{"id":"https://openalex.org/W4387871925","doi":"https://doi.org/10.1073/pnas.2305375120","title":"A mechanism-based theory of cellular and tissue plasticity","display_name":"A mechanism-based theory of cellular and tissue plasticity","publication_year":2023,"publication_date":"2023-10-23","ids":{"openalex":"https://openalex.org/W4387871925","doi":"https://doi.org/10.1073/pnas.2305375120","pmid":"https://pubmed.ncbi.nlm.nih.gov/37871208"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.2305375120","doi":"https://doi.org/10.1073/pnas.2305375120","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2305375120","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1073/pnas.2305375120","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000846439","display_name":"Fuqiang Sun","orcid":"https://orcid.org/0000-0001-5687-7483","observed_orcids":["https://orcid.org/0000-0001-5687-7483"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Fuqiang Sun","raw_affiliation_strings":["Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China","The University of Hong Kong-Shenzhen Institute of Research and Innovation, Shenzhen 518057, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"The University of Hong Kong-Shenzhen Institute of Research and Innovation, Shenzhen 518057, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021895004","display_name":"Chao Fang","orcid":"https://orcid.org/0000-0002-0645-7613","observed_orcids":["https://orcid.org/0000-0002-0645-7613"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]},{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN","SG"],"is_corresponding":false,"raw_author_name":"Chao Fang","raw_affiliation_strings":["School of Science, Harbin Institute of Technology, Shenzhen 518055, China","Nanyang Technological University, Singapore"],"raw_orcid":"https://orcid.org/0000-0002-0645-7613","affiliations":[{"raw_affiliation_string":"School of Science, Harbin Institute of Technology, Shenzhen 518055, China","institution_ids":["https://openalex.org/I204983213"]},{"raw_affiliation_string":"Nanyang Technological University, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075971119","display_name":"Xueying Shao","orcid":"https://orcid.org/0000-0002-8964-2733","observed_orcids":["https://orcid.org/0000-0002-8964-2733"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Xueying Shao","raw_affiliation_strings":["Advanced Biomedical Instrumentation Centre, Hong Kong Science Park, Hong Kong, China","Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China"],"raw_orcid":"https://orcid.org/0000-0002-8964-2733","affiliations":[{"raw_affiliation_string":"Advanced Biomedical Instrumentation Centre, Hong Kong Science Park, Hong Kong, China","institution_ids":[]},{"raw_affiliation_string":"Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001073146","display_name":"Huajian Gao","orcid":"https://orcid.org/0000-0002-8656-846X","observed_orcids":["https://orcid.org/0000-0002-8656-846X"]},"institutions":[{"id":"https://openalex.org/I172675005","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302","country_code":"SG","type":"education","lineage":["https://openalex.org/I172675005"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Huajian Gao","raw_affiliation_strings":["College of Engineering, Nanyang Technological University, Singapore 639798, Singapore"],"raw_orcid":"https://orcid.org/0000-0002-8656-846X","affiliations":[{"raw_affiliation_string":"College of Engineering, Nanyang Technological University, Singapore 639798, Singapore","institution_ids":["https://openalex.org/I172675005"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063947720","display_name":"Yuan Lin","orcid":"https://orcid.org/0000-0002-3882-174X","observed_orcids":["https://orcid.org/0000-0002-3882-174X"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Yuan Lin","raw_affiliation_strings":["Advanced Biomedical Instrumentation Centre, Hong Kong Science Park, Hong Kong, China","Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China","The University of Hong Kong-Shenzhen Institute of Research and Innovation, Shenzhen 518057, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Biomedical Instrumentation Centre, Hong Kong Science Park, Hong Kong, China","institution_ids":[]},{"raw_affiliation_string":"Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I889458895"]},{"raw_affiliation_string":"The University of Hong Kong-Shenzhen Institute of Research and Innovation, Shenzhen 518057, China","institution_ids":["https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1938,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.7596649,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"120","issue":"44","first_page":"e2305375120","last_page":"e2305375120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11737","display_name":"Advanced Materials and Mechanics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cellular-plasticity","display_name":"cellular plasticity","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tissue-plasticity","display_name":"tissue plasticity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/active-contraction","display_name":"active contraction","score":0.6859999895095825},{"id":"https://openalex.org/keywords/endocytic-vesicles","display_name":"endocytic vesicles","score":0.8510000109672546},{"id":"https://openalex.org/keywords/mechanochemical-feedback","display_name":"mechanochemical feedback","score":0.8119999766349792},{"id":"https://openalex.org/keywords/collective-cell-migration","display_name":"collective cell migration","score":0.7710000276565552},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/morphogenesis","display_name":"morphogenesis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/thermal-fluctuations","display_name":"thermal fluctuations","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C79186407","wikidata":"https://www.wikidata.org/wiki/Q472074","display_name":"Plasticity","level":2,"score":0.6490248441696167},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.6462435126304626},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.6394126415252686},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6227573156356812},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.5947732925415039},{"id":"https://openalex.org/C40692019","wikidata":"https://www.wikidata.org/wiki/Q815547","display_name":"Morphogenesis","level":3,"score":0.5286600589752197},{"id":"https://openalex.org/C39579648","wikidata":"https://www.wikidata.org/wiki/Q4779796","display_name":"Apical constriction","level":4,"score":0.4619676470756531},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.4380939304828644},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34818875789642334},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3129616975784302},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.28975188732147217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26166003942489624},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.16122552752494812},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.1530725657939911},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007365","descriptor_name":"Intercellular Junctions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.2305375120","doi":"https://doi.org/10.1073/pnas.2305375120","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2305375120","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:37871208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37871208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10622945","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10622945","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10622945/pdf/pnas.202305375.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:dr.ntu.edu.sg:10356/173208","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10356/173208","pdf_url":null,"source":{"id":"https://openalex.org/S4306402609","display_name":"DR-NTU (Nanyang Technological University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172675005","host_organization_name":"Nanyang Technological University","host_organization_lineage":["https://openalex.org/I172675005"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:hub.hku.hk:10722/347920","doi":null,"is_oa":false,"landing_page_url":"http://hub.hku.hk/bitstream/10722/347920/1/re01.htm","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1073/pnas.2305375120","doi":"https://doi.org/10.1073/pnas.2305375120","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.2305375120","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4021546550","display_name":null,"funder_award_id":"002479\u201300001","funder_id":"https://openalex.org/F4320320766","funder_display_name":"Nanyang Technological University"},{"id":"https://openalex.org/G5615679275","display_name":null,"funder_award_id":"GRF/17210618 GRF/17210520","funder_id":"https://openalex.org/F4320321592","funder_display_name":"Research Grants Council, University Grants Committee"}],"funders":[{"id":"https://openalex.org/F4320320696","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09"},{"id":"https://openalex.org/F4320320766","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321592","display_name":"Research Grants Council, University Grants Committee","ror":"https://ror.org/00djwmt25"},{"id":"https://openalex.org/F4320324196","display_name":"Innovation and Technology Commission - Hong Kong","ror":"https://ror.org/04vf9tr09"},{"id":"https://openalex.org/F4320329815","display_name":"Hong Kong Government","ror":"https://ror.org/034179816"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W562467826","https://openalex.org/W1018855955","https://openalex.org/W1595283676","https://openalex.org/W1636022800","https://openalex.org/W1964597029","https://openalex.org/W1970570245","https://openalex.org/W1975703565","https://openalex.org/W1978932874","https://openalex.org/W1981431290","https://openalex.org/W1993006648","https://openalex.org/W1997114875","https://openalex.org/W2007916811","https://openalex.org/W2030274279","https://openalex.org/W2052192720","https://openalex.org/W2067510267","https://openalex.org/W2076619081","https://openalex.org/W2085529478","https://openalex.org/W2100667554","https://openalex.org/W2106217679","https://openalex.org/W2112940322","https://openalex.org/W2122796192","https://openalex.org/W2237694874","https://openalex.org/W2254650429","https://openalex.org/W2443474297","https://openalex.org/W2465151324","https://openalex.org/W2576799546","https://openalex.org/W2606063864","https://openalex.org/W2735252841","https://openalex.org/W2735656245","https://openalex.org/W2759276314","https://openalex.org/W2759932886","https://openalex.org/W2770430675","https://openalex.org/W2884396138","https://openalex.org/W2889000610","https://openalex.org/W2899148412","https://openalex.org/W2950275625","https://openalex.org/W2955418269","https://openalex.org/W2967768480","https://openalex.org/W2972685086","https://openalex.org/W2978894168","https://openalex.org/W2980824804","https://openalex.org/W2997944126","https://openalex.org/W3010015564","https://openalex.org/W3014344225","https://openalex.org/W3023737870","https://openalex.org/W3034141515","https://openalex.org/W3080362910","https://openalex.org/W3080784905","https://openalex.org/W3089738900","https://openalex.org/W3108145103","https://openalex.org/W3111199374","https://openalex.org/W3121063139","https://openalex.org/W3121436404","https://openalex.org/W3128006499","https://openalex.org/W3152670943","https://openalex.org/W3161293549","https://openalex.org/W3169756137","https://openalex.org/W3196593073","https://openalex.org/W4220963742","https://openalex.org/W4221085690","https://openalex.org/W4225115450","https://openalex.org/W4225278599","https://openalex.org/W4225300185","https://openalex.org/W4280550860","https://openalex.org/W4280557628","https://openalex.org/W4293412890","https://openalex.org/W4309563898","https://openalex.org/W4310155564","https://openalex.org/W4317567753","https://openalex.org/W4318225021"],"related_works":["https://openalex.org/W1996619733","https://openalex.org/W2555937715","https://openalex.org/W3012617179","https://openalex.org/W2080098793","https://openalex.org/W2791677059","https://openalex.org/W2173958468","https://openalex.org/W2128877649","https://openalex.org/W158464399","https://openalex.org/W2971901053","https://openalex.org/W2624118253"],"abstract_inverted_index":{"Plastic":[0],"deformation":[1,226],"in":[2,13,30,97,189,202,221],"cells":[3,32,132,201],"and":[4,19,33,49,62,81,107,111,124,133,141,167,213],"tissues":[5],"has":[6],"been":[7],"found":[8],"to":[9,99,118,159,207],"play":[10],"crucial":[11],"roles":[12],"collective":[14],"cell":[15,79,122,173],"migration,":[16],"cancer":[17],"metastasis,":[18],"morphogenesis.":[20],"However,":[21],"the":[22,37,60,73,104,211,222,229],"fundamental":[23],"question":[24],"of":[25,47,64,75,113,121,172,200,215,224],"how":[26],"plasticity":[27,51],"is":[28,182,237],"initiated":[29],"individual":[31],"then":[34],"propagates":[35],"within":[36,228],"tissue":[38,50,203],"remains":[39],"elusive.":[40],"Here,":[41],"we":[42],"develop":[43],"a":[44,155,168,179,232],"mechanism-based":[45],"theory":[46,85,149],"cellular":[48],"that":[52,83,125,151,198],"accounts":[53],"for":[54],"all":[55,90,188],"key":[56],"processes":[57],"involved,":[58],"including":[59],"activation":[61],"development":[63],"active":[65,136,216],"contraction":[66,106,137,217],"at":[67],"different":[68],"scales":[69],"as":[70,72,146,210],"well":[71],"formation":[74,110],"endocytic":[76,114,152],"vesicles":[77,115,153],"on":[78],"junctions":[80,123,174],"show":[82],"this":[84],"achieves":[86],"quantitative":[87,190],"agreement":[88,191],"with":[89,154,192,231,239],"existing":[91],"experiments.":[92,193],"Specifically,":[93],"it":[94],"reveals":[95],"that,":[96],"response":[98],"optical":[100],"or":[101],"mechanical":[102],"stimuli,":[103],"myosin":[105],"thermal":[108],"fluctuation-assisted":[109],"pinching":[112],"could":[116,175],"lead":[117],"permanent":[119],"shortening":[120,171],"such":[126],"plastic":[127,144,225],"constriction":[128,199],"can":[129,204],"stretch":[130],"neighboring":[131],"trigger":[134],"their":[135,143],"through":[138],"mechanochemical":[139],"feedbacks":[140],"eventually":[142],"deformations":[145],"well.":[147],"Our":[148,194],"predicts":[150],"size":[156],"around":[157],"1":[158],"2":[160],"\u00b5m":[161],"will":[162],"most":[163],"likely":[164],"be":[165,176],"formed":[166],"higher":[169],"irreversible":[170],"achieved":[177],"if":[178],"long":[180],"stimulation":[181],"split":[183],"into":[184],"multiple":[185],"short":[186],"ones,":[187],"analysis":[195],"also":[196],"shows":[197],"undergo":[205],"elastic/unratcheted":[206],"plastic/ratcheted":[208],"transition":[209],"magnitude":[212],"duration":[214],"increases,":[218],"ultimately":[219],"resulting":[220],"propagation":[223],"waves":[227],"monolayer":[230],"constant":[233],"speed":[234],"which":[235],"again":[236],"consistent":[238],"experimental":[240],"observations.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}