{"id":"https://openalex.org/W4387908049","doi":"https://doi.org/10.30629/2618-6667-2023-21-5-77-85","title":"Fragments of Oxidized Extracellular DNA Affect the Development of Oxidative Stress in the Peripheral Blood Mononuclear Cells in vitro in Patients with Childhood Autism","display_name":"Fragments of Oxidized Extracellular DNA Affect the Development of Oxidative Stress in the Peripheral Blood Mononuclear Cells in vitro in Patients with Childhood Autism","publication_year":2023,"publication_date":"2023-10-24","ids":{"openalex":"https://openalex.org/W4387908049","doi":"https://doi.org/10.30629/2618-6667-2023-21-5-77-85"},"language":"en","primary_location":{"id":"doi:10.30629/2618-6667-2023-21-5-77-85","doi":"https://doi.org/10.30629/2618-6667-2023-21-5-77-85","is_oa":true,"landing_page_url":"http://dx.doi.org/10.30629/2618-6667-2023-21-5-77-85","pdf_url":"https://www.journalpsychiatry.com/jour/article/download/1047/657","source":{"id":"https://openalex.org/S4210182900","display_name":"Psikhiatriya","issn_l":"1683-8319","issn":["1683-8319","2618-6667"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psikhiatriya","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4387908049"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.journalpsychiatry.com/jour/article/download/1047/657","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083482238","display_name":"Yu. M. Chudakova","orcid":"https://orcid.org/0000-0002-0299-426X","observed_orcids":["https://orcid.org/0000-0002-0299-426X"]},"institutions":[{"id":"https://openalex.org/I126527374","display_name":"Peoples' Friendship University of Russia","ror":"https://ror.org/02dn9h927","country_code":"RU","type":"education","lineage":["https://openalex.org/I126527374"]},{"id":"https://openalex.org/I4210126689","display_name":"Research Centre for Medical Genetics","ror":"https://ror.org/03dhz7247","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126689"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ju. M. Chudakova","raw_affiliation_strings":["FSBSI \u201cResearch Centre for Medical Genetics\u201d; The Patrice Lumumba Peoples\u2019 Friendship University of Russia"],"raw_orcid":"https://orcid.org/0000-0002-0299-426X","affiliations":[{"raw_affiliation_string":"FSBSI \u201cResearch Centre for Medical Genetics\u201d; The Patrice Lumumba Peoples\u2019 Friendship University of Russia","institution_ids":["https://openalex.org/I126527374","https://openalex.org/I4210126689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031442003","display_name":"\u041d\u0438\u043a\u0438\u0442\u0438\u043d\u0430 \u0421\u0432\u0435\u0442\u043b\u0430\u043d\u0430 \u0413\u0435\u043d\u043d\u0430\u0434\u044c\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0000-0002-7775-1692","observed_orcids":["https://orcid.org/0000-0002-7775-1692"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. G. Nikitina","raw_affiliation_strings":["FSBSI \u201cMental Health Research Centre\u201d"],"raw_orcid":"https://orcid.org/0000-0002-7775-1692","affiliations":[{"raw_affiliation_string":"FSBSI \u201cMental Health Research Centre\u201d","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044304912","display_name":"Lev N. Porokhovnik","orcid":"https://orcid.org/0000-0002-3664-6685","observed_orcids":["https://orcid.org/0000-0002-3664-6685"]},"institutions":[{"id":"https://openalex.org/I4210126689","display_name":"Research Centre for Medical Genetics","ror":"https://ror.org/03dhz7247","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126689"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L. N. Porokhovnik","raw_affiliation_strings":["FSBSI \u201cResearch Centre for Medical Genetics\u201d"],"raw_orcid":"https://orcid.org/0000-0002-3664-6685","affiliations":[{"raw_affiliation_string":"FSBSI \u201cResearch Centre for Medical Genetics\u201d","institution_ids":["https://openalex.org/I4210126689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054405791","display_name":"Elizaveta Sergeevna Ershova","orcid":"https://orcid.org/0000-0003-1206-5832","observed_orcids":["https://orcid.org/0000-0003-1206-5832"]},"institutions":[{"id":"https://openalex.org/I4210126689","display_name":"Research Centre for Medical Genetics","ror":"https://ror.org/03dhz7247","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126689"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. S. Ershova","raw_affiliation_strings":["FSBSI \u201cResearch Centre for Medical Genetics\u201d"],"raw_orcid":"https://orcid.org/0000-0003-1206-5832","affiliations":[{"raw_affiliation_string":"FSBSI \u201cResearch Centre for Medical Genetics\u201d","institution_ids":["https://openalex.org/I4210126689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039131110","display_name":"\u0413. \u0412. \u0428\u043c\u0430\u0440\u0438\u043d\u0430","orcid":"https://orcid.org/0000-0003-4851-8987","observed_orcids":["https://orcid.org/0000-0003-4851-8987"]},"institutions":[{"id":"https://openalex.org/I4210126689","display_name":"Research Centre for Medical Genetics","ror":"https://ror.org/03dhz7247","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126689"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"G. V. Shmarina","raw_affiliation_strings":["FSBSI \u201cResearch Centre for Medical Genetics\u201d"],"raw_orcid":"https://orcid.org/0000-0003-4851-8987","affiliations":[{"raw_affiliation_string":"FSBSI \u201cResearch Centre for Medical Genetics\u201d","institution_ids":["https://openalex.org/I4210126689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079881874","display_name":"\u041d. \u041d. \u0412\u0435\u0439\u043a\u043e","orcid":"https://orcid.org/0000-0003-1847-0548","observed_orcids":["https://orcid.org/0000-0003-1847-0548"]},"institutions":[{"id":"https://openalex.org/I4210126689","display_name":"Research Centre for Medical Genetics","ror":"https://ror.org/03dhz7247","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126689"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"N. N. Veiko","raw_affiliation_strings":["FSBSI \u201cResearch Centre for Medical Genetics\u201d"],"raw_orcid":"https://orcid.org/0000-0003-1847-0548","affiliations":[{"raw_affiliation_string":"FSBSI \u201cResearch Centre for Medical Genetics\u201d","institution_ids":["https://openalex.org/I4210126689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067776668","display_name":"\u0410. \u0412. \u041c\u0430\u0440\u0442\u044b\u043d\u043e\u0432","orcid":"https://orcid.org/0000-0002-6697-8306","observed_orcids":["https://orcid.org/0000-0002-6697-8306"]},"institutions":[{"id":"https://openalex.org/I4210126689","display_name":"Research Centre for Medical Genetics","ror":"https://ror.org/03dhz7247","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126689"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"A. V. Martynov","raw_affiliation_strings":["FSBSI \u201cResearch Centre for Medical Genetics\u201d"],"raw_orcid":"https://orcid.org/0000-0002-6697-8306","affiliations":[{"raw_affiliation_string":"FSBSI \u201cResearch Centre for Medical Genetics\u201d","institution_ids":["https://openalex.org/I4210126689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091476251","display_name":"\u0415. \u0410. \u0411\u0430\u043b\u0430\u043a\u0438\u0440\u0435\u0432\u0430","orcid":"https://orcid.org/0000-0002-3919-7045","observed_orcids":["https://orcid.org/0000-0002-3919-7045"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. E. Balakireva","raw_affiliation_strings":["FSBSI \u201cMental Health Research Centre\u201d"],"raw_orcid":"https://orcid.org/0000-0002-3919-7045","affiliations":[{"raw_affiliation_string":"FSBSI \u201cMental Health Research Centre\u201d","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111062222","display_name":"Svetlana Kostuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126689","display_name":"Research Centre for Medical Genetics","ror":"https://ror.org/03dhz7247","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210126689"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"S. E. Kostuk","raw_affiliation_strings":["FSBSI \u201cResearch Centre for Medical Genetics\u201d"],"raw_orcid":"https://orcid.org/0000-0002-6336-9900","affiliations":[{"raw_affiliation_string":"FSBSI \u201cResearch Centre for Medical Genetics\u201d","institution_ids":["https://openalex.org/I4210126689"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.233,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.42721136,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"21","issue":"5","first_page":"77","last_page":"85"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-autism","display_name":"childhood autism","score":0.9909999966621399},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.7919999957084656},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9670000076293945},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9490000009536743},{"id":"https://openalex.org/keywords/dna-oxidation","display_name":"DNA oxidation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/8-hydroxy-2-deoxyguanosine","display_name":"8-hydroxy-2'-deoxyguanosine","score":0.8479999899864197},{"id":"https://openalex.org/keywords/gamma-h2ax","display_name":"\u03b3H2AX","score":0.8289999961853027},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.8429999947547913},{"id":"https://openalex.org/keywords/chromosomal-damage","display_name":"chromosomal damage","score":0.8029999732971191},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.5649999976158142},{"id":"https://openalex.org/keywords/autism-pathogenesis","display_name":"autism pathogenesis","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.8459385633468628},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6975326538085938},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6939740180969238},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6115541458129883},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5389500260353088},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5015010833740234},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4624960422515869},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4400511682033539},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3989272713661194},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38329002261161804},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36488983035087585},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35952621698379517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3189024031162262},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23228666186332703},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20905324816703796}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.30629/2618-6667-2023-21-5-77-85","doi":"https://doi.org/10.30629/2618-6667-2023-21-5-77-85","is_oa":true,"landing_page_url":"http://dx.doi.org/10.30629/2618-6667-2023-21-5-77-85","pdf_url":"https://www.journalpsychiatry.com/jour/article/download/1047/657","source":{"id":"https://openalex.org/S4210182900","display_name":"Psikhiatriya","issn_l":"1683-8319","issn":["1683-8319","2618-6667"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psikhiatriya","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.30629/2618-6667-2023-21-5-77-85","doi":"https://doi.org/10.30629/2618-6667-2023-21-5-77-85","is_oa":true,"landing_page_url":"http://dx.doi.org/10.30629/2618-6667-2023-21-5-77-85","pdf_url":"https://www.journalpsychiatry.com/jour/article/download/1047/657","source":{"id":"https://openalex.org/S4210182900","display_name":"Psikhiatriya","issn_l":"1683-8319","issn":["1683-8319","2618-6667"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psikhiatriya","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387908049.pdf","grobid_xml":"https://content.openalex.org/works/W4387908049.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W2052206341","https://openalex.org/W2057810394","https://openalex.org/W2081816257","https://openalex.org/W2103913197","https://openalex.org/W2120423982","https://openalex.org/W2126239952","https://openalex.org/W2128294896","https://openalex.org/W2130603879","https://openalex.org/W2167684047","https://openalex.org/W2217230681","https://openalex.org/W2332766086","https://openalex.org/W2417325310","https://openalex.org/W2580871841","https://openalex.org/W2750097589","https://openalex.org/W2790139502","https://openalex.org/W2793006112","https://openalex.org/W2793552722","https://openalex.org/W2960920107","https://openalex.org/W2981275956","https://openalex.org/W3014767518","https://openalex.org/W3022652372","https://openalex.org/W3042712693","https://openalex.org/W3140131020","https://openalex.org/W4200311191","https://openalex.org/W4319763570","https://openalex.org/W4324360358","https://openalex.org/W4360600181"],"related_works":["https://openalex.org/W4200311191","https://openalex.org/W3042712693","https://openalex.org/W2152240719","https://openalex.org/W4296526971","https://openalex.org/W4308075229","https://openalex.org/W2099480695","https://openalex.org/W2120337985","https://openalex.org/W4321507026","https://openalex.org/W2769245551"],"abstract_inverted_index":{"Background:":[0],"the":[1,12,24,31,41,60,72,82,89,101,115,147,164,179,203,211,215,219,226,238,245,259,262,274,283],"etiology":[2],"and":[3,39,67,71,95,113,126,156,194,232,244],"pathogenesis":[4,284],"of":[5,11,16,26,59,84,91,97,152,167,181,222,228,247,261,276,278,285],"childhood":[6],"autism":[7],"(CA)":[8],"is":[9,266],"one":[10],"important":[13],"unresolved":[14],"problems":[15],"child":[17],"psychiatry.":[18],"It":[19],"has":[20],"been":[21],"shown":[22],"that":[23],"concentration":[25],"extracellular":[27,280],"DNA":[28,62,69,99,144,177,189,230,281],"(cfDNA)":[29],"in":[30,35,44,65,100,106,108,160,171,218,282],"blood":[32,103,149],"significantly":[33,56],"increases":[34],"children":[36,109,130,153,223],"with":[37,46,50,110,121,154,224],"CA,":[38,225],"to":[40,80,124,173,175,210,253,268],"greatest":[42],"extent":[43],"patients":[45,119],"severe":[47,52],"CA.":[48,111,286],"Patients":[49,112],"more":[51,242],"CA":[53,155],"also":[54,235],"have":[55],"elevated":[57],"levels":[58,180,227,246],"oxidized":[61,85,142,176,279],"marker":[63,75],"8-OHdG":[64],"cfDNA":[66,86],"nuclear":[68,98],"samples":[70],"double-strand":[73],"break":[74],"\u03b3H2AX.":[76],"The":[77],"aim":[78],"was":[79],"study":[81,116],"effect":[83],"fragments":[87,145,277],"on":[88,258],"formation":[90],"free":[92],"radicals,":[93],"oxidation":[94,190],"breaks":[96],"peripheral":[102,148],"mononuclear":[104,150,165,220],"cells":[105,151,166,221],"vitro":[107],"methods:":[114],"involved":[117],"13":[118],"diagnosed":[120],"F84.02":[122],"according":[123],"ICD-10":[125],"10":[127],"conditionally":[128,157,168],"healthy":[129,158,169],"as":[131],"a":[132,271],"control":[133],"group.":[134],"Clinical-psychopathological,":[135],"molecularbiological,":[136],"statistical":[137],"methods":[138],"were":[139],"used.":[140],"Results:":[141],"model":[143],"affect":[146],"donors":[159],"different":[161],"ways.":[162],"In":[163],"donors,":[170],"response":[172],"exposure":[174],"fragments,":[178],"ROS":[182],"(reactive":[183],"oxygen":[184],"species)":[185],"(p":[186,191,197],"<":[187,192,198],"0.05),":[188],"0.05)":[193,199],"chromosome":[195,233],"damage":[196,234],"increase,":[200,236],"but":[201,237],"within":[202],"next":[204],"24":[205],"hours":[206],"these":[207,248],"indicators":[208,249],"return":[209,252],"previous":[212,255],"level.":[213],"At":[214],"same":[216],"time,":[217],"ROS,":[229],"oxidation,":[231],"subsequent":[239],"decrease":[240],"occurs":[241],"slowly,":[243],"do":[250],"not":[251],"their":[254],"values.":[256],"Conclusion:":[257],"basis":[260],"obtained":[263],"results,":[264],"it":[265],"possible":[267],"put":[269],"forward":[270],"hypothesis":[272],"about":[273],"participation":[275]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2023-10-25T00:00:00"}
