{"id":"https://openalex.org/W4387924978","doi":"https://doi.org/10.1016/j.lfs.2023.122210","title":"LCZ696 attenuates sepsis-induced liver dysfunction in rats; the role of oxidative stress, apoptosis, and JNK1/2-P38 signaling pathways","display_name":"LCZ696 attenuates sepsis-induced liver dysfunction in rats; the role of oxidative stress, apoptosis, and JNK1/2-P38 signaling pathways","publication_year":2023,"publication_date":"2023-10-24","ids":{"openalex":"https://openalex.org/W4387924978","doi":"https://doi.org/10.1016/j.lfs.2023.122210","pmid":"https://pubmed.ncbi.nlm.nih.gov/37883863"},"language":"en","primary_location":{"id":"doi:10.1016/j.lfs.2023.122210","doi":"https://doi.org/10.1016/j.lfs.2023.122210","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lfs.2023.122210","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058286068","display_name":"Reham H. Mohyeldin","orcid":"https://orcid.org/0000-0003-3749-2427","observed_orcids":["https://orcid.org/0000-0003-3749-2427"]},"institutions":[{"id":"https://openalex.org/I4401727001","display_name":"Deraya University","ror":"https://ror.org/05252fg05","country_code":"EG","type":"education","lineage":["https://openalex.org/I4401727001"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Reham H. Mohyeldin","raw_affiliation_strings":["Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt. Electronic address: reham.hassan@deraya.edu.eg","Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt. Electronic address: reham.hassan@deraya.edu.eg","institution_ids":["https://openalex.org/I4401727001"]},{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt","institution_ids":["https://openalex.org/I4401727001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060129859","display_name":"Rania Alaaeldin","orcid":"https://orcid.org/0000-0002-1084-7323","observed_orcids":["https://orcid.org/0000-0002-1084-7323"]},"institutions":[{"id":"https://openalex.org/I4401727001","display_name":"Deraya University","ror":"https://ror.org/05252fg05","country_code":"EG","type":"education","lineage":["https://openalex.org/I4401727001"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Rania Alaaeldin","raw_affiliation_strings":["Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt. Electronic address: rania.alaadin@deraya.edu.eg","Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt. Electronic address: rania.alaadin@deraya.edu.eg","institution_ids":["https://openalex.org/I4401727001"]},{"raw_affiliation_string":"Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt","institution_ids":["https://openalex.org/I4401727001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091966197","display_name":"Ehab E Sharata","orcid":"https://orcid.org/0009-0002-6517-7221","observed_orcids":["https://orcid.org/0009-0002-6517-7221"]},"institutions":[{"id":"https://openalex.org/I4401727001","display_name":"Deraya University","ror":"https://ror.org/05252fg05","country_code":"EG","type":"education","lineage":["https://openalex.org/I4401727001"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ehab E. Sharata","raw_affiliation_strings":["Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt. Electronic address: ehab.essam@deraya.edu.eg","Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt. Electronic address: ehab.essam@deraya.edu.eg","institution_ids":["https://openalex.org/I4401727001"]},{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt","institution_ids":["https://openalex.org/I4401727001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059778120","display_name":"Mina Ezzat Attya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Mina Ezzat Attya","raw_affiliation_strings":["Department of Pathology, Faculty of Medicine, Minia University, Minia 61519, Egypt. Electronic address: mena.ezzat@mu.edu.eg","Department of Pathology, Faculty of Medicine, Minia University, Minia 61519, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, Minia University, Minia 61519, Egypt. Electronic address: mena.ezzat@mu.edu.eg","institution_ids":["https://openalex.org/I89466785"]},{"raw_affiliation_string":"Department of Pathology, Faculty of Medicine, Minia University, Minia 61519, Egypt","institution_ids":["https://openalex.org/I89466785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022826812","display_name":"Eyad Y. Elhamadany","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4401727001","display_name":"Deraya University","ror":"https://ror.org/05252fg05","country_code":"EG","type":"education","lineage":["https://openalex.org/I4401727001"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Eyad Y. Elhamadany","raw_affiliation_strings":["Innovative Research Center, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt. Electronic address: eyad.yehya_1190103@student.deraya.edu.eg","Innovative Research Center, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Innovative Research Center, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt. Electronic address: eyad.yehya_1190103@student.deraya.edu.eg","institution_ids":["https://openalex.org/I4401727001"]},{"raw_affiliation_string":"Innovative Research Center, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt","institution_ids":["https://openalex.org/I4401727001"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033903086","display_name":"Moustafa Fathy","orcid":"https://orcid.org/0000-0002-0734-5007","observed_orcids":["https://orcid.org/0000-0002-0734-5007"]},"institutions":[{"id":"https://openalex.org/I89466785","display_name":"Minia University","ror":"https://ror.org/02hcv4z63","country_code":"EG","type":"education","lineage":["https://openalex.org/I89466785"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Moustafa Fathy","raw_affiliation_strings":["Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt. Electronic address: mostafa_fathe@minia.edu.eg","Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt. Electronic address: mostafa_fathe@minia.edu.eg","institution_ids":["https://openalex.org/I89466785"]},{"raw_affiliation_string":"Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt","institution_ids":["https://openalex.org/I89466785"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033903086"],"corresponding_institution_ids":["https://openalex.org/I89466785"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":5.1966,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.9640794,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"334","issue":null,"first_page":"122210","last_page":"122210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sacubitril-valsartan","display_name":"sacubitril/valsartan","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.9010000228881836},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8349999785423279},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/jnk1-2-signaling","display_name":"JNK1/2 signaling","score":0.949999988079071},{"id":"https://openalex.org/keywords/p38-mapk-signaling","display_name":"p38 MAPK signaling","score":0.8679999709129333},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.7820000052452087},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8349999785423279},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8650000095367432},{"id":"https://openalex.org/keywords/angiotensin-receptor-blockers","display_name":"angiotensin receptor blockers","score":0.8309999704360962},{"id":"https://openalex.org/keywords/neprilysin-inhibitors","display_name":"neprilysin inhibitors","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C2777387769","wikidata":"https://www.wikidata.org/wiki/Q155472","display_name":"Valsartan","level":3,"score":0.6633570194244385},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6033269166946411},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5668099522590637},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.5453763008117676},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.54152911901474},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5093575716018677},{"id":"https://openalex.org/C2779679107","wikidata":"https://www.wikidata.org/wiki/Q412474","display_name":"Aspartate transaminase","level":4,"score":0.5091008543968201},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.4886615574359894},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.4532604217529297},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.4468895196914673},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43948984146118164},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41900914907455444},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.41167041659355164},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33282798528671265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2416597306728363},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.20163831114768982},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.18171468377113342},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.12019553780555725},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10415804386138916},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068756","descriptor_name":"Valsartan","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000068756","descriptor_name":"Valsartan","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000613","descriptor_name":"Aminobutyrates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001713","descriptor_name":"Biphenyl Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.lfs.2023.122210","doi":"https://doi.org/10.1016/j.lfs.2023.122210","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.lfs.2023.122210","pdf_url":null,"source":{"id":"https://openalex.org/S175775512","display_name":"Life Sciences","issn_l":"0024-3205","issn":["0024-3205","1879-0631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life Sciences","raw_type":"journal-article"},{"id":"pmid:37883863","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37883863","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Life sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W9660048","https://openalex.org/W803682140","https://openalex.org/W1821665499","https://openalex.org/W1965909642","https://openalex.org/W1976652640","https://openalex.org/W1980045113","https://openalex.org/W1993322737","https://openalex.org/W2018466091","https://openalex.org/W2020053961","https://openalex.org/W2029619625","https://openalex.org/W2032877170","https://openalex.org/W2037405671","https://openalex.org/W2045499771","https://openalex.org/W2050856345","https://openalex.org/W2063953032","https://openalex.org/W2071272265","https://openalex.org/W2073456593","https://openalex.org/W2098615156","https://openalex.org/W2116965731","https://openalex.org/W2121000910","https://openalex.org/W2123710523","https://openalex.org/W2125000572","https://openalex.org/W2136953729","https://openalex.org/W2147550589","https://openalex.org/W2151311812","https://openalex.org/W2160167304","https://openalex.org/W2274614736","https://openalex.org/W2341452993","https://openalex.org/W2495566817","https://openalex.org/W2590902226","https://openalex.org/W2782989835","https://openalex.org/W2795193116","https://openalex.org/W2884114138","https://openalex.org/W2913483701","https://openalex.org/W2955313267","https://openalex.org/W2998004290","https://openalex.org/W2998853022","https://openalex.org/W3000324902","https://openalex.org/W3010949090","https://openalex.org/W3087243951","https://openalex.org/W3095580586","https://openalex.org/W3142849547","https://openalex.org/W3188883398","https://openalex.org/W3194911931","https://openalex.org/W3197967652","https://openalex.org/W4200407083","https://openalex.org/W4214671422","https://openalex.org/W4283768839","https://openalex.org/W4288809189","https://openalex.org/W4313453446","https://openalex.org/W4313473435","https://openalex.org/W4323830543","https://openalex.org/W4361214669","https://openalex.org/W4376879251","https://openalex.org/W4380538202","https://openalex.org/W4385620143","https://openalex.org/W6600399998","https://openalex.org/W6678201021","https://openalex.org/W6781586553","https://openalex.org/W6800497052","https://openalex.org/W6839358712","https://openalex.org/W6854921904"],"related_works":["https://openalex.org/W4405071442","https://openalex.org/W4394760241","https://openalex.org/W4323830543","https://openalex.org/W4415236665","https://openalex.org/W2897114025","https://openalex.org/W4413031246","https://openalex.org/W2359485442","https://openalex.org/W1573864939","https://openalex.org/W3008977274","https://openalex.org/W2006150041"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":10}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-10-25T00:00:00"}