{"id":"https://openalex.org/W4387799307","doi":"https://doi.org/10.1080/17425255.2023.2273384","title":"Common gastrointestinal drug-drug interactions in geriatrics and the importance of careful planning","display_name":"Common gastrointestinal drug-drug interactions in geriatrics and the importance of careful planning","publication_year":2023,"publication_date":"2023-10-20","ids":{"openalex":"https://openalex.org/W4387799307","doi":"https://doi.org/10.1080/17425255.2023.2273384","pmid":"https://pubmed.ncbi.nlm.nih.gov/37862038"},"language":"en","primary_location":{"id":"doi:10.1080/17425255.2023.2273384","doi":"https://doi.org/10.1080/17425255.2023.2273384","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17425255.2023.2273384","pdf_url":null,"source":{"id":"https://openalex.org/S102336391","display_name":"Expert Opinion on Drug Metabolism & Toxicology","issn_l":"1742-5255","issn":["1742-5255","1744-7607"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Metabolism &amp; Toxicology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023355051","display_name":"Shilan Mozaffari","orcid":"https://orcid.org/0000-0002-2139-1448","observed_orcids":["https://orcid.org/0000-0002-2139-1448"]},"institutions":[{"id":"https://openalex.org/I4403928403","display_name":"Pharmaceutical Sciences Research Center","ror":"https://ror.org/02m2rj159","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4403928403","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Shilan Mozaffari","raw_affiliation_strings":["Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center (PSRC), Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0002-2139-1448","affiliations":[{"raw_affiliation_string":"Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center (PSRC), Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4403928403","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012478690","display_name":"Taraneh Mousavi","orcid":"https://orcid.org/0000-0003-1976-6789","observed_orcids":["https://orcid.org/0000-0003-1976-6789"]},"institutions":[{"id":"https://openalex.org/I4403928403","display_name":"Pharmaceutical Sciences Research Center","ror":"https://ror.org/02m2rj159","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4403928403","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Taraneh Mousavi","raw_affiliation_strings":["Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center (PSRC), Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0003-1976-6789","affiliations":[{"raw_affiliation_string":"Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center (PSRC), Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4403928403","https://openalex.org/I70640408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025053518","display_name":"Shekoufeh Nikfar","orcid":"https://orcid.org/0000-0002-5206-6197","observed_orcids":["https://orcid.org/0000-0002-5206-6197"]},"institutions":[{"id":"https://openalex.org/I4403928333","display_name":"Personalized Medicine Research Center","ror":"https://ror.org/04690an59","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4403928185","https://openalex.org/I4403928333","https://openalex.org/I4403928377","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Shekoufeh Nikfar","raw_affiliation_strings":["Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran","Personalized Medicine Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0002-5206-6197","affiliations":[{"raw_affiliation_string":"Department of Pharmacoeconomics and Pharmaceutical Administration, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I70640408"]},{"raw_affiliation_string":"Personalized Medicine Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4403928333","https://openalex.org/I70640408"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068915111","display_name":"Mohammad Reza Abdollahi","orcid":"https://orcid.org/0000-0003-0123-1209","observed_orcids":["https://orcid.org/0000-0003-0123-1209","https://orcid.org/0009-0001-0204-3093"]},"institutions":[{"id":"https://openalex.org/I4403928403","display_name":"Pharmaceutical Sciences Research Center","ror":"https://ror.org/02m2rj159","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4403928403","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I70640408","display_name":"Tehran University of Medical Sciences","ror":"https://ror.org/01c4pz451","country_code":"IR","type":"education","lineage":["https://openalex.org/I70640408"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mohammad Abdollahi","raw_affiliation_strings":["Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center (PSRC), Tehran University of Medical Sciences, Tehran, Iran"],"raw_orcid":"https://orcid.org/0000-0003-0123-1209","affiliations":[{"raw_affiliation_string":"Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center (PSRC), Tehran University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I4403928403","https://openalex.org/I70640408"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068915111"],"corresponding_institution_ids":["https://openalex.org/I4403928403","https://openalex.org/I70640408"],"apc_list":null,"apc_paid":null,"fwci":0.6605,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.52298851,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"19","issue":"11","first_page":"807","last_page":"828"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13970","display_name":"Pharmacy and Medical Practices","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.9440000057220459},{"id":"https://openalex.org/keywords/gastrointestinal-drugs","display_name":"gastrointestinal drugs","score":0.7419999837875366},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.7900000214576721},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8109999895095825},{"id":"https://openalex.org/keywords/geriatric-pharmacology","display_name":"geriatric pharmacology","score":0.652999997138977},{"id":"https://openalex.org/keywords/gastroesophageal-reflux-disease","display_name":"gastroesophageal reflux disease","score":0.8610000014305115},{"id":"https://openalex.org/keywords/peptic-ulcer","display_name":"peptic ulcer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":0.9380000233650208},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":1.0},{"id":"https://openalex.org/keywords/constipation","display_name":"constipation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.996999979019165},{"id":"https://openalex.org/keywords/medication-errors","display_name":"medication errors","score":0.843999981880188},{"id":"https://openalex.org/keywords/individualized-treatment-planning","display_name":"personalized treatment planning","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C36434225","wikidata":"https://www.wikidata.org/wiki/Q1895998","display_name":"Polypharmacy","level":2,"score":0.878931999206543},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8489344120025635},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.6591538786888123},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.61394202709198},{"id":"https://openalex.org/C54183767","wikidata":"https://www.wikidata.org/wiki/Q10384","display_name":"Geriatrics","level":2,"score":0.5745710134506226},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.5386189818382263},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5191727876663208},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.48963838815689087},{"id":"https://openalex.org/C2777014526","wikidata":"https://www.wikidata.org/wiki/Q223591","display_name":"GERD","level":4,"score":0.4455382525920868},{"id":"https://openalex.org/C53875530","wikidata":"https://www.wikidata.org/wiki/Q814106","display_name":"Beers Criteria","level":3,"score":0.4299839735031128},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.20008468627929688},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.19969621300697327},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14907047152519226},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C43270747","wikidata":"https://www.wikidata.org/wiki/Q898610","display_name":"Reflux","level":3,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005765","descriptor_name":"Gastrointestinal Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005853","descriptor_name":"Geriatrics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019338","descriptor_name":"Polypharmacy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/17425255.2023.2273384","doi":"https://doi.org/10.1080/17425255.2023.2273384","is_oa":false,"landing_page_url":"https://doi.org/10.1080/17425255.2023.2273384","pdf_url":null,"source":{"id":"https://openalex.org/S102336391","display_name":"Expert Opinion on Drug Metabolism & Toxicology","issn_l":"1742-5255","issn":["1742-5255","1744-7607"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Drug Metabolism &amp; Toxicology","raw_type":"journal-article"},{"id":"pmid:37862038","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37862038","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on drug metabolism & toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W45699460","https://openalex.org/W1479822772","https://openalex.org/W1521766620","https://openalex.org/W1530712258","https://openalex.org/W1601202529","https://openalex.org/W1972766738","https://openalex.org/W1990333964","https://openalex.org/W1996075855","https://openalex.org/W1997677647","https://openalex.org/W2001661890","https://openalex.org/W2003147380","https://openalex.org/W2004792984","https://openalex.org/W2020188527","https://openalex.org/W2029243163","https://openalex.org/W2041581988","https://openalex.org/W2042615016","https://openalex.org/W2050769859","https://openalex.org/W2055245690","https://openalex.org/W2059302510","https://openalex.org/W2071957690","https://openalex.org/W2076385877","https://openalex.org/W2080928595","https://openalex.org/W2081963513","https://openalex.org/W2086599197","https://openalex.org/W2094438616","https://openalex.org/W2095778413","https://openalex.org/W2104517179","https://openalex.org/W2107933782","https://openalex.org/W2110602156","https://openalex.org/W2115203492","https://openalex.org/W2134404506","https://openalex.org/W2138857851","https://openalex.org/W2141840620","https://openalex.org/W2164912981","https://openalex.org/W2167961448","https://openalex.org/W2247668659","https://openalex.org/W2317593597","https://openalex.org/W2328871453","https://openalex.org/W2414808818","https://openalex.org/W2499576648","https://openalex.org/W2517797865","https://openalex.org/W2560875146","https://openalex.org/W2587083591","https://openalex.org/W2741664350","https://openalex.org/W2745826951","https://openalex.org/W2753632319","https://openalex.org/W2784084032","https://openalex.org/W2795702526","https://openalex.org/W2871087315","https://openalex.org/W2892141896","https://openalex.org/W2897031692","https://openalex.org/W2897189621","https://openalex.org/W2901980248","https://openalex.org/W2904281537","https://openalex.org/W2910325484","https://openalex.org/W2914940203","https://openalex.org/W2921461746","https://openalex.org/W2922240680","https://openalex.org/W2942690310","https://openalex.org/W2989174650","https://openalex.org/W2989791679","https://openalex.org/W2992639523","https://openalex.org/W2993013049","https://openalex.org/W3008544558","https://openalex.org/W3023076058","https://openalex.org/W3024321726","https://openalex.org/W3038032130","https://openalex.org/W3038441428","https://openalex.org/W3045720717","https://openalex.org/W3089393691","https://openalex.org/W3091599384","https://openalex.org/W3095677925","https://openalex.org/W3162432653","https://openalex.org/W3164090309","https://openalex.org/W3174497344","https://openalex.org/W3181309628","https://openalex.org/W3184072051","https://openalex.org/W4200486648","https://openalex.org/W4206461032","https://openalex.org/W4206496683","https://openalex.org/W4210784438","https://openalex.org/W4214738298","https://openalex.org/W4280572593","https://openalex.org/W4283157307","https://openalex.org/W4299691173","https://openalex.org/W4309515977","https://openalex.org/W4319455683","https://openalex.org/W4368359338"],"related_works":["https://openalex.org/W2035513528","https://openalex.org/W2071846711","https://openalex.org/W4409186476","https://openalex.org/W3135282797","https://openalex.org/W3150935620","https://openalex.org/W7216229145","https://openalex.org/W7222846198","https://openalex.org/W4283725853","https://openalex.org/W2427096889","https://openalex.org/W4409380922"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Polypharmacy,":[1],"which":[2],"uses":[3],"multiple":[4],"medications":[5],"to":[6,19,43,50,61,130,150],"treat":[7],"chronic":[8],"illnesses,":[9],"is":[10,48],"common":[11,73],"among":[12],"elderly":[13],"patients.":[14],"However,":[15],"it":[16,47],"can":[17,34,122],"lead":[18],"drug":[20,32,91,135],"interactions,":[21],"especially":[22],"with":[23,113],"gastrointestinal":[24],"(GI)":[25],"medicines":[26],"that":[27],"are":[28],"extensively":[29],"used.":[30],"These":[31],"interactions":[33,57,92],"have":[35],"severe":[36],"consequences":[37],"and":[38,58,85,93,103,147],"pose":[39],"a":[40,114,143],"significant":[41],"challenge":[42],"healthcare":[44,138],"providers.":[45],"Therefore,":[46,137],"crucial":[49],"identify":[51],"the":[52,125],"underlying":[53],"mechanisms":[54],"of":[55,116,134],"these":[56],"develop":[59],"strategies":[60],"minimize":[62],"medication":[63],"errors.":[64],"AREAS":[65],"COVERED:":[66],"We":[67],"analyzed":[68],"databases":[69,97],"on":[70],"GI":[71],"illnesses":[72],"in":[74],"older":[75],"adults,":[76],"including":[77],"GERD,":[78],"peptic":[79],"ulcer":[80],"disease,":[81],"IBS,":[82],"IBD,":[83],"constipation,":[84],"diarrhea.":[86],"Our":[87],"research":[88],"identified":[89],"noteworthy":[90],"utilized":[94],"major":[95],"electronic":[96],"such":[98],"as":[99],"USFDA,":[100],"PubMed,":[101],"Scopus,":[102],"Google":[104],"Scholar":[105],"until":[106],"15":[107],"May":[108,110],"202315":[109],"2023,":[111],"along":[112],"review":[115],"reference":[117],"lists.":[118],"EXPERT":[119],"OPINION:":[120],"Aging":[121],"affect":[123],"how":[124],"body":[126],"processes":[127],"drugs,":[128],"leading":[129],"an":[131],"increased":[132],"risk":[133],"interactions.":[136],"professionals":[139],"must":[140],"carefully":[141],"evaluate":[142],"patient's":[144],"medical":[145],"history":[146],"health":[148],"condition":[149],"design":[151],"personalized":[152],"treatment":[153],"plans.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-10-21T00:00:00"}
