{"id":"https://openalex.org/W4387908024","doi":"https://doi.org/10.3892/etm.2023.12268","title":"Effect of autologous lyophilized platelet\u2011rich fibrin on the reconstruction of osteochondral defects in rabbits","display_name":"Effect of autologous lyophilized platelet\u2011rich fibrin on the reconstruction of osteochondral defects in rabbits","publication_year":2023,"publication_date":"2023-10-24","ids":{"openalex":"https://openalex.org/W4387908024","doi":"https://doi.org/10.3892/etm.2023.12268","pmid":"https://pubmed.ncbi.nlm.nih.gov/37954116","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10632968"},"language":"en","primary_location":{"id":"doi:10.3892/etm.2023.12268","doi":"https://doi.org/10.3892/etm.2023.12268","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2023.12268","pdf_url":"https://www.spandidos-publications.com/10.3892/etm.2023.12268/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4387908024"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.spandidos-publications.com/10.3892/etm.2023.12268/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jianwei Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianwei Sun","raw_affiliation_strings":["The Fourth Recuperate Area, Guangzhou Special Service Recuperation Center of People's Liberation Army (PLA) of China Rocket Force, Guangzhou, Guangdong 510515, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Fourth Recuperate Area, Guangzhou Special Service Recuperation Center of People's Liberation Army (PLA) of China Rocket Force, Guangzhou, Guangdong 510515, P.R. China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102282839","display_name":"Leng Han","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leng Han","raw_affiliation_strings":["Department of Pathology, General Hospital of Southern Theater Command of PLA, Guangzhou, Guangdong 510010, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, General Hospital of Southern Theater Command of PLA, Guangzhou, Guangdong 510010, P.R. China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103238688","display_name":"Chundong Liu","orcid":"https://orcid.org/0000-0003-2166-2487","observed_orcids":["https://orcid.org/0000-0003-2166-2487"]},"institutions":[{"id":"https://openalex.org/I4210120929","display_name":"Zhujiang Hospital","ror":"https://ror.org/02mhxa927","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120929"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chundong Liu","raw_affiliation_strings":["Department of Stomatology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China","institution_ids":["https://openalex.org/I4210120929","https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017946052","display_name":"Junli Ma","orcid":"https://orcid.org/0000-0001-7233-5940","observed_orcids":["https://orcid.org/0000-0001-7233-5940"]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junli Ma","raw_affiliation_strings":["Department of Stomatology, General Hospital of Southern Theater Command of PLA, Guangzhou, Guangdong 510010, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology, General Hospital of Southern Theater Command of PLA, Guangzhou, Guangdong 510010, P.R. China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045171873","display_name":"Xiao Li","orcid":"https://orcid.org/0000-0003-3373-6797","observed_orcids":["https://orcid.org/0000-0003-3373-6797"]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Li","raw_affiliation_strings":["Department of Stomatology, General Hospital of Southern Theater Command of PLA, Guangzhou, Guangdong 510010, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology, General Hospital of Southern Theater Command of PLA, Guangzhou, Guangdong 510010, P.R. China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005107041","display_name":"Shuohui Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuohui Sun","raw_affiliation_strings":["Department of Stomatology, General Hospital of Southern Theater Command of PLA, Guangzhou, Guangdong 510010, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology, General Hospital of Southern Theater Command of PLA, Guangzhou, Guangdong 510010, P.R. China","institution_ids":["https://openalex.org/I4210160531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038655983","display_name":"Zhifa Wang","orcid":"https://orcid.org/0000-0001-7363-5101","observed_orcids":["https://orcid.org/0000-0001-7363-5101"]},"institutions":[{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhifa Wang","raw_affiliation_strings":["Department of Stomatology, General Hospital of Southern Theater Command of PLA, Guangzhou, Guangdong 510010, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stomatology, General Hospital of Southern Theater Command of PLA, Guangzhou, Guangdong 510010, P.R. China","institution_ids":["https://openalex.org/I4210160531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5005107041","https://openalex.org/A5038655983"],"corresponding_institution_ids":["https://openalex.org/I4210160531"],"apc_list":null,"apc_paid":null,"fwci":0.6796,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.62956734,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"26","issue":"6","first_page":"569","last_page":"569"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-rich-fibrin","display_name":"platelet-rich fibrin","score":0.8960000276565552},{"id":"https://openalex.org/keywords/osteochondral-lesions","display_name":"osteochondral defects","score":0.9679999947547913},{"id":"https://openalex.org/keywords/cartilage-regeneration","display_name":"cartilage regeneration","score":0.824999988079071},{"id":"https://openalex.org/keywords/subchondral-bone-regeneration","display_name":"subchondral bone regeneration","score":0.9750000238418579},{"id":"https://openalex.org/keywords/freeze-drying","display_name":"freeze-drying","score":0.7900000214576721},{"id":"https://openalex.org/keywords/autologous-platelet-concentrate","display_name":"autologous platelet concentrate","score":0.828000009059906},{"id":"https://openalex.org/keywords/bioactive-scaffolds","display_name":"bioactive scaffolds","score":0.7549999952316284},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.5789999961853027}],"concepts":[{"id":"https://openalex.org/C54173615","wikidata":"https://www.wikidata.org/wiki/Q27205","display_name":"Fibrin","level":2,"score":0.8029438257217407},{"id":"https://openalex.org/C2777560349","wikidata":"https://www.wikidata.org/wiki/Q18388934","display_name":"Platelet-rich fibrin","level":3,"score":0.7584732174873352},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7028822898864746},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6568233966827393},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.49801087379455566},{"id":"https://openalex.org/C3018615303","wikidata":"https://www.wikidata.org/wiki/Q1801229","display_name":"Subchondral bone","level":5,"score":0.4937637746334076},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4624254107475281},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.44748905301094055},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.3359403610229492},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3351094126701355},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29676252603530884},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.27587783336639404},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.2561034858226776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1297658383846283},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.058886051177978516},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3892/etm.2023.12268","doi":"https://doi.org/10.3892/etm.2023.12268","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2023.12268","pdf_url":"https://www.spandidos-publications.com/10.3892/etm.2023.12268/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10632968","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10632968","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10632968/pdf/etm-26-06-12268.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Exp Ther Med","raw_type":"Text"},{"id":"pmid:37954116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37954116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and therapeutic medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/etm.2023.12268","doi":"https://doi.org/10.3892/etm.2023.12268","is_oa":true,"landing_page_url":"https://doi.org/10.3892/etm.2023.12268","pdf_url":"https://www.spandidos-publications.com/10.3892/etm.2023.12268/download","source":{"id":"https://openalex.org/S151424340","display_name":"Experimental and Therapeutic Medicine","issn_l":"1792-0981","issn":["1792-0981","1792-1015"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","poland-40","vabb-shw"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental and Therapeutic Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387908024.pdf","grobid_xml":"https://content.openalex.org/works/W4387908024.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W131698121","https://openalex.org/W1780423747","https://openalex.org/W1851902100","https://openalex.org/W1942368225","https://openalex.org/W1987349642","https://openalex.org/W1988592246","https://openalex.org/W1991051450","https://openalex.org/W2019501710","https://openalex.org/W2020700245","https://openalex.org/W2025951027","https://openalex.org/W2035183755","https://openalex.org/W2041180426","https://openalex.org/W2042065329","https://openalex.org/W2054250836","https://openalex.org/W2059486645","https://openalex.org/W2068119864","https://openalex.org/W2075540043","https://openalex.org/W2094650509","https://openalex.org/W2096699701","https://openalex.org/W2114783134","https://openalex.org/W2120616795","https://openalex.org/W2125064090","https://openalex.org/W2126164238","https://openalex.org/W2127664721","https://openalex.org/W2157332721","https://openalex.org/W2253079622","https://openalex.org/W2519793735","https://openalex.org/W2611047807","https://openalex.org/W2796419404","https://openalex.org/W2805919689","https://openalex.org/W2895011813","https://openalex.org/W2902158419","https://openalex.org/W2906654887","https://openalex.org/W2911507054","https://openalex.org/W2911549248","https://openalex.org/W2912234050","https://openalex.org/W2912550985","https://openalex.org/W2982404329","https://openalex.org/W3088589750","https://openalex.org/W3092867728","https://openalex.org/W3133542186","https://openalex.org/W4307772216"],"related_works":["https://openalex.org/W2752307133","https://openalex.org/W2765689563","https://openalex.org/W2164816019","https://openalex.org/W2762686019","https://openalex.org/W4412707928","https://openalex.org/W4378904978","https://openalex.org/W2809307678","https://openalex.org/W7095836898","https://openalex.org/W6966901655","https://openalex.org/W3136467866"],"abstract_inverted_index":{"Osteochondral":[0],"defects":[1,49,85,134,190],"caused":[2],"by":[3,111],"degenerative":[4],"diseases":[5],"of":[6,19,39,47,73,138,144,157,184,200,213],"joints,":[7],"traumas":[8],"and":[9,28,62,64,75,102,141,161,169,186,198,216],"inflammation":[10],"are":[11,24],"important":[12],"issues":[13],"in":[14,26,50,88,172,178,191],"clinical":[15],"practice.":[16],"Different":[17],"types":[18],"autologous":[20],"platelet":[21],"concentrate":[22],"(PCs)":[23],"used":[25],"bone":[27,218],"cartilage":[29,108,160,215],"regeneration.":[30],"The":[31,182],"present":[32],"study":[33],"aimed":[34],"to":[35,69,90,124,194],"investigate":[36],"the":[37,45,71,103,112,154,179,210],"effect":[38],"lyophilized":[40],"platelet-rich":[41],"fibrin":[42],"(L-PRF)":[43],"on":[44,94],"repair":[46,96,109],"osteochondral":[48,84,133,189,201],"rabbits.":[51],"L-PRF":[52,74,118,185],"was":[53],"first":[54],"prepared":[55],"from":[56],"fresh":[57],"PRF":[58],"(F-PRF)":[59],"through":[60,167],"freeze-drying,":[61],"histological":[63,100,121],"microstructural":[65],"observations":[66,101,171],"were":[67,81,147],"performed":[68],"compare":[70],"characteristics":[72],"F-PRF.":[76,125],"Thereafter,":[77],"these":[78],"bioactive":[79,207],"scaffolds":[80],"implanted":[82],"into":[83],"surgically":[86],"created":[87],"rabbits":[89,192],"assess":[91],"their":[92],"effects":[93],"tissue":[95],"using":[97],"micro-CT":[98],"scanning,":[99],"evaluation":[104],"scoring":[105],"method":[106],"for":[107,188,209],"established":[110],"International":[113],"Cartilage":[114],"Repair":[115],"Society":[116],"(ICRS).":[117],"had":[119],"a":[120,136,142,205],"structure":[122],"similar":[123],"At":[126],"16":[127],"weeks":[128],"after":[129],"implantation":[130],"surgery,":[131],"full-thickness":[132],"with":[135,149,176],"diameter":[137],"5":[139],"mm":[140,146],"depth":[143],"4":[145],"well-filled":[148],"newly":[150],"regenerated":[151],"tissues,":[152,202],"exhibiting":[153],"simultaneous":[155,211],"regeneration":[156],"avascular":[158],"articular":[159,214],"well-vascularized":[162],"subchondral":[163,217],"bone,":[164],"as":[165],"proven":[166],"macroscopic":[168],"microscopic":[170],"PRF-treated":[173],"groups":[174],"compared":[175],"that":[177],"untreated":[180],"group.":[181],"application":[183],"F-PRF":[187],"contributed":[193],"massive":[195],"host":[196],"remodeling":[197],"reconstruction":[199,212],"thus":[203],"offering":[204],"prospective":[206],"scaffold":[208],"tissue.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-10-25T00:00:00"}