":[128],"specific":[132],"subpopulations,":[133],"such":[134],"as":[135],"immunocompromised":[136],"patients,":[137],"those":[138],"kidney":[141],"disease,":[142],"pregnant":[143],"women,":[144],"children.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-10-26T00:00:00"}
