{"id":"https://openalex.org/W4387872434","doi":"https://doi.org/10.1021/acs.biomac.3c00680","title":"Stabilization of Synthetic Collagen Triple Helices: Charge Pairs and Covalent Capture","display_name":"Stabilization of Synthetic Collagen Triple Helices: Charge Pairs and Covalent Capture","publication_year":2023,"publication_date":"2023-10-23","ids":{"openalex":"https://openalex.org/W4387872434","doi":"https://doi.org/10.1021/acs.biomac.3c00680","pmid":"https://pubmed.ncbi.nlm.nih.gov/37871141"},"language":"en","primary_location":{"id":"doi:10.1021/acs.biomac.3c00680","doi":"https://doi.org/10.1021/acs.biomac.3c00680","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biomac.3c00680","pdf_url":null,"source":{"id":"https://openalex.org/S11629336","display_name":"Biomacromolecules","issn_l":"1525-7797","issn":["1525-7797","1526-4602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003469900","display_name":"Carson C. Cole","orcid":"https://orcid.org/0000-0002-7573-1882","observed_orcids":["https://orcid.org/0000-0002-7573-1882"]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carson C. Cole","raw_affiliation_strings":["Department of Chemistry, Rice University, Houston, Texas 77005, United States"],"raw_orcid":"https://orcid.org/0000-0002-7573-1882","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101875797","display_name":"Le Tracy Yu","orcid":"https://orcid.org/0000-0001-9904-6460","observed_orcids":["https://orcid.org/0000-0001-9904-6460"]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Le Tracy Yu","raw_affiliation_strings":["Department of Chemistry, Rice University, Houston, Texas 77005, United States"],"raw_orcid":"https://orcid.org/0000-0001-9904-6460","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046618031","display_name":"Mikita M. Misiura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mikita Misiura","raw_affiliation_strings":["Department of Chemistry, Rice University, Houston, Texas 77005, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043185675","display_name":"Joseph W. Williams","orcid":"https://orcid.org/0000-0003-4521-4902","observed_orcids":["https://orcid.org/0000-0003-4521-4902"]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Williams","raw_affiliation_strings":["Department of Chemistry, Rice University, Houston, Texas 77005, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101511823","display_name":"Thi H. Bui","orcid":"https://orcid.org/0009-0006-6662-3130","observed_orcids":["https://orcid.org/0009-0006-6662-3130"]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thi H. Bui","raw_affiliation_strings":["Department of Chemistry, Rice University, Houston, Texas 77005, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071074539","display_name":"Jeffrey D. Hartgerink","orcid":"https://orcid.org/0000-0002-3186-5395","observed_orcids":["https://orcid.org/0000-0002-3186-5395"]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey D. Hartgerink","raw_affiliation_strings":["Department of Bioengineering, Rice University, 6100 Main Street, Houston, Texas 77005, United States","Department of Chemistry, Rice University, Houston, Texas 77005, United States"],"raw_orcid":"https://orcid.org/0000-0002-3186-5395","affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Rice University, 6100 Main Street, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Department of Chemistry, Rice University, Houston, Texas 77005, United States","institution_ids":["https://openalex.org/I74775410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071074539"],"corresponding_institution_ids":["https://openalex.org/I74775410"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.5099,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.48976589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"24","issue":"11","first_page":"5083","last_page":"5090"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.7167999744415283,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12085","display_name":"Collagen: Extraction and Characterization","score":0.7167999744415283,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":0.19539999961853027,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.04129999876022339,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/collagen-mimetic-peptides","display_name":"collagen mimetic peptides","score":0.9459999799728394},{"id":"https://openalex.org/keywords/covalent-capture","display_name":"covalent capture","score":0.8840000033378601},{"id":"https://openalex.org/keywords/supramolecular-self-assembly","display_name":"supramolecular self-assembly","score":0.8379999995231628},{"id":"https://openalex.org/keywords/helix-stabilization","display_name":"helix stabilization","score":0.6290000081062317},{"id":"https://openalex.org/keywords/peptide-design","display_name":"peptide design","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C10919887","wikidata":"https://www.wikidata.org/wiki/Q7843514","display_name":"Triple helix","level":2,"score":0.9495448470115662},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.7572264671325684},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.7004061341285706},{"id":"https://openalex.org/C93275456","wikidata":"https://www.wikidata.org/wiki/Q756449","display_name":"Supramolecular chemistry","level":3,"score":0.6754069328308105},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.6496343612670898},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6094061136245728},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.5692370533943176},{"id":"https://openalex.org/C155181932","wikidata":"https://www.wikidata.org/wiki/Q24768908","display_name":"Collagen helix","level":3,"score":0.52009117603302},{"id":"https://openalex.org/C188082385","wikidata":"https://www.wikidata.org/wiki/Q73792","display_name":"Charge (physics)","level":2,"score":0.4346930682659149},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4280930757522583},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3800482153892517},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33252203464508057},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.32631170749664307},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14878195524215698},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13025709986686707},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.1054689884185791},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09752711653709412},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.05804762244224548},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2779965526","wikidata":"https://www.wikidata.org/wiki/Q308841","display_name":"Snail","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008239","descriptor_name":"Lysine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/acs.biomac.3c00680","doi":"https://doi.org/10.1021/acs.biomac.3c00680","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.biomac.3c00680","pdf_url":null,"source":{"id":"https://openalex.org/S11629336","display_name":"Biomacromolecules","issn_l":"1525-7797","issn":["1525-7797","1526-4602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"journal-article"},{"id":"pmid:37871141","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37871141","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G306366463","display_name":null,"funder_award_id":"C\u20102141","funder_id":"https://openalex.org/F4320306196","funder_display_name":"Welch Foundation"},{"id":"https://openalex.org/G4696735351","display_name":null,"funder_award_id":"CHE 2203937","funder_id":"https://openalex.org/F4320337393","funder_display_name":"Division of Chemistry"},{"id":"https://openalex.org/G6829658994","display_name":null,"funder_award_id":"1842494","funder_id":"https://openalex.org/F4320337368","funder_display_name":"Division of Graduate Education"}],"funders":[{"id":"https://openalex.org/F4320306196","display_name":"Welch Foundation","ror":"https://ror.org/00np6vq88"},{"id":"https://openalex.org/F4320337368","display_name":"Division of Graduate Education","ror":"https://ror.org/00whkrf32"},{"id":"https://openalex.org/F4320337393","display_name":"Division of Chemistry","ror":"https://ror.org/01ar8dr59"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1579799438","https://openalex.org/W1969293769","https://openalex.org/W1969946367","https://openalex.org/W1985842673","https://openalex.org/W1991706766","https://openalex.org/W1997093560","https://openalex.org/W2004738770","https://openalex.org/W2010127700","https://openalex.org/W2011669549","https://openalex.org/W2059671784","https://openalex.org/W2088418501","https://openalex.org/W2089352289","https://openalex.org/W2095351662","https://openalex.org/W2106320506","https://openalex.org/W2161162374","https://openalex.org/W2303665092","https://openalex.org/W2317418395","https://openalex.org/W2328792848","https://openalex.org/W2404280981","https://openalex.org/W2468002626","https://openalex.org/W2587569089","https://openalex.org/W2783855936","https://openalex.org/W2954706232","https://openalex.org/W3001283138","https://openalex.org/W3080716667","https://openalex.org/W3130438518","https://openalex.org/W3176097379","https://openalex.org/W3190095640","https://openalex.org/W4212835810","https://openalex.org/W4220933043","https://openalex.org/W4224233479","https://openalex.org/W4253764099","https://openalex.org/W4306173278"],"related_works":["https://openalex.org/W4212835810","https://openalex.org/W2954706232","https://openalex.org/W3080716667","https://openalex.org/W2035481474","https://openalex.org/W7203524367","https://openalex.org/W7203522594","https://openalex.org/W2969366548","https://openalex.org/W3154582384","https://openalex.org/W6999778146","https://openalex.org/W7203526054"],"abstract_inverted_index":{"Collagen":[0],"mimetic":[1],"peptides":[2],"are":[3,150],"composed":[4],"of":[5,22,33,41,59,100,134,155],"triple":[6,24,47,105,157],"helices.":[7],"Triple":[8],"helical":[9,106,158],"formation":[10],"frequently":[11],"utilizes":[12],"charge":[13,64,132,146],"pair":[14,65],"interactions":[15],"to":[16,29,55,142],"direct":[17],"protein":[18],"assembly.":[19,62],"The":[20],"design":[21,159],"synthetic":[23],"helices":[25],"is":[26],"challenging":[27],"due":[28],"the":[30,37,60,94,126,153],"large":[31],"number":[32],"competing":[34],"species":[35],"and":[36,52,72,84,97,130,136,140,160],"overall":[38],"fragile":[39],"nature":[40],"collagen":[42,156],"mimetics.":[43],"A":[44],"successfully":[45],"designed":[46],"helix":[48,82],"incorporates":[49],"both":[50,79],"positive":[51],"negative":[53],"criteria":[54],"achieve":[56],"maximum":[57],"specificity":[58,83],"supramolecular":[61,115],"Intrahelical":[63],"interactions,":[66],"particularly":[67],"those":[68],"involved":[69],"in":[70,80,103],"lysine-aspartate":[71],"lysine-glutamate":[73],"pairs,":[74],"have":[75,108],"been":[76,110],"especially":[77],"successful":[78],"driving":[81],"for":[85,113],"subsequent":[86],"stabilization":[87],"by":[88],"covalent":[89,118],"capture.":[90],"Despite":[91],"this":[92,122],"progress,":[93],"important":[95],"sequential":[96],"geometric":[98],"relationships":[99],"charged":[101],"residues":[102],"a":[104],"context":[107,154],"not":[109],"fully":[111],"explored":[112],"either":[114],"assembly":[116],"or":[117],"capture":[119],"stabilization.":[120],"In":[121],"study,":[123],"we":[124],"compare":[125],"eight":[127],"canonical":[128],"axial":[129],"lateral":[131],"pairs":[133],"lysine":[135],"arginine":[137],"with":[138],"glutamate":[139],"aspartate":[141],"their":[143],"noncanonical,":[144],"reversed":[145],"pairs.":[147],"These":[148],"findings":[149],"put":[151],"into":[152],"synthesis.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-10-24T00:00:00"}
