{"id":"https://openalex.org/W4387909052","doi":"https://doi.org/10.3390/ph16111512","title":"DP2, a Carbohydrate Derivative, Enhances In Vitro Osteoblast Mineralisation","display_name":"DP2, a Carbohydrate Derivative, Enhances In Vitro Osteoblast Mineralisation","publication_year":2023,"publication_date":"2023-10-24","ids":{"openalex":"https://openalex.org/W4387909052","doi":"https://doi.org/10.3390/ph16111512","pmid":"https://pubmed.ncbi.nlm.nih.gov/38004380","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10674337"},"language":"en","primary_location":{"id":"doi:10.3390/ph16111512","doi":"https://doi.org/10.3390/ph16111512","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ph16111512","pdf_url":"https://www.mdpi.com/1424-8247/16/11/1512/pdf?version=1698146627","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1424-8247/16/11/1512/pdf?version=1698146627","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065860894","display_name":"Nissrine Ballout","orcid":"https://orcid.org/0000-0001-8301-3170","observed_orcids":["https://orcid.org/0000-0001-8301-3170"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4387153827","display_name":"Institut Toulousain des Maladies Infectieuses et Inflammatoires","ror":"https://ror.org/00n90tt57","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4387153827","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405269606","display_name":"SATT Nord (France)","ror":"https://ror.org/04prezx56","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405269606"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nissrine Ballout","raw_affiliation_strings":["Institut Toulousain des Maladies Infectieuses et Inflammatoires, INSERM UMR1291, CNRS UMR5051, University of Toulouse III, 31024 Toulouse, France","Service de Biochimie, Institut F\u00e9d\u00e9ratif de Biologie, CHU Toulouse, 31024 Toulouse, France","Soci\u00e9t\u00e9 d\u2019Acc\u00e9l\u00e9ration du Transfert de Technologie-Nord, 59800 Lille, France","Infinity - Institut Toulousain des Maladies Infectieuses et Inflammatoires (BP 3028 \r\n31024 Toulouse Cedex 3 - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Toulousain des Maladies Infectieuses et Inflammatoires, INSERM UMR1291, CNRS UMR5051, University of Toulouse III, 31024 Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4387153827","https://openalex.org/I4405258862"]},{"raw_affiliation_string":"Service de Biochimie, Institut F\u00e9d\u00e9ratif de Biologie, CHU Toulouse, 31024 Toulouse, France","institution_ids":["https://openalex.org/I3019448017"]},{"raw_affiliation_string":"Soci\u00e9t\u00e9 d\u2019Acc\u00e9l\u00e9ration du Transfert de Technologie-Nord, 59800 Lille, France","institution_ids":["https://openalex.org/I4405269606"]},{"raw_affiliation_string":"Infinity - Institut Toulousain des Maladies Infectieuses et Inflammatoires (BP 3028 \r\n31024 Toulouse Cedex 3 - France)","institution_ids":["https://openalex.org/I4387153827","https://openalex.org/I4405258862"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071804019","display_name":"Agn\u00e8s Boullier","orcid":"https://orcid.org/0000-0003-3721-3934","observed_orcids":["https://orcid.org/0000-0003-3721-3934"]},"institutions":[{"id":"https://openalex.org/I4210096553","display_name":"Centre Hospitalier Universitaire Amiens-Picardie","ror":"https://ror.org/010567a58","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210096553"]},{"id":"https://openalex.org/I4401200359","display_name":"M\u00e9canismes physiopathologiques et cons\u00e9quences des calcifications cardiovasculaires","ror":"https://ror.org/00bgnvd66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Agn\u00e8s Boullier","raw_affiliation_strings":["Laboratory of Biochemistry, CHU Amiens-Picardie, 80054 Amiens, France","M\u00e9canismes Physiopathologiques et Cons\u00e9quences des Calcifications Cardiovasculaires, UR7517, Centre Universitaire de Recherche en Sant\u00e9, CURS-UPJV, University of Picardy Jules Verne, 80054 Amiens, France"],"raw_orcid":"https://orcid.org/0000-0003-3721-3934","affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry, CHU Amiens-Picardie, 80054 Amiens, France","institution_ids":["https://openalex.org/I4210096553"]},{"raw_affiliation_string":"M\u00e9canismes Physiopathologiques et Cons\u00e9quences des Calcifications Cardiovasculaires, UR7517, Centre Universitaire de Recherche en Sant\u00e9, CURS-UPJV, University of Picardy Jules Verne, 80054 Amiens, France","institution_ids":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033610833","display_name":"Walaa Darwiche","orcid":"https://orcid.org/0000-0002-8647-2468","observed_orcids":["https://orcid.org/0000-0002-8647-2468"]},"institutions":[{"id":"https://openalex.org/I4405269606","display_name":"SATT Nord (France)","ror":"https://ror.org/04prezx56","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405269606"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Walaa Darwiche","raw_affiliation_strings":["Soci\u00e9t\u00e9 d\u2019Acc\u00e9l\u00e9ration du Transfert de Technologie-Nord, 59800 Lille, France"],"raw_orcid":"https://orcid.org/0000-0002-8647-2468","affiliations":[{"raw_affiliation_string":"Soci\u00e9t\u00e9 d\u2019Acc\u00e9l\u00e9ration du Transfert de Technologie-Nord, 59800 Lille, France","institution_ids":["https://openalex.org/I4405269606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047333076","display_name":"Katia A\u00eft-Mohand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210105717","display_name":"Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources","ror":"https://ror.org/01gje7n16","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210105717","https://openalex.org/I4210128300","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Katia Ait-Mohand","raw_affiliation_strings":["Laboratoire de Glycochimie et des Agroressources d\u2019Amiens, UR 7378, CNRS, Universit\u00e9 de Picardie Jules Verne, 80039 Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de Glycochimie et des Agroressources d\u2019Amiens, UR 7378, CNRS, Universit\u00e9 de Picardie Jules Verne, 80039 Amiens, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210105717","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052809537","display_name":"E. Tr\u00e9cherel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4401200359","display_name":"M\u00e9canismes physiopathologiques et cons\u00e9quences des calcifications cardiovasculaires","ror":"https://ror.org/00bgnvd66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eric Tr\u00e9cherel","raw_affiliation_strings":["M\u00e9canismes Physiopathologiques et Cons\u00e9quences des Calcifications Cardiovasculaires, UR7517, Centre Universitaire de Recherche en Sant\u00e9, CURS-UPJV, University of Picardy Jules Verne, 80054 Amiens, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M\u00e9canismes Physiopathologiques et Cons\u00e9quences des Calcifications Cardiovasculaires, UR7517, Centre Universitaire de Recherche en Sant\u00e9, CURS-UPJV, University of Picardy Jules Verne, 80054 Amiens, France","institution_ids":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093119518","display_name":"Th\u00e9o Gall\u00e9go","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269606","display_name":"SATT Nord (France)","ror":"https://ror.org/04prezx56","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405269606"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Th\u00e9o Gall\u00e9go","raw_affiliation_strings":["Soci\u00e9t\u00e9 d\u2019Acc\u00e9l\u00e9ration du Transfert de Technologie-Nord, 59800 Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soci\u00e9t\u00e9 d\u2019Acc\u00e9l\u00e9ration du Transfert de Technologie-Nord, 59800 Lille, France","institution_ids":["https://openalex.org/I4405269606"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007493626","display_name":"Cathy Gomila","orcid":"https://orcid.org/0000-0003-4260-3312","observed_orcids":["https://orcid.org/0000-0003-4260-3312"]},"institutions":[{"id":"https://openalex.org/I4401200359","display_name":"M\u00e9canismes physiopathologiques et cons\u00e9quences des calcifications cardiovasculaires","ror":"https://ror.org/00bgnvd66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cathy Gomila","raw_affiliation_strings":["M\u00e9canismes Physiopathologiques et Cons\u00e9quences des Calcifications Cardiovasculaires, UR7517, Centre Universitaire de Recherche en Sant\u00e9, CURS-UPJV, University of Picardy Jules Verne, 80054 Amiens, France"],"raw_orcid":"https://orcid.org/0000-0003-4260-3312","affiliations":[{"raw_affiliation_string":"M\u00e9canismes Physiopathologiques et Cons\u00e9quences des Calcifications Cardiovasculaires, UR7517, Centre Universitaire de Recherche en Sant\u00e9, CURS-UPJV, University of Picardy Jules Verne, 80054 Amiens, France","institution_ids":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038813892","display_name":"Linda Yaker","orcid":"https://orcid.org/0000-0002-6849-7098","observed_orcids":["https://orcid.org/0000-0002-6849-7098"]},"institutions":[{"id":"https://openalex.org/I4401200359","display_name":"M\u00e9canismes physiopathologiques et cons\u00e9quences des calcifications cardiovasculaires","ror":"https://ror.org/00bgnvd66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Linda Yaker","raw_affiliation_strings":["M\u00e9canismes Physiopathologiques et Cons\u00e9quences des Calcifications Cardiovasculaires, UR7517, Centre Universitaire de Recherche en Sant\u00e9, CURS-UPJV, University of Picardy Jules Verne, 80054 Amiens, France"],"raw_orcid":"https://orcid.org/0000-0002-6849-7098","affiliations":[{"raw_affiliation_string":"M\u00e9canismes Physiopathologiques et Cons\u00e9quences des Calcifications Cardiovasculaires, UR7517, Centre Universitaire de Recherche en Sant\u00e9, CURS-UPJV, University of Picardy Jules Verne, 80054 Amiens, France","institution_ids":["https://openalex.org/I4401200359","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026290571","display_name":"Isabelle Gennero","orcid":"https://orcid.org/0000-0002-8572-7852","observed_orcids":["https://orcid.org/0000-0002-8572-7852"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4387153827","display_name":"Institut Toulousain des Maladies Infectieuses et Inflammatoires","ror":"https://ror.org/00n90tt57","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4387153827","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isabelle Gennero","raw_affiliation_strings":["Institut Toulousain des Maladies Infectieuses et Inflammatoires, INSERM UMR1291, CNRS UMR5051, University of Toulouse III, 31024 Toulouse, France","Service de Biochimie, Institut F\u00e9d\u00e9ratif de Biologie, CHU Toulouse, 31024 Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Toulousain des Maladies Infectieuses et Inflammatoires, INSERM UMR1291, CNRS UMR5051, University of Toulouse III, 31024 Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4387153827","https://openalex.org/I4405258862"]},{"raw_affiliation_string":"Service de Biochimie, Institut F\u00e9d\u00e9ratif de Biologie, CHU Toulouse, 31024 Toulouse, France","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085837006","display_name":"Jos\u00e9 Kovensky","orcid":"https://orcid.org/0000-0002-6398-2721","observed_orcids":["https://orcid.org/0000-0002-6398-2721"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210105717","display_name":"Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources","ror":"https://ror.org/01gje7n16","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210105717","https://openalex.org/I4210128300","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Kovensky","raw_affiliation_strings":["Laboratoire de Glycochimie et des Agroressources d\u2019Amiens, UR 7378, CNRS, Universit\u00e9 de Picardie Jules Verne, 80039 Amiens, France"],"raw_orcid":"https://orcid.org/0000-0002-6398-2721","affiliations":[{"raw_affiliation_string":"Laboratoire de Glycochimie et des Agroressources d\u2019Amiens, UR 7378, CNRS, Universit\u00e9 de Picardie Jules Verne, 80039 Amiens, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210105717","https://openalex.org/I4647051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021072051","display_name":"J\u00e9r\u00f4me Ausseil","orcid":"https://orcid.org/0000-0002-3059-9777","observed_orcids":["https://orcid.org/0000-0002-3059-9777"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019448017","display_name":"Centre Hospitalier Universitaire de Toulouse","ror":"https://ror.org/017h5q109","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017"]},{"id":"https://openalex.org/I4387153827","display_name":"Institut Toulousain des Maladies Infectieuses et Inflammatoires","ror":"https://ror.org/00n90tt57","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4387153827","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I4405258862","display_name":"Universit\u00e9 de Toulouse","ror":"https://ror.org/01ahyrz84","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"J\u00e9r\u00f4me Ausseil","raw_affiliation_strings":["Institut Toulousain des Maladies Infectieuses et Inflammatoires, INSERM UMR1291, CNRS UMR5051, University of Toulouse III, 31024 Toulouse, France","Service de Biochimie, Institut F\u00e9d\u00e9ratif de Biologie, CHU Toulouse, 31024 Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Toulousain des Maladies Infectieuses et Inflammatoires, INSERM UMR1291, CNRS UMR5051, University of Toulouse III, 31024 Toulouse, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4387153827","https://openalex.org/I4405258862"]},{"raw_affiliation_string":"Service de Biochimie, Institut F\u00e9d\u00e9ratif de Biologie, CHU Toulouse, 31024 Toulouse, France","institution_ids":["https://openalex.org/I3019448017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010170269","display_name":"Sylvestre Toumieux","orcid":"https://orcid.org/0000-0001-5035-6732","observed_orcids":["https://orcid.org/0000-0001-5035-6732"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210105717","display_name":"Laboratoire de Glycochimie, des Antimicrobiens et des Agroressources","ror":"https://ror.org/01gje7n16","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210105717","https://openalex.org/I4210128300","https://openalex.org/I4647051"]},{"id":"https://openalex.org/I4647051","display_name":"Universit\u00e9 de Picardie Jules Verne","ror":"https://ror.org/01gyxrk03","country_code":"FR","type":"education","lineage":["https://openalex.org/I4647051"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Sylvestre Toumieux","raw_affiliation_strings":["Laboratoire de Glycochimie et des Agroressources d\u2019Amiens, UR 7378, CNRS, Universit\u00e9 de Picardie Jules Verne, 80039 Amiens, France"],"raw_orcid":"https://orcid.org/0000-0001-5035-6732","affiliations":[{"raw_affiliation_string":"Laboratoire de Glycochimie et des Agroressources d\u2019Amiens, UR 7378, CNRS, Universit\u00e9 de Picardie Jules Verne, 80039 Amiens, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210105717","https://openalex.org/I4647051"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5010170269","https://openalex.org/A5021072051"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I3019448017","https://openalex.org/I4210105717","https://openalex.org/I4387153827","https://openalex.org/I4405258862","https://openalex.org/I4647051"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2447},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2447},"fwci":0.2043,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.33342334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"16","issue":"11","first_page":"1512","last_page":"1512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.6172000169754028,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.6172000169754028,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.3041999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disaccharides","display_name":"disaccharides","score":0.828000009059906},{"id":"https://openalex.org/keywords/fracture-healing","display_name":"fracture healing","score":0.8709999918937683},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.859000027179718},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.8519999980926514},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.8379999995231628},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":1.0},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.9710000157356262},{"id":"https://openalex.org/keywords/bone-tissue-engineering","display_name":"bone tissue engineering","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.8521451354026794},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.7313838005065918},{"id":"https://openalex.org/C2776363554","wikidata":"https://www.wikidata.org/wiki/Q14907085","display_name":"RUNX2","level":4,"score":0.6610985994338989},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.6233614087104797},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.5808638334274292},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5606708526611328},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.46453338861465454},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.4425647556781769},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.43463003635406494},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.4292319416999817},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40516945719718933},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38994210958480835},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37595412135124207},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32007139921188354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26417291164398193},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24743670225143433},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24656614661216736},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.20831257104873657},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1092265248298645},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/ph16111512","doi":"https://doi.org/10.3390/ph16111512","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ph16111512","pdf_url":"https://www.mdpi.com/1424-8247/16/11/1512/pdf?version=1698146627","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10674337","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10674337","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10674337/pdf/pharmaceuticals-16-01512.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel)","raw_type":"Text"},{"id":"pmid:38004380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38004380","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04345194v1","doi":null,"is_oa":false,"landing_page_url":"https://www.mdpi.com/1424-8247/16/11/1512/pdf?version=1698146627","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceuticals, 2023, 16 (11), pp.1512. ⟨10.3390/ph16111512⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:d6163f796d494d689c2dc1e66048285e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d6163f796d494d689c2dc1e66048285e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmaceuticals, Vol 16, Iss 11, p 1512 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ph16111512","doi":"https://doi.org/10.3390/ph16111512","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3390/ph16111512","pdf_url":"https://www.mdpi.com/1424-8247/16/11/1512/pdf?version=1698146627","source":{"id":"https://openalex.org/S16322639","display_name":"Pharmaceuticals","issn_l":"1424-8247","issn":["1424-8247"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmaceuticals","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3640262662","display_name":null,"funder_award_id":"M0290","funder_id":"https://openalex.org/F4320330625","funder_display_name":"Soci\u00e9t\u00e9 d'Acc\u00e9l\u00e9ration du Transfert de Technologies"},{"id":"https://openalex.org/G4349196561","display_name":"SATT NORD","funder_award_id":"ANR-10-SATT-0007","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320330625","display_name":"Soci\u00e9t\u00e9 d'Acc\u00e9l\u00e9ration du Transfert de Technologies","ror":"https://ror.org/04prezx56"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387909052.pdf","grobid_xml":"https://content.openalex.org/works/W4387909052.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1966887326","https://openalex.org/W1981089517","https://openalex.org/W1996326320","https://openalex.org/W1998531735","https://openalex.org/W2001094576","https://openalex.org/W2004208751","https://openalex.org/W2021306647","https://openalex.org/W2022557971","https://openalex.org/W2036557984","https://openalex.org/W2066541040","https://openalex.org/W2071756412","https://openalex.org/W2074645659","https://openalex.org/W2076020571","https://openalex.org/W2088972765","https://openalex.org/W2097943906","https://openalex.org/W2102131116","https://openalex.org/W2109293470","https://openalex.org/W2109882510","https://openalex.org/W2111469399","https://openalex.org/W2117802681","https://openalex.org/W2125728570","https://openalex.org/W2147806383","https://openalex.org/W2154094043","https://openalex.org/W2164833748","https://openalex.org/W2169635106","https://openalex.org/W2405381679","https://openalex.org/W2539243579","https://openalex.org/W2587573568","https://openalex.org/W2600380571","https://openalex.org/W2623981860","https://openalex.org/W2791103531","https://openalex.org/W2885189035","https://openalex.org/W2892313859","https://openalex.org/W3011094403","https://openalex.org/W3033932089","https://openalex.org/W3125837796","https://openalex.org/W3160932252","https://openalex.org/W3164857664","https://openalex.org/W3176415813","https://openalex.org/W4210583963","https://openalex.org/W6682055846"],"related_works":["https://openalex.org/W4407189430","https://openalex.org/W4390689605","https://openalex.org/W1985452128","https://openalex.org/W3133922279","https://openalex.org/W1974717771","https://openalex.org/W1991477586","https://openalex.org/W2353847032","https://openalex.org/W1972472502","https://openalex.org/W2585682951","https://openalex.org/W2341750407"],"abstract_inverted_index":{"Bone":[0,25],"fracture":[1,74,196],"healing":[2],"is":[3,173,188],"a":[4,28,69,106,189],"complex":[5],"biological":[6],"process":[7],"involving":[8],"four":[9],"phases":[10],"coordinated":[11],"over":[12],"time:":[13],"hematoma":[14],"formation,":[15,18,21],"granulation":[16],"tissue":[17,55],"bony":[19],"callus":[20],"and":[22,37,54,84,90,127,148,170,178],"bone":[23,63,85,195],"remodelling.":[24],"fractures":[26,47],"represent":[27],"significant":[29],"health":[30],"problem,":[31],"particularly":[32],"among":[33],"the":[34,49,77,103,112,118,130,180],"elderly":[35],"population":[36],"patients":[38],"with":[39],"comorbidities.":[40],"Therapeutic":[41],"strategies":[42],"proposed":[43],"to":[44,72,110,162],"treat":[45],"such":[46],"include":[48],"use":[50,104],"of":[51,80,105,120,168],"autografts,":[52],"allografts,":[53],"engineering":[56],"strategies.":[57],"It":[58],"has":[59,68],"been":[60,93],"shown":[61],"that":[62,136],"morphogenetic":[64],"protein":[65,181],"2":[66],"(BMP-2)":[67],"therapeutic":[70],"potential":[71,190],"enhance":[73],"healing.":[75],"Despite":[76],"clinical":[78],"efficacy":[79],"BMP-2":[81,163],"in":[82,96,98,155,158,175],"osteoinduction":[83],"repair,":[86],"adverse":[87],"side":[88],"effects":[89],"complications":[91],"have":[92],"reported.":[94],"Therefore,":[95],"this":[97],"vitro":[99,156],"study,":[100],"we":[101],"propose":[102],"disaccharide":[107],"compound":[108],"(DP2)":[109],"improve":[111],"mineralisation":[113,157],"process.":[114],"We":[115],"first":[116],"evaluated":[117],"effect":[119],"DP2":[121,138,152,172,187],"on":[122],"primary":[123],"human":[124],"osteoblasts":[125],"(HOb),":[126],"then":[128],"investigated":[129],"mechanisms":[131],"involved.":[132],"Our":[133],"findings":[134],"showed":[135],"(i)":[137],"improved":[139],"osteoblast":[140],"differentiation":[141],"by":[142,165],"inducing":[143],"alkaline":[144],"phosphatase":[145],"activity,":[146],"osteopontin,":[147],"osteocalcin":[149],"expression;":[150],"(ii)":[151],"induced":[153],"earlier":[154,166],"HOb":[159,176],"cells":[160,177],"compared":[161],"mainly":[164],"activation":[167],"Runx2;":[169],"(iii)":[171],"internalized":[174],"activates":[179],"kinase":[182],"C":[183],"signalling":[184],"pathway.":[185],"Consequently,":[186],"therapeutical":[191],"candidate":[192],"molecule":[193],"for":[194],"repair.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-10-25T00:00:00"}