{"id":"https://openalex.org/W4387908077","doi":"https://doi.org/10.3390/biomedicines11112877","title":"The Antioxidative Effects of Flavones in Hypertensive Disease","display_name":"The Antioxidative Effects of Flavones in Hypertensive Disease","publication_year":2023,"publication_date":"2023-10-24","ids":{"openalex":"https://openalex.org/W4387908077","doi":"https://doi.org/10.3390/biomedicines11112877","pmid":"https://pubmed.ncbi.nlm.nih.gov/38001878","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10669108"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines11112877","doi":"https://doi.org/10.3390/biomedicines11112877","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines11112877","pdf_url":"https://www.mdpi.com/2227-9059/11/11/2877/pdf?version=1698135427","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/11/11/2877/pdf?version=1698135427","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020125932","display_name":"Alexandria Porcia Haynes","orcid":"https://orcid.org/0009-0004-3723-0325","observed_orcids":["https://orcid.org/0009-0004-3723-0325"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandria Porcia Haynes","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, 2215 Garland Avenue, P415C Medical Research Building IV, Nashville, TN 37212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, 2215 Garland Avenue, P415C Medical Research Building IV, Nashville, TN 37212, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093119350","display_name":"Selam Desta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137853757","display_name":"Howard University","ror":"https://ror.org/05gt1vc06","country_code":"US","type":"education","lineage":["https://openalex.org/I137853757"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Selam Desta","raw_affiliation_strings":["Department of Biology, College of Arts and Sciences, Howard University, Washington, DC 20059, USA","Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, 2215 Garland Avenue, P415C Medical Research Building IV, Nashville, TN 37212, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, College of Arts and Sciences, Howard University, Washington, DC 20059, USA","institution_ids":["https://openalex.org/I137853757"]},{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, 2215 Garland Avenue, P415C Medical Research Building IV, Nashville, TN 37212, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029191129","display_name":"Taseer Ahmad","orcid":"https://orcid.org/0000-0003-4545-9598","observed_orcids":["https://orcid.org/0000-0003-4545-9598"]},"institutions":[{"id":"https://openalex.org/I160968435","display_name":"University of Sargodha","ror":"https://ror.org/0086rpr26","country_code":"PK","type":"education","lineage":["https://openalex.org/I160968435"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["PK","US"],"is_corresponding":false,"raw_author_name":"Taseer Ahmad","raw_affiliation_strings":["Department of Pharmacology, College of Pharmacy, University of Sargodha, University Road, Sargodha 40100, Punjab, Pakistan","Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, 2215 Garland Avenue, P415C Medical Research Building IV, Nashville, TN 37212, USA"],"raw_orcid":"https://orcid.org/0000-0003-4545-9598","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, College of Pharmacy, University of Sargodha, University Road, Sargodha 40100, Punjab, Pakistan","institution_ids":["https://openalex.org/I160968435"]},{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, 2215 Garland Avenue, P415C Medical Research Building IV, Nashville, TN 37212, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077137538","display_name":"Kit Neikirk","orcid":"https://orcid.org/0000-0003-0994-0333","observed_orcids":["https://orcid.org/0000-0003-0994-0333"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kit Neikirk","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University, 2201 West End Ave, Nashville, TN 37235, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University, 2201 West End Ave, Nashville, TN 37235, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005382653","display_name":"Antentor Othrell Hinton Jr.","orcid":"https://orcid.org/0000-0002-7730-952X","observed_orcids":["https://orcid.org/0000-0002-7730-952X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antentor Hinton","raw_affiliation_strings":["Department of Molecular Physiology and Biophysics, Vanderbilt University, 2201 West End Ave, Nashville, TN 37235, USA"],"raw_orcid":"https://orcid.org/0000-0002-7730-952X","affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology and Biophysics, Vanderbilt University, 2201 West End Ave, Nashville, TN 37235, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065305905","display_name":"Nathaniel C. Bloodworth","orcid":"https://orcid.org/0000-0002-5758-003X","observed_orcids":["https://orcid.org/0000-0002-5758-003X"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nathaniel Bloodworth","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, 2215 Garland Avenue, P415C Medical Research Building IV, Nashville, TN 37212, USA"],"raw_orcid":"https://orcid.org/0000-0002-5758-003X","affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, 2215 Garland Avenue, P415C Medical Research Building IV, Nashville, TN 37212, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091099970","display_name":"Annet Kirabo","orcid":"https://orcid.org/0000-0001-8580-9359","observed_orcids":["https://orcid.org/0000-0001-8580-9359"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Annet Kirabo","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, 2215 Garland Avenue, P415C Medical Research Building IV, Nashville, TN 37212, USA"],"raw_orcid":"https://orcid.org/0000-0001-8580-9359","affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, 2215 Garland Avenue, P415C Medical Research Building IV, Nashville, TN 37212, USA","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5065305905","https://openalex.org/A5091099970"],"corresponding_institution_ids":["https://openalex.org/I901861585"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2447},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2447},"fwci":0.2378,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.37174211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"11","issue":"11","first_page":"2877","last_page":"2877"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.49709999561309814,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.49709999561309814,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.32670000195503235,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13023","display_name":"Synthesis of Organic Compounds","score":0.046300001442432404,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flavones","display_name":"flavones","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8700000047683716},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7099999785423279},{"id":"https://openalex.org/keywords/diosmetin","display_name":"diosmetin","score":0.7770000100135803},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.5770000219345093},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.5490000247955322},{"id":"https://openalex.org/keywords/enac","display_name":"epithelial sodium channel","score":0.824999988079071},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9599999785423279},{"id":"https://openalex.org/keywords/dietary-salt","display_name":"dietary salt","score":0.6169999837875366},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.7409999966621399},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/isolevuglandins","display_name":"isolevuglandins","score":0.9330000281333923},{"id":"https://openalex.org/keywords/vasodilation","display_name":"vasodilation","score":0.753000020980835},{"id":"https://openalex.org/keywords/cardiovascular-disease-prevention","display_name":"cardiovascular disease prevention","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8065837621688843},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.6658452153205872},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6220085024833679},{"id":"https://openalex.org/C2776292868","wikidata":"https://www.wikidata.org/wiki/Q424525","display_name":"Flavones","level":2,"score":0.6064116954803467},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5607830882072449},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5070421695709229},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4780433773994446},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.4393366873264313},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.41378387808799744},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38858044147491455},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3156896233558655},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28810474276542664},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27288979291915894},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines11112877","doi":"https://doi.org/10.3390/biomedicines11112877","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines11112877","pdf_url":"https://www.mdpi.com/2227-9059/11/11/2877/pdf?version=1698135427","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10669108","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10669108","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10669108/pdf/biomedicines-11-02877.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmid:38001878","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/38001878","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:aade5931be904862a9f4da06ce3be350","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/aade5931be904862a9f4da06ce3be350","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 11, Iss 11, p 2877 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines11112877","doi":"https://doi.org/10.3390/biomedicines11112877","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines11112877","pdf_url":"https://www.mdpi.com/2227-9059/11/11/2877/pdf?version=1698135427","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1221739687","display_name":null,"funder_award_id":"DK,059637","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1356008085","display_name":"Advancing drug repositioning and development for Alzheimer's Disease using functional genomics and computational phenomics","funder_award_id":"R56AG068026","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2250880259","display_name":"Functional heterogeneity of cardiac reparative cells after injury","funder_award_id":"R01HL138519","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2615776415","display_name":null,"funder_award_id":"UL1TR002243","funder_id":"https://openalex.org/F4320316438","funder_display_name":"Georgia Clinical and Translational Science Alliance"},{"id":"https://openalex.org/G3181196069","display_name":"Vanderbilt Hypertension and Blood Pressure Regulation Program","funder_award_id":"T32HL144446","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4099681973","display_name":"Vanderbilt Mouse Metabolic Phenotyping Center","funder_award_id":"U24DK059637","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4410787187","display_name":null,"funder_award_id":"UL1 TR002243","funder_id":"https://openalex.org/F4320313998","funder_display_name":"Vanderbilt University Medical Center"},{"id":"https://openalex.org/G4424950377","display_name":null,"funder_award_id":"DK059637","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G8282954169","display_name":"Deep phenotypic and functional characterization of salt-responsive immune cells in human salt senstive hypertension using CTE-seq","funder_award_id":"R03HL155041","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000052735","display_name":null,"funder_award_id":"DK-020593","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000860136","display_name":"ENaC regulation and its role in blood pressure homeostasis","funder_award_id":"R01HL147818","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000865370","display_name":"Immune Mechanisms of Salt-Sensitive hypertension","funder_award_id":"R01HL144941","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000872578","display_name":"Vanderbilt Institute for Clinical and Translational Research (VICTR)","funder_award_id":"UL1TR002243","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000900818","display_name":"Vanderbilt Diabetes Research Center","funder_award_id":"P30DK020593","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000916097","display_name":"Anti-cytomegalovirus Immune Responses in Atherosclerotic Cardiovascular Disease in Persons Living with HIV","funder_award_id":"K23HL156759","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320313998","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74"},{"id":"https://openalex.org/F4320316438","display_name":"Georgia Clinical and Translational Science Alliance","ror":"https://ror.org/034hw7m59"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387908077.pdf","grobid_xml":"https://content.openalex.org/works/W4387908077.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W167717536","https://openalex.org/W1617145133","https://openalex.org/W2017019443","https://openalex.org/W2018393112","https://openalex.org/W2029588268","https://openalex.org/W2032707824","https://openalex.org/W2063322657","https://openalex.org/W2064194276","https://openalex.org/W2065398758","https://openalex.org/W2068087430","https://openalex.org/W2086099890","https://openalex.org/W2094939646","https://openalex.org/W2099766466","https://openalex.org/W2104209180","https://openalex.org/W2121173772","https://openalex.org/W2126816808","https://openalex.org/W2136491537","https://openalex.org/W2142583550","https://openalex.org/W2142742192","https://openalex.org/W2148678392","https://openalex.org/W2163956097","https://openalex.org/W2204695023","https://openalex.org/W2213776593","https://openalex.org/W2418065255","https://openalex.org/W2565383127","https://openalex.org/W2586933469","https://openalex.org/W2604881436","https://openalex.org/W2748053146","https://openalex.org/W2758757285","https://openalex.org/W2765521509","https://openalex.org/W2770837559","https://openalex.org/W2785069458","https://openalex.org/W2789391988","https://openalex.org/W2793988446","https://openalex.org/W2883624246","https://openalex.org/W2893910294","https://openalex.org/W2901215621","https://openalex.org/W2909346807","https://openalex.org/W2910199594","https://openalex.org/W2914563881","https://openalex.org/W2923194742","https://openalex.org/W2946687847","https://openalex.org/W2952684089","https://openalex.org/W2955179958","https://openalex.org/W2965542317","https://openalex.org/W2974882876","https://openalex.org/W2991666958","https://openalex.org/W3012160466","https://openalex.org/W3013574851","https://openalex.org/W3014550287","https://openalex.org/W3023529892","https://openalex.org/W3024860770","https://openalex.org/W3032174505","https://openalex.org/W3034765389","https://openalex.org/W3044288852","https://openalex.org/W3045150712","https://openalex.org/W3046527607","https://openalex.org/W3083341372","https://openalex.org/W3093208992","https://openalex.org/W3110258185","https://openalex.org/W3137453670","https://openalex.org/W3143437408","https://openalex.org/W3153494025","https://openalex.org/W3164719796","https://openalex.org/W3165088505","https://openalex.org/W3176130204","https://openalex.org/W3183000838","https://openalex.org/W3198396671","https://openalex.org/W3199888270","https://openalex.org/W4200337903","https://openalex.org/W4200394929","https://openalex.org/W4210571652","https://openalex.org/W4211063923","https://openalex.org/W4220930810","https://openalex.org/W4285041859","https://openalex.org/W4289204868","https://openalex.org/W4297540010","https://openalex.org/W4307052075","https://openalex.org/W4310197307","https://openalex.org/W4313362474","https://openalex.org/W4319925253","https://openalex.org/W4320495670","https://openalex.org/W4378675053","https://openalex.org/W4385009748","https://openalex.org/W4407177572","https://openalex.org/W6746134454"],"related_works":["https://openalex.org/W2945573963","https://openalex.org/W3009172670","https://openalex.org/W4394797620","https://openalex.org/W3212712390","https://openalex.org/W2940719564","https://openalex.org/W3203416460","https://openalex.org/W2173978055","https://openalex.org/W7116883285","https://openalex.org/W4412110927","https://openalex.org/W7171938020"],"abstract_inverted_index":{"Hypertension":[0],"is":[1,21,39,160],"the":[2,13,50,112,177],"leading":[3,60],"remediable":[4],"risk":[5],"factor":[6],"for":[7,72,155],"cardiovascular":[8],"morbidity":[9],"and":[10,55,86,104,129,185],"mortality":[11],"in":[12,167],"United":[14],"States.":[15],"Excess":[16],"dietary":[17],"salt":[18],"consumption,":[19],"which":[20,79,159],"a":[22,69,121,137],"catalyst":[23,71],"of":[24,32,64,139,179],"hypertension,":[25,156],"initiates":[26],"an":[27,87],"inflammatory":[28,88],"cascade":[29],"via":[30],"activation":[31],"antigen-presenting":[33],"cells":[34],"(APCs).":[35],"This":[36,172],"pro-inflammatory":[37],"response":[38],"driven":[40],"primarily":[41],"by":[42,49,100],"sodium":[43,52],"ions":[44],"(Na+)":[45],"transporting":[46],"into":[47],"APCs":[48],"epithelial":[51],"channel":[53],"(ENaC)":[54],"subsequent":[56],"NADPH":[57],"oxidase":[58],"activation,":[59],"to":[61,116,150,162,181],"high":[62],"levels":[63],"oxidative":[65],"stress.":[66],"Oxidative":[67],"stress,":[68],"well-known":[70],"hypertension-related":[73],"illness":[74],"development,":[75],"disturbs":[76],"redox":[77],"homeostasis,":[78],"ultimately":[80],"promotes":[81],"lipid":[82],"peroxidation,":[83],"isolevuglandin":[84],"production":[85],"response.":[89],"Natural":[90],"medicinal":[91],"compounds":[92],"derived":[93],"from":[94],"organic":[95],"materials":[96],"that":[97,141,146],"are":[98,136],"characterized":[99],"their":[101,117],"anti-inflammatory,":[102],"anti-oxidative,":[103],"anti-mutagenic":[105],"properties":[106],"have":[107,125,142],"recently":[108],"gained":[109],"traction":[110],"amongst":[111],"pharmacology":[113],"community":[114],"due":[115],"therapeutic":[118,127,153,187],"effects.":[119],"Flavonoids,":[120],"natural":[122],"phenolic":[123],"compound,":[124],"these":[126],"benefits":[128],"can":[130],"potentially":[131],"serve":[132],"as":[133,152],"anti-hypertensives.":[134],"Flavones":[135],"type":[138],"flavonoid":[140],"increased":[143],"anti-inflammatory":[144],"effects":[145],"may":[147],"allow":[148],"them":[149],"act":[151],"agents":[154],"including":[157],"diosmetin,":[158],"able":[161],"induce":[163],"significant":[164],"arterial":[165],"vasodilation":[166],"several":[168],"different":[169],"animal":[170],"models.":[171],"review":[173],"will":[174],"focus":[175],"on":[176],"activity":[178],"flavones":[180],"illuminate":[182],"potential":[183,186],"preventative":[184],"mechanisms":[188],"against":[189],"hypertension.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-10-25T00:00:00"}