{"id":"https://openalex.org/W4387930826","doi":"https://doi.org/10.1681/asn.0000000000000248","title":"Effect of SGLT2 Inhibitors on Discontinuation of Renin\u2013angiotensin System Blockade: A Joint Analysis of the CREDENCE and DAPA-CKD Trials","display_name":"Effect of SGLT2 Inhibitors on Discontinuation of Renin\u2013angiotensin System Blockade: A Joint Analysis of the CREDENCE and DAPA-CKD Trials","publication_year":2023,"publication_date":"2023-10-25","ids":{"openalex":"https://openalex.org/W4387930826","doi":"https://doi.org/10.1681/asn.0000000000000248","pmid":"https://pubmed.ncbi.nlm.nih.gov/37876229","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10703073"},"language":"en","primary_location":{"id":"doi:10.1681/asn.0000000000000248","doi":"https://doi.org/10.1681/asn.0000000000000248","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.0000000000000248","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10703073/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Robert A. Fletcher","orcid":"https://orcid.org/0000-0002-0885-1788","observed_orcids":["https://orcid.org/0000-0002-0885-1788"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Robert A. Fletcher","raw_affiliation_strings":["The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia"],"raw_orcid":"https://orcid.org/0000-0002-0885-1788","affiliations":[{"raw_affiliation_string":"The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210110309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018701033","display_name":"Niels Jongs","orcid":"https://orcid.org/0000-0002-0882-3656","observed_orcids":["https://orcid.org/0000-0002-0882-3656"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Niels Jongs","raw_affiliation_strings":["Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-0882-3656","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034939991","display_name":"Glenn Matthew Chertow","orcid":"https://orcid.org/0000-0002-7599-0534","observed_orcids":["https://orcid.org/0000-0002-7599-0534"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Glenn M. Chertow","raw_affiliation_strings":["Departments of Medicine, Epidemiology and Population Health, and Health Policy, Stanford University School of Medicine, Stanford, California"],"raw_orcid":"https://orcid.org/0000-0002-7599-0534","affiliations":[{"raw_affiliation_string":"Departments of Medicine, Epidemiology and Population Health, and Health Policy, Stanford University School of Medicine, Stanford, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027213857","display_name":"John J.V. McMurray","orcid":"https://orcid.org/0000-0002-6317-3975","observed_orcids":["https://orcid.org/0000-0002-6317-3975"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John J.V. McMurray","raw_affiliation_strings":["Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-6317-3975","affiliations":[{"raw_affiliation_string":"Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040550338","display_name":"Clare Gabrielle Arnott","orcid":"https://orcid.org/0000-0001-9370-9913","observed_orcids":["https://orcid.org/0000-0001-9370-9913"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2799732068","display_name":"Royal Prince Alfred Hospital","ror":"https://ror.org/05gpvde20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799732068"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Clare Arnott","raw_affiliation_strings":["Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia","Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia","The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia"],"raw_orcid":"https://orcid.org/0000-0001-9370-9913","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I2799732068"]},{"raw_affiliation_string":"Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210110309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107481474","display_name":"Meg Jardine","orcid":"https://orcid.org/0000-0002-0160-2375","observed_orcids":["https://orcid.org/0000-0002-0160-2375"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Meg J. Jardine","raw_affiliation_strings":["NHMRC Clinical Trials Centre, University of Sydney, New South Wales, Australia","The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia"],"raw_orcid":"https://orcid.org/0000-0002-0160-2375","affiliations":[{"raw_affiliation_string":"NHMRC Clinical Trials Centre, University of Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210110309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039432822","display_name":"Kenneth W. Mahaffey","orcid":"https://orcid.org/0000-0002-3791-2148","observed_orcids":["https://orcid.org/0000-0002-3791-2148"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth W. Mahaffey","raw_affiliation_strings":["Department of Medicine, Stanford Center for Clinical Research, Stanford University School of Medicine, Stanford, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Stanford Center for Clinical Research, Stanford University School of Medicine, Stanford, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027520502","display_name":"Vlado Perkovic","orcid":"https://orcid.org/0000-0002-4257-7620","observed_orcids":["https://orcid.org/0000-0002-4257-7620"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Vlado Perkovic","raw_affiliation_strings":["Faculty of Medicine and Health, UNSW, Sydney, New South Wales, Australia","The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine and Health, UNSW, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210110309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052668207","display_name":"Patrick Rockenschaub","orcid":"https://orcid.org/0000-0002-6499-7933","observed_orcids":["https://orcid.org/0000-0002-6499-7933"]},"institutions":[{"id":"https://openalex.org/I4210139777","display_name":"Berlin Institute of Health at Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/0493xsw21","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210139777","https://openalex.org/I7877124"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Patrick Rockenschaub","raw_affiliation_strings":["Charit\u00e9 Lab for Artificial Intelligence in Medicine, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany","QUEST Center for Transforming Biomedical Research, Berlin Institute of Health (BIH), Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6499-7933","affiliations":[{"raw_affiliation_string":"Charit\u00e9 Lab for Artificial Intelligence in Medicine, Charit\u00e9 Universit\u00e4tsmedizin Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]},{"raw_affiliation_string":"QUEST Center for Transforming Biomedical Research, Berlin Institute of Health (BIH), Berlin, Germany","institution_ids":["https://openalex.org/I4210139777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085592050","display_name":"Peter R Rossing","orcid":"https://orcid.org/0000-0002-1531-4294","observed_orcids":["https://orcid.org/0000-0002-1531-4294","https://orcid.org/0009-0004-5073-0009"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4405255865","display_name":"Steno Diabetes Center Copenhagen","ror":"https://ror.org/03gqzdg87","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I1339947260","https://openalex.org/I2802567020","https://openalex.org/I4210145385","https://openalex.org/I4405255865"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["AU","DK","NL","US"],"is_corresponding":false,"raw_author_name":"Peter Rossing","raw_affiliation_strings":["Complications Research, Steno Diabetes Center Copenhagen, Copenhagen, Denmark","Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","Departments of Medicine, Epidemiology and Population Health, and Health Policy, Stanford University School of Medicine, Stanford, California","The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia"],"raw_orcid":"https://orcid.org/0000-0002-1531-4294","affiliations":[{"raw_affiliation_string":"Complications Research, Steno Diabetes Center Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I4405255865"]},{"raw_affiliation_string":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"Departments of Medicine, Epidemiology and Population Health, and Health Policy, Stanford University School of Medicine, Stanford, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210110309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060560730","display_name":"Ricardo Correa\u2010Rotter","orcid":"https://orcid.org/0000-0003-0100-8285","observed_orcids":["https://orcid.org/0000-0003-0100-8285"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210097900","display_name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n","ror":"https://ror.org/00xgvev73","country_code":"MX","type":"facility","lineage":["https://openalex.org/I4210095685","https://openalex.org/I4210097900","https://openalex.org/I4210128723"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]},{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["AU","GB","MX"],"is_corresponding":false,"raw_author_name":"Ricardo Correa-Rotter","raw_affiliation_strings":["National Medical Science and Nutrition Institute Salvador Zubir\u00e1n, Mexico City, Mexico","Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom","The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Medical Science and Nutrition Institute Salvador Zubir\u00e1n, Mexico City, Mexico","institution_ids":["https://openalex.org/I4210097900"]},{"raw_affiliation_string":"Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom","institution_ids":["https://openalex.org/I7882870"]},{"raw_affiliation_string":"The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210110309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008309890","display_name":"Robert D. Toto","orcid":"https://orcid.org/0000-0001-9531-1749","observed_orcids":["https://orcid.org/0000-0001-9531-1749"]},"institutions":[{"id":"https://openalex.org/I2799732068","display_name":"Royal Prince Alfred Hospital","ror":"https://ror.org/05gpvde20","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799732068"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Robert D. Toto","raw_affiliation_strings":["Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas","Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia","The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I2799732068"]},{"raw_affiliation_string":"The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210110309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061881316","display_name":"Muthiah Vaduganathan","orcid":"https://orcid.org/0000-0003-0885-1953","observed_orcids":["https://orcid.org/0000-0003-0885-1953"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Muthiah Vaduganathan","raw_affiliation_strings":["Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts","Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia","The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210110309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069865054","display_name":"David Collins. Wheeler","orcid":"https://orcid.org/0000-0003-0745-3478","observed_orcids":["https://orcid.org/0000-0003-0745-3478"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"David C. Wheeler","raw_affiliation_strings":["Department of Renal Medicine, University College London, London, United Kingdom","The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia"],"raw_orcid":"https://orcid.org/0000-0003-0745-3478","affiliations":[{"raw_affiliation_string":"Department of Renal Medicine, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210110309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031624913","display_name":"Hiddo J.L. Heerspink","orcid":"https://orcid.org/0000-0002-3126-3730","observed_orcids":["https://orcid.org/0000-0002-3126-3730"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]}],"countries":["AU","NL"],"is_corresponding":false,"raw_author_name":"Hiddo J.L. Heerspink","raw_affiliation_strings":["Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia"],"raw_orcid":"https://orcid.org/0000-0002-3126-3730","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]},{"raw_affiliation_string":"The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210110309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015488634","display_name":"Brendon Lange Neuen","orcid":"https://orcid.org/0000-0001-9276-8380","observed_orcids":["https://orcid.org/0000-0001-9276-8380"]},"institutions":[{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210110309","display_name":"The George Institute for Global Health","ror":"https://ror.org/023331s46","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210110309"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["AU","US"],"is_corresponding":true,"raw_author_name":"Brendon L. Neuen","raw_affiliation_strings":["Royal North Shore Hospital, Sydney, New South Wales, Australia","The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia","Department of Medicine, Stanford Center for Clinical Research, Stanford University School of Medicine, Stanford, California"],"raw_orcid":"https://orcid.org/0000-0001-9276-8380","affiliations":[{"raw_affiliation_string":"Royal North Shore Hospital, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I2800079252"]},{"raw_affiliation_string":"The George Institute for Global Health, UNSW, Sydney, New South Wales, Australia","institution_ids":["https://openalex.org/I31746571","https://openalex.org/I4210110309"]},{"raw_affiliation_string":"Department of Medicine, Stanford Center for Clinical Research, Stanford University School of Medicine, Stanford, California","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5015488634"],"corresponding_institution_ids":["https://openalex.org/I2800079252","https://openalex.org/I31746571","https://openalex.org/I4210110309","https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":null,"apc_paid":null,"fwci":7.9988,"has_fulltext":true,"cited_by_count":45,"citation_normalized_percentile":{"value":0.98222309,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"34","issue":"12","first_page":"1965","last_page":"1975"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.885699987411499,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.885699987411499,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.042500000447034836,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.02979999966919422,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/renin-angiotensin-system-blockade","display_name":"renin-angiotensin system blockade","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9660000205039978},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.703000009059906},{"id":"https://openalex.org/keywords/medication-discontinuation","display_name":"drug discontinuation","score":0.765999972820282},{"id":"https://openalex.org/keywords/canagliflozin","display_name":"canagliflozin","score":0.8840000033378601},{"id":"https://openalex.org/keywords/dapagliflozin","display_name":"dapagliflozin","score":1.0},{"id":"https://openalex.org/keywords/credence-trial","display_name":"CREDENCE trial","score":0.8019999861717224},{"id":"https://openalex.org/keywords/dapa-ckd-trial","display_name":"DAPA-CKD trial","score":0.9990000128746033},{"id":"https://openalex.org/keywords/albumin-creatinine-ratio","display_name":"albumin-creatinine ratio","score":0.8029999732971191},{"id":"https://openalex.org/keywords/hyperkalemia","display_name":"hyperkalemia","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.8195465803146362},{"id":"https://openalex.org/C2779513410","wikidata":"https://www.wikidata.org/wiki/Q25351567","display_name":"Credence","level":2,"score":0.739111065864563},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.6940157413482666},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.6427386999130249},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.565974235534668},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44855931401252747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41144800186157227},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3208666145801544},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12758073210716248},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.06951364874839783},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.06419482827186584},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077203","descriptor_name":"Sodium-Glucose Transporter 2 Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000418","descriptor_name":"Albumins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000806","descriptor_name":"Angiotensin-Converting Enzyme Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001559","descriptor_name":"Benzhydryl Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003404","descriptor_name":"Creatinine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012084","descriptor_name":"Renin-Angiotensin System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D051436","descriptor_name":"Renal Insufficiency, Chronic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D057911","descriptor_name":"Angiotensin Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D057911","descriptor_name":"Angiotensin Receptor Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1681/asn.0000000000000248","doi":"https://doi.org/10.1681/asn.0000000000000248","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.0000000000000248","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},{"id":"pmid:37876229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37876229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology : JASN","raw_type":"Meta-Analysis"},{"id":"pmh:oai:pubmedcentral.nih.gov:10703073","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10703073/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Soc Nephrol","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire/972d2e74-9520-4fb0-b700-608437c98928","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/972d2e74-9520-4fb0-b700-608437c98928","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fletcher, R A, Jongs, N, Chertow, G M, McMurray, J J V, Arnott, C, Jardine, M J, Mahaffey, K W, Perkovic, V, Rockenschaub, P, Rossing, P, Correa-Rotter, R, Toto, R D, Vaduganathan, M, Wheeler, D C, Heerspink, H J L & Neuen, B L 2023, 'Effect of SGLT2 Inhibitors on Discontinuation of Renin\u2013angiotensin System Blockade : A Joint Analysis of the CREDENCE and DAPA-CKD Trials', Journal of the American Society of Nephrology, vol. 34, no. 12, pp. 1965-1975. https://doi.org/10.1681/ASN.0000000000000248","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10182172","doi":null,"is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10182172/","pdf_url":"https://discovery.ucl.ac.uk/id/eprint/10182172/1/Fletcher%20RAS%20discontinuation%20submission%20KI%20draft_Proof_hi.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the American Society of Nephrology , 34 (12) pp. 1965-1975. (2023)","raw_type":"Article"},{"id":"pmh:oai:eprints.gla.ac.uk:312838","doi":null,"is_oa":true,"landing_page_url":"https://eprints.gla.ac.uk/312838/","pdf_url":null,"source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Articles"},{"id":"pmh:oai:pure.rug.nl:openaire/ebdb4c38-9a29-4cb6-a5ce-7c54a90ff80a","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11370/ebdb4c38-9a29-4cb6-a5ce-7c54a90ff80a","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fletcher, R A, Jongs, N, Chertow, G M, McMurray, J J V, Arnott, C, Jardine, M J, Mahaffey, K W, Perkovic, V, Rockenschaub, P, Rossing, P, Correa-Rotter, R, Toto, R D, Vaduganathan, M, Wheeler, D C, Heerspink, H J L & Neuen, B L 2023, 'Effect of SGLT2 Inhibitors on Discontinuation of Renin\u2013angiotensin System Blockade : A Joint Analysis of the CREDENCE and DAPA-CKD Trials', Journal of the American Society of Nephrology, vol. 34, no. 12, pp. 1965-1975. https://doi.org/10.1681/ASN.0000000000000248","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10703073","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10703073/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Soc Nephrol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306605","display_name":"American Society of Nephrology","ror":"https://ror.org/014pcm848"},{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320308269","display_name":"Alexander von Humboldt-Stiftung","ror":"https://ror.org/012kf4317"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320309056","display_name":"Alnylam Pharmaceuticals","ror":"https://ror.org/00thr3w71"},{"id":"https://openalex.org/F4320310420","display_name":"CSL Behring","ror":"https://ror.org/01jxhxv92"},{"id":"https://openalex.org/F4320311600","display_name":"Regeneron Pharmaceuticals","ror":"https://ror.org/02f51rf24"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320312286","display_name":"Ablynx","ror":"https://ror.org/05s030550"},{"id":"https://openalex.org/F4320313467","display_name":"Alan Turing Institute","ror":"https://ror.org/035dkdb55"},{"id":"https://openalex.org/F4320315432","display_name":"Cytokinetics","ror":"https://ror.org/03tx9ss94"},{"id":"https://openalex.org/F4320316729","display_name":"MyoKardia","ror":"https://ror.org/03efe6r86"},{"id":"https://openalex.org/F4320317866","display_name":"Verily Life Sciences","ror":"https://ror.org/047305x76"},{"id":"https://openalex.org/F4320320337","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"},{"id":"https://openalex.org/F4320323906","display_name":"Vifor Pharma","ror":"https://ror.org/0185z7g17"},{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"},{"id":"https://openalex.org/F4320330753","display_name":"Akebia Therapeutics","ror":"https://ror.org/003br8b23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320334874","display_name":"Defense Acquisition Program Administration","ror":"https://ror.org/04bjg9m96"},{"id":"https://openalex.org/F4320336263","display_name":"Relypsa","ror":"https://ror.org/05japc090"},{"id":"https://openalex.org/F4906014721","display_name":"Medical Research Future Fund","ror":"https://ror.org/0513v5k17"},{"id":"https://openalex.org/F7757660664","display_name":"Health Data Research UK","ror":"https://ror.org/04rtjaj74"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387930826.pdf","grobid_xml":"https://content.openalex.org/works/W4387930826.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W2044773944","https://openalex.org/W2056976690","https://openalex.org/W2063210769","https://openalex.org/W2475261460","https://openalex.org/W2615684303","https://openalex.org/W2935276033","https://openalex.org/W2939222610","https://openalex.org/W2948831315","https://openalex.org/W2949536534","https://openalex.org/W2971414122","https://openalex.org/W3010053023","https://openalex.org/W3088173406","https://openalex.org/W3116941945","https://openalex.org/W3128563134","https://openalex.org/W3139205149","https://openalex.org/W3176071760","https://openalex.org/W3194556280","https://openalex.org/W3194757951","https://openalex.org/W4206148207","https://openalex.org/W4206944595","https://openalex.org/W4223640637","https://openalex.org/W4281938364","https://openalex.org/W4308054131","https://openalex.org/W4308183941","https://openalex.org/W4308291843","https://openalex.org/W4310779918","https://openalex.org/W4323036455","https://openalex.org/W4323306814","https://openalex.org/W4380564289"],"related_works":["https://openalex.org/W4200036147","https://openalex.org/W4380626159","https://openalex.org/W7125117804","https://openalex.org/W2920979216","https://openalex.org/W4361219046","https://openalex.org/W7139982851","https://openalex.org/W4401881901","https://openalex.org/W4310071619","https://openalex.org/W4398234338","https://openalex.org/W4293071026"],"abstract_inverted_index":{"SIGNIFICANCE":[0],"STATEMENT:":[1],"Angiotensin-converting":[2],"enzyme":[3],"(ACE)":[4],"inhibitors":[5,41,70,115,122,153,201,316,378],"and":[6,26,42,60,71,123,172,183,185,259,277,372,394],"angiotensin":[7],"receptor":[8],"blockers":[9],"(ARBs)":[10],"are":[11,17,23,107],"foundational":[12],"therapy":[13],"for":[14,99,230,302],"CKD":[15,45,144,191,370],"but":[16],"underused,":[18],"in":[19,44,77,91,125,143,175,190,202,310],"part":[20],"because":[21],"they":[22],"frequently":[24],"withheld":[25],"not":[27],"restarted":[28],"due":[29],"to":[30,80,131,140,161,212,248,271,313,322,359],"hyperkalemia,":[31],"AKI,":[32],"or":[33,215,228,235],"hospitalization.":[34],"Consequently,":[35],"ensuring":[36],"persistent":[37,133],"use":[38,119,134,381],"of":[39,57,66,68,104,120,135,151,156,170,187,199,218,224,285,292,304,382],"ACE":[40,69,121,226],"ARBs":[43,72,124],"has":[46,159],"long":[47,146],"been":[48,147],"a":[49,167,401],"major":[50],"clinical":[51,180],"priority.":[52],"In":[53,366],"this":[54],"joint":[55,168],"analysis":[56,169],"the":[58,63,101,108,239,250,380],"CREDENCE":[59],"DAPA-CKD":[61],"trials,":[62,290],"relative":[64,300,335],"risk":[65,301],"discontinuation":[67,155,217,303,340],"was":[73,88,210,307,341],"reduced":[74],"by":[75],"15%":[76,308],"patients":[78,92,126,203,295,311,345,367],"randomized":[79,312],"sodium-glucose":[81],"cotransporter":[82],"2":[83,375],"(SGLT2)":[84],"inhibitors.":[85],"This":[86,398],"effect":[87,150,336],"more":[89,342],"pronounced":[90,343],"with":[93,127,177,204,267,324,346,368,371],"urine":[94],"albumin:creatinine":[95,349],"ratio":[96,350],"\u22651000":[97,351],"mg/g,":[98],"whom":[100],"absolute":[102],"benefits":[103],"these":[105],"medications":[106],"greatest.":[109],"These":[110],"findings":[111],"indicate":[112],"that":[113],"SGLT2":[114,152,200,315,377],"may":[116],"enable":[117,132],"better":[118],"CKD.":[128,206],"BACKGROUND:":[129],"Strategies":[130],"renin-angiotensin":[136],"system":[137],"(RAS)":[138],"blockade":[139,158,306,339],"improve":[141],"outcomes":[142,189],"have":[145],"sought.":[148],"The":[149,207,299,334],"on":[154,337],"RAS":[157,219,297,305,338,383],"yet":[160],"be":[162],"evaluated.":[163],"METHODS:":[164],"We":[165],"conducted":[166],"canagliflozin":[171],"renal":[173],"events":[174],"diabetes":[176],"established":[178],"nephropathy":[179],"evaluation":[181],"(CREDENCE)":[182],"dapagliflozin":[184],"prevention":[186],"adverse":[188],"(DAPA-CKD),":[192],"two":[193],"randomized,":[194],"double-blind,":[195],"placebo-controlled,":[196],"event-driven":[197],"trials":[198,328],"albuminuric":[205,369],"main":[208],"outcome":[209],"time":[211],"incident":[213],"temporary":[214],"permanent":[216],"blockade,":[220],"defined":[221],"as":[222],"interruption":[223],"an":[225],"inhibitor":[227],"ARB":[229],"at":[231,403],"least":[232],"4":[233],"weeks":[234],"complete":[236],"cessation":[237],"during":[238],"double-blind":[240],"on-treatment":[241],"period.":[242],"Cox":[243],"regression":[244],"analyses":[245],"were":[246,265],"used":[247],"estimate":[249],"treatment":[251,274],"effects":[252,269,326],"from":[253],"each":[254],"trial.":[255],"Hazard":[256],"ratios":[257],"(HRs)":[258],"corresponding":[260],"95%":[261,319,356],"confidence":[262],"intervals":[263],"(CIs)":[264],"pooled":[266],"fixed":[268],"meta-analysis":[270],"obtain":[272],"summary":[273],"effects,":[275],"overall":[276],"across":[278,288,327],"key":[279],"subgroups.":[280],"RESULTS:":[281],"During":[282],"median":[283],"follow-up":[284],"2.2":[286],"years":[287],"both":[289],"740":[291],"8483":[293],"(8.7%)":[294],"discontinued":[296],"blockade.":[298,384],"lower":[309],"receiving":[314],"(HR,":[317],"0.85;":[318],"CI,":[320,357],"0.74":[321],"0.99),":[323],"consistent":[325],"(":[329],"P":[330,361],"-heterogeneity":[331,362],"=":[332,363],"0.92).":[333],"among":[344],"baseline":[347],"urinary":[348],"mg/g":[352],"(pooled":[353],"HR,":[354],"0.77;":[355],"0.63":[358],"0.94;":[360],"0.009).":[364],"CONCLUSIONS:":[365],"without":[373],"type":[374],"diabetes,":[376],"facilitate":[379],"CLINICAL":[385],"TRIAL":[386],"REGISTRY":[387],"NAME":[388],"AND":[389],"REGISTRATION":[390],"NUMBER:":[391],"ClinicalTrials.gov,":[392],"NCT02065791":[393],"NCT03036150":[395],".":[396],"PODCAST:":[397],"article":[399],"contains":[400],"podcast":[402],"https://dts.podtrac.com/redirect.mp3/www.asn-online.org/media/podcast/JASN/2023_11_21_JASN0000000000000248.mp3.":[404]},"counts_by_year":[{"year":2026,"cited_by_count":18},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-10-26T00:00:00"}
