{"id":"https://openalex.org/W4387899092","doi":"https://doi.org/10.3389/fimmu.2023.1284334","title":"The safety and anti-tumor effect of multiple peptides-pulsed dendritic cells combined with induced specific cytotoxic T lymphocytes for patients with solid tumors","display_name":"The safety and anti-tumor effect of multiple peptides-pulsed dendritic cells combined with induced specific cytotoxic T lymphocytes for patients with solid tumors","publication_year":2023,"publication_date":"2023-10-24","ids":{"openalex":"https://openalex.org/W4387899092","doi":"https://doi.org/10.3389/fimmu.2023.1284334","pmid":"https://pubmed.ncbi.nlm.nih.gov/37942324","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10628471"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2023.1284334","doi":"https://doi.org/10.3389/fimmu.2023.1284334","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1284334","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1284334/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1284334/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100645344","display_name":"Xuan Zhao","orcid":"https://orcid.org/0000-0002-5650-0747","observed_orcids":["https://orcid.org/0000-0002-5650-0747"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuan Zhao","raw_affiliation_strings":["Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan, China","State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100733124","display_name":"Zhen Zhang","orcid":"https://orcid.org/0000-0002-9898-054X","observed_orcids":["https://orcid.org/0000-0002-9898-054X","https://orcid.org/0009-0000-0085-0345","https://orcid.org/0009-0004-7531-8918"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Zhang","raw_affiliation_strings":["Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan, China","State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002340704","display_name":"Chunli Wen","orcid":"https://orcid.org/0000-0002-1606-2201","observed_orcids":["https://orcid.org/0000-0002-1606-2201"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunli Wen","raw_affiliation_strings":["Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018466261","display_name":"Jianmin Huang","orcid":"https://orcid.org/0000-0002-1861-7442","observed_orcids":["https://orcid.org/0000-0002-1861-7442"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianmin Huang","raw_affiliation_strings":["Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan, China","State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109421612","display_name":"Shuangning Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuangning Yang","raw_affiliation_strings":["Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan, China","State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064348390","display_name":"Jinyan Liu","orcid":"https://orcid.org/0000-0003-0504-2181","observed_orcids":["https://orcid.org/0000-0003-0504-2181","https://orcid.org/0009-0002-6936-8439","https://orcid.org/0009-0006-8697-4309"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinyan Liu","raw_affiliation_strings":["Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan, China","State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan, China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huizhen Geng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huizhen Geng","raw_affiliation_strings":["Hebei Bio-High Technology Development Co., LTD. Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebei Bio-High Technology Development Co., LTD. Shijiazhuang, Hebei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bing Peng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bing Peng","raw_affiliation_strings":["Hebei Bio-High Technology Development Co., LTD. Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebei Bio-High Technology Development Co., LTD. Shijiazhuang, Hebei, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zibo Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zibo Li","raw_affiliation_strings":["Hebei Bio-High Technology Development Co., LTD. Shijiazhuang, Hebei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebei Bio-High Technology Development Co., LTD. Shijiazhuang, Hebei, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100388089","display_name":"Yi Zhang","orcid":"https://orcid.org/0000-0001-9861-4681","observed_orcids":["https://orcid.org/0000-0001-9861-4681"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]},{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi Zhang","raw_affiliation_strings":["Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan, China","School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China","State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotherapy Center & Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I4210156804"]},{"raw_affiliation_string":"Henan Key Laboratory for Tumor Immunology and Biotherapy, Zhengzhou, Henan, China","institution_ids":[]},{"raw_affiliation_string":"School of Life Sciences, Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I38877650"]},{"raw_affiliation_string":"State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, China","institution_ids":["https://openalex.org/I38877650"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100388089","https://openalex.org/A5100645344"],"corresponding_institution_ids":["https://openalex.org/I38877650","https://openalex.org/I4210156804"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.3272,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.50825717,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"14","issue":null,"first_page":"1284334","last_page":"1284334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cell-immunotherapy","display_name":"dendritic cell immunotherapy","score":0.7760000228881836},{"id":"https://openalex.org/keywords/peptide-pulsed-dendritic-cells","display_name":"peptide-pulsed dendritic cells","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.9599999785423279},{"id":"https://openalex.org/keywords/autologous-dendritic-cells","display_name":"autologous dendritic cells","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7689999938011169},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.8370000123977661},{"id":"https://openalex.org/keywords/dendritic-cell-maturation","display_name":"dendritic cell maturation","score":0.8870000243186951},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.7549999952316284},{"id":"https://openalex.org/keywords/tumor-specific-immunity","display_name":"tumor-specific immunity","score":0.503000020980835},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.8240000009536743},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.799267053604126},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5695157647132874},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.43909990787506104},{"id":"https://openalex.org/C2993640289","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Solid tumor","level":3,"score":0.4283450245857239},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39063701033592224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3344283103942871},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32132211327552795},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17628031969070435},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17371198534965515},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15965744853019714},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09638938307762146}],"mesh":[{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2023.1284334","doi":"https://doi.org/10.3389/fimmu.2023.1284334","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1284334","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1284334/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10628471","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10628471","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10628471/pdf/fimmu-14-1284334.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Immunol","raw_type":"Text"},{"id":"pmid:37942324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37942324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:40bdfb065b6b48a3a2318e2ba5b9efa3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/40bdfb065b6b48a3a2318e2ba5b9efa3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 14 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2023.1284334","doi":"https://doi.org/10.3389/fimmu.2023.1284334","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2023.1284334","pdf_url":"https://www.frontiersin.org/articles/10.3389/fimmu.2023.1284334/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1563836948","display_name":null,"funder_award_id":"82102868","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6450518440","display_name":null,"funder_award_id":"82272873","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387899092.pdf","grobid_xml":"https://content.openalex.org/works/W4387899092.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W2135700359","https://openalex.org/W2550266317","https://openalex.org/W2743410869","https://openalex.org/W2776381230","https://openalex.org/W2925090624","https://openalex.org/W2928897803","https://openalex.org/W2970536272","https://openalex.org/W2976549091","https://openalex.org/W2997458556","https://openalex.org/W3005932828","https://openalex.org/W3015199669","https://openalex.org/W3038004940","https://openalex.org/W3039484069","https://openalex.org/W3081454379","https://openalex.org/W3087526274","https://openalex.org/W3093424538","https://openalex.org/W3096921712","https://openalex.org/W3110268403","https://openalex.org/W3123510155","https://openalex.org/W3132486917","https://openalex.org/W3135111247","https://openalex.org/W3147981919","https://openalex.org/W3157103680","https://openalex.org/W3157124650","https://openalex.org/W3162648617","https://openalex.org/W3164575871","https://openalex.org/W3165010430","https://openalex.org/W3165170726","https://openalex.org/W3174490926","https://openalex.org/W3175873348","https://openalex.org/W3184572062","https://openalex.org/W3185362863","https://openalex.org/W3186513334","https://openalex.org/W3189789292","https://openalex.org/W3196267524","https://openalex.org/W3206739041","https://openalex.org/W3215143750","https://openalex.org/W3216178734","https://openalex.org/W4200149492","https://openalex.org/W4210387120","https://openalex.org/W4213017351","https://openalex.org/W4220873354","https://openalex.org/W4220878148","https://openalex.org/W4229009660","https://openalex.org/W4253894793","https://openalex.org/W4293004820","https://openalex.org/W4295007622","https://openalex.org/W4304014325","https://openalex.org/W4323531825","https://openalex.org/W4362699582","https://openalex.org/W4383186893"],"related_works":["https://openalex.org/W2149250918","https://openalex.org/W2604830835","https://openalex.org/W1983467202","https://openalex.org/W2066857894","https://openalex.org/W203177496","https://openalex.org/W2115439647","https://openalex.org/W2027804050","https://openalex.org/W2138913424","https://openalex.org/W2476887592","https://openalex.org/W2007610332"],"abstract_inverted_index":{"Objective:":[0],"The":[1,57],"aim":[2],"of":[3,13,61,67,88,105,128,136],"this":[4],"study":[5],"was":[6,50],"to":[7,119,124,144],"explore":[8],"the":[9,64,99],"safety":[10,168],"and":[11,39,44,52,59,63,84,92,98,169],"efficacy":[12,171],"multiple":[14,159],"peptide-pulsed":[15,160],"autologous":[16],"dendritic":[17],"cells":[18,110],"(DCs)":[19],"combined":[20,162],"with":[21,28,34,96,163],"cytotoxic":[22],"T":[23],"lymphocytes":[24],"(CTLs)":[25],"in":[26],"patients":[27,32,68,113,130],"cancer.":[29,183],"Methods:":[30],"Five":[31],"diagnosed":[33],"cancer":[35,173],"between":[36],"November":[37],"2020":[38],"June":[40],"2021":[41],"were":[42,55,69,152],"enrolled":[43],"received":[45],"DC-CTLs":[46,62,100],"therapy.":[47],"Peripheral":[48,107],"blood":[49,108],"collected":[51],"antigenic":[53],"peptides":[54,120],"analyzed.":[56],"phenotype":[58,83],"function":[60],"immune":[65,117,134],"status":[66],"detected":[70],"using":[71],"flow":[72],"cytometry":[73],"or":[74],"IFN-\u03b3":[75],"ELISPOT":[76],"analysis.":[77],"Results:":[78],"DCs":[79,161],"acquired":[80],"a":[81,115,132,178],"mature":[82],"expressed":[85],"high":[86,103],"levels":[87,104],"CD80,":[89],"CD86,":[90],"CD83,":[91],"HLA-DR":[93],"after":[94],"co-culture":[95],"peptides,":[97],"also":[101],"exhibited":[102],"IFN-\u03b3.":[106],"mononuclear":[109],"from":[111],"post-treatment":[112],"showed":[114],"stronger":[116],"response":[118],"than":[121],"those":[122],"prior":[123],"treatment.":[125],"Importantly,":[126],"four":[127],"five":[129],"maintained":[131],"favorable":[133],"status,":[135],"which":[137,175],"one":[138],"patient's":[139],"disease-free":[140],"survival":[141],"lasted":[142],"up":[143],"28.2":[145],"months.":[146],"No":[147],"severe":[148],"treatment-related":[149],"adverse":[150],"events":[151],"observed.":[153],"Conclusion:":[154],"Our":[155],"results":[156],"show":[157],"that":[158],"CTLs":[164],"therapy":[165],"has":[166],"manageable":[167],"promising":[170],"for":[172,182],"patients,":[174],"might":[176],"provide":[177],"precise":[179],"immunotherapeutic":[180],"strategy":[181]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-10-25T00:00:00"}
