{"id":"https://openalex.org/W4387934221","doi":"https://doi.org/10.1021/acsinfecdis.3c00264","title":"Integrated Transcriptomic and Metabolomic Mapping Reveals the Mechanism of Action of Ceftazidime/Avibactam against Pan-Drug-Resistant Klebsiella pneumoniae","display_name":"Integrated Transcriptomic and Metabolomic Mapping Reveals the Mechanism of Action of Ceftazidime/Avibactam against Pan-Drug-Resistant Klebsiella pneumoniae","publication_year":2023,"publication_date":"2023-10-25","ids":{"openalex":"https://openalex.org/W4387934221","doi":"https://doi.org/10.1021/acsinfecdis.3c00264","pmid":"https://pubmed.ncbi.nlm.nih.gov/37878861","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10714405"},"language":"en","primary_location":{"id":"doi:10.1021/acsinfecdis.3c00264","doi":"https://doi.org/10.1021/acsinfecdis.3c00264","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.3c00264","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.3c00264","source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.3c00264","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088232304","display_name":"Maytham H. Hussein","orcid":"https://orcid.org/0000-0001-5922-7312","observed_orcids":["https://orcid.org/0000-0001-5922-7312"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Maytham Hussein","raw_affiliation_strings":["Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":"https://orcid.org/0000-0001-5922-7312","affiliations":[{"raw_affiliation_string":"Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087689299","display_name":"Rafah Allobawi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rafah Allobawi","raw_affiliation_strings":["Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000189190","display_name":"Jinxin Zhao","orcid":"https://orcid.org/0000-0002-0604-3541","observed_orcids":["https://orcid.org/0000-0002-0604-3541"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jinxin Zhao","raw_affiliation_strings":["Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038799329","display_name":"Heidi H. Yu","orcid":"https://orcid.org/0000-0002-3337-1399","observed_orcids":["https://orcid.org/0000-0002-3337-1399"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Heidi Yu","raw_affiliation_strings":["Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044723237","display_name":"Stephanie L. Neville","orcid":"https://orcid.org/0000-0002-7298-9335","observed_orcids":["https://orcid.org/0000-0002-7298-9335"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Stephanie L. Neville","raw_affiliation_strings":["Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045310019","display_name":"Jonathan J. Wilksch","orcid":"https://orcid.org/0000-0002-5125-8285","observed_orcids":["https://orcid.org/0000-0002-5125-8285"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jonathan Wilksch","raw_affiliation_strings":["Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria 3010, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009398254","display_name":"Labell J. M. Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Labell J. M. Wong","raw_affiliation_strings":["Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067380502","display_name":"Mark A. Baker","orcid":"https://orcid.org/0000-0003-3933-9784","observed_orcids":["https://orcid.org/0000-0003-3933-9784"]},"institutions":[{"id":"https://openalex.org/I78757542","display_name":"University of Newcastle Australia","ror":"https://ror.org/00eae9z71","country_code":"AU","type":"education","lineage":["https://openalex.org/I78757542"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark Baker","raw_affiliation_strings":["Discipline of Biological Sciences, Priority Research Centre in Reproductive Biology, Faculty of Science and IT, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discipline of Biological Sciences, Priority Research Centre in Reproductive Biology, Faculty of Science and IT, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia","institution_ids":["https://openalex.org/I78757542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066853094","display_name":"Christopher A. McDevitt","orcid":"https://orcid.org/0000-0003-1596-4841","observed_orcids":["https://orcid.org/0000-0003-1596-4841"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210105123","display_name":"Peter Doherty Institute","ror":"https://ror.org/016899r71","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1320473756","https://openalex.org/I165779595","https://openalex.org/I4210105123","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Christopher A. McDevitt","raw_affiliation_strings":["Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria 3010, Australia"],"raw_orcid":"https://orcid.org/0000-0003-1596-4841","affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Victoria 3010, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210105123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090898735","display_name":"Gauri G. Rao","orcid":"https://orcid.org/0000-0002-8704-7770","observed_orcids":["https://orcid.org/0000-0002-8704-7770"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gauri G. Rao","raw_affiliation_strings":["Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7355, United States"],"raw_orcid":"https://orcid.org/0000-0002-8704-7770","affiliations":[{"raw_affiliation_string":"Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7355, United States","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402427","display_name":"Jian Li","orcid":"https://orcid.org/0000-0001-7953-8230","observed_orcids":["https://orcid.org/0000-0001-7953-8230"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Jian Li","raw_affiliation_strings":["Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":"https://orcid.org/0000-0001-7953-8230","affiliations":[{"raw_affiliation_string":"Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020748618","display_name":"Tony Velkov","orcid":"https://orcid.org/0000-0002-0017-7952","observed_orcids":["https://orcid.org/0000-0002-0017-7952"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Tony Velkov","raw_affiliation_strings":["Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":"https://orcid.org/0000-0002-0017-7952","affiliations":[{"raw_affiliation_string":"Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5020748618","https://openalex.org/A5100402427"],"corresponding_institution_ids":["https://openalex.org/I56590836"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":0.759,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.62004292,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"9","issue":"12","first_page":"2409","last_page":"2422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ceftazidime-avibactam","display_name":"ceftazidime-avibactam","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antibiotic-mechanism-of-action","display_name":"antibiotic mechanism of action","score":0.8259999752044678},{"id":"https://openalex.org/keywords/peptidoglycan-synthesis","display_name":"peptidoglycan biosynthesis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/lipopolysaccharide-biosynthesis","display_name":"lipopolysaccharide biosynthesis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/lipid-a","display_name":"lipid A","score":0.753000020980835},{"id":"https://openalex.org/keywords/central-carbon-metabolism","display_name":"central carbon metabolism","score":0.8899999856948853},{"id":"https://openalex.org/keywords/pentose-phosphate-pathway","display_name":"pentose phosphate pathway","score":0.9670000076293945},{"id":"https://openalex.org/keywords/tricarboxylic-acid-cycle","display_name":"TCA cycle","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ceftazidime-resistance","display_name":"ceftazidime resistance","score":0.7870000004768372},{"id":"https://openalex.org/keywords/urinary-tract-infection","display_name":"urinary tract infection","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cell-envelope-biogenesis","display_name":"cell envelope biogenesis","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.7188425064086914},{"id":"https://openalex.org/C2776634448","wikidata":"https://www.wikidata.org/wiki/Q206920","display_name":"Peptidoglycan","level":3,"score":0.668290913105011},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6531627774238586},{"id":"https://openalex.org/C2775933652","wikidata":"https://www.wikidata.org/wiki/Q15410251","display_name":"Ceftazidime/avibactam","level":5,"score":0.646436870098114},{"id":"https://openalex.org/C2776968632","wikidata":"https://www.wikidata.org/wiki/Q808845","display_name":"Ceftazidime","level":4,"score":0.6449384689331055},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6001732349395752},{"id":"https://openalex.org/C3409486","wikidata":"https://www.wikidata.org/wiki/Q827489","display_name":"Pentose phosphate pathway","level":4,"score":0.4831535220146179},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4720343351364136},{"id":"https://openalex.org/C2779110727","wikidata":"https://www.wikidata.org/wiki/Q140475","display_name":"Burkholderia pseudomallei","level":3,"score":0.46715182065963745},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4555349349975586},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.43625566363334656},{"id":"https://openalex.org/C2777406300","wikidata":"https://www.wikidata.org/wiki/Q15410251","display_name":"Avibactam","level":5,"score":0.41205158829689026},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.1940189003944397},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.1901978850364685},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.15491995215415955},{"id":"https://openalex.org/C125235067","wikidata":"https://www.wikidata.org/wiki/Q128700","display_name":"Cell wall","level":2,"score":0.12192344665527344},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.12096241116523743},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0869075357913971},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.06970879435539246}],"mesh":[{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002244","descriptor_name":"Carbon","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002442","descriptor_name":"Ceftazidime","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010457","descriptor_name":"Peptidoglycan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053961","descriptor_name":"Azabicyclo Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1021/acsinfecdis.3c00264","doi":"https://doi.org/10.1021/acsinfecdis.3c00264","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.3c00264","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.3c00264","source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10714405","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10714405","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10714405/pdf/id3c00264.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infect Dis","raw_type":"Text"},{"id":"pmid:37878861","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37878861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:jupiter.its.unimelb.edu.au:11343/339553","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11343/339553","pdf_url":null,"source":{"id":"https://openalex.org/S4377196259","display_name":"Minerva Access (University of Melbourne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165779595","host_organization_name":"The University of Melbourne","host_organization_lineage":["https://openalex.org/I165779595"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:uon:54174","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1959.13/1496557","pdf_url":null,"source":{"id":"https://openalex.org/S4377196471","display_name":"NOVA (University of Newcastle Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I78757542","host_organization_name":"University of Newcastle Australia","host_organization_lineage":["https://openalex.org/I78757542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1021/acsinfecdis.3c00264","doi":"https://doi.org/10.1021/acsinfecdis.3c00264","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsinfecdis.3c00264","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.3c00264","source":{"id":"https://openalex.org/S2764646616","display_name":"ACS Infectious Diseases","issn_l":"2373-8227","issn":["2373-8227"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2771619536","display_name":"Pharmacology of intrathecal/intraventricular polymyxins: A systems-based approach","funder_award_id":"R01AI146241","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5759567083","display_name":null,"funder_award_id":"R01AI170889","funder_id":"https://openalex.org/F4320309123","funder_display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6849526509","display_name":null,"funder_award_id":"R01AI146241","funder_id":"https://openalex.org/F4320309123","funder_display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000868029","display_name":"Development of a broad spectrum teixobactin-lipopeptide hybrid for the treatment of lung infections caused by pan-drug resistant \u2018superbugs\u2019","funder_award_id":"R01AI170889","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320309123","display_name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387934221.pdf","grobid_xml":"https://content.openalex.org/works/W4387934221.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W26641785","https://openalex.org/W1523447849","https://openalex.org/W1591161572","https://openalex.org/W1685574292","https://openalex.org/W1964010911","https://openalex.org/W1969697451","https://openalex.org/W1976034271","https://openalex.org/W1977150791","https://openalex.org/W1985744248","https://openalex.org/W1990891055","https://openalex.org/W1993562651","https://openalex.org/W1994397833","https://openalex.org/W2005137875","https://openalex.org/W2023741270","https://openalex.org/W2025156623","https://openalex.org/W2036377473","https://openalex.org/W2045340639","https://openalex.org/W2045395403","https://openalex.org/W2060350133","https://openalex.org/W2072494970","https://openalex.org/W2074414424","https://openalex.org/W2081305186","https://openalex.org/W2082706597","https://openalex.org/W2089720823","https://openalex.org/W2098627421","https://openalex.org/W2100776225","https://openalex.org/W2101004558","https://openalex.org/W2110888222","https://openalex.org/W2117727921","https://openalex.org/W2120061656","https://openalex.org/W2125640608","https://openalex.org/W2127527061","https://openalex.org/W2138110959","https://openalex.org/W2139191220","https://openalex.org/W2147044107","https://openalex.org/W2155222839","https://openalex.org/W2155800098","https://openalex.org/W2158293950","https://openalex.org/W2162716119","https://openalex.org/W2163236212","https://openalex.org/W2164085556","https://openalex.org/W2167136009","https://openalex.org/W2171680926","https://openalex.org/W2179242062","https://openalex.org/W2267402813","https://openalex.org/W2336704559","https://openalex.org/W2488112774","https://openalex.org/W2508929198","https://openalex.org/W2525692508","https://openalex.org/W2646336719","https://openalex.org/W2745930292","https://openalex.org/W2785435803","https://openalex.org/W2793325503","https://openalex.org/W2803067360","https://openalex.org/W2885761488","https://openalex.org/W2905870662","https://openalex.org/W2913045108","https://openalex.org/W2913385089","https://openalex.org/W2944297467","https://openalex.org/W2980256983","https://openalex.org/W3011704511","https://openalex.org/W3029782267","https://openalex.org/W3080130157","https://openalex.org/W3085434918","https://openalex.org/W3112448915","https://openalex.org/W3127726407","https://openalex.org/W3129180247","https://openalex.org/W3213543470","https://openalex.org/W3215926100","https://openalex.org/W4214649725","https://openalex.org/W4224315183","https://openalex.org/W4280523527","https://openalex.org/W4281762508","https://openalex.org/W4296060396"],"related_works":["https://openalex.org/W4285498548","https://openalex.org/W4396779251","https://openalex.org/W4386614815","https://openalex.org/W3210739725","https://openalex.org/W2625478116","https://openalex.org/W7163641142","https://openalex.org/W3135228551","https://openalex.org/W4396621784","https://openalex.org/W7135377198","https://openalex.org/W2990218567"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"Here,":[7],"we":[8],"employed":[9],"an":[10],"integrated":[11],"metabolomics":[12,158,161],"and":[13,46,60,84,91,123,142,162,200,212,245],"transcriptomics":[14,163],"approach":[15],"to":[16,82],"investigate":[17],"the":[18,44,49,100,107,118,138,147,157,174,184,195,219,239,243],"molecular":[19],"mechanism(s)":[20],"of":[21,23,48,103,112,120,126,149,177,187,198,221,248],"action":[22],"ceftazidime/avibactam":[24,96,131,188,223,249],"against":[25],"a":[26,33,66,109],"pan-drug-resistant":[27],"K.":[28],"pneumoniae":[29],"clinical":[30],"isolate":[31],"from":[32],"patient":[34],"with":[35,55,156,166,173],"urinary":[36],"tract":[37],"infection.":[38],"Ceftazidime/avibactam":[39],"induced":[40],"time-dependent":[41],"perturbations":[42],"in":[43,69,73,106,230],"metabolome":[45],"transcriptome":[47],"bacterium,":[50],"mainly":[51],"at":[52,58],"6":[53],"h,":[54],"minimal":[56],"effects":[57],"1":[59],"3":[61],"h.":[62],"Metabolomics":[63],"analysis":[64],"revealed":[65,218],"notable":[67],"reduction":[68],"essential":[70],"lipids":[71],"involved":[72],"outer":[74],"membrane":[75],"glycerolipid":[76],"biogenesis.":[77],"This":[78,192],"disruption":[79],"effect":[80],"extended":[81],"peptidoglycan":[83,104,128,190,228],"lipopolysaccharide":[85,258],"biosynthetic":[86],"pathways,":[87],"including":[88,205,254],"lipid":[89],"A":[90],"O":[92],"-antigen":[93],"assembly.":[94],"Importantly,":[95],"not":[97],"only":[98],"affected":[99],"final":[101],"steps":[102],"biosynthesis":[105],"periplasm,":[108],"common":[110],"mechanism":[111],"ceftazidime":[113,167,199],"action,":[114],"but":[115],"also":[116,170,182],"influenced":[117],"synthesis":[119],"lipid-linked":[121],"intermediates":[122],"early":[124],"stages":[125],"cytoplasmic":[127],"synthesis.":[129],"Furthermore,":[130],"substantially":[132],"inhibited":[133],"central":[134,213],"carbon":[135,214],"metabolism":[136],"(e.g.,":[137],"pentose":[139],"phosphate":[140],"pathway":[141],"tricarboxylic":[143],"acid":[144],"cycle).":[145],"Consistently,":[146],"dysregulation":[148],"genes":[150],"governing":[151],"these":[152],"metabolic":[153],"pathways":[154],"aligned":[155],"findings.":[159],"Certain":[160],"signatures":[164],"associated":[165],"resistance":[168,246],"were":[169],"perturbed.":[171],"Consistent":[172],"primary":[175],"target":[176],"antibiotic":[178],"activity,":[179],"biochemical":[180],"assays":[181],"confirmed":[183],"direct":[185],"impact":[186,207,256],"on":[189,208,257],"production.":[191],"study":[193,237],"explored":[194],"intricate":[196],"interactions":[197],"avibactam":[201],"within":[202],"bacterial":[203],"cells,":[204],"their":[206],"cell":[209],"envelope":[210],"biogenesis":[211],"metabolism.":[215],"Our":[216],"findings":[217],"complexities":[220],"how":[222],"operates,":[224],"such":[225],"as":[226],"hindering":[227],"formation":[229],"different":[231],"cellular":[232],"compartments.":[233],"In":[234],"summary,":[235],"this":[236],"confirms":[238],"existing":[240],"hypotheses":[241],"about":[242],"antibacterial":[244],"mechanisms":[247],"while":[250],"uncovering":[251],"novel":[252],"insights,":[253],"its":[255],"formation.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-10-26T00:00:00"}
