{"id":"https://openalex.org/W4387895090","doi":"https://doi.org/10.1186/s13578-023-01140-1","title":"ZSCAN4 interacts with PARP1 to promote DNA repair in mouse embryonic stem cells","display_name":"ZSCAN4 interacts with PARP1 to promote DNA repair in mouse embryonic stem cells","publication_year":2023,"publication_date":"2023-10-24","ids":{"openalex":"https://openalex.org/W4387895090","doi":"https://doi.org/10.1186/s13578-023-01140-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/37875990","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10594928"},"language":"en","primary_location":{"id":"doi:10.1186/s13578-023-01140-1","doi":"https://doi.org/10.1186/s13578-023-01140-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13578-023-01140-1","pdf_url":"https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/s13578-023-01140-1","source":{"id":"https://openalex.org/S14303005","display_name":"Cell & Bioscience","issn_l":"2045-3701","issn":["2045-3701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & Bioscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/s13578-023-01140-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087642331","display_name":"Li\u2010Kuang Tsai","orcid":"https://orcid.org/0000-0002-5714-4879","observed_orcids":["https://orcid.org/0000-0002-5714-4879"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Li-Kuang Tsai","raw_affiliation_strings":["Institute of Biotechnology, National Taiwan University, Taipei, 106, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, National Taiwan University, Taipei, 106, Taiwan, ROC","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046122727","display_name":"Min Peng","orcid":"https://orcid.org/0000-0002-5675-0607","observed_orcids":["https://orcid.org/0000-0002-5675-0607"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Min Peng","raw_affiliation_strings":["Institute of Biotechnology, National Taiwan University, Taipei, 106, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, National Taiwan University, Taipei, 106, Taiwan, ROC","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111560151","display_name":"Chia-Chun J. Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Chun Chang","raw_affiliation_strings":["Institute of Biotechnology, National Taiwan University, Taipei, 106, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, National Taiwan University, Taipei, 106, Taiwan, ROC","institution_ids":["https://openalex.org/I16733864"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071722998","display_name":"Luan Wen","orcid":"https://orcid.org/0000-0001-9408-8709","observed_orcids":["https://orcid.org/0000-0001-9408-8709"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luan Wen","raw_affiliation_strings":["Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018991654","display_name":"Lin Liu","orcid":"https://orcid.org/0000-0001-9881-6830","observed_orcids":["https://orcid.org/0000-0001-9881-6830"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]},{"id":"https://openalex.org/I4391767646","display_name":"State Key Laboratory of Medicinal Chemical Biology","ror":"https://ror.org/032p70522","country_code":"CN","type":"facility","lineage":["https://openalex.org/I205237279","https://openalex.org/I4391767646"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Liu","raw_affiliation_strings":["State Key Laboratory of Medicinal Chemical Biology, Department of Cell Biology and Genetics, College of Life Sciences, Nankai University, Tianjin, 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Medicinal Chemical Biology, Department of Cell Biology and Genetics, College of Life Sciences, Nankai University, Tianjin, 300071, China","institution_ids":["https://openalex.org/I205237279","https://openalex.org/I4391767646"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021513239","display_name":"Xiubin Liang","orcid":"https://orcid.org/0000-0001-9169-0390","observed_orcids":["https://orcid.org/0000-0001-9169-0390"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiubin Liang","raw_affiliation_strings":["Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109934154","display_name":"Y. Eugene Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Eugene Chen","raw_affiliation_strings":["Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008649792","display_name":"Jie Xu","orcid":"https://orcid.org/0000-0001-9452-2878","observed_orcids":["https://orcid.org/0000-0001-9452-2878"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jie Xu","raw_affiliation_strings":["Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. jiex@med.umich.edu","Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. jiex@med.umich.edu","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026813306","display_name":"Li\u2010Ying Sung","orcid":"https://orcid.org/0000-0003-1221-2476","observed_orcids":["https://orcid.org/0000-0003-1221-2476"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210146572","display_name":"Agricultural Biotechnology Research Center, Academia Sinica","ror":"https://ror.org/04zkdcw61","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210146572","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Li-Ying Sung","raw_affiliation_strings":["Agricultural Biotechnology Research Center, Academia Sinica, Taipei, 115, Taiwan, ROC. liyingsung@ntu.edu.tw","Center for Biotechnology, National Taiwan University, Taipei, 106, Taiwan, ROC. liyingsung@ntu.edu.tw","Center for Developmental Biology and Regenerative Medicine, Taipei, 106, Taiwan, ROC. liyingsung@ntu.edu.tw","Institute of Biotechnology, National Taiwan University, Taipei, 106, Taiwan, ROC. liyingsung@ntu.edu.tw","Center for Developmental Biology and Regenerative Medicine, Taipei, 106, Taiwan, ROC"],"raw_orcid":"https://orcid.org/0000-0003-1221-2476","affiliations":[{"raw_affiliation_string":"Agricultural Biotechnology Research Center, Academia Sinica, Taipei, 115, Taiwan, ROC. liyingsung@ntu.edu.tw","institution_ids":["https://openalex.org/I4210146572","https://openalex.org/I84653119"]},{"raw_affiliation_string":"Center for Biotechnology, National Taiwan University, Taipei, 106, Taiwan, ROC. liyingsung@ntu.edu.tw","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Center for Developmental Biology and Regenerative Medicine, Taipei, 106, Taiwan, ROC. liyingsung@ntu.edu.tw","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Institute of Biotechnology, National Taiwan University, Taipei, 106, Taiwan, ROC. liyingsung@ntu.edu.tw","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Center for Developmental Biology and Regenerative Medicine, Taipei, 106, Taiwan, ROC","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5008649792","https://openalex.org/A5026813306"],"corresponding_institution_ids":["https://openalex.org/I16733864","https://openalex.org/I27837315","https://openalex.org/I4210114445","https://openalex.org/I4210146572","https://openalex.org/I84653119"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":0.6917,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.63385154,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"13","issue":"1","first_page":"193","last_page":"193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zscan4","display_name":"Zscan4","score":1.0},{"id":"https://openalex.org/keywords/parp-1","display_name":"PARP1","score":1.0},{"id":"https://openalex.org/keywords/dna-double-strand-breaks","display_name":"DNA double-strand breaks","score":0.765999972820282},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8339999914169312},{"id":"https://openalex.org/keywords/alternative-nhej","display_name":"alternative NHEJ","score":0.8939999938011169},{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.9729999899864197},{"id":"https://openalex.org/keywords/zinc-finger","display_name":"zinc finger","score":0.8209999799728394},{"id":"https://openalex.org/keywords/genomic-stability","display_name":"genome stability","score":0.9200000166893005},{"id":"https://openalex.org/keywords/parp1-inhibition","display_name":"PARP1 inhibition","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C2778480876","wikidata":"https://www.wikidata.org/wiki/Q21112674","display_name":"PARP1","level":5,"score":0.8960811495780945},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.6774131655693054},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6527746915817261},{"id":"https://openalex.org/C102744134","wikidata":"https://www.wikidata.org/wiki/Q22280388","display_name":"Homologous recombination","level":3,"score":0.624660074710846},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.5830540657043457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5753263831138611},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.5238226056098938},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5037495493888855},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5002222061157227},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4959641396999359},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.43018287420272827},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.39435356855392456},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3550416827201843},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3148965835571289},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.279945969581604},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.19685021042823792}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13578-023-01140-1","doi":"https://doi.org/10.1186/s13578-023-01140-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13578-023-01140-1","pdf_url":"https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/s13578-023-01140-1","source":{"id":"https://openalex.org/S14303005","display_name":"Cell & Bioscience","issn_l":"2045-3701","issn":["2045-3701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & Bioscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10594928","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10594928","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10594928/pdf/13578_2023_Article_1140.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biosci","raw_type":"Text"},{"id":"pmid:37875990","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37875990","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & bioscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7dffff95d442413cad8b10bee359437b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7dffff95d442413cad8b10bee359437b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell & Bioscience, Vol 13, Iss 1, Pp 1-11 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13578-023-01140-1","doi":"https://doi.org/10.1186/s13578-023-01140-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13578-023-01140-1","pdf_url":"https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/s13578-023-01140-1","source":{"id":"https://openalex.org/S14303005","display_name":"Cell & Bioscience","issn_l":"2045-3701","issn":["2045-3701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & Bioscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2205640134","display_name":null,"funder_award_id":"MOST 109","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G3247110960","display_name":"Zscan4 in Telomere Syndrome: an Animal Model-Based Study","funder_award_id":"MOST111-2313-B002-063","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"},{"id":"https://openalex.org/G4601303115","display_name":null,"funder_award_id":"NTU-CC- 112L895304","funder_id":"https://openalex.org/F4320323900","funder_display_name":"National Taiwan University"},{"id":"https://openalex.org/G6536561842","display_name":"Assisted Reproductive Technologies and Induced Pluripotent Stem Cells for Preserving Bornean Orangutan","funder_award_id":"MOST109-2313-B002-003-MY2","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320323900","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387895090.pdf","grobid_xml":"https://content.openalex.org/works/W4387895090.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1977709885","https://openalex.org/W1987369963","https://openalex.org/W1989187489","https://openalex.org/W1989924028","https://openalex.org/W1998129814","https://openalex.org/W2005808461","https://openalex.org/W2007321086","https://openalex.org/W2007414762","https://openalex.org/W2007859567","https://openalex.org/W2008185037","https://openalex.org/W2015594699","https://openalex.org/W2033590354","https://openalex.org/W2034923684","https://openalex.org/W2037147607","https://openalex.org/W2044387885","https://openalex.org/W2062154047","https://openalex.org/W2075174658","https://openalex.org/W2103332087","https://openalex.org/W2106136726","https://openalex.org/W2117249342","https://openalex.org/W2119642223","https://openalex.org/W2167279371","https://openalex.org/W2168396953","https://openalex.org/W2171975889","https://openalex.org/W2267919061","https://openalex.org/W2547837907","https://openalex.org/W2732346161","https://openalex.org/W2747599497","https://openalex.org/W2806699383","https://openalex.org/W3011291325","https://openalex.org/W3042931248","https://openalex.org/W3112443477","https://openalex.org/W3177914501"],"related_works":["https://openalex.org/W6977039820","https://openalex.org/W2033988165","https://openalex.org/W7098115062","https://openalex.org/W2026405645","https://openalex.org/W3135215220","https://openalex.org/W2946903351","https://openalex.org/W2974992562","https://openalex.org/W2487376052","https://openalex.org/W3011291325","https://openalex.org/W3168851962"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,77],"eukaryotic":[2],"cells,":[3],"DNA":[4,58],"double":[5],"strand":[6],"breaks":[7],"(DSB)":[8],"are":[9,84,104,138],"primarily":[10],"repaired":[11],"by":[12,48,60,106,162],"canonical":[13],"non-homologous":[14],"end":[15],"joining":[16],"(c-NHEJ),":[17],"homologous":[18],"recombination":[19],"(HR)":[20],"and":[21,27,126,130,149,155],"alternative":[22],"NHEJ":[23],"(alt-NHEJ).":[24],"Zinc":[25],"finger":[26,134],"SCAN":[28],"domain":[29],"containing":[30],"4":[31],"(ZSCAN4),":[32],"sporadically":[33],"expressed":[34],"in":[35,118,167],"1-5%":[36],"mouse":[37],"embryonic":[38],"stem":[39],"cells":[40],"(mESCs),":[41],"is":[42,69],"known":[43],"to":[44,96,124],"regulate":[45],"genome":[46],"stability":[47],"promoting":[49],"HR.":[50],"RESULTS:":[51],"Here":[52],"we":[53],"show":[54],"that":[55,147],"ZSCAN4":[56,103,137,150,164],"promotes":[57],"repair":[59],"acting":[61],"with":[62,86,102],"Poly":[63],"(ADP-ribose)":[64],"polymerase":[65],"1":[66],"(PARP1),":[67],"which":[68,163],"a":[70,152],"key":[71],"member":[72],"of":[73,80,89,136],"the":[74,78,127,131,159],"alt-NHEJ":[75],"pathway.":[76],"presence":[79],"PARP1,":[81],"ZSCAN4-expressing":[82],"mESCs":[83],"associated":[85,101],"lower":[87],"extent":[88],"endogenous":[90],"or":[91,115],"chemical":[92],"induced":[93],"DSB":[94,166],"comparing":[95],"ZSCAN4-negative":[97],"ones.":[98],"Reduced":[99],"DSBs":[100],"abolished":[105],"PARP1":[107,121,148],"inhibition,":[108],"achieved":[109],"either":[110],"through":[111],"small":[112],"molecule":[113],"inhibitor":[114],"gene":[116],"knockout":[117],"mESCs.":[119,168],"Furthermore,":[120],"binds":[122],"directly":[123],"ZSCAN4,":[125],"second":[128],"\u237a-helix":[129],"fourth":[132],"zinc":[133],"motif":[135],"critical":[139],"for":[140],"this":[141],"binding.":[142],"CONCLUSIONS:":[143],"These":[144],"data":[145],"reveal":[146],"have":[151],"protein-protein":[153],"interaction,":[154],"shed":[156],"light":[157],"on":[158],"molecular":[160],"mechanisms":[161],"reduces":[165]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-25T00:00:00"}