{"id":"https://openalex.org/W4387808641","doi":"https://doi.org/10.1099/acmi.0.000460.v3","title":"Effective amelioration of the Lucio phenomenon with adjuvant tofacitinib therapy in a patient with dual infection of Mycobacterium leprae and Mycobacterium lepromatosis: a case report from India","display_name":"Effective amelioration of the Lucio phenomenon with adjuvant tofacitinib therapy in a patient with dual infection of Mycobacterium leprae and Mycobacterium lepromatosis: a case report from India","publication_year":2023,"publication_date":"2023-10-01","ids":{"openalex":"https://openalex.org/W4387808641","doi":"https://doi.org/10.1099/acmi.0.000460.v3","pmid":"https://pubmed.ncbi.nlm.nih.gov/37970083","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10634479"},"language":"en","primary_location":{"id":"doi:10.1099/acmi.0.000460.v3","doi":"https://doi.org/10.1099/acmi.0.000460.v3","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.0.000460.v3","pdf_url":null,"source":{"id":"https://openalex.org/S4210207429","display_name":"Access Microbiology","issn_l":"2516-8290","issn":["2516-8290"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Access Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1099/acmi.0.000460.v3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084235611","display_name":"Nayankumar Harshadkumar Patel","orcid":"https://orcid.org/0000-0001-5578-2335","observed_orcids":["https://orcid.org/0000-0001-5578-2335"]},"institutions":[{"id":"https://openalex.org/I4405260799","display_name":"GCS Medical College","ror":"https://ror.org/049s68q83","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210089564","https://openalex.org/I4405260799"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nayankumar Harshadkumar Patel","raw_affiliation_strings":["Gcs Medical College,\n      Dermatology,\n      Opp Drm Office,\n      Near Chamunda Bridge,\n      Kalupur Naroda Road,\n      Ahmedabad","GCS Medical College Hospital and Research Centre, Ahmedabad, India"],"raw_orcid":"https://orcid.org/0000-0001-5578-2335","affiliations":[{"raw_affiliation_string":"Gcs Medical College,\n      Dermatology,\n      Opp Drm Office,\n      Near Chamunda Bridge,\n      Kalupur Naroda Road,\n      Ahmedabad","institution_ids":["https://openalex.org/I4405260799"]},{"raw_affiliation_string":"GCS Medical College Hospital and Research Centre, Ahmedabad, India","institution_ids":["https://openalex.org/I4405260799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041874101","display_name":"Jignaben Krunal Padhiyar","orcid":"https://orcid.org/0000-0003-2331-3598","observed_orcids":["https://orcid.org/0000-0003-2331-3598"]},"institutions":[{"id":"https://openalex.org/I4405260799","display_name":"GCS Medical College","ror":"https://ror.org/049s68q83","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210089564","https://openalex.org/I4405260799"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jignaben Krunal Padhiyar","raw_affiliation_strings":["GCS Medical College Hospital and Research Centre, Ahmedabad","GCS Medical College Hospital and Research Centre, Ahmedabad, India"],"raw_orcid":"https://orcid.org/0000-0003-2331-3598","affiliations":[{"raw_affiliation_string":"GCS Medical College Hospital and Research Centre, Ahmedabad","institution_ids":["https://openalex.org/I4405260799"]},{"raw_affiliation_string":"GCS Medical College Hospital and Research Centre, Ahmedabad, India","institution_ids":["https://openalex.org/I4405260799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052752126","display_name":"Kathak Ashok Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260799","display_name":"GCS Medical College","ror":"https://ror.org/049s68q83","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210089564","https://openalex.org/I4405260799"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kathak Ashok Patel","raw_affiliation_strings":["GCS Medical College Hospital and Research Centre, Ahmedabad","GCS Medical College Hospital and Research Centre, Ahmedabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GCS Medical College Hospital and Research Centre, Ahmedabad","institution_ids":["https://openalex.org/I4405260799"]},{"raw_affiliation_string":"GCS Medical College Hospital and Research Centre, Ahmedabad, India","institution_ids":["https://openalex.org/I4405260799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077869796","display_name":"Jahnvi Rakeshkumar Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260799","display_name":"GCS Medical College","ror":"https://ror.org/049s68q83","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210089564","https://openalex.org/I4405260799"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jahnvi Rakeshkumar Patel","raw_affiliation_strings":["GCS Medical College Hospital and Research Centre, Ahmedabad","GCS Medical College Hospital and Research Centre, Ahmedabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GCS Medical College Hospital and Research Centre, Ahmedabad","institution_ids":["https://openalex.org/I4405260799"]},{"raw_affiliation_string":"GCS Medical College Hospital and Research Centre, Ahmedabad, India","institution_ids":["https://openalex.org/I4405260799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020671637","display_name":"Megha Pratapabhai Lakum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405260799","display_name":"GCS Medical College","ror":"https://ror.org/049s68q83","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210089564","https://openalex.org/I4405260799"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Megha Pratapabhai Lakum","raw_affiliation_strings":["GCS Medical College Hospital and Research Centre, Ahmedabad","GCS Medical College Hospital and Research Centre, Ahmedabad, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GCS Medical College Hospital and Research Centre, Ahmedabad","institution_ids":["https://openalex.org/I4405260799"]},{"raw_affiliation_string":"GCS Medical College Hospital and Research Centre, Ahmedabad, India","institution_ids":["https://openalex.org/I4405260799"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001680992","display_name":"Itu Singh","orcid":"https://orcid.org/0000-0003-0596-8566","observed_orcids":["https://orcid.org/0000-0003-0596-8566"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Itu Singh","raw_affiliation_strings":["Stanley Browne Laboratory, TLM Community Hospital, Nand Nagari, Delhi","Stanley Browne Laboratory, TLM Community Hospital, Nand Nagari, Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanley Browne Laboratory, TLM Community Hospital, Nand Nagari, Delhi","institution_ids":[]},{"raw_affiliation_string":"Stanley Browne Laboratory, TLM Community Hospital, Nand Nagari, Delhi, India","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":700,"currency":"GBP","value_usd":858},"apc_paid":{"value":700,"currency":"GBP","value_usd":858},"fwci":0.7704,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.660965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"5","issue":"10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lucio-phenomenon","display_name":"Lucio phenomenon","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lepromatous-leprosy","display_name":"lepromatous leprosy","score":0.8529999852180481},{"id":"https://openalex.org/keywords/mycobacterium-leprae","display_name":"Mycobacterium leprae","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mycobacterium-lepromatosis","display_name":"Mycobacterium lepromatosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/coinfection","display_name":"co-infection","score":0.7630000114440918},{"id":"https://openalex.org/keywords/tofacitinib","display_name":"tofacitinib","score":0.8659999966621399},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/leprosy-reactions","display_name":"leprosy reactions","score":0.593999981880188},{"id":"https://openalex.org/keywords/thalidomide","display_name":"thalidomide","score":0.8429999947547913},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.859000027179718}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.835911750793457},{"id":"https://openalex.org/C2779823659","wikidata":"https://www.wikidata.org/wiki/Q155891","display_name":"Mycobacterium leprae","level":3,"score":0.7815288305282593},{"id":"https://openalex.org/C2780695269","wikidata":"https://www.wikidata.org/wiki/Q36956","display_name":"Leprosy","level":2,"score":0.6070325374603271},{"id":"https://openalex.org/C2778886723","wikidata":"https://www.wikidata.org/wiki/Q3530324","display_name":"Tofacitinib","level":3,"score":0.5015311241149902},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.48140883445739746},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.45261910557746887},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4185757637023926},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32308655977249146},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.09295034408569336}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1099/acmi.0.000460.v3","doi":"https://doi.org/10.1099/acmi.0.000460.v3","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.0.000460.v3","pdf_url":null,"source":{"id":"https://openalex.org/S4210207429","display_name":"Access Microbiology","issn_l":"2516-8290","issn":["2516-8290"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Access Microbiology","raw_type":"journal-article"},{"id":"doi:10.1099/acmi.0.000460.v2","doi":"https://doi.org/10.1099/acmi.0.000460.v2","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.0.000460.v2","pdf_url":"https://www.microbiologyresearch.org/deliver/fulltext/acmi/10.1099/acmi.0.000460.v1/acmi.0.000460.v1.1.pdf?itemId=/content/reviewreports/10.1099/acmi.0.000460.v1.1&mimeType=pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"doi:10.1099/acmi.0.000460.v1","doi":"https://doi.org/10.1099/acmi.0.000460.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.0.000460.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10634479","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10634479","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10634479/pdf/acmi-5-460.v3.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Access Microbiol","raw_type":"Text"},{"id":"pmid:37970083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37970083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Access microbiology","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1099/acmi.0.000460.v3","doi":"https://doi.org/10.1099/acmi.0.000460.v3","is_oa":true,"landing_page_url":"https://doi.org/10.1099/acmi.0.000460.v3","pdf_url":null,"source":{"id":"https://openalex.org/S4210207429","display_name":"Access Microbiology","issn_l":"2516-8290","issn":["2516-8290"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Access Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387808641.pdf","grobid_xml":"https://content.openalex.org/works/W4387808641.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1527011538","https://openalex.org/W1623271373","https://openalex.org/W1714314557","https://openalex.org/W1830576118","https://openalex.org/W2097596553","https://openalex.org/W2269492454","https://openalex.org/W2936820761","https://openalex.org/W3011477932"],"related_works":["https://openalex.org/W4205809805","https://openalex.org/W4403371660","https://openalex.org/W2266179692","https://openalex.org/W2766935630","https://openalex.org/W3126134166","https://openalex.org/W7126189691","https://openalex.org/W2289302217","https://openalex.org/W7135411684","https://openalex.org/W4412058118","https://openalex.org/W4285258687"],"abstract_inverted_index":{"Introduction.":[0],"The":[1,150],"Lucio":[2],"phenomenon":[3],"(LP)":[4],"is":[5,43],"a":[6,46,60,69,246],"characteristic":[7],"reaction":[8],"pattern":[9],"seen":[10],"in":[11,26,68,226,240],"patients":[12],"with":[13,20,45,71,79,106,116,200,221],"diffuse":[14],"lepromatous":[15],"leprosy":[16,63,148],"(DLL).":[17],"Dual":[18],"infection":[19,78,220],"Mycobacterium":[21,24],"leprae":[22,81,154,223],"and":[23,53,73,82,94,120,131,134,139,147,155,176,206,224],"lepromatosis":[25,84,157,225],"DLL":[27,74,236],"has":[28],"been":[29],"confirmed":[30,159],"from":[31,39,169],"other":[32],"endemic":[33,241],"countries":[34],"but":[35],"not":[36],"previously":[37],"documented":[38],"India.":[40,227],"Conventionally,":[41],"LP":[42,72,146,210],"treated":[44],"high":[47],"dose":[48],"of":[49,62,128,145,152,166,191,202,208,218,235],"systemic":[50,95],"glucocorticoid":[51],"(GC)":[52],"anti-leprosy":[54,172],"treatment":[55],"(ALT).":[56],"Here":[57],"we":[58],"report":[59],"case":[61,214],"lymphadenitis":[64],"at":[65],"initial":[66,233],"presentation":[67,234],"patient":[70,180,195],"due":[75],"to":[76,88,92,102,182],"dual":[77,219],"M.":[80,83,153,156,222],"who":[85],"responded":[86],"favourably":[87],"tofacitinib":[89],"as":[90,231],"adjuvant":[91,192,249],"ALT":[93],"GC":[96,175],"therapy.":[97],"Case":[98],"report.":[99],"A":[100],"20-":[101],"30-year-old":[103],"man":[104],"presented":[105],"swelling":[107],"over":[108],"the":[109,126,179,189,194,216],"bilateral":[110],"inguinal":[111],"region,":[112],"pus-filled":[113],"skin":[114],"lesions":[115,205],"multiple":[117],"ulcers,":[118],"fever":[119],"joint":[121],"pain.":[122],"Post-hospitalization":[123],"investigations":[124],"showed":[125,196],"presence":[127,151,217],"anaemia,":[129],"leukocytosis,":[130],"elevated":[132],"acute":[133],"chronic":[135],"inflammatory":[136],"markers.":[137],"Skin":[138],"lymph":[140],"node":[141,229],"biopsies":[142],"were":[143],"suggestive":[144],"lymphadenitis.":[149],"was":[158],"by":[160,163],"PCR":[161,167],"followed":[162],"DNA":[164],"sequencing":[165],"amplicons":[168],"tissue.":[170],"Despite":[171],"treatment,":[173],"oral":[174],"thalidomide":[177],"therapy,":[178],"continued":[181],"develop":[183],"new":[184,209,248],"lesions.":[185,211],"One":[186],"month":[187],"after":[188],"commencement":[190],"tofacitinib,":[193],"excellent":[197],"clinical":[198],"improvement":[199],"healing":[201],"all":[203],"existing":[204],"cessation":[207],"Conclusion.":[212],"Our":[213],"confirms":[215],"Lymph":[228],"involvement":[230],"an":[232],"should":[237],"be":[238,245],"considered":[239],"areas.":[242],"Tofacitinib":[243],"may":[244],"promising":[247],"therapy":[250],"for":[251],"recalcitrant":[252],"lepra":[253],"reactions.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-10-21T00:00:00"}
