{"id":"https://openalex.org/W4387826344","doi":"https://doi.org/10.1016/j.annonc.2023.09.685","title":"739P Penile squamous cell carcinoma tissue associated macrophages captured by multiplex immunfluorence are associated with clinical outcomes","display_name":"739P Penile squamous cell carcinoma tissue associated macrophages captured by multiplex immunfluorence are associated with clinical outcomes","publication_year":2023,"publication_date":"2023-10-01","ids":{"openalex":"https://openalex.org/W4387826344","doi":"https://doi.org/10.1016/j.annonc.2023.09.685"},"language":"en","primary_location":{"id":"doi:10.1016/j.annonc.2023.09.685","doi":"https://doi.org/10.1016/j.annonc.2023.09.685","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2023.09.685","pdf_url":"http://www.annalsofoncology.org/article/S0923753423015211/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.annalsofoncology.org/article/S0923753423015211/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014154182","display_name":"Jad Chahoud","orcid":"https://orcid.org/0000-0002-8435-0264","observed_orcids":["https://orcid.org/0000-0002-8435-0264"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Chahoud","raw_affiliation_strings":["GU Oncology, H. Lee Moffitt Cancer Center&Research Institute-Magnolia Campus, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GU Oncology, H. Lee Moffitt Cancer Center&Research Institute-Magnolia Campus, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005275342","display_name":"Filip Ionescu","orcid":"https://orcid.org/0000-0003-3097-8985","observed_orcids":["https://orcid.org/0000-0003-3097-8985"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Ionescu","raw_affiliation_strings":["GU, Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GU, Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045198316","display_name":"Mahati Paravathaneni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Paravathaneni","raw_affiliation_strings":["Medical Oncology, Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000377318","display_name":"Logan W. Zemp","orcid":"https://orcid.org/0000-0002-7701-5070","observed_orcids":["https://orcid.org/0000-0002-7701-5070"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Zemp","raw_affiliation_strings":["GU, Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GU, Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026427115","display_name":"Alice Yu","orcid":"https://orcid.org/0000-0002-9547-9258","observed_orcids":["https://orcid.org/0000-0002-9547-9258"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Yu","raw_affiliation_strings":["GU, Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GU, Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086603901","display_name":"Steven A. Eschrich","orcid":"https://orcid.org/0000-0002-9833-2788","observed_orcids":["https://orcid.org/0000-0002-9833-2788"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Eschrich","raw_affiliation_strings":["Biostat, Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostat, Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023248270","display_name":"Y. Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Kim","raw_affiliation_strings":["Biostat, Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostat, Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112560159","display_name":"Daniel Grass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Grass","raw_affiliation_strings":["Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Oncology, Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015862974","display_name":"Jasreman Dhillon","orcid":"https://orcid.org/0000-0001-6785-3487","observed_orcids":["https://orcid.org/0000-0001-6785-3487"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Dhillon","raw_affiliation_strings":["Pathology, Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071641697","display_name":"Brandon J. Manley","orcid":"https://orcid.org/0000-0001-8545-7816","observed_orcids":["https://orcid.org/0000-0001-8545-7816"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Manley","raw_affiliation_strings":["GU, Moffitt Cancer Center, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GU, Moffitt Cancer Center, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033353421","display_name":"Philippe E. Spiess","orcid":"https://orcid.org/0000-0002-5723-1972","observed_orcids":["https://orcid.org/0000-0002-5723-1972"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Spiess","raw_affiliation_strings":["GU Oncology, H. Lee Moffitt Cancer Center&Research Institute-Magnolia Campus, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GU Oncology, H. Lee Moffitt Cancer Center&Research Institute-Magnolia Campus, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":{"value":4060,"currency":"USD","value_usd":4060},"apc_paid":{"value":4060,"currency":"USD","value_usd":4060},"fwci":0.2684,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.57302713,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"34","issue":null,"first_page":"S506","last_page":"S506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11713","display_name":"Genital Health and Disease","score":0.6470000147819519,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.21889999508857727,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/penile-squamous-cell-carcinoma","display_name":"penile squamous cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.9900000095367432},{"id":"https://openalex.org/keywords/clinical-outcomes","display_name":"clinical outcomes","score":0.8360000252723694},{"id":"https://openalex.org/keywords/multiplex-immunofluorescence","display_name":"multiplex immunofluorescence","score":0.8880000114440918},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7357467412948608},{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.6833309531211853},{"id":"https://openalex.org/C2776460901","wikidata":"https://www.wikidata.org/wiki/Q21109693","display_name":"CD68","level":3,"score":0.5574684143066406},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.5459359288215637},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.49909472465515137},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4887854754924774},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.43554770946502686},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4335048198699951},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.42473259568214417},{"id":"https://openalex.org/C18031839","wikidata":"https://www.wikidata.org/wiki/Q5009796","display_name":"CD20","level":3,"score":0.42071279883384705},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41971462965011597},{"id":"https://openalex.org/C2779929431","wikidata":"https://www.wikidata.org/wiki/Q2948600","display_name":"High-power field","level":3,"score":0.4187215268611908},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.36085981130599976},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3287407159805298},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2818673253059387},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1264280080795288}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.annonc.2023.09.685","doi":"https://doi.org/10.1016/j.annonc.2023.09.685","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2023.09.685","pdf_url":"http://www.annalsofoncology.org/article/S0923753423015211/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.annonc.2023.09.685","doi":"https://doi.org/10.1016/j.annonc.2023.09.685","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2023.09.685","pdf_url":"http://www.annalsofoncology.org/article/S0923753423015211/pdf","source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387826344.pdf","grobid_xml":"https://content.openalex.org/works/W4387826344.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3006767832","https://openalex.org/W3020819029","https://openalex.org/W4391303433","https://openalex.org/W4407700078","https://openalex.org/W4390741682","https://openalex.org/W3105724755","https://openalex.org/W7124151126","https://openalex.org/W4407701132","https://openalex.org/W7133215969","https://openalex.org/W4324136189"],"abstract_inverted_index":{"Penile":[0],"squamous":[1],"cell":[2],"carcinoma":[3],"(PSCC)":[4],"is":[5],"rare":[6],"and":[7,28],"the":[8,21],"immune":[9,22],"enviroment":[10],"of":[11],"PSCC":[12],"remains":[13],"poorly":[14],"characterized.":[15],"In":[16],"this":[17],"study,":[18],"we":[19],"characterize":[20],"microenvironment":[23],"using":[24],"multiplex":[25],"immunofluorescence":[26],"(mIF)":[27],"image":[29],"analysis":[30],"approaches":[31],"in":[32],"57":[33],"patients":[34],"with":[35],"PSCC.":[36]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-02T10:15:12.560889","created_date":"2023-10-21T00:00:00"}