{"id":"https://openalex.org/W4387796765","doi":"https://doi.org/10.3897/pharmacia.70.e110924","title":"Influence of experimental heart failure therapy with different generations of \u03b2-adrenergic blockers on Cardiac Electrical Activity (ECG) and Autonomic Regulation of Heart Rhythm (ARHR)","display_name":"Influence of experimental heart failure therapy with different generations of \u03b2-adrenergic blockers on Cardiac Electrical Activity (ECG) and Autonomic Regulation of Heart Rhythm (ARHR)","publication_year":2023,"publication_date":"2023-10-19","ids":{"openalex":"https://openalex.org/W4387796765","doi":"https://doi.org/10.3897/pharmacia.70.e110924"},"language":"en","primary_location":{"id":"doi:10.3897/pharmacia.70.e110924","doi":"https://doi.org/10.3897/pharmacia.70.e110924","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3897/pharmacia.70.e110924","pdf_url":"https://pharmacia.pensoft.net/article/110924/download/pdf/","source":{"id":"https://openalex.org/S4210231629","display_name":"Pharmacia","issn_l":"0428-0296","issn":["0428-0296","2603-557X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://pharmacia.pensoft.net/article/110924/download/pdf/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103270542","display_name":"Olexiy Goncharov","orcid":"https://orcid.org/0009-0000-1315-5181","observed_orcids":["https://orcid.org/0009-0000-1315-5181"]},"institutions":[{"id":"https://openalex.org/I2802984365","display_name":"Zaporizhzhia State Medical and Pharmaceutical University","ror":"https://ror.org/01pc8e529","country_code":"UA","type":"education","lineage":["https://openalex.org/I2802984365"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Olexiy Goncharov","raw_affiliation_strings":["Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine"],"raw_orcid":"https://orcid.org/0009-0000-1315-5181","affiliations":[{"raw_affiliation_string":"Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine","institution_ids":["https://openalex.org/I2802984365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084420106","display_name":"Igor F. Belenichev","orcid":"https://orcid.org/0000-0003-1273-5314","observed_orcids":["https://orcid.org/0000-0003-1273-5314"]},"institutions":[{"id":"https://openalex.org/I2802984365","display_name":"Zaporizhzhia State Medical and Pharmaceutical University","ror":"https://ror.org/01pc8e529","country_code":"UA","type":"education","lineage":["https://openalex.org/I2802984365"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Igor Belenichev","raw_affiliation_strings":["Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine"],"raw_orcid":"https://orcid.org/0000-0003-1273-5314","affiliations":[{"raw_affiliation_string":"Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine","institution_ids":["https://openalex.org/I2802984365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058478633","display_name":"\u0410. \u0412. \u0410\u0431\u0440\u0430\u043c\u043e\u0432","orcid":"https://orcid.org/0000-0001-8520-2258","observed_orcids":["https://orcid.org/0000-0001-8520-2258"]},"institutions":[{"id":"https://openalex.org/I2802984365","display_name":"Zaporizhzhia State Medical and Pharmaceutical University","ror":"https://ror.org/01pc8e529","country_code":"UA","type":"education","lineage":["https://openalex.org/I2802984365"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Andrii Abramov","raw_affiliation_strings":["Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine"],"raw_orcid":"https://orcid.org/0000-0001-8520-2258","affiliations":[{"raw_affiliation_string":"Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine","institution_ids":["https://openalex.org/I2802984365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067586439","display_name":"Olena Popazova","orcid":"https://orcid.org/0000-0001-7740-460X","observed_orcids":["https://orcid.org/0000-0001-7740-460X"]},"institutions":[{"id":"https://openalex.org/I2802984365","display_name":"Zaporizhzhia State Medical and Pharmaceutical University","ror":"https://ror.org/01pc8e529","country_code":"UA","type":"education","lineage":["https://openalex.org/I2802984365"]}],"countries":["UA"],"is_corresponding":true,"raw_author_name":"Olena Popazova","raw_affiliation_strings":["Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine"],"raw_orcid":"https://orcid.org/0000-0001-7740-460X","affiliations":[{"raw_affiliation_string":"Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine","institution_ids":["https://openalex.org/I2802984365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020211913","display_name":"\u041b. \u0406. \u041a\u0443\u0447\u0435\u0440\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0003-2229-0232","observed_orcids":["https://orcid.org/0000-0003-2229-0232"]},"institutions":[{"id":"https://openalex.org/I2802984365","display_name":"Zaporizhzhia State Medical and Pharmaceutical University","ror":"https://ror.org/01pc8e529","country_code":"UA","type":"education","lineage":["https://openalex.org/I2802984365"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Liudmyla Kucherenko","raw_affiliation_strings":["Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine"],"raw_orcid":"https://orcid.org/0000-0003-2229-0232","affiliations":[{"raw_affiliation_string":"Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine","institution_ids":["https://openalex.org/I2802984365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113976048","display_name":"Nina V. Bukhtiyarova","orcid":"https://orcid.org/0000-0002-7948-708X","observed_orcids":["https://orcid.org/0000-0002-7948-708X"]},"institutions":[{"id":"https://openalex.org/I2802984365","display_name":"Zaporizhzhia State Medical and Pharmaceutical University","ror":"https://ror.org/01pc8e529","country_code":"UA","type":"education","lineage":["https://openalex.org/I2802984365"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"Nina Bukhtiyarova","raw_affiliation_strings":["Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine"],"raw_orcid":"https://orcid.org/0000-0003-3499-3111","affiliations":[{"raw_affiliation_string":"Zaporizhzhia State Medical and Pharmaceutical University, Zaporizhzhia, Ukraine","institution_ids":["https://openalex.org/I2802984365"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109663673","display_name":"I. V. Pavliuk","orcid":"https://orcid.org/0000-0002-6423-8777","observed_orcids":["https://orcid.org/0000-0002-6423-8777"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivan Pavliuk","raw_affiliation_strings":["Zaporizhzhia Research Experimental Forensic Center of the Ministry of Internal Affairs of Ukraine, Zaporizhzhia, Ukraine"],"raw_orcid":"https://orcid.org/0000-0002-6423-8777","affiliations":[{"raw_affiliation_string":"Zaporizhzhia Research Experimental Forensic Center of the Ministry of Internal Affairs of Ukraine, Zaporizhzhia, Ukraine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5067586439"],"corresponding_institution_ids":["https://openalex.org/I2802984365"],"apc_list":{"value":100,"currency":"EUR","value_usd":107},"apc_paid":{"value":100,"currency":"EUR","value_usd":107},"fwci":1.2649,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.80660588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"70","issue":"4","first_page":"1157","last_page":"1165"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.6362000107765198,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.6362000107765198,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.16459999978542328,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.1136000007390976,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-heart-failure","display_name":"chronic heart failure","score":0.9879999756813049},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.9350000023841858},{"id":"https://openalex.org/keywords/carvedilol","display_name":"carvedilol","score":0.9399999976158142},{"id":"https://openalex.org/keywords/nebivolol","display_name":"nebivolol","score":0.9710000157356262},{"id":"https://openalex.org/keywords/bisoprolol","display_name":"bisoprolol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metoprolol","display_name":"metoprolol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardiac-electrical-activity","display_name":"cardiac electrical activity","score":0.6779999732971191},{"id":"https://openalex.org/keywords/autonomic-regulation-of-heart-rhythm","display_name":"autonomic regulation of heart rhythm","score":0.8450000286102295},{"id":"https://openalex.org/keywords/myocardial-repolarization","display_name":"myocardial repolarization","score":0.7639999985694885},{"id":"https://openalex.org/keywords/negative-chronotropic-effect","display_name":"negative chronotropic effect","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.703000009059906},{"id":"https://openalex.org/keywords/electrocardiographic-changes","display_name":"electrocardiographic changes","score":0.6110000014305115},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C2780591200","wikidata":"https://www.wikidata.org/wiki/Q412534","display_name":"Carvedilol","level":3,"score":0.8931165933609009},{"id":"https://openalex.org/C2779670145","wikidata":"https://www.wikidata.org/wiki/Q412515","display_name":"Bisoprolol","level":3,"score":0.8926213383674622},{"id":"https://openalex.org/C2781280847","wikidata":"https://www.wikidata.org/wiki/Q409468","display_name":"Metoprolol","level":2,"score":0.8902208805084229},{"id":"https://openalex.org/C158328960","wikidata":"https://www.wikidata.org/wiki/Q1088369","display_name":"Chronotropic","level":4,"score":0.872275173664093},{"id":"https://openalex.org/C2777537511","wikidata":"https://www.wikidata.org/wiki/Q418130","display_name":"Nebivolol","level":3,"score":0.8124551773071289},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7165551781654358},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.657947838306427},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.549389660358429},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4865816831588745},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42531827092170715},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42045944929122925},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3661958873271942},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1989591419696808}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.3897/pharmacia.70.e110924","doi":"https://doi.org/10.3897/pharmacia.70.e110924","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3897/pharmacia.70.e110924","pdf_url":"https://pharmacia.pensoft.net/article/110924/download/pdf/","source":{"id":"https://openalex.org/S4210231629","display_name":"Pharmacia","issn_l":"0428-0296","issn":["0428-0296","2603-557X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacia","raw_type":"journal-article"},{"id":"pmh:10.3897/pharmacia.70.e110924","doi":null,"is_oa":true,"landing_page_url":"https://pharmacia.pensoft.net/article/110924/","pdf_url":null,"source":{"id":"https://openalex.org/S199213172","display_name":"ZooKeys","issn_l":"1313-2970","issn":["1313-2970","1313-2989"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","oarl","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacia 70(4): 1157-1165","raw_type":"Research Article"},{"id":"pmh:oai:doaj.org/article:a56c9592af784ce38a2436151bde2631","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a56c9592af784ce38a2436151bde2631","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pharmacia, Vol 70, Iss 4, Pp 1157-1165 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3897/pharmacia.70.e110924","doi":"https://doi.org/10.3897/pharmacia.70.e110924","is_oa":true,"landing_page_url":"http://dx.doi.org/10.3897/pharmacia.70.e110924","pdf_url":"https://pharmacia.pensoft.net/article/110924/download/pdf/","source":{"id":"https://openalex.org/S4210231629","display_name":"Pharmacia","issn_l":"0428-0296","issn":["0428-0296","2603-557X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387796765.pdf","grobid_xml":"https://content.openalex.org/works/W4387796765.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1995813639","https://openalex.org/W2037424126","https://openalex.org/W2051363181","https://openalex.org/W2053387643","https://openalex.org/W2058263096","https://openalex.org/W2069982201","https://openalex.org/W2082191129","https://openalex.org/W2084304742","https://openalex.org/W2103588309","https://openalex.org/W2294791259","https://openalex.org/W2328226837","https://openalex.org/W2563031060","https://openalex.org/W2606264734","https://openalex.org/W2937392638","https://openalex.org/W2948077402","https://openalex.org/W3062364896","https://openalex.org/W3129173702","https://openalex.org/W3132494856","https://openalex.org/W3133511216","https://openalex.org/W4200217548","https://openalex.org/W4317566589"],"related_works":["https://openalex.org/W4401957998","https://openalex.org/W357649213","https://openalex.org/W2032973671","https://openalex.org/W2037359883","https://openalex.org/W1976305698","https://openalex.org/W2034315036","https://openalex.org/W820813013","https://openalex.org/W2106061295","https://openalex.org/W1970691934","https://openalex.org/W4200217548"],"abstract_inverted_index":{"Abstract:":[0],"In":[1,49],"the":[2,24,52,64,159,190,253,265,270,309,319,323,350],"complex":[3],"treatment":[4,351],"of":[5,27,42,57,67,78,84,90,108,114,142,161,174,189,224,239,255,272,292,299,304,311,322,352],"chronic":[6],"heart":[7,79,101,175,293],"failure":[8,102],"(CHF)":[9],"\u03b2-adrenoblockers":[10,89,330],"(carvedilol,":[11],"nebivolol,":[12],"bisoprolol,":[13],"metoprolol)":[14],"are":[15],"used,":[16],"which":[17],"due":[18],"to":[19,62,117,264,342],"their":[20],"pharmacological":[21],"properties":[22],"increase":[23],"survival":[25],"rate":[26],"patients,":[28],"improve":[29],"cardio-":[30],"and":[31,46,75,98,171,207,213,227,258,268,280,296,301,334,336],"haemodynamic":[32],"parameters,":[33],"metabolism.":[34],"However,":[35],"modern":[36],"realities":[37],"in":[38,81,86,110,218,284,308],"medicine":[39],"require":[40],"creation":[41],"new":[43,324],"more":[44],"effective":[45],"safe":[47],"\u03b2-adrenoblockers.":[48],"this":[50],"regard,":[51],"potential":[53],"drug":[54,162,348],"Hypertirl":[55],"is":[56],"interest.":[58],"The":[59,125,187,315],"aim":[60],"was":[61,103],"evaluate":[63],"cardioprotective":[65],"effect":[66],"1-(b-phenylethyl)-4-amino-1,2,4-triazolium":[68],"bromide":[69],"(Hypertril)":[70,327],"on":[71,344],"cardiac":[72,312],"electrical":[73,273],"activity":[74,298],"autonomic":[76,172,290,305],"regulation":[77,173,295],"rhythm":[80,176,294],"a":[82,111,181,195,219,347],"model":[83],"CHF":[85],"comparison":[87],"with":[88,286],"different":[91],"generations":[92],"(Nebivolol,":[93],"Carvedilol,":[94],"Bisoprolol,":[95],"Metoprolol).":[96],"Materials":[97],"methods:":[99],"Chronic":[100],"induced":[104],"by":[105],"14-day":[106],"administration":[107,163,216],"doxorubicin":[109,131],"cumulative":[112],"dose":[113,141],"15":[115,147],"mg/kg":[116],"white":[118],"mongrel":[119],"rats":[120],"weighing":[121],"190\u2013220g":[122],"(total":[123],"85).":[124],"investigated":[126],"drugs":[127],"were":[128,178,192,247],"administered":[129],"after":[130],"course":[132],"for":[133,200,349],"30":[134],"days:":[135],"Hypertril":[136,215,277,288],"at":[137],"an":[138],"experimentally":[139,337],"substantiated":[140],"3.5":[143],"mg/kg,":[144,148,151,154],"Metoprolol":[145],"succinate":[146],"Nebivolol":[149],"10":[150,156],"Carvedilol":[152,333],"50":[153],"Bisoprolol":[155],"mg/kg.":[157],"At":[158],"end":[160],"under":[164],"thiopental":[165],"anaesthesia":[166],"(40":[167],"mg/kg),":[168],"electrocardiogram":[169],"(ECG)":[170],"(ARHR)":[177],"analysed":[179],"using":[180,194],"computer":[182],"analyser":[183],"CardioCom-2000plus":[184],"(KAI-Medica,":[185],"Ukraine).":[186],"results":[188,317],"study":[191,341],"calculated":[193],"standard":[196],"statistical":[197],"package":[198],"\u201cSTATISTICA":[199],"Windows":[201],"6.0\u201d":[202],"(StatSoftInc.,":[203],"\u2116AXXR712D833214FAN5),":[204],"\u201cSPSS":[205],"16.0\u201d":[206],"\u201cMicrosoft":[208],"Office":[209],"Excell":[210],"2003\u201d.":[211],"Results":[212],"discussion:":[214],"resulted":[217],"negative":[220],"chronotropic":[221],"effect,":[222],"normalisation":[223],"atrial":[225,256],"(P)":[226,257],"ventricular":[228,240,259],"(R)":[229],"spike":[230,246],"amplitude,":[231],"ST":[232],"segment":[233],"inversion":[234],"below":[235],"isoline,":[236],"increased":[237],"amplitude":[238],"myocardial":[241,282],"repolarisation":[242,245],"T.":[243],"Myocardial":[244],"observed,":[248],"as":[249,251],"well":[250],"normalised":[252],"duration":[254,271],"depolarisation":[260],"phase":[261],"(QRS":[262],"complex)":[263],"intact":[266],"value":[267],"restored":[269,289],"diastole":[274],"(TR":[275],"interval).":[276],"reduced":[278],"systolic":[279],"diastolic":[281],"dysfunction":[283],"animals":[285],"CHF.":[287,353],"mechanisms":[291],"balanced":[297],"sympathetic":[300],"parasympathetic":[302],"parts":[303],"nervous":[306],"system":[307],"control":[310],"function.":[313],"Conclusion:":[314],"obtained":[316],"demonstrated":[318],"undoubted":[320],"advantage":[321],"original":[325],"molecule":[326],"over":[328],"basic":[329],"(Metoprolol,":[331],"Nebivolol,":[332],"Bisoprolol)":[335],"justify":[338],"further":[339],"in-depth":[340],"create":[343],"its":[345],"basis":[346]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-22T09:42:04.148104","created_date":"2023-10-20T00:00:00"}