{"id":"https://openalex.org/W4387859628","doi":"https://doi.org/10.1080/08880018.2023.2271013","title":"Access to Methotrexate Monitoring in Latin America: A Multicountry Survey of Supportive Care Capacity","display_name":"Access to Methotrexate Monitoring in Latin America: A Multicountry Survey of Supportive Care Capacity","publication_year":2023,"publication_date":"2023-10-22","ids":{"openalex":"https://openalex.org/W4387859628","doi":"https://doi.org/10.1080/08880018.2023.2271013","pmid":"https://pubmed.ncbi.nlm.nih.gov/37865916"},"language":"en","primary_location":{"id":"doi:10.1080/08880018.2023.2271013","doi":"https://doi.org/10.1080/08880018.2023.2271013","is_oa":true,"landing_page_url":"https://doi.org/10.1080/08880018.2023.2271013","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/08880018.2023.2271013?needAccess=true","source":{"id":"https://openalex.org/S101758675","display_name":"Pediatric Hematology and Oncology","issn_l":"0888-0018","issn":["0888-0018","1521-0669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Hematology and Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/08880018.2023.2271013?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066162188","display_name":"Gabriela Abigail Villanueva","orcid":"https://orcid.org/0000-0002-6159-1882","observed_orcids":["https://orcid.org/0000-0002-6159-1882"]},"institutions":[{"id":"https://openalex.org/I4387153510","display_name":"Resonance (United States)","ror":"https://ror.org/044ze3t60","country_code":"US","type":"company","lineage":["https://openalex.org/I4387153510"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gabriela Villanueva","raw_affiliation_strings":["Department of Clinical Research, Resonance, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, Resonance, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I4387153510"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jennifer Lowe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153510","display_name":"Resonance (United States)","ror":"https://ror.org/044ze3t60","country_code":"US","type":"company","lineage":["https://openalex.org/I4387153510"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Lowe","raw_affiliation_strings":["Department of Clinical Research, Resonance, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, Resonance, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I4387153510"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069842759","display_name":"Nicol\u00e1s Tentoni","orcid":"https://orcid.org/0000-0002-9402-5086","observed_orcids":["https://orcid.org/0000-0002-9402-5086"]},"institutions":[{"id":"https://openalex.org/I4387153510","display_name":"Resonance (United States)","ror":"https://ror.org/044ze3t60","country_code":"US","type":"company","lineage":["https://openalex.org/I4387153510"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicol\u00e1s Tentoni","raw_affiliation_strings":["Department of Clinical Research, Resonance, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, Resonance, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I4387153510"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043733252","display_name":"Ankit Taluja","orcid":"https://orcid.org/0000-0001-5215-7032","observed_orcids":["https://orcid.org/0000-0001-5215-7032"]},"institutions":[{"id":"https://openalex.org/I4387153510","display_name":"Resonance (United States)","ror":"https://ror.org/044ze3t60","country_code":"US","type":"company","lineage":["https://openalex.org/I4387153510"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ankit Taluja","raw_affiliation_strings":["Department of Clinical Research, Resonance, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, Resonance, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I4387153510"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059549851","display_name":"Milena Villarroel C.","orcid":"https://orcid.org/0000-0002-2985-614X","observed_orcids":["https://orcid.org/0000-0002-2985-614X"]},"institutions":[{"id":"https://openalex.org/I4210109374","display_name":"Hospital Luis Calvo Mackenna","ror":"https://ror.org/02k2v9264","country_code":"CL","type":"healthcare","lineage":["https://openalex.org/I4210109374"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Milena Villarroel","raw_affiliation_strings":["Department of Pediatric Oncology and Hematology, Hospital Dr. Luis Calvo Mackenna, Santiago de Chile, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology and Hematology, Hospital Dr. Luis Calvo Mackenna, Santiago de Chile, Chile","institution_ids":["https://openalex.org/I4210109374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111061435","display_name":"Carlos E. Narv\u00e1ez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos E. Narv\u00e1ez","raw_affiliation_strings":["Department of Pediatric Oncology, Cl\u00ednica Imbanaco, Grupo Quir\u00f3n Salud, Cali, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology, Cl\u00ednica Imbanaco, Grupo Quir\u00f3n Salud, Cali, Colombia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106560370","display_name":"Sandra Alarc\u00f3n-Le\u00f3n","orcid":"https://orcid.org/0000-0002-4824-5627","observed_orcids":["https://orcid.org/0000-0002-4824-5627"]},"institutions":[{"id":"https://openalex.org/I4210123325","display_name":"Instituto Nacional de Enfermedades Neopl\u00e1sicas","ror":"https://ror.org/03674y156","country_code":"PE","type":"healthcare","lineage":["https://openalex.org/I4210123325"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Sandra Alarc\u00f3n Le\u00f3n","raw_affiliation_strings":["Department of Pediatric Oncology, Instituto Nacional de Enfermedades Neopl\u00e1sicas, Lima, Peru"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology, Instituto Nacional de Enfermedades Neopl\u00e1sicas, Lima, Peru","institution_ids":["https://openalex.org/I4210123325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102830456","display_name":"Diana Lorena Valencia Libreros","orcid":"https://orcid.org/0000-0001-6633-9275","observed_orcids":["https://orcid.org/0000-0001-6633-9275"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diana L. Valencia Libreros","raw_affiliation_strings":["Department of Pediatric Oncology, IMAT Oncomedica AUNA, Monteria, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology, IMAT Oncomedica AUNA, Monteria, Colombia","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Natalia Gonzalez Su\u00e1rez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111964","display_name":"Hospital Militar Central","ror":"https://ror.org/02bx25k35","country_code":"CO","type":"healthcare","lineage":["https://openalex.org/I4210111964"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Natalia Gonzalez Su\u00e1rez","raw_affiliation_strings":["Department of Pediatric Oncology, Hospital Militar Central, Bogota, Colombia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology, Hospital Militar Central, Bogota, Colombia","institution_ids":["https://openalex.org/I4210111964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033326521","display_name":"Torben Stamm Mikkelsen","orcid":"https://orcid.org/0000-0001-8188-2188","observed_orcids":["https://orcid.org/0000-0001-8188-2188"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Torben S. Mikkelsen","raw_affiliation_strings":["Department of Pediatric Oncology and Hematology, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology and Hematology, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011622752","display_name":"Scott C. Howard","orcid":"https://orcid.org/0000-0003-2244-1686","observed_orcids":["https://orcid.org/0000-0003-2244-1686"]},"institutions":[{"id":"https://openalex.org/I4387153510","display_name":"Resonance (United States)","ror":"https://ror.org/044ze3t60","country_code":"US","type":"company","lineage":["https://openalex.org/I4387153510"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott C. Howard","raw_affiliation_strings":["Department of Clinical Research, Resonance, Memphis, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research, Resonance, Memphis, Tennessee, USA","institution_ids":["https://openalex.org/I4387153510"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5066162188"],"corresponding_institution_ids":["https://openalex.org/I4387153510"],"apc_list":null,"apc_paid":null,"fwci":1.7835,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.84234943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"41","issue":"2","first_page":"135","last_page":"149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9086999893188477,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13123","display_name":"Advances in Oncology and Radiotherapy","score":0.03720000013709068,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-dose-methotrexate","display_name":"high-dose methotrexate","score":0.9819999933242798},{"id":"https://openalex.org/keywords/latin-america","display_name":"Latin America","score":0.7319999933242798},{"id":"https://openalex.org/keywords/pediatric-oncology","display_name":"pediatric oncology","score":0.9399999976158142},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9079999923706055},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.8140000104904175},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.878000020980835},{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":0.8389999866485596},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.7509999871253967},{"id":"https://openalex.org/keywords/drug-shortages","display_name":"drug shortages","score":0.5899999737739563},{"id":"https://openalex.org/keywords/laboratory-access","display_name":"laboratory access","score":0.7120000123977661},{"id":"https://openalex.org/keywords/dose-reduction","display_name":"dose reduction","score":0.33500000834465027},{"id":"https://openalex.org/keywords/resource-limited-settings","display_name":"resource-limited settings","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9358580112457275},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.6588574647903442},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.44326409697532654},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3745768666267395},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32217204570770264}],"mesh":[{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002528","descriptor_name":"Cerebellar Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007843","descriptor_name":"Latin America","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1080/08880018.2023.2271013","doi":"https://doi.org/10.1080/08880018.2023.2271013","is_oa":true,"landing_page_url":"https://doi.org/10.1080/08880018.2023.2271013","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/08880018.2023.2271013?needAccess=true","source":{"id":"https://openalex.org/S101758675","display_name":"Pediatric Hematology and Oncology","issn_l":"0888-0018","issn":["0888-0018","1521-0669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Hematology and Oncology","raw_type":"journal-article"},{"id":"pmid:37865916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37865916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric hematology and oncology","raw_type":"Multicenter Study"},{"id":"pmh:oai:figshare.com:article/24418156","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Access_to_Methotrexate_Monitoring_in_Latin_America_A_Multicountry_Survey_of_Supportive_Care_Capacity/24418156","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire/084db498-33d4-4486-9628-ab3dd65c83f2","doi":null,"is_oa":true,"landing_page_url":"https://pure.au.dk/portal/en/publications/084db498-33d4-4486-9628-ab3dd65c83f2","pdf_url":null,"source":null,"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Villanueva, G, Lowe, J, Tentoni, N, Taluja, A, Villarroel, M, Narv\u00e1ez, C E, Le\u00f3n, S A, Valencia Libreros, D L, Gonzalez Su\u00e1rez, N, Mikkelsen, T S & Howard, S C 2024, 'Access to Methotrexate Monitoring in Latin America : A\u00a0Multicountry Survey of Supportive Care Capacity', Pediatric Hematology\u00a0and Oncology, vol. 41, no. 2, pp. 135-149. https://doi.org/10.1080/08880018.2023.2271013","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorio.inen.sld.pe:20.500.14703/358","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.14703/358","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"instacron:INEN","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.6084/m9.figshare.24418156.v1","doi":"https://doi.org/10.6084/m9.figshare.24418156.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.24418156.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1080/08880018.2023.2271013","doi":"https://doi.org/10.1080/08880018.2023.2271013","is_oa":true,"landing_page_url":"https://doi.org/10.1080/08880018.2023.2271013","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/08880018.2023.2271013?needAccess=true","source":{"id":"https://openalex.org/S101758675","display_name":"Pediatric Hematology and Oncology","issn_l":"0888-0018","issn":["0888-0018","1521-0669"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric Hematology and Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387859628.pdf","grobid_xml":"https://content.openalex.org/works/W4387859628.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1579768579","https://openalex.org/W1983930052","https://openalex.org/W2014346676","https://openalex.org/W2018584517","https://openalex.org/W2045786089","https://openalex.org/W2046750551","https://openalex.org/W2058922193","https://openalex.org/W2086338003","https://openalex.org/W2112315036","https://openalex.org/W2124815378","https://openalex.org/W2126447088","https://openalex.org/W2152829853","https://openalex.org/W2154832101","https://openalex.org/W2166334998","https://openalex.org/W2493103431","https://openalex.org/W2758897838","https://openalex.org/W2766169840","https://openalex.org/W2768394516","https://openalex.org/W2803165542","https://openalex.org/W2921430890","https://openalex.org/W2949002175","https://openalex.org/W2969424706","https://openalex.org/W3011960787","https://openalex.org/W3025919594","https://openalex.org/W3036860556","https://openalex.org/W3080518003","https://openalex.org/W3081491793","https://openalex.org/W3136471464","https://openalex.org/W4214898668","https://openalex.org/W4295357815"],"related_works":["https://openalex.org/W7160904933","https://openalex.org/W3080518003","https://openalex.org/W7212180997","https://openalex.org/W2901228403","https://openalex.org/W7111094101","https://openalex.org/W3136471464","https://openalex.org/W3110693464","https://openalex.org/W4385658084","https://openalex.org/W2970004913","https://openalex.org/W2803165542"],"abstract_inverted_index":{"High-dose":[0],"methotrexate":[1],"(HDMTX)":[2],"is":[3,29,205],"used":[4,86],"to":[5,44,58,87,114,165,171,236],"treat":[6,88],"a":[7],"broad":[8],"spectrum":[9],"of":[10,40,191,199,202,219,224,230,239,242],"cancers.":[11],"Methotrexate":[12],"(MTX)":[13],"monitoring":[14,52,123,173,226],"and":[15,35,50,61,104,118,138,148,158,227],"adequate":[16],"supportive":[17,47,211],"care":[18,48,212],"are":[19],"critical":[20],"for":[21,63,178],"safe":[22,217],"drug":[23],"administration;":[24],"however,":[25],"MTX":[26,51,119,122,150,172,176,187,203,220,225,243],"level":[27],"timing":[28],"not":[30,140,185],"always":[31],"possible":[32],"in":[33,54,108,130,136,142,156,162,188],"low-":[34],"middle-income":[36],"countries.":[37],"The":[38],"aim":[39],"this":[41],"study":[42],"was":[43,68,85,124,139,152],"evaluate":[45],"HDMTX":[46,84,110],"capacity":[49,213],"practices":[53],"Latin":[55],"America":[56],"(LATAM)":[57],"identify":[59],"gaps":[60],"opportunities":[62],"improvement.":[64],"A":[65],"multicenter":[66],"survey":[67],"conducted":[69],"among":[70],"LATAM":[71],"pediatric":[72],"oncologists.":[73],"Twenty":[74],"healthcare":[75],"providers":[76],"from":[77],"20":[78],"institutions":[79],"answered":[80],"the":[81,175,189,216,228,246],"online":[82],"questionnaire.":[83],"acute":[89],"lymphoblastic":[90],"leukemia":[91],"(ALL;":[92],"100%),":[93],"non-Hodgkin":[94],"lymphoma":[95,100],"(84.2%),":[96],"diffuse":[97],"large":[98],"B-cell":[99],"(47.4%),":[101],"osteosarcoma":[102],"(78.9%),":[103],"medulloblastoma":[105],"(31.6%).":[106],"Delays":[107],"starting":[109],"infusion":[111],"were":[112],"related":[113,164],"bed":[115],"shortages":[116,120],"(47.4%)":[117],"(21.1%).":[121],"performed":[125],"at":[126,132],"an":[127,133],"in-hospital":[128],"laboratory":[129,135,166],"52%,":[131],"external/nearby":[134],"31.6%,":[137],"available":[141],"10.5%.":[143],"Median":[144],"interval":[145],"between":[146],"sampling":[147],"obtaining":[149,231],"levels":[151,204],"\u2264":[153],"2":[154],"h":[155,161],"45%":[157],"\u2265":[159],"6":[160],"30%,":[163],"location.":[167],"Sites":[168],"without":[169],"access":[170],"reduced":[174],"dose":[177],"patients":[179,192],"with":[180,193],"high-risk":[181],"ALL":[182],"or":[183],"did":[184],"include":[186],"treatment":[190],"osteosarcoma.":[194],"Respondents":[195],"reported":[196],"that":[197],"implementation":[198],"point-of-care":[200],"testing":[201],"feasible.":[206],"In":[207],"LATAM,":[208],"highly":[209],"variable":[210],"may":[214],"affect":[215],"administration":[218],"doses.":[221],"Improving":[222],"accessibility":[223],"speed":[229],"results":[232],"should":[233],"be":[234],"prioritized":[235],"allow":[237],"delivery":[238],"full":[240],"doses":[241],"required":[244],"by":[245],"current":[247],"protocols.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-10-23T00:00:00"}
