{"id":"https://openalex.org/W4387926919","doi":"https://doi.org/10.1002/j.1939-4640.1992.tb03327.x","title":"Reactive Oxygen Species and Human Spermatozoa","display_name":"Reactive Oxygen Species and Human Spermatozoa","publication_year":1992,"publication_date":"1992-09-10","ids":{"openalex":"https://openalex.org/W4387926919","doi":"https://doi.org/10.1002/j.1939-4640.1992.tb03327.x","mag":"2141462357","pmid":"https://pubmed.ncbi.nlm.nih.gov/1331006"},"language":"en","primary_location":{"id":"doi:10.1002/j.1939-4640.1992.tb03327.x","doi":"https://doi.org/10.1002/j.1939-4640.1992.tb03327.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1939-4640.1992.tb03327.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1939-4640.1992.tb03327.x","source":{"id":"https://openalex.org/S4394735507","display_name":"Journal of Andrology","issn_l":"0196-3635","issn":["0196-3635","1939-4640"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Andrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1939-4640.1992.tb03327.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018083616","display_name":"Eve de Lamirande","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088756","display_name":"Royal Victoria Hospital","ror":"https://ror.org/00arwy491","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210088756","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"EVE DE LAMIRANDE","raw_affiliation_strings":["Urology Research Laboratory, Royal Victoria Hospital, and Faculty of Medicine, McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology Research Laboratory, Royal Victoria Hospital, and Faculty of Medicine, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210088756","https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110062077","display_name":"Claude Gagnon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088756","display_name":"Royal Victoria Hospital","ror":"https://ror.org/00arwy491","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832","https://openalex.org/I2801902503","https://openalex.org/I4210088756","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"CLAUDE GAGNON","raw_affiliation_strings":["Urology Research Laboratory, Royal Victoria Hospital, and Faculty of Medicine, McGill University, Montreal, Quebec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Urology Research Laboratory, Royal Victoria Hospital, and Faculty of Medicine, McGill University, Montreal, Quebec, Canada","institution_ids":["https://openalex.org/I4210088756","https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018083616"],"corresponding_institution_ids":["https://openalex.org/I4210088756","https://openalex.org/I5023651"],"apc_list":null,"apc_paid":null,"fwci":7.6647,"has_fulltext":true,"cited_by_count":638,"citation_normalized_percentile":{"value":0.98744848,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"13","issue":"5","first_page":"368","last_page":"378"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":1.0},{"id":"https://openalex.org/keywords/spermatozoa","display_name":"spermatozoa","score":0.8640000224113464},{"id":"https://openalex.org/keywords/sperm-immobilization","display_name":"sperm immobilization","score":0.828000009059906},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.8619999885559082},{"id":"https://openalex.org/keywords/xanthine-xanthine-oxidase","display_name":"xanthine/xanthine oxidase","score":0.8610000014305115},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.878000020980835},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.5709999799728394},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.593999981880188},{"id":"https://openalex.org/keywords/hydroxyl-radicals","display_name":"hydroxyl radicals","score":0.9779999852180481},{"id":"https://openalex.org/keywords/ros-scavengers","display_name":"ROS scavengers","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.8320109844207764},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.7710801362991333},{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.6766927242279053},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6073386669158936},{"id":"https://openalex.org/C533411734","wikidata":"https://www.wikidata.org/wiki/Q171877","display_name":"Hydrogen peroxide","level":2,"score":0.5999235510826111},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.597147524356842},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5809876322746277},{"id":"https://openalex.org/C2777632594","wikidata":"https://www.wikidata.org/wiki/Q27116486","display_name":"Sperm motility","level":3,"score":0.5406060218811035},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.488591730594635},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4866850972175598},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.46138742566108704},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41817939281463623},{"id":"https://openalex.org/C2779470414","wikidata":"https://www.wikidata.org/wiki/Q50980","display_name":"Xanthine","level":3,"score":0.41055548191070557},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.38400399684906006},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.36878347396850586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24184241890907288},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.23608821630477905},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013081","descriptor_name":"Sperm Motility","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013082","descriptor_name":"Sperm Tail","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014969","descriptor_name":"Xanthine Oxidase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014970","descriptor_name":"Xanthines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019820","descriptor_name":"Xanthine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/j.1939-4640.1992.tb03327.x","doi":"https://doi.org/10.1002/j.1939-4640.1992.tb03327.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1939-4640.1992.tb03327.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1939-4640.1992.tb03327.x","source":{"id":"https://openalex.org/S4394735507","display_name":"Journal of Andrology","issn_l":"0196-3635","issn":["0196-3635","1939-4640"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Andrology","raw_type":"journal-article"},{"id":"pmid:1331006","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1331006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of andrology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.317.3085","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.317.3085","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.andrologyjournal.org/cgi/reprint/13/5/368.pdf","raw_type":"text"},{"id":"mag:2141462357","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1331006","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.1002/j.1939-4640.1992.tb03327.x","doi":"https://doi.org/10.1002/j.1939-4640.1992.tb03327.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1939-4640.1992.tb03327.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1939-4640.1992.tb03327.x","source":{"id":"https://openalex.org/S4394735507","display_name":"Journal of Andrology","issn_l":"0196-3635","issn":["0196-3635","1939-4640"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Andrology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324195","display_name":"Medical Research Council Canada","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387926919.pdf","grobid_xml":"https://content.openalex.org/works/W4387926919.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W76102735","https://openalex.org/W164441968","https://openalex.org/W1488958486","https://openalex.org/W1495125935","https://openalex.org/W1510590961","https://openalex.org/W1533084749","https://openalex.org/W1561433308","https://openalex.org/W1600112653","https://openalex.org/W1603594423","https://openalex.org/W1684021943","https://openalex.org/W1859350038","https://openalex.org/W1974819250","https://openalex.org/W1983662609","https://openalex.org/W1994291765","https://openalex.org/W2003188074","https://openalex.org/W2004617962","https://openalex.org/W2004827271","https://openalex.org/W2007034973","https://openalex.org/W2014296507","https://openalex.org/W2025962977","https://openalex.org/W2046034387","https://openalex.org/W2053192002","https://openalex.org/W2058113939","https://openalex.org/W2065235858","https://openalex.org/W2074106627","https://openalex.org/W2074387820","https://openalex.org/W2086581266","https://openalex.org/W2088618789","https://openalex.org/W2091711268","https://openalex.org/W2091719073","https://openalex.org/W2095909669","https://openalex.org/W2097873227","https://openalex.org/W2101422765","https://openalex.org/W2128718884","https://openalex.org/W2138063739","https://openalex.org/W2158170522","https://openalex.org/W2160235865","https://openalex.org/W2240504736","https://openalex.org/W2272838734","https://openalex.org/W2322612078","https://openalex.org/W2413311136"],"related_works":["https://openalex.org/W2141462357","https://openalex.org/W7096430273","https://openalex.org/W2615205751","https://openalex.org/W2111247340","https://openalex.org/W2040316987","https://openalex.org/W2007304295","https://openalex.org/W2059100986","https://openalex.org/W1988313730","https://openalex.org/W7099875779","https://openalex.org/W2132323127"],"abstract_inverted_index":{"Mammalian":[0],"spermatozoa":[1,35,77,108,170],"are":[2,189],"sensitive":[3],"to":[4,21,57,94,113,119,184,198],"oxygen-induced":[5],"damages":[6],"mediated":[7],"by":[8,171],"lipid":[9],"peroxidation":[10],"of":[11,17,86,102,106,116,131,153,169,181],"the":[12,42,82,97,103,150,154],"cell":[13],"membrane.":[14],"The":[15,173],"aim":[16],"this":[18],"study":[19],"was":[20,52,149],"evaluate":[22],"whether":[23],"reactive":[24],"oxygen":[25],"species":[26],"(ROS)":[27],"could":[28],"also":[29,163],"induce":[30,178],"axonemal":[31],"damage.":[32],"When":[33],"Percoll-separated":[34],"were":[36],"treated":[37],"with":[38,123],"hydrogen":[39,147],"peroxide,":[40],"or":[41],"combination":[43],"xanthine":[44,46],"and":[45,84,125,143,160,191],"oxidase":[47],"(X":[48],"+":[49],"XO),":[50],"there":[51],"a":[53,58,69,165,179],"progressive":[54],"decrease,":[55],"leading":[56,183],"complete":[59],"arrest,":[60],"in":[61,68,89,96,167],"sperm":[62,185],"flagellar":[63],"beat":[64,126],"frequency.":[65],"Once":[66],"demembranated":[67],"medium":[70],"containing":[71],"magnesium":[72],"adenosine":[73],"triphosphate":[74],"(Mg.ATP),":[75],"ROS-immobilized":[76],"still":[78],"reactivated":[79],"motility;":[80],"however,":[81],"percentage":[83],"duration":[85],"motility":[87,105],"obtained":[88],"these":[90,200],"tests":[91],"gradually":[92],"decreased":[93],"zero":[95],"next":[98],"hour.":[99],"In":[100],"50%":[101],"cases,":[104],"intact":[107],"spontaneously":[109],"reinitiated":[110],"after":[111],"6":[112],"24":[114],"hours":[115],"immobilization":[117,168],"due":[118],"ROS":[120,136,155,177],"treatment,":[121],"although":[122],"percentages":[124],"frequencies":[127],"lower":[128],"than":[129],"those":[130],"untreated":[132],"spermatozoa.":[133],"Studies":[134],"using":[135],"scavengers":[137],"(such":[138],"as":[139],"catalase,":[140],"superoxide":[141],"dismutase,":[142],"dimethylsulfoxide)":[144],"indicated":[145],"that":[146,158,176,187,192],"peroxide":[148],"most":[151],"toxic":[152],"involved,":[156],"but":[157],".O2-":[159],".OH":[161],"probably":[162],"played":[164],"role":[166],"ROS.":[172],"data":[174],"suggest":[175],"chain":[180],"events":[182],"immobilization,":[186],"axonemes":[188],"affected,":[190],"limited":[193],"endogenous":[194],"repair":[195],"mechanisms":[196],"exist":[197],"reverse":[199],"damages.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":32},{"year":2014,"cited_by_count":33},{"year":2013,"cited_by_count":36},{"year":2012,"cited_by_count":33}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-10-25T00:00:00"}