{"id":"https://openalex.org/W4387872671","doi":"https://doi.org/10.1002/j.1875-9114.1992.tb04475.x","title":"In Vivo and In Vitro \u03b22\u2010Adrenergic Receptor Responsiveness in Young and Elderly Asthmatics","display_name":"In Vivo and In Vitro \u03b22\u2010Adrenergic Receptor Responsiveness in Young and Elderly Asthmatics","publication_year":1992,"publication_date":"1992-09-10","ids":{"openalex":"https://openalex.org/W4387872671","doi":"https://doi.org/10.1002/j.1875-9114.1992.tb04475.x","mag":"1952703192","pmid":"https://pubmed.ncbi.nlm.nih.gov/1331993"},"language":"en","primary_location":{"id":"doi:10.1002/j.1875-9114.1992.tb04475.x","doi":"https://doi.org/10.1002/j.1875-9114.1992.tb04475.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1875-9114.1992.tb04475.x","pdf_url":null,"source":{"id":"https://openalex.org/S122731057","display_name":"Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy","issn_l":"0277-0008","issn":["0277-0008","1875-9114"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111775601","display_name":"Bettina A. Hamelin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bettina A. Hamelin","raw_affiliation_strings":["From the College of Pharmacy (Drs. Chandler, Hamelin, Blouin, and Clifton) and the College of Medicine (Dr. Wolf), University of Kentucky, and VA Medical Center, Lexington, Kentucky (Dr. Wolf). Dr. Chandler is an Associate, Sanders-Brown Center on Aging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the College of Pharmacy (Drs. Chandler, Hamelin, Blouin, and Clifton) and the College of Medicine (Dr. Wolf), University of Kentucky, and VA Medical Center, Lexington, Kentucky (Dr. Wolf). Dr. Chandler is an Associate, Sanders-Brown Center on Aging","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110537749","display_name":"Robert A. Blouin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A. Blouin","raw_affiliation_strings":["From the College of Pharmacy (Drs. Chandler, Hamelin, Blouin, and Clifton) and the College of Medicine (Dr. Wolf), University of Kentucky, and VA Medical Center, Lexington, Kentucky (Dr. Wolf). Dr. Chandler is an Associate, Sanders-Brown Center on Aging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the College of Pharmacy (Drs. Chandler, Hamelin, Blouin, and Clifton) and the College of Medicine (Dr. Wolf), University of Kentucky, and VA Medical Center, Lexington, Kentucky (Dr. Wolf). Dr. Chandler is an Associate, Sanders-Brown Center on Aging","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111940572","display_name":"Karen M. Wolf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen M. Wolf","raw_affiliation_strings":["From the College of Pharmacy (Drs. Chandler, Hamelin, Blouin, and Clifton) and the College of Medicine (Dr. Wolf), University of Kentucky, and VA Medical Center, Lexington, Kentucky (Dr. Wolf). Dr. Chandler is an Associate, Sanders-Brown Center on Aging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the College of Pharmacy (Drs. Chandler, Hamelin, Blouin, and Clifton) and the College of Medicine (Dr. Wolf), University of Kentucky, and VA Medical Center, Lexington, Kentucky (Dr. Wolf). Dr. Chandler is an Associate, Sanders-Brown Center on Aging","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111697767","display_name":"G. Dennis Clifton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Dennis Clifton","raw_affiliation_strings":["From the College of Pharmacy (Drs. Chandler, Hamelin, Blouin, and Clifton) and the College of Medicine (Dr. Wolf), University of Kentucky, and VA Medical Center, Lexington, Kentucky (Dr. Wolf). Dr. Chandler is an Associate, Sanders-Brown Center on Aging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the College of Pharmacy (Drs. Chandler, Hamelin, Blouin, and Clifton) and the College of Medicine (Dr. Wolf), University of Kentucky, and VA Medical Center, Lexington, Kentucky (Dr. Wolf). Dr. Chandler is an Associate, Sanders-Brown Center on Aging","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111746291","display_name":"Mary H.H. Chandler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mary H. H. Chandler","raw_affiliation_strings":["From the College of Pharmacy (Drs. Chandler, Hamelin, Blouin, and Clifton) and the College of Medicine (Dr. Wolf), University of Kentucky, and VA Medical Center, Lexington, Kentucky (Dr. Wolf). Dr. Chandler is an Associate, Sanders-Brown Center on Aging"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the College of Pharmacy (Drs. Chandler, Hamelin, Blouin, and Clifton) and the College of Medicine (Dr. Wolf), University of Kentucky, and VA Medical Center, Lexington, Kentucky (Dr. Wolf). Dr. Chandler is an Associate, Sanders-Brown Center on Aging","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111746291"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":{"value":4030,"currency":"USD","value_usd":4030},"apc_paid":null,"fwci":0.3846,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.71353033,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"5","first_page":"376","last_page":"382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.6949999928474426},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9570000171661377},{"id":"https://openalex.org/keywords/terbutaline","display_name":"terbutaline","score":0.8930000066757202},{"id":"https://openalex.org/keywords/bronchodilation","display_name":"bronchodilation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.6970000267028809},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.7300000190734863},{"id":"https://openalex.org/keywords/beta1-adrenergic-receptor","display_name":"beta1-adrenergic receptor","score":0.9440000057220459},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.6819999814033508},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.8140000104904175},{"id":"https://openalex.org/keywords/plasma-potassium","display_name":"plasma potassium","score":0.49399998784065247},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.6430000066757202},{"id":"https://openalex.org/keywords/lung-function","display_name":"lung function","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C2780252434","wikidata":"https://www.wikidata.org/wiki/Q424340","display_name":"Terbutaline","level":3,"score":0.9385622143745422},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7151041030883789},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6836645603179932},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.670423686504364},{"id":"https://openalex.org/C40465926","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Adrenergic receptor","level":3,"score":0.4977402985095978},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.49741867184638977},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4844529628753662},{"id":"https://openalex.org/C2908646376","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilation","level":4,"score":0.4725722372531891},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.46981504559516907},{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.4516991972923279},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.44147852063179016},{"id":"https://openalex.org/C158453852","wikidata":"https://www.wikidata.org/wiki/Q4684738","display_name":"Adrenergic","level":3,"score":0.43646252155303955},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.4316941499710083},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41213223338127136},{"id":"https://openalex.org/C2781018748","wikidata":"https://www.wikidata.org/wiki/Q927234","display_name":"Bronchodilator","level":3,"score":0.3204723000526428},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1550142467021942},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001774","descriptor_name":"Blood Chemical Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012129","descriptor_name":"Respiratory Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013726","descriptor_name":"Terbutaline","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013726","descriptor_name":"Terbutaline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/j.1875-9114.1992.tb04475.x","doi":"https://doi.org/10.1002/j.1875-9114.1992.tb04475.x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/j.1875-9114.1992.tb04475.x","pdf_url":null,"source":{"id":"https://openalex.org/S122731057","display_name":"Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy","issn_l":"0277-0008","issn":["0277-0008","1875-9114"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy","raw_type":"journal-article"},{"id":"pmid:1331993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1331993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacotherapy","raw_type":"Comparative Study"},{"id":"mag:1952703192","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1331993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7770846615","display_name":"BIOMEDICAL RESEARCH SUPPORT","funder_award_id":"S07RR005857","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W132138455","https://openalex.org/W1547871242","https://openalex.org/W1550978342","https://openalex.org/W1964634703","https://openalex.org/W1965861435","https://openalex.org/W1968493849","https://openalex.org/W1973280875","https://openalex.org/W1974599861","https://openalex.org/W1977307635","https://openalex.org/W1986829012","https://openalex.org/W1987796832","https://openalex.org/W1999594767","https://openalex.org/W2001428635","https://openalex.org/W2008271145","https://openalex.org/W2014881573","https://openalex.org/W2025409639","https://openalex.org/W2026675160","https://openalex.org/W2039849556","https://openalex.org/W2051462224","https://openalex.org/W2053814557","https://openalex.org/W2057309255","https://openalex.org/W2059608216","https://openalex.org/W2062558899","https://openalex.org/W2063373458","https://openalex.org/W2067862917","https://openalex.org/W2072111883","https://openalex.org/W2078256286","https://openalex.org/W2108094183","https://openalex.org/W2149044200","https://openalex.org/W2151329345","https://openalex.org/W2159598272","https://openalex.org/W2321655475","https://openalex.org/W2327298537","https://openalex.org/W2327384329","https://openalex.org/W2401050002","https://openalex.org/W2414715525","https://openalex.org/W2430971724","https://openalex.org/W4236639597","https://openalex.org/W4298877390"],"related_works":["https://openalex.org/W1952703192","https://openalex.org/W1585960420","https://openalex.org/W3021471018","https://openalex.org/W2021458659","https://openalex.org/W2036397963","https://openalex.org/W2008271145","https://openalex.org/W1987796832","https://openalex.org/W2090294194","https://openalex.org/W1593123206","https://openalex.org/W2034187594"],"abstract_inverted_index":{"This":[0],"pilot":[1],"study":[2],"was":[3,29,51,84,121],"undertaken":[4],"to":[5,32,96],"characterize":[6],"age-related":[7],"alterations":[8],"in":[9,70,99,102],"airway":[10],"and":[11,38,45,66,69,91,141],"metabolic":[12],"beta":[13,87,114,134],"2-adrenergic":[14],"receptor":[15,116],"response":[16,89],"using":[17],"terbutaline":[18,26,147],"as":[19],"a":[20],"probe.":[21],"A":[22],"single":[23],"dose":[24],"of":[25,78,145],"0.007":[27],"mg/kg":[28],"administered":[30],"subcutaneously":[31],"10":[33,39],"young":[34,103],"(range":[35,41],"20-35":[36],"yrs)":[37,43],"elderly":[40,100,138],"60-73":[42],"men":[44],"women":[46],"with":[47],"asthma.":[48],"beta-Receptor":[49],"function":[50,56],"assessed":[52],"by":[53],"serial":[54],"pulmonary":[55,133],"tests,":[57],"heart":[58],"rate,":[59],"blood":[60,119],"pressure,":[61],"plasma":[62],"potassium,":[63],"glucose,":[64],"insulin,":[65],"catecholamine":[67],"levels,":[68],"vitro":[71],"3',":[72],"5'-cyclic":[73],"adenosine":[74],"monophosphate":[75],"(cAMP)":[76],"production":[77,95],"pure":[79],"T":[80,92,128],"lymphocytes.":[81],"The":[82],"trend":[83],"for":[85],"lung":[86],"2-receptor":[88,135],"(bronchodilation)":[90],"lymphocyte":[93,129],"cAMP":[94],"be":[97],"lower":[98],"than":[101,148],"asthmatics,":[104],"but":[105],"differences":[106],"did":[107],"not":[108],"reach":[109],"statistical":[110],"significance.":[111],"Elderly":[112],"subjects'":[113],"1-adrenergic":[115],"responsiveness":[117],"(systolic":[118],"pressure)":[120],"also":[122],"dampened.":[123],"These":[124],"data":[125],"suggest":[126],"that":[127],"stimulation":[130],"does":[131],"reflect":[132],"response.":[136],"Whether":[137],"asthmatics":[139,150],"require":[140],"tolerate":[142],"higher":[143],"dosages":[144],"parenteral":[146],"younger":[149],"deserves":[151],"further":[152],"study.":[153]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-10-24T00:00:00"}