{"id":"https://openalex.org/W4387931786","doi":"https://doi.org/10.1002/mc.23631","title":"Single\u2010cell sequencing reveals SATB2/NOTCH1 signaling promotes the progression of malignancy of epithelial cells from papillary thyroid cancer","display_name":"Single\u2010cell sequencing reveals SATB2/NOTCH1 signaling promotes the progression of malignancy of epithelial cells from papillary thyroid cancer","publication_year":2023,"publication_date":"2023-10-25","ids":{"openalex":"https://openalex.org/W4387931786","doi":"https://doi.org/10.1002/mc.23631","pmid":"https://pubmed.ncbi.nlm.nih.gov/37877736"},"language":"en","primary_location":{"id":"doi:10.1002/mc.23631","doi":"https://doi.org/10.1002/mc.23631","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mc.23631","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mc.23631","source":{"id":"https://openalex.org/S133439003","display_name":"Molecular Carcinogenesis","issn_l":"0899-1987","issn":["0899-1987","1098-2744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mc.23631","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048717888","display_name":"WenQian Zhang","orcid":"https://orcid.org/0000-0003-4009-303X","observed_orcids":["https://orcid.org/0000-0003-4009-303X"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenqian Zhang","raw_affiliation_strings":["Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Shenyang, China"],"raw_orcid":"https://orcid.org/0000-0003-4009-303X","affiliations":[{"raw_affiliation_string":"Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378656","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0003-1580-1356","observed_orcids":["https://orcid.org/0000-0003-1580-1356","https://orcid.org/0009-0009-7012-5216","https://orcid.org/0000-0002-1980-539X"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103249446","display_name":"Dongning Huang","orcid":"https://orcid.org/0000-0001-8075-4264","observed_orcids":["https://orcid.org/0000-0001-8075-4264"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongning Huang","raw_affiliation_strings":["Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100380642","display_name":"Zhu Liu","orcid":"https://orcid.org/0000-0003-4073-7237","observed_orcids":["https://orcid.org/0000-0003-4073-7237"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhu Liu","raw_affiliation_strings":["Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tie Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tie Lu","raw_affiliation_strings":["Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102004264","display_name":"Cui Chen","orcid":"https://orcid.org/0000-0002-1377-4211","observed_orcids":["https://orcid.org/0000-0002-1377-4211"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Cui","raw_affiliation_strings":["Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001648423","display_name":"Zhendong Li","orcid":"https://orcid.org/0000-0002-6697-0582","observed_orcids":["https://orcid.org/0000-0002-6697-0582"]},"institutions":[{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhendong Li","raw_affiliation_strings":["Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Shenyang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Neck Surgery, Cancer Hospital of China Medical University, Shenyang, China","institution_ids":["https://openalex.org/I91656880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001648423"],"corresponding_institution_ids":["https://openalex.org/I91656880"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":1.1255,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.7977671,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"63","issue":"1","first_page":"22","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/satb2","display_name":"SATB2","score":0.8709999918937683},{"id":"https://openalex.org/keywords/notch1-signaling","display_name":"Notch1 signaling","score":0.9649999737739563},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6129999756813049},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.656000018119812},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.7300000190734863},{"id":"https://openalex.org/keywords/papillary-thyroid-microcarcinoma","display_name":"papillary thyroid microcarcinoma","score":0.847000002861023},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.7070000171661377},{"id":"https://openalex.org/keywords/cell-proliferation-and-migration","display_name":"cell proliferation and migration","score":0.8579999804496765},{"id":"https://openalex.org/keywords/transcriptional-trajectories","display_name":"transcriptional trajectories","score":0.5429999828338623},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7603143453598022},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6561474204063416},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6016886234283447},{"id":"https://openalex.org/C2781461381","wikidata":"https://www.wikidata.org/wiki/Q2292945","display_name":"Papillary thyroid cancer","level":4,"score":0.6002359390258789},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5708309412002563},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.553591787815094},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.5481942892074585},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4979522228240967},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4726860821247101},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.4528123736381531},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4433424472808838},{"id":"https://openalex.org/C174749747","wikidata":"https://www.wikidata.org/wiki/Q15917269","display_name":"Single cell sequencing","level":5,"score":0.43002697825431824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32071805000305176},{"id":"https://openalex.org/C16671776","wikidata":"https://www.wikidata.org/wiki/Q5420592","display_name":"Exome sequencing","level":4,"score":0.2423015832901001},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21618729829788208},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12556025385856628},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1157492995262146},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.10442325472831726}],"mesh":[{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000077273","descriptor_name":"Thyroid Cancer, Papillary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036961","descriptor_name":"Matrix Attachment Region Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D036961","descriptor_name":"Matrix Attachment Region Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051881","descriptor_name":"Receptor, Notch1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/mc.23631","doi":"https://doi.org/10.1002/mc.23631","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mc.23631","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mc.23631","source":{"id":"https://openalex.org/S133439003","display_name":"Molecular Carcinogenesis","issn_l":"0899-1987","issn":["0899-1987","1098-2744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:37877736","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37877736","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular carcinogenesis","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/mc.23631","doi":"https://doi.org/10.1002/mc.23631","is_oa":true,"landing_page_url":"https://doi.org/10.1002/mc.23631","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mc.23631","source":{"id":"https://openalex.org/S133439003","display_name":"Molecular Carcinogenesis","issn_l":"0899-1987","issn":["0899-1987","1098-2744"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Carcinogenesis","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387931786.pdf","grobid_xml":"https://content.openalex.org/works/W4387931786.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1540592014","https://openalex.org/W1994252736","https://openalex.org/W2001957066","https://openalex.org/W2508926319","https://openalex.org/W2511711677","https://openalex.org/W2548265008","https://openalex.org/W2603577764","https://openalex.org/W2746288782","https://openalex.org/W2889646458","https://openalex.org/W2924269422","https://openalex.org/W2946657092","https://openalex.org/W2947593654","https://openalex.org/W2949161518","https://openalex.org/W2951746311","https://openalex.org/W2993946442","https://openalex.org/W2997425419","https://openalex.org/W2999417355","https://openalex.org/W3022968840","https://openalex.org/W3083725095","https://openalex.org/W3086050244","https://openalex.org/W3131976426","https://openalex.org/W3206346662","https://openalex.org/W3209181483","https://openalex.org/W4367676267"],"related_works":["https://openalex.org/W7167824655","https://openalex.org/W4385064251","https://openalex.org/W4414419251","https://openalex.org/W3130368211","https://openalex.org/W4413803352","https://openalex.org/W4224245243","https://openalex.org/W3209181483","https://openalex.org/W3094085965","https://openalex.org/W4404342505","https://openalex.org/W4389366631"],"abstract_inverted_index":{"Although":[0],"most":[1],"papillary":[2,84],"thyroid":[3,78,85,109],"cancers":[4,87],"(PTCs)":[5],"are":[6],"deemed":[7],"to":[8,41,48,106,147],"have":[9],"a":[10,107,113,128],"favorable":[11],"clinical":[12,151],"course":[13],"and":[14,53,75,99,150,155,162,178],"outcome,":[15],"some":[16],"develop":[17],"an":[18],"aggressive":[19],"biological":[20],"behavior":[21],"at":[22],"diagnosis":[23],"or":[24],"during":[25],"treatment.":[26],"Single-cell":[27,121],"RNA":[28,116],"sequencing":[29,68,122],"(scRNA-seq),":[30],"which":[31],"is":[32],"based":[33],"on":[34,69],"quantifying":[35],"the":[36,55,59,133,137,148,159,172,179,182,188,191],"features":[37],"of":[38,139,153,164,176,181,187,194],"individual":[39],"cells":[40],"resolve":[42],"tumor":[43,79],"tissue":[44],"heterogeneity,":[45],"was":[46,127,145,171,185],"used":[47],"uncover":[49],"gene":[50,175],"regulatory":[51],"relationships":[52],"trace":[54],"transcriptional":[56],"trajectories":[57],"underlying":[58],"malignant":[60],"transformation.":[61],"In":[62],"this":[63,195],"study,":[64],"we":[65],"performed":[66],"single-cell":[67,119],"samples":[70],"from":[71],"four":[72],"PTC":[73,93,115,134,165],"patients":[74,94],"one":[76,100,186],"benign":[77,108],"patient.":[80],"These":[81],"included":[82],"two":[83,90],"microcarcinoma":[86],"(PTMC)":[88],"patients,":[89],"age-matched":[91],"advanced":[92],"with":[95],"invading":[96],"surrounding":[97],"tissues,":[98],"patient":[101],"undergoing":[102],"surgical":[103],"treatment":[104],"due":[105],"tumor.":[110],"We":[111,167],"constructed":[112],"new":[114],"spectrum":[117],"using":[118],"sequencing.":[120],"analysis":[123],"indicated":[124],"that":[125,169],"there":[126],"highly":[129],"invasive":[130],"subgroup":[131],"in":[132],"epithelial":[135],"cells,":[136],"expression":[138],"SATB2":[140,156],"(special":[141],"AT-rich":[142],"binding":[143],"protein-2)":[144],"related":[146],"prognosis":[149],"progress":[152],"PTC,":[154],"could":[157],"promote":[158],"proliferation,":[160],"migration,":[161],"invasion":[163],"cells.":[166],"found":[168],"NOTCH1":[170],"key":[173],"target":[174],"SATB2,":[177],"activation":[180],"SATB2/NOTCH1":[183],"pathway":[184],"reasons":[189],"for":[190],"high":[192],"carcinogenicity":[193],"subgroup.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-26T00:00:00"}