{"id":"https://openalex.org/W4387809845","doi":"https://doi.org/10.9734/ajbgmb/2023/v15i3339","title":"Genotoxic and Cytotoxicity Activities of Leaf Extract of Setaria megaphylla","display_name":"Genotoxic and Cytotoxicity Activities of Leaf Extract of Setaria megaphylla","publication_year":2023,"publication_date":"2023-10-20","ids":{"openalex":"https://openalex.org/W4387809845","doi":"https://doi.org/10.9734/ajbgmb/2023/v15i3339"},"language":"en","primary_location":{"id":"doi:10.9734/ajbgmb/2023/v15i3339","doi":"https://doi.org/10.9734/ajbgmb/2023/v15i3339","is_oa":true,"landing_page_url":"http://dx.doi.org/10.9734/ajbgmb/2023/v15i3339","pdf_url":"https://journalajbgmb.com/index.php/AJBGMB/article/download/339/674","source":{"id":"https://openalex.org/S4210229028","display_name":"Asian Journal of Biochemistry Genetics and Molecular Biology","issn_l":"2582-3698","issn":["2582-3698"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Biochemistry, Genetics and Molecular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://journalajbgmb.com/index.php/AJBGMB/article/download/339/674","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062025679","display_name":"Jude Efiom Okokon","orcid":"https://orcid.org/0000-0002-2587-4535","observed_orcids":["https://orcid.org/0000-0002-2587-4535"]},"institutions":[{"id":"https://openalex.org/I37797678","display_name":"University of Uyo","ror":"https://ror.org/0127mpp72","country_code":"NG","type":"education","lineage":["https://openalex.org/I37797678"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Okokon J. E.","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo,  Akwa-ibom State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo,  Akwa-ibom State, Nigeria","institution_ids":["https://openalex.org/I37797678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092917578","display_name":"E. B. Ochigbo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I37797678","display_name":"University of Uyo","ror":"https://ror.org/0127mpp72","country_code":"NG","type":"education","lineage":["https://openalex.org/I37797678"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Ochigbo E. B.","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo,  Akwa-ibom State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo,  Akwa-ibom State, Nigeria","institution_ids":["https://openalex.org/I37797678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083824745","display_name":"Imoh Imeh Johnny","orcid":"https://orcid.org/0000-0002-1384-6449","observed_orcids":["https://orcid.org/0000-0002-1384-6449"]},"institutions":[{"id":"https://openalex.org/I37797678","display_name":"University of Uyo","ror":"https://ror.org/0127mpp72","country_code":"NG","type":"education","lineage":["https://openalex.org/I37797678"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Johnny I. I.","raw_affiliation_strings":["Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria","institution_ids":["https://openalex.org/I37797678"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092593170","display_name":"Martin O. Anagboso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118095","display_name":"Madonna University","ror":"https://ror.org/01r5xd980","country_code":"NG","type":"education","lineage":["https://openalex.org/I4210118095"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Anagboso M. O.","raw_affiliation_strings":["Department of Microbiology, Madonna University, Elele, Rivers State, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Madonna University, Elele, Rivers State, Nigeria","institution_ids":["https://openalex.org/I4210118095"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060474021","display_name":"Nwakaego Omonigho Ebong","orcid":"https://orcid.org/0000-0002-8629-4390","observed_orcids":["https://orcid.org/0000-0002-8629-4390"]},"institutions":[{"id":"https://openalex.org/I4210118095","display_name":"Madonna University","ror":"https://ror.org/01r5xd980","country_code":"NG","type":"education","lineage":["https://openalex.org/I4210118095"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"Ebong N. O.","raw_affiliation_strings":["Department of Pharmacology and Toxicology, Faculty of Pharmacy, Madonna University, Elele,  Rivers State, Nigeria. Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Madonna University, Elele,  Rivers State, Nigeria. Nigeria","institution_ids":["https://openalex.org/I4210118095"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.456,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.52923799,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"3","first_page":"56","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/setaria-megaphylla","display_name":"Setaria megaphylla","score":1.0},{"id":"https://openalex.org/keywords/leaf-extract","display_name":"leaf extract","score":0.9440000057220459},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"genotoxicity","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":1.0},{"id":"https://openalex.org/keywords/allium-cepa-root-meristem","display_name":"Allium cepa root meristem","score":0.9079999923706055},{"id":"https://openalex.org/keywords/micronuclei","display_name":"micronuclei","score":0.8790000081062317},{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.996999979019165},{"id":"https://openalex.org/keywords/root-growth-inhibition","display_name":"root growth inhibition","score":0.878000020980835},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.6710000038146973},{"id":"https://openalex.org/keywords/ethnomedicine","display_name":"ethnomedicine","score":0.7099999785423279},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C2776460402","wikidata":"https://www.wikidata.org/wiki/Q49391","display_name":"Allium","level":2,"score":0.7592647671699524},{"id":"https://openalex.org/C45080847","wikidata":"https://www.wikidata.org/wiki/Q1658004","display_name":"Micronucleus test","level":3,"score":0.7046305537223816},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6605026721954346},{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.5896967649459839},{"id":"https://openalex.org/C3019361144","wikidata":"https://www.wikidata.org/wiki/Q367359","display_name":"Negative control","level":2,"score":0.5854606628417969},{"id":"https://openalex.org/C2776843538","wikidata":"https://www.wikidata.org/wiki/Q157389","display_name":"Setaria","level":2,"score":0.5579151511192322},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5467984080314636},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.529283344745636},{"id":"https://openalex.org/C2991965276","wikidata":"https://www.wikidata.org/wiki/Q1392652","display_name":"Root tip","level":2,"score":0.5083913207054138},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4719763696193695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47027021646499634},{"id":"https://openalex.org/C3018223157","wikidata":"https://www.wikidata.org/wiki/Q7233257","display_name":"Positive control","level":2,"score":0.46147677302360535},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4308810830116272},{"id":"https://openalex.org/C126021549","wikidata":"https://www.wikidata.org/wiki/Q207604","display_name":"Meristem","level":3,"score":0.4191240668296814},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.3854864835739136},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18924015760421753},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1795831024646759},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.16897010803222656},{"id":"https://openalex.org/C21410773","wikidata":"https://www.wikidata.org/wiki/Q220869","display_name":"Shoot","level":2,"score":0.14279818534851074},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09326693415641785},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.9734/ajbgmb/2023/v15i3339","doi":"https://doi.org/10.9734/ajbgmb/2023/v15i3339","is_oa":true,"landing_page_url":"http://dx.doi.org/10.9734/ajbgmb/2023/v15i3339","pdf_url":"https://journalajbgmb.com/index.php/AJBGMB/article/download/339/674","source":{"id":"https://openalex.org/S4210229028","display_name":"Asian Journal of Biochemistry Genetics and Molecular Biology","issn_l":"2582-3698","issn":["2582-3698"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Biochemistry, Genetics and Molecular Biology","raw_type":"journal-article"},{"id":"pmh:oai:journalajbgmb.com:article/339","doi":null,"is_oa":true,"landing_page_url":"https://journalajbgmb.com/index.php/AJBGMB/article/view/339","pdf_url":null,"source":{"id":"https://openalex.org/S4210229028","display_name":"Asian Journal of Biochemistry Genetics and Molecular Biology","issn_l":"2582-3698","issn":["2582-3698"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2582-3698","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-05176044v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05176044","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Asian Journal of Biochemistry, Genetics and Molecular Biology, 2023, 15 (3), pp.56-64","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.9734/ajbgmb/2023/v15i3339","doi":"https://doi.org/10.9734/ajbgmb/2023/v15i3339","is_oa":true,"landing_page_url":"http://dx.doi.org/10.9734/ajbgmb/2023/v15i3339","pdf_url":"https://journalajbgmb.com/index.php/AJBGMB/article/download/339/674","source":{"id":"https://openalex.org/S4210229028","display_name":"Asian Journal of Biochemistry Genetics and Molecular Biology","issn_l":"2582-3698","issn":["2582-3698"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320855","host_organization_name":"Sciencedomain International","host_organization_lineage":["https://openalex.org/P4310320855"],"host_organization_lineage_names":["Sciencedomain International"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Asian Journal of Biochemistry, Genetics and Molecular Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8374000191688538}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387809845.pdf","grobid_xml":"https://content.openalex.org/works/W4387809845.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1970355078","https://openalex.org/W1997007001","https://openalex.org/W1999826657","https://openalex.org/W2002889942","https://openalex.org/W2034140820","https://openalex.org/W2035625663","https://openalex.org/W2045327379","https://openalex.org/W2084094191","https://openalex.org/W2140194403","https://openalex.org/W2161971257","https://openalex.org/W2275507034","https://openalex.org/W2463337193","https://openalex.org/W2519594641","https://openalex.org/W2614028845"],"related_works":["https://openalex.org/W4393863290","https://openalex.org/W4414066875","https://openalex.org/W1991719156","https://openalex.org/W4407274784","https://openalex.org/W4404197055","https://openalex.org/W7095532461","https://openalex.org/W2159360173","https://openalex.org/W4386935188","https://openalex.org/W4408882728","https://openalex.org/W7149650424"],"abstract_inverted_index":{"Setaria":[0,159],"megaphylla":[1,160],"a":[2,60,68,174],"medicinal":[3],"plant,":[4],"used":[5,58],"in":[6,111,123],"ethnomedicine":[7],"for":[8,19,50],"the":[9,27,47,75,91,96,100],"treatment":[10,141],"of":[11,26,30,34,46,85,99,176],"malaria,":[12],"diabetes":[13],"and":[14,21,42,52,63,120,151,165],"inflammatory":[15],"diseases":[16],"was":[17,57,78],"investigated":[18],"cytotoxic":[20,106,164],"genotoxic":[22,166],"effects":[23,107,167],"on":[24,72,108,168],"cells":[25,128,146],"root":[28,86,126],"meristem":[29],"Allium":[31],"cepa.":[32,113],"Bulbs":[33],"Onion":[35],"were":[36,102,129],"exposed":[37],"to":[38,104],"2.5":[39],"mg/ml,":[40],"5mg/ml,":[41],"10":[43],"mg/ml":[44],"concentrations":[45,98],"leaf":[48,161],"extract":[49,101,140,162],"macroscopic":[51],"microscopic":[53],"study.":[54],"Tap":[55],"water":[56],"as":[59,67,173],"negative":[61,92],"control":[62,93,137],"Methotrexate":[64],"(0.1":[65],"mg/ml)":[66],"positive":[69],"control.":[70],"Depending":[71],"concentration":[73],"by":[74],"extract,":[76],"there":[77],"statistically":[79],"significant":[80,130],"(P":[81,131],"<":[82,132],".05)":[83,133],"inhibition":[84],"growth":[87],"when":[88,134],"compared":[89,135],"with":[90,136],"group.":[94,138],"All":[95],"tested":[97],"observed":[103],"have":[105],"cell":[109,149],"division":[110],"A.":[112,124,169],"The":[114,139],"extract-":[115],"induced":[116],"micronuclei":[117],"(MNC)":[118],"formations":[119],"chromosomal":[121],"aberrations":[122],"cepa":[125,170],"tip":[127],"further":[142],"induced,":[143],"ghost":[144],"cells,":[145],"membrane":[147],"damage,":[148],"death,":[150],"bi":[152],"nucleated":[153],"cells.":[154],"These":[155],"results":[156,175],"implies":[157],"that":[158],"possess":[163],"which":[171],"is":[172],"its":[177],"phytochemical":[178],"constituents.":[179]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-25T09:29:13.331239","created_date":"2023-10-21T00:00:00"}