{"id":"https://openalex.org/W4387872273","doi":"https://doi.org/10.17918/00001789","title":"Modified agarose hydrogel scaffold for neural stem cell transplantation in spinal cord injuries","display_name":"Modified agarose hydrogel scaffold for neural stem cell transplantation in spinal cord injuries","publication_year":2023,"publication_date":"2023-06-01","ids":{"openalex":"https://openalex.org/W4387872273","doi":"https://doi.org/10.17918/00001789"},"language":"en","primary_location":{"id":"doi:10.17918/00001789","doi":"https://doi.org/10.17918/00001789","is_oa":true,"landing_page_url":"https://doi.org/10.17918/00001789","pdf_url":null,"source":null,"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drexel University","raw_type":"dissertation"},"volume":null,"type":"dissertation","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.17918/00001789","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081330296","display_name":"Maleah Spicer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Maleah Spicer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065410577","display_name":"Fred D. Allen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fred D. Allen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5103055762","display_name":"Yinghui Zhong","orcid":"https://orcid.org/0000-0002-1363-9466","observed_orcids":["https://orcid.org/0000-0002-1363-9466"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yinghui Zhong","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1363-9466","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5081330296"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.06430000066757202,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.9909999966621399},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.7850000262260437},{"id":"https://openalex.org/keywords/divinyl-sulfone","display_name":"divinyl sulfone","score":0.8880000114440918},{"id":"https://openalex.org/keywords/michael-addition","display_name":"Michael addition","score":0.8180000185966492},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7059999704360962},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.6159999966621399},{"id":"https://openalex.org/keywords/neural-tissue-engineering","display_name":"neural tissue engineering","score":0.6179999709129333},{"id":"https://openalex.org/keywords/mechanical-properties","display_name":"mechanical properties","score":0.3540000021457672},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.35100001096725464},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.3269999921321869},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.4620000123977661},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.5460000038146973},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.7680000066757202},{"id":"https://openalex.org/keywords/axonal-transection","display_name":"axon transection","score":0.7739999890327454},{"id":"https://openalex.org/keywords/secondary-injury","display_name":"secondary injury","score":0.3790000081062317}],"concepts":[{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.7201616764068604},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.6805977821350098},{"id":"https://openalex.org/C2778476535","wikidata":"https://www.wikidata.org/wiki/Q390697","display_name":"Agarose","level":2,"score":0.6607837677001953},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6450349688529968},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.5602460503578186},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.5436865091323853},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.47804123163223267},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.39216089248657227},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3275279998779297},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2704744040966034},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2694258689880371},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2481989562511444},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19192641973495483},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16420835256576538},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.055059581995010376}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.17918/00001789","doi":"https://doi.org/10.17918/00001789","is_oa":true,"landing_page_url":"https://doi.org/10.17918/00001789","pdf_url":null,"source":null,"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drexel University","raw_type":"dissertation"},{"id":"pmh:oai:alma.01DRXU_INST:11492710910004721","doi":null,"is_oa":true,"landing_page_url":"https://researchdiscovery.drexel.edu/esploro/outputs/graduate/Modified-agarose-hydrogel-scaffold-for-neural/991021212214004721","pdf_url":null,"source":{"id":"https://openalex.org/S7407064447","display_name":"iDEA - Drexel University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Masters Thesis"}],"best_oa_location":{"id":"doi:10.17918/00001789","doi":"https://doi.org/10.17918/00001789","is_oa":true,"landing_page_url":"https://doi.org/10.17918/00001789","pdf_url":null,"source":null,"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drexel University","raw_type":"dissertation"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4324094162","https://openalex.org/W4411577362","https://openalex.org/W6989900725","https://openalex.org/W4311281215","https://openalex.org/W4400099336","https://openalex.org/W4200153986","https://openalex.org/W2775940086","https://openalex.org/W2783421523","https://openalex.org/W2295958410","https://openalex.org/W2958157831"],"abstract_inverted_index":{"Spinal":[0],"cord":[1],"injury":[2,135],"(SCI)":[3],"is":[4,194,232,248,289,322,638],"a":[5,19,81,116,123,128,174,182,195,212,221,235,249,258,278,290,329,341,440,548,653],"debilitating":[6],"neurological":[7],"condition":[8],"that":[9,185,421,445,547,572,656],"results":[10,177],"from":[11,73],"direct":[12,74],"trauma":[13,75],"to":[14,28,76,93,115,137,199,238,304,316,332,346,349,458,475,531,560,562,582,647,651],"the":[15,31,56,77,96,108,164,170,205,215,244,314,333,350,354,384,399,422,434,462,471,488,508,515,524,537,563,567,573,578,603,608,648,658],"tissue":[16,78,262],"and":[17,24,43,63,79,89,142,152,203,241,270,286,300,370,376,381,411,425,468,483,498,512,519,591,596,626],"causes":[18],"loss":[20,85],"of":[21,33,41,51,67,86,98,118,131,214,225,243,277,295,361,383,436,465,480,503,526,540,551,580,610,660],"motor,":[22,87],"sensory,":[23,88],"autonomic":[25,90],"functions":[26,91],"caudal":[27,92],"or":[29,83,94],"below":[30,95],"site":[32,97,110],"injury.":[34,99],"Globally,":[35],"SCI":[36,68,103,179],"has":[37],"an":[38,47,226,477],"incidence":[39],"rate":[40],"250,000":[42],"500,000":[44],"cases":[45,66],"with":[46,229,252,313,324,364,505,542,577],"annual":[48],"economic":[49],"impact":[50],"$4":[52],"billion":[53],"USD.":[54],"In":[55],"United":[57],"States,":[58],"there":[59],"are":[60,104,358],"between":[61,495],"11,000":[62],"20,000":[64],"new":[65],"each":[69],"year.":[70],"SCIs":[71],"result":[72,213],"cause":[80],"partial":[82],"complete":[84],"The":[100,133,275,373,501],"most":[101,400,604],"frequent":[102],"contusion":[105],"injuries":[106],"where":[107],"lesion":[109,217],"expands":[111],"over":[112,433],"time":[113],"due":[114],"wave":[117],"secondary":[119,134],"degeneration":[120],"resulting":[121],"in":[122,169,178,209,302,529,587,606,617,623,629,640],"cystic":[124],"cavity":[125,218],"surrounded":[126],"by":[127,146],"thin":[129],"rim":[130],"tissue.":[132],"leads":[136],"further":[138,419],"neuronal":[139],"loss,":[140],"demyelination,":[141],"axon":[143],"transection":[144],"caused":[145],"mechanisms":[147],"such":[148],"as":[149,234,257,612],"bleeding,":[150],"swelling,":[151,518],"elevated":[153],"reactive":[154],"oxygen":[155],"species":[156],"(ROS).":[157],"Since":[158],"neurons":[159,202],"have":[160,317],"limited":[161],"regenerative":[162],"capacity,":[163],"transected":[165],"axons":[166],"cannot":[167,271],"regenerate":[168],"hostile":[171],"microenvironment":[172],"after":[173,219],"SCI.":[175,210],"This":[176,337],"patients":[180],"having":[181],"lifelong":[183],"disability":[184],"requires":[186],"continuous":[187],"care.":[188],"Neural":[189],"stem/progenitor":[190],"cells":[191],"(NSPCs)":[192],"transplantation":[193],"promising":[196,605,639],"therapeutic":[197],"strategy":[198],"replace":[200],"lost":[201],"rebuild":[204],"damaged":[206],"neural":[207,261],"circuitry":[208],"As":[211],"large":[216],"SCI,":[220],"biomaterial":[222,259,654],"scaffold":[223,655],"composed":[224],"agarose":[227,265,311,386,504,541],"hydrogel":[228,388],"laminin":[230,319],"incorporated":[231],"needed":[233],"supporting":[236],"matrix":[237,293],"promote":[239],"attachment":[240,285],"survival":[242,609,616,659],"transplanted":[245],"NSPCs.":[246,661],"Agarose":[247],"biocompatible":[250],"polysaccharide":[251],"thermo-reversible":[253],"properties":[254,464],"commonly":[255],"used":[256],"for":[260,340,406,409,413,557,593],"engineering.":[263],"However,":[264],"lacks":[266],"cell":[267,279,284,296],"adhesion":[268],"motifs":[269],"encourage":[272,283],"neuron":[273],"growth.":[274,287],"incorporation":[276],"binding":[280],"domain":[281],"can":[282],"Laminin":[288],"key":[291],"extracellular":[292],"regulator":[294],"adhesion,":[297],"differentiation,":[298],"proliferation,":[299],"migration":[301],"addition":[303,618],"maintaining":[305],"blood-brain":[306],"barrier":[307],"integrity.":[308],"To":[309],"develop":[310],"hydrogels":[312,472],"ability":[315],"thiol-functionalized":[318],"attached,":[320],"it":[321,535,545,613,619],"modified":[323,355,363],"divinyl":[325],"sulfone":[326],"(DVS)":[327],"via":[328],"Michael":[330],"Addition":[331],"primary":[334],"hydroxyl":[335],"groups.":[336,565],"modification":[338,502,539,575,637],"allows":[339],"thiolated":[342,527,643],"bioactive":[343,644],"molecule,":[344],"thiolated-laminin,":[345,581],"be":[347],"attached":[348],"DVS":[351,385,564,574,649],"groups":[352,650],"on":[353],"agarose.":[356],"There":[357],"three":[359],"types":[360],"agaroses":[362],"DVS:":[365],"SeaPrep":[366],"(SP),":[367],"SeaPlaque":[368],"(SPQ),":[369],"SeaKem":[371],"(SK).":[372],"stability,":[374,516],"swelling":[375,442,450,624],"degradation":[377,417,432,456],"degree,":[378,584],"mechanical":[379,463],"properties,":[380],"cytocompatibility":[382],"(DVS-Ag)":[387],"at":[389,553],"various":[390],"concentrations":[391],"were":[392,473],"conducted.":[393],"A":[394,415],"seven-day":[395,416],"stability":[396],"study":[397,418,443,570],"revealed":[398],"stable":[401],"concentration":[402],"(w/v)":[403],"was":[404,491,585,634],"1.2%":[405],"DVS-SP,":[407],"1.0%":[408,423,446,466,499,597,600],"DVS-SPQ,":[410],"0.75%":[412,426,452,469,496,594],"DVS-SK.":[414],"demonstrated":[420],"DVS-SPQ":[424,447,467,601],"DVS-SK":[427,453,497,595],"had":[428,448,620],"less":[429],"than":[430],"30%":[431],"course":[435],"7":[437],"days.":[438],"Additionally,":[439,487],"four-day":[441],"showed":[444],"minimal":[449],"while":[451],"experienced":[454],"some":[455,583,630],"prior":[457],"swelling.":[459],"For":[460],"determining":[461],"DVS-SK,":[470],"compressed":[474],"find":[476],"elastic":[478],"modulus":[479,490],"0.0116":[481],"kPa":[482],"0.0107":[484],"kPa,":[485],"respectively.":[486],"compressive":[489,520],"not":[492],"statistically":[493],"significant":[494],"DVS-SPQ.":[500,598],"DVS,":[506],"disorganized":[507],"double":[509],"helical":[510],"structure":[511],"subsequently":[513],"impacted":[514],"degradation,":[517],"modulus.":[521],"When":[522],"assessing":[523],"amount":[525],"molecules":[528,533,645],"comparison":[530],"non-thiolated":[532],"released,":[534],"confirmed":[536],"successful":[538,586],"DVS.":[543],"Furthermore,":[544],"identified":[546],"lower":[549,621],"dosage":[550],"thiolated-molecules":[552,559],"100":[554],"[mu]g/mL":[555],"allowed":[556],"more":[558],"adhere":[561],"Moreover,":[566],"cytotoxic":[568],"analysis":[569],"indicated":[571],"combined":[576],"conjugation":[579],"promoting":[588,607],"Nph":[589,615],"viability":[590],"proliferation":[592],"Overall,":[599],"seemed":[602],"NSPCs":[611],"promoted":[614],"cycling":[622],"degree":[625],"degradation.":[627],"While":[628],"measures":[631],"this":[632,636],"approach":[633],"successful,":[635],"exploring":[641],"different":[642],"conjugated":[646],"create":[652],"promotes":[657]},"counts_by_year":[],"updated_date":"2026-09-03T10:48:47.769340","created_date":"2023-10-24T00:00:00"}
