{"id":"https://openalex.org/W4387899338","doi":"https://doi.org/10.23922/jarc.2023-033","title":"Effects of Hyperbaric Oxygen Therapy for Clostridioides difficile-associated Colitis: A Retrospective Study","display_name":"Effects of Hyperbaric Oxygen Therapy for Clostridioides difficile-associated Colitis: A Retrospective Study","publication_year":2023,"publication_date":"2023-10-24","ids":{"openalex":"https://openalex.org/W4387899338","doi":"https://doi.org/10.23922/jarc.2023-033","pmid":"https://pubmed.ncbi.nlm.nih.gov/37900689","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10600261"},"language":"en","primary_location":{"id":"doi:10.23922/jarc.2023-033","doi":"https://doi.org/10.23922/jarc.2023-033","is_oa":true,"landing_page_url":"https://doi.org/10.23922/jarc.2023-033","pdf_url":"https://www.jstage.jst.go.jp/article/jarc/7/4/7_2023-033/_pdf","source":{"id":"https://openalex.org/S4210221505","display_name":"Journal of the Anus Rectum and Colon","issn_l":"2432-3853","issn":["2432-3853"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4323288782","host_organization_name":"The Japan Society of Coloproctology","host_organization_lineage":["https://openalex.org/P4323288782"],"host_organization_lineage_names":["The Japan Society of Coloproctology"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Anus, Rectum and Colon","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jstage.jst.go.jp/article/jarc/7/4/7_2023-033/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085962041","display_name":"Daisuke Muroya","orcid":"https://orcid.org/0009-0004-8064-5411","observed_orcids":["https://orcid.org/0009-0004-8064-5411","https://orcid.org/0000-0001-8996-7717"]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Daisuke Muroya","raw_affiliation_strings":["Department of Surgery, Kurume University School of Medicine","Department of Surgery, Tobata Kyoritsu Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kurume University School of Medicine","institution_ids":["https://openalex.org/I105296287"]},{"raw_affiliation_string":"Department of Surgery, Tobata Kyoritsu Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093117446","display_name":"Shinya Nadayoshi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shinya Nadayoshi","raw_affiliation_strings":["Department of Clinical Engineering, Tobata Kyoritsu Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Engineering, Tobata Kyoritsu Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114093534","display_name":"Koito Yamada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Koito Yamada","raw_affiliation_strings":["Department of Clinical Engineering, Tobata Kyoritsu Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Engineering, Tobata Kyoritsu Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113030182","display_name":"Yutaro Kai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yutaro Kai","raw_affiliation_strings":["Department of Clinical Engineering, Tobata Kyoritsu Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Engineering, Tobata Kyoritsu Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Naoki Masuda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naoki Masuda","raw_affiliation_strings":["Department of Surgery, Tobata Kyoritsu Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Tobata Kyoritsu Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047487125","display_name":"Takamichi Nishida","orcid":"https://orcid.org/0009-0002-6513-5718","observed_orcids":["https://orcid.org/0009-0002-6513-5718"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takamichi Nishida","raw_affiliation_strings":["Department of Internal Medicine, Tobata Kyoritsu Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Tobata Kyoritsu Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085302948","display_name":"Masayuki Shimokobe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masayuki Shimokobe","raw_affiliation_strings":["Department of Internal Medicine, Tobata Kyoritsu Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Tobata Kyoritsu Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109491567","display_name":"Toru Hisaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I105296287","display_name":"Kurume University","ror":"https://ror.org/057xtrt18","country_code":"JP","type":"education","lineage":["https://openalex.org/I105296287"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Hisaka","raw_affiliation_strings":["Department of Surgery, Kurume University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Kurume University School of Medicine","institution_ids":["https://openalex.org/I105296287"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":200000,"currency":"JPY","value_usd":1507},"apc_paid":{"value":200000,"currency":"JPY","value_usd":1507},"fwci":0.7704,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.660965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":95},"biblio":{"volume":"7","issue":"4","first_page":"264","last_page":"272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11625","display_name":"Abdominal vascular conditions and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperbaric-oxygen-therapy","display_name":"hyperbaric oxygen therapy","score":0.9919999837875366},{"id":"https://openalex.org/keywords/clostridium-difficile-infection","display_name":"Clostridium difficile infection","score":0.8799999952316284},{"id":"https://openalex.org/keywords/recurrence-prevention","display_name":"recurrence prevention","score":0.7540000081062317},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.4970000088214874},{"id":"https://openalex.org/keywords/antibiotic-associated-diarrhea","display_name":"antibiotic-associated diarrhea","score":0.6819999814033508},{"id":"https://openalex.org/keywords/anaerobic-bacteria","display_name":"anaerobic bacteria","score":0.6880000233650208}],"concepts":[{"id":"https://openalex.org/C2910067853","wikidata":"https://www.wikidata.org/wiki/Q27438828","display_name":"Clostridioides","level":2,"score":0.9609125852584839},{"id":"https://openalex.org/C2994405533","wikidata":"https://www.wikidata.org/wiki/Q731615","display_name":"Hyperbaric oxygen","level":2,"score":0.7030280828475952},{"id":"https://openalex.org/C2779116991","wikidata":"https://www.wikidata.org/wiki/Q309465","display_name":"Clostridium perfringens","level":3,"score":0.6475836038589478},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6235013604164124},{"id":"https://openalex.org/C5140985","wikidata":"https://www.wikidata.org/wiki/Q483866","display_name":"Anaerobic exercise","level":2,"score":0.5812473893165588},{"id":"https://openalex.org/C2992397963","wikidata":"https://www.wikidata.org/wiki/Q189790","display_name":"Anaerobic bacteria","level":3,"score":0.4917810261249542},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.48711514472961426},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4552721679210663},{"id":"https://openalex.org/C2993328841","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotic therapy","level":3,"score":0.45090949535369873},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.43482688069343567},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.43104827404022217},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39924880862236023},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3838738203048706},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.24515879154205322},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.2147464156150818},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17916589975357056},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.09594818949699402},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.23922/jarc.2023-033","doi":"https://doi.org/10.23922/jarc.2023-033","is_oa":true,"landing_page_url":"https://doi.org/10.23922/jarc.2023-033","pdf_url":"https://www.jstage.jst.go.jp/article/jarc/7/4/7_2023-033/_pdf","source":{"id":"https://openalex.org/S4210221505","display_name":"Journal of the Anus Rectum and Colon","issn_l":"2432-3853","issn":["2432-3853"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4323288782","host_organization_name":"The Japan Society of Coloproctology","host_organization_lineage":["https://openalex.org/P4323288782"],"host_organization_lineage_names":["The Japan Society of Coloproctology"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Anus, Rectum and Colon","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10600261","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10600261","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10600261/pdf/2432-3853-7-0264.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Anus Rectum Colon","raw_type":"Text"},{"id":"pmid:37900689","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37900689","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the anus, rectum and colon","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a3f2b8a262ec4466be025efe5651b0a6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a3f2b8a262ec4466be025efe5651b0a6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the Anus, Rectum and Colon, Vol 7, Iss 4, Pp 264-272 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.23922/jarc.2023-033","doi":"https://doi.org/10.23922/jarc.2023-033","is_oa":true,"landing_page_url":"https://doi.org/10.23922/jarc.2023-033","pdf_url":"https://www.jstage.jst.go.jp/article/jarc/7/4/7_2023-033/_pdf","source":{"id":"https://openalex.org/S4210221505","display_name":"Journal of the Anus Rectum and Colon","issn_l":"2432-3853","issn":["2432-3853"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4323288782","host_organization_name":"The Japan Society of Coloproctology","host_organization_lineage":["https://openalex.org/P4323288782"],"host_organization_lineage_names":["The Japan Society of Coloproctology"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Anus, Rectum and Colon","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387899338.pdf","grobid_xml":"https://content.openalex.org/works/W4387899338.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W120153313","https://openalex.org/W124140706","https://openalex.org/W182833207","https://openalex.org/W315912018","https://openalex.org/W1874478037","https://openalex.org/W1965629335","https://openalex.org/W1974402925","https://openalex.org/W1976325511","https://openalex.org/W1979012796","https://openalex.org/W1982322400","https://openalex.org/W2003788503","https://openalex.org/W2011542551","https://openalex.org/W2011927695","https://openalex.org/W2023418793","https://openalex.org/W2046852765","https://openalex.org/W2071273298","https://openalex.org/W2072159569","https://openalex.org/W2082205311","https://openalex.org/W2087050793","https://openalex.org/W2097297514","https://openalex.org/W2118195673","https://openalex.org/W2120459847","https://openalex.org/W2122125017","https://openalex.org/W2123661267","https://openalex.org/W2125156390","https://openalex.org/W2132991207","https://openalex.org/W2134897177","https://openalex.org/W2139566520","https://openalex.org/W2143057800","https://openalex.org/W2161990844","https://openalex.org/W2162133321","https://openalex.org/W2162904770","https://openalex.org/W2165291521","https://openalex.org/W2265789540","https://openalex.org/W2318911370","https://openalex.org/W2321823406","https://openalex.org/W2335372630","https://openalex.org/W2345528828","https://openalex.org/W2402595239","https://openalex.org/W2464112039","https://openalex.org/W2624518873","https://openalex.org/W2778416039","https://openalex.org/W2889551008","https://openalex.org/W2900381242","https://openalex.org/W3007555042","https://openalex.org/W4211034832","https://openalex.org/W4224308954","https://openalex.org/W4281388859"],"related_works":["https://openalex.org/W2147179937","https://openalex.org/W4406334145","https://openalex.org/W165353538","https://openalex.org/W4390499391","https://openalex.org/W3112463741","https://openalex.org/W2016587777","https://openalex.org/W3041217530","https://openalex.org/W1976325511","https://openalex.org/W4392585694","https://openalex.org/W4406698919"],"abstract_inverted_index":{"Objectives:":[0],"(CD)":[1],"is":[2,9,20,42],"an":[3,44],"anaerobic":[4,45],"spore-forming":[5],"Gram-positive":[6],"rod":[7],"that":[8,32],"a":[10,21,157,167],"major":[11],"cause":[12],"of":[13,37],"antibiotic-associated":[14],"diarrhea.":[15],"Hyperbaric":[16],"oxygen":[17],"therapy":[18,56,92],"(HBO)":[19],"well-established":[22],"treatment":[23],"for":[24,90],"Clostridium":[25],"perfringens,":[26],"but":[27],"there":[28,130],"are":[29],"no":[30,132],"reports":[31],"have":[33,179],"examined":[34,53],"the":[35,58,127,153,186],"efficacy":[36],"HBO":[38,55,86,91,150,154,177],"against":[39],"CD,":[40],"which":[41],"also":[43],"bacterium.":[46],"Methods:":[47],"In":[48,126],"this":[49],"study,":[50],"we":[51],"retrospectively":[52],"whether":[54],"affects":[57],"prognosis":[59],"following":[60],"CD":[61],"infections":[62],"(CDI).":[63],"This":[64],"study":[65],"included":[66],"92":[67],"inpatients":[68],"diagnosed":[69],"with":[70],"CDI":[71,183],"at":[72],"our":[73],"hospital":[74],"between":[75,142],"January":[76],"2013":[77],"and":[78,113,146,166,189],"December":[79],"2022.":[80],"Of":[81],"these,":[82],"16":[83],"patients":[84,143],"received":[85],"therapy.":[87,151],"The":[88,118],"indications":[89],"were":[93],"stroke":[94],"in":[95,99,103,110,115,135],"five":[96],"patients,":[97,101,105,112],"ileus":[98],"four":[100],"cancer":[102],"two":[104,111],"acute":[106],"peripheral":[107],"circulatory":[108],"disturbance":[109],"others":[114],"three":[116],"patients.":[117],"mean":[119],"observation":[120],"period":[121,170,188],"was":[122,131],"5.4":[123],"years.":[124],"Results:":[125],"univariate":[128],"analysis,":[129],"significant":[133],"difference":[134],"severity,":[136],"mortality,":[137],"hospitalization,":[138],"or":[139],"overall":[140],"survival":[141],"who":[144],"did":[145,147],"not":[148],"receive":[149],"However,":[152],"group":[155],"had":[156],"significantly":[158],"lower":[159],"recurrence":[160],"rate":[161],"(0%":[162],"vs.":[163,172],"22.4%,":[164],"p=0.0363)":[165],"shorter":[168],"symptomatic":[169,187],"(6.2":[171],"13.6":[173],"days,":[174],"p=0.0217).":[175],"Conclusions:":[176],"may":[178],"beneficial":[180],"effect":[181],"on":[182],"by":[184],"shortening":[185],"preventing":[190],"recurrence.":[191]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-10-25T00:00:00"}