{"id":"https://openalex.org/W4387855875","doi":"https://doi.org/10.1002/j.1939-4640.1991.tb01604.x","title":"17\u03b2\u2010Estradiol Inhibition of Leydig Cell Regeneration in the Ethane Dimethylsulfonate\u2010Treated Mature Rat","display_name":"17\u03b2\u2010Estradiol Inhibition of Leydig Cell Regeneration in the Ethane Dimethylsulfonate\u2010Treated Mature Rat","publication_year":1991,"publication_date":"1991-09-10","ids":{"openalex":"https://openalex.org/W4387855875","doi":"https://doi.org/10.1002/j.1939-4640.1991.tb01604.x","mag":"1918893870","pmid":"https://pubmed.ncbi.nlm.nih.gov/1662673"},"language":"en","primary_location":{"id":"doi:10.1002/j.1939-4640.1991.tb01604.x","doi":"https://doi.org/10.1002/j.1939-4640.1991.tb01604.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1939-4640.1991.tb01604.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1939-4640.1991.tb01604.x","source":{"id":"https://openalex.org/S4394735507","display_name":"Journal of Andrology","issn_l":"0196-3635","issn":["0196-3635","1939-4640"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Andrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1939-4640.1991.tb01604.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111810427","display_name":"Tom O. Abney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"TOM O. ABNEY","raw_affiliation_strings":["Department of Physiology and Endocrinology, Medical College of Georgia, Augusta, Georgia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Endocrinology, Medical College of Georgia, Augusta, Georgia","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109246603","display_name":"Russell B. Myers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RUSSELL B. MYERS","raw_affiliation_strings":["Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111810427"],"corresponding_institution_ids":["https://openalex.org/I25041050"],"apc_list":null,"apc_paid":null,"fwci":0.8903,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.71280476,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"12","issue":"5","first_page":"295","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.03909999877214432,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9399999976158142},{"id":"https://openalex.org/keywords/leydig-cell-regeneration","display_name":"Leydig cell regeneration","score":0.9700000286102295},{"id":"https://openalex.org/keywords/testicular-interstitial-cells","display_name":"testicular interstitial cells","score":0.703000009059906},{"id":"https://openalex.org/keywords/leydig-cell-development","display_name":"Leydig cell development","score":0.8700000047683716},{"id":"https://openalex.org/keywords/human-chorionic-gonadotropin","display_name":"human chorionic gonadotropin","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hcg-binding","display_name":"hCG binding","score":0.6669999957084656},{"id":"https://openalex.org/keywords/testis","display_name":"testis","score":0.4269999861717224},{"id":"https://openalex.org/keywords/male-rats","display_name":"male rats","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C2777736315","wikidata":"https://www.wikidata.org/wiki/Q636846","display_name":"Leydig cell","level":4,"score":0.896774411201477},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7014323472976685},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6681221723556519},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6363012790679932},{"id":"https://openalex.org/C2775948956","wikidata":"https://www.wikidata.org/wiki/Q407172","display_name":"Human chorionic gonadotropin","level":3,"score":0.523076593875885},{"id":"https://openalex.org/C2779066085","wikidata":"https://www.wikidata.org/wiki/Q9384","display_name":"Testicle","level":2,"score":0.48609256744384766},{"id":"https://openalex.org/C2780159080","wikidata":"https://www.wikidata.org/wiki/Q1400536","display_name":"Intraperitoneal injection","level":2,"score":0.48108479380607605},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4766288995742798},{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.46618956327438354},{"id":"https://openalex.org/C2910555652","wikidata":"https://www.wikidata.org/wiki/Q4000420","display_name":"Leydig Cell Tumor","level":5,"score":0.42274805903434753},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.41700297594070435},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41067248582839966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35471397638320923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27568429708480835},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.14628461003303528},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1443403959274292},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.08280247449874878},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.05961814522743225},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05848577618598938}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006063","descriptor_name":"Chorionic Gonadotropin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007985","descriptor_name":"Leydig Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008698","descriptor_name":"Mesylates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013739","descriptor_name":"Testosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/j.1939-4640.1991.tb01604.x","doi":"https://doi.org/10.1002/j.1939-4640.1991.tb01604.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1939-4640.1991.tb01604.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1939-4640.1991.tb01604.x","source":{"id":"https://openalex.org/S4394735507","display_name":"Journal of Andrology","issn_l":"0196-3635","issn":["0196-3635","1939-4640"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Andrology","raw_type":"journal-article"},{"id":"pmid:1662673","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1662673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of andrology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.325.3921","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.325.3921","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.andrologyjournal.org/cgi/reprint/12/5/295.pdf","raw_type":"text"},{"id":"mag:1918893870","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1662673","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.1002/j.1939-4640.1991.tb01604.x","doi":"https://doi.org/10.1002/j.1939-4640.1991.tb01604.x","is_oa":true,"landing_page_url":"https://doi.org/10.1002/j.1939-4640.1991.tb01604.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1939-4640.1991.tb01604.x","source":{"id":"https://openalex.org/S4394735507","display_name":"Journal of Andrology","issn_l":"0196-3635","issn":["0196-3635","1939-4640"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Andrology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2025081235","display_name":"BIOMEDICAL RESEARCH SUPPORT","funder_award_id":"S07RR005635","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4387855875.pdf"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W93269911","https://openalex.org/W1550106832","https://openalex.org/W1795916275","https://openalex.org/W1895702731","https://openalex.org/W1943214388","https://openalex.org/W1960748297","https://openalex.org/W1967504190","https://openalex.org/W1970871407","https://openalex.org/W1976572262","https://openalex.org/W1979078413","https://openalex.org/W1979188852","https://openalex.org/W1985665219","https://openalex.org/W1987446085","https://openalex.org/W1987931974","https://openalex.org/W1990215840","https://openalex.org/W1997425733","https://openalex.org/W2003605133","https://openalex.org/W2004543369","https://openalex.org/W2005596215","https://openalex.org/W2005598524","https://openalex.org/W2010026951","https://openalex.org/W2011793441","https://openalex.org/W2015320512","https://openalex.org/W2016242080","https://openalex.org/W2020507716","https://openalex.org/W2021861947","https://openalex.org/W2023230221","https://openalex.org/W2025913358","https://openalex.org/W2027076894","https://openalex.org/W2027933172","https://openalex.org/W2038116648","https://openalex.org/W2041990051","https://openalex.org/W2052528438","https://openalex.org/W2057966419","https://openalex.org/W2061554880","https://openalex.org/W2075682488","https://openalex.org/W2075909743","https://openalex.org/W2076720104","https://openalex.org/W2083531638","https://openalex.org/W2084371773","https://openalex.org/W2091121192","https://openalex.org/W2093812262","https://openalex.org/W2094135706","https://openalex.org/W2109562999","https://openalex.org/W2123984015","https://openalex.org/W2129222205","https://openalex.org/W2131727903","https://openalex.org/W2149942004","https://openalex.org/W2151589782","https://openalex.org/W2153832418","https://openalex.org/W2158094566","https://openalex.org/W2169798916","https://openalex.org/W2171711773","https://openalex.org/W2196462121","https://openalex.org/W2294983724","https://openalex.org/W2884808951","https://openalex.org/W3117416719"],"related_works":["https://openalex.org/W1918893870","https://openalex.org/W7100661676","https://openalex.org/W2005598524","https://openalex.org/W2090266069","https://openalex.org/W2063134547","https://openalex.org/W2036119676","https://openalex.org/W2083531638","https://openalex.org/W2094461365","https://openalex.org/W2057966419","https://openalex.org/W2884808951"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,227,234],"designed":[3],"to":[4,21,204],"determine":[5],"the":[6,17,75,140,148,179,190,208,217,239],"effects":[7],"of":[8,32,48,51,58,74,101,104,110,138,147,176,192,210,241],"17":[9],"beta-estradiol":[10],"(E2)":[11],"on":[12,85,132,189],"Leydig":[13,149,196,211,244,258],"cell":[14,221,259],"development":[15],"in":[16,153,155,219,238],"rat.":[18],"Mature":[19],"(60":[20],"65":[22],"days":[23,86,115,182,202,231,263],"old)":[24],"male":[25],"rats":[26,41,53,106],"received":[27,55,107],"a":[28,72],"single":[29],"intraperitoneal":[30],"injection":[31],"ethane":[33],"dimethylsulfonate":[34],"(EDS,":[35],"100":[36],"mg/kg":[37],"body":[38,64],"weight);":[39],"untreated":[40],"served":[42],"as":[43],"controls.":[44],"In":[45,98,135],"one":[46],"series":[47,100,137],"experiments,":[49,102,139],"groups":[50,103],"EDS-treated":[52,105],"also":[54,164],"daily":[56,108],"injections":[57,109],"either":[59],"E2":[60,113,174,200,225],"(25":[61],"micrograms/100":[62],"g":[63],"weight),":[65],"human":[66],"chorionic":[67],"gonadotropin":[68],"(hCG,":[69],"20":[70],"IU/day),":[71],"combination":[73],"two,":[76],"or":[77,122,243],"vehicle":[78],"only":[79],"(EDS":[80],"controls).":[81],"Animals":[82],"were":[83,130,151,163],"killed":[84,131],"2,":[87],"4,":[88],"10,":[89],"16,":[90],"24,":[91],"30,":[92,121],"and":[93,112,129,143,166,171,195,213,265],"36":[94],"after":[95,126,183],"EDS":[96,127,184],"treatment.":[97],"another":[99],"hCG":[111,144],"during":[114,178,201],"0":[116],"through":[117,120,124],"5,":[118],"5":[119,181,203,264],"16":[123,230,266],"30":[125,205],"treatment,":[128],"day":[133],"30.":[134],"both":[136],"steroidogenic":[141],"capacity":[142,146],"binding":[145],"cells":[150,194,212],"examined":[152,167],"short-term":[154],"vitro":[156],"incubations":[157],"using":[158],"collagenase-dispersed":[159],"interstitial":[160,193,220,242],"cells.":[161,197,245],"Testes":[162],"prepared":[165],"histologically":[168],"by":[169],"light":[170],"electron":[172],"microscopy.":[173],"treatment":[175,226],"animals":[177],"initial":[180],"administration":[185],"had":[186],"no":[187,235],"effect":[188],"regeneration":[191,209,240,260],"Treatment":[198],"with":[199],"post-EDS":[206],"blocked":[207],"thereby":[214],"significantly":[215],"reduced":[216],"increase":[218],"numbers.":[222],"Finally,":[223],"when":[224],"delayed":[228],"until":[229],"post-EDS,":[232],"there":[233],"significant":[236],"reduction":[237],"These":[246],"data":[247],"suggest":[248],"that":[249,254],"an":[250],"important":[251],"developmental":[252],"process":[253],"is":[255],"necessary":[256],"for":[257],"occurs":[261],"between":[262],"post-EDS.(ABSTRACT":[267],"TRUNCATED":[268],"AT":[269],"250":[270],"WORDS)":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-10-23T00:00:00"}