{"id":"https://openalex.org/W4387809384","doi":"https://doi.org/10.15789/2220-7619-vna-8054","title":"Virus neutralizing antibodies in pseudovirus particle neutralization reaction as a bioanalytical part of a Salnavac\u00ae vaccine clinical trial","display_name":"Virus neutralizing antibodies in pseudovirus particle neutralization reaction as a bioanalytical part of a Salnavac\u00ae vaccine clinical trial","publication_year":2023,"publication_date":"2023-10-20","ids":{"openalex":"https://openalex.org/W4387809384","doi":"https://doi.org/10.15789/2220-7619-vna-8054"},"language":"en","primary_location":{"id":"doi:10.15789/2220-7619-vna-8054","doi":"https://doi.org/10.15789/2220-7619-vna-8054","is_oa":true,"landing_page_url":"https://doi.org/10.15789/2220-7619-vna-8054","pdf_url":null,"source":{"id":"https://openalex.org/S2737768552","display_name":"Russian Journal of Infection and Immunity","issn_l":"2220-7619","issn":["2220-7619","2313-7398"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312780","host_organization_name":"Sankt-Peterburg : NII\u00c8M imeni Pastera","host_organization_lineage":["https://openalex.org/P4310312780"],"host_organization_lineage_names":["Sankt-Peterburg : NII\u00c8M imeni Pastera"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Infection and Immunity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.15789/2220-7619-vna-8054","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088568202","display_name":"E. V. Zuev","orcid":"https://orcid.org/0000-0001-5519-8358","observed_orcids":["https://orcid.org/0000-0001-5519-8358"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Evgeniy V. Zuev","raw_affiliation_strings":["GENERIUM JSC"],"raw_orcid":"https://orcid.org/0000-0001-5519-8358","affiliations":[{"raw_affiliation_string":"GENERIUM JSC","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035417997","display_name":"\u041e. \u0410. Markova","orcid":"https://orcid.org/0000-0002-1179-3881","observed_orcids":["https://orcid.org/0000-0002-1179-3881"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oksana Anatolievna Markova","raw_affiliation_strings":["GENERIUM GSC"],"raw_orcid":"https://orcid.org/0000-0002-1179-3881","affiliations":[{"raw_affiliation_string":"GENERIUM GSC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077439712","display_name":"Sergey V. Kulemzin","orcid":"https://orcid.org/0000-0002-4706-623X","observed_orcids":["https://orcid.org/0000-0002-4706-623X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sergey V. Kulemzin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4706-623X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063696712","display_name":"Dmitry A. Poteryaev","orcid":"https://orcid.org/0000-0003-2695-8869","observed_orcids":["https://orcid.org/0000-0003-2695-8869"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitry A. Poteryaev","raw_affiliation_strings":["GENERIUM JSC"],"raw_orcid":"https://orcid.org/0000-0003-2695-8869","affiliations":[{"raw_affiliation_string":"GENERIUM JSC","institution_ids":["https://openalex.org/I4405272539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037182280","display_name":"Natalia A. Litvinova","orcid":"https://orcid.org/0000-0003-1430-8105","observed_orcids":["https://orcid.org/0000-0003-1430-8105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalya A. Litvinova","raw_affiliation_strings":["GENERIUM GSC"],"raw_orcid":"https://orcid.org/0000-0003-1430-8105","affiliations":[{"raw_affiliation_string":"GENERIUM GSC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029957063","display_name":"Ilya A. Korotkevich","orcid":"https://orcid.org/0000-0003-1872-419X","observed_orcids":["https://orcid.org/0000-0003-1872-419X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ilya A. Korotkevich","raw_affiliation_strings":["GENERIUM GSC"],"raw_orcid":"https://orcid.org/0000-0003-1872-419X","affiliations":[{"raw_affiliation_string":"GENERIUM GSC","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113027985","display_name":"Taisiya V. Grigiryeva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taisiya V. Grigiryeva","raw_affiliation_strings":["GENERIUM GSC"],"raw_orcid":"https://orcid.org/0000-0002-8658-7142","affiliations":[{"raw_affiliation_string":"GENERIUM GSC","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015374870","display_name":"\u0425\u0430\u043c\u0438\u0442\u043e\u0432 \u0420\u0430\u0432\u0438\u043b\u044c \u0410\u0432\u0433\u0430\u0442\u043e\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0002-1314-894X","observed_orcids":["https://orcid.org/0000-0002-1314-894X"]},"institutions":[{"id":"https://openalex.org/I4405272539","display_name":"Generium Pharmaceuticals (Russia)","ror":"https://ror.org/04anvdv29","country_code":"RU","type":"company","lineage":["https://openalex.org/I4405272539"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ravil A. Khamitov","raw_affiliation_strings":["\u0410\u041e \u0413\u0415\u041d\u0415\u0420\u0418\u0423\u041c"],"raw_orcid":"https://orcid.org/0000-0002-1314-894X","affiliations":[{"raw_affiliation_string":"\u0410\u041e \u0413\u0415\u041d\u0415\u0420\u0418\u0423\u041c","institution_ids":["https://openalex.org/I4405272539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5778,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.60469635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"13","issue":"5","first_page":"853","last_page":"863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virus-neutralizing-antibodies","display_name":"virus-neutralizing antibodies","score":0.8619999885559082},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9599999785423279},{"id":"https://openalex.org/keywords/covid-19-vaccines","display_name":"COVID-19 vaccines","score":0.8479999899864197},{"id":"https://openalex.org/keywords/gam-covid-vac","display_name":"Gam-COVID-Vac","score":0.9800000190734863},{"id":"https://openalex.org/keywords/intranasal-vaccine","display_name":"intranasal vaccine","score":0.7820000052452087},{"id":"https://openalex.org/keywords/intramuscular-vaccine","display_name":"intramuscular vaccine","score":0.8920000195503235},{"id":"https://openalex.org/keywords/pseudovirus-neutralization","display_name":"pseudovirus neutralization","score":0.7200000286102295},{"id":"https://openalex.org/keywords/anti-rbd-igg","display_name":"anti-RBD IgG","score":0.7720000147819519},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.8970000147819519},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.6069999933242798},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.5830000042915344},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.8077093362808228},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6743414402008057},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.6702232360839844},{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.6125756502151489},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.5866944193840027},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.5599854588508606},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5530232191085815},{"id":"https://openalex.org/C2776291583","wikidata":"https://www.wikidata.org/wiki/Q432083","display_name":"Intramuscular injection","level":2,"score":0.4720911383628845},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4567834138870239},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4342005252838135},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.42160648107528687},{"id":"https://openalex.org/C106192422","wikidata":"https://www.wikidata.org/wiki/Q736798","display_name":"Herd immunity","level":3,"score":0.4101417660713196},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3876376152038574},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.31934356689453125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19040128588676453}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.15789/2220-7619-vna-8054","doi":"https://doi.org/10.15789/2220-7619-vna-8054","is_oa":true,"landing_page_url":"https://doi.org/10.15789/2220-7619-vna-8054","pdf_url":null,"source":{"id":"https://openalex.org/S2737768552","display_name":"Russian Journal of Infection and Immunity","issn_l":"2220-7619","issn":["2220-7619","2313-7398"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312780","host_organization_name":"Sankt-Peterburg : NII\u00c8M imeni Pastera","host_organization_lineage":["https://openalex.org/P4310312780"],"host_organization_lineage_names":["Sankt-Peterburg : NII\u00c8M imeni Pastera"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Infection and Immunity","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:bf26d6d9c231466fbb3e96dcac5045db","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bf26d6d9c231466fbb3e96dcac5045db","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0418\u043d\u0444\u0435\u043a\u0446\u0438\u044f \u0438 \u0438\u043c\u043c\u0443\u043d\u0438\u0442\u0435\u0442, Vol 13, Iss 5, Pp 853-863 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.15789/2220-7619-vna-8054","doi":"https://doi.org/10.15789/2220-7619-vna-8054","is_oa":true,"landing_page_url":"https://doi.org/10.15789/2220-7619-vna-8054","pdf_url":null,"source":{"id":"https://openalex.org/S2737768552","display_name":"Russian Journal of Infection and Immunity","issn_l":"2220-7619","issn":["2220-7619","2313-7398"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312780","host_organization_name":"Sankt-Peterburg : NII\u00c8M imeni Pastera","host_organization_lineage":["https://openalex.org/P4310312780"],"host_organization_lineage_names":["Sankt-Peterburg : NII\u00c8M imeni Pastera"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Russian Journal of Infection and Immunity","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1696638240","https://openalex.org/W2154296350","https://openalex.org/W3005079553","https://openalex.org/W3007933225","https://openalex.org/W3049195189","https://openalex.org/W3139251053","https://openalex.org/W3152577942","https://openalex.org/W3155000349","https://openalex.org/W3193676801","https://openalex.org/W3205410383","https://openalex.org/W3217661335","https://openalex.org/W4206025511","https://openalex.org/W4282928458","https://openalex.org/W4294724523","https://openalex.org/W4294877344","https://openalex.org/W4304112065"],"related_works":["https://openalex.org/W4399672333","https://openalex.org/W4313313113","https://openalex.org/W4391434512","https://openalex.org/W4205489950","https://openalex.org/W4297311351","https://openalex.org/W4415397147","https://openalex.org/W4308498114","https://openalex.org/W3172785218","https://openalex.org/W4293538589","https://openalex.org/W4220878608"],"abstract_inverted_index":{"Introduction.":[0],"The":[1,113,268],"SARS-CoV-2":[2,200,224],"coronavirus":[3],"pandemic":[4],"has":[5,45],"been":[6],"a":[7,17,130,148,160,185,192,251],"major":[8],"challenge":[9],"for":[10,73],"all":[11],"areas":[12],"of":[13,19,49,54,69,82,88,115,122,143,214,243,258,271,333],"medical":[14],"science,":[15],"causing":[16],"surge":[18],"new":[20],"developments":[21],"in":[22,59,101,232,283,328],"various":[23],"fields":[24],"ranging":[25],"from":[26],"diagnostic":[27],"techniques":[28,84],"to":[29,40,119,199,309],"therapeutic":[30],"and":[31,97,124,136,140,163,174,191,210,230,246,281,296,307],"preventive":[32],"approaches.":[33],"Intranasal":[34],"vaccination":[35,99,126],"is":[36,67],"an":[37],"innovative":[38],"approach":[39],"immunization":[41,158],"against":[42,127,223],"SARS-CoV-2,":[43],"which":[44,78],"attracted":[46],"the":[47,70,86,94,116,233,264,272,284,311],"attention":[48],"many":[50],"drug":[51],"developers.":[52],"Dynamics":[53],"blood":[55],"virus-neutralizing":[56],"antibodies":[57,206],"(VNAs)":[58],"recovered":[60],"COVID-19":[61,128],"patients":[62],"or":[63,167],"vaccinated":[64],"healthy":[65,145],"volunteers":[66,146],"one":[68],"objective":[71,114],"parameters":[72],"assessing":[74],"vaccine":[75,169,323,326],"immunological":[76,241],"efficacy,":[77],"requires":[79],"high":[80,252],"standards":[81],"bioanalytical":[83],"within":[85],"framework":[87],"clinical":[89,107,315],"trials.":[90],"Immunogenicity":[91,177],"data":[92,238,319],"on":[93,171,180,207,225,250],"two-component":[95,161],"Salnavak\u00ae(intranasal)":[96],"Gam-COVID-Vac\u00ae(intramuscular)":[98],"obtained":[100],"randomized":[102],"double-blind":[103],"multicenter":[104],"phase":[105],"3":[106],"trial":[108],"interim":[109,318],"analysis":[110,183],"are":[111],"presented.":[112],"study":[117],"was":[118,217,228,279,292,304],"assess":[120],"immunogenicity":[121],"intranasal":[123,166,247,322],"intramuscular":[125,168,245,325],"using":[129,184,263,301],"neutralization":[131,186,266],"reaction":[132,187,300],"with":[133,147,188],"pseudoviral":[134,189,265,302],"particles":[135,190,303],"HEK293T-hACE2":[137,193],"cell":[138,194],"culture.Materials":[139],"methods.A":[141],"total":[142],"137":[144],"baseline":[149],"anti-RBD":[150,273,297],"IgG":[151,205,274],"level":[152,178,254,275],"not":[153],"exceeding":[154],"100":[155,261],"BAU/ml":[156],"received":[157],"by":[159,276],"(Ad26":[162],"Ad5":[164],"based)":[165],"administered":[170],"day":[172,175,226,277],"1":[173],"21.":[176],"based":[179,249],"VNA":[181,221,256,312],"quantitative":[182],"culture":[195],"as":[196,198],"well":[197],"S-protein":[201],"receptor-binding":[202],"domain":[203],"(anti-RBD)":[204],"days":[208],"21":[209],"42":[211,227,278],"after":[212],"administration":[213],"component":[215],"I":[216],"assessed.Results.The":[218],"geometric":[219,269],"mean":[220,270],"titer":[222,257,313],"238.34\u00b13.93":[229],"616.94\u00b13.73":[231],"Salnavac\u00aeand":[234,285],"Gam-COVID-Vac\u00aegroups,":[235],"respectively.":[236,287],"Trial":[237,317],"shows":[239],"sufficient":[240,331],"efficacy":[242],"both":[244],"vaccines":[248],"protection":[253],"at":[255],"more":[259],"than":[260],"while":[262],"method.":[267],"131.22\u00b13.91":[280],"782.03\u00b13.04":[282],"Gam-COVID-Vak\u00aegroups,":[286],"A":[288],"direct":[289],"moderate":[290],"correlation":[291],"shown":[293],"between":[294],"VHA":[295],"IgG.Conclusion.":[298],"Neutralization":[299],"successfully":[305],"validated":[306],"used":[308],"determine":[310],"during":[314],"trial.":[316],"revealed":[320],"that":[321],"Salnavac\u00aevs":[324],"Gam-COVID-Vak\u00aeresulted":[327],"lower":[329],"but":[330],"stringency":[332],"humoral":[334],"immunity.":[335]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-10-21T00:00:00"}
