{"id":"https://openalex.org/W4387779786","doi":"https://doi.org/10.3389/fcell.2023.1273641","title":"Differential responses to maternal diabetes in embryo and visceral yolk sac","display_name":"Differential responses to maternal diabetes in embryo and visceral yolk sac","publication_year":2023,"publication_date":"2023-10-19","ids":{"openalex":"https://openalex.org/W4387779786","doi":"https://doi.org/10.3389/fcell.2023.1273641","pmid":"https://pubmed.ncbi.nlm.nih.gov/37928898","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10620973"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2023.1273641","doi":"https://doi.org/10.3389/fcell.2023.1273641","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2023.1273641","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcell.2023.1273641","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081287874","display_name":"J. Michael Salbaum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I107341208","display_name":"Louisiana State University System","ror":"https://ror.org/022gnbj15","country_code":"US","type":"education","lineage":["https://openalex.org/I107341208"]},{"id":"https://openalex.org/I121820613","display_name":"Louisiana State University","ror":"https://ror.org/05ect4e57","country_code":"US","type":"education","lineage":["https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Michael Salbaum","raw_affiliation_strings":["Department of Regulation of Gene Expression, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Regulation of Gene Expression, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I107341208","https://openalex.org/I121820613"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030161956","display_name":"Kirsten P. Stone","orcid":"https://orcid.org/0000-0001-5511-1638","observed_orcids":["https://orcid.org/0000-0001-5511-1638"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I107341208","display_name":"Louisiana State University System","ror":"https://ror.org/022gnbj15","country_code":"US","type":"education","lineage":["https://openalex.org/I107341208"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirsten P. Stone","raw_affiliation_strings":["Department of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I107341208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008616471","display_name":"Claudia Kr\u00fcger","orcid":"https://orcid.org/0000-0002-6468-5665","observed_orcids":["https://orcid.org/0000-0002-6468-5665"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I107341208","display_name":"Louisiana State University System","ror":"https://ror.org/022gnbj15","country_code":"US","type":"education","lineage":["https://openalex.org/I107341208"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia Kruger","raw_affiliation_strings":["Department of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I107341208"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034957321","display_name":"Claudia Kappen","orcid":"https://orcid.org/0000-0002-1035-465X","observed_orcids":["https://orcid.org/0000-0002-1035-465X"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]},{"id":"https://openalex.org/I107341208","display_name":"Louisiana State University System","ror":"https://ror.org/022gnbj15","country_code":"US","type":"education","lineage":["https://openalex.org/I107341208"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Claudia Kappen","raw_affiliation_strings":["Department of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States","institution_ids":["https://openalex.org/I103990859","https://openalex.org/I107341208"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034957321"],"corresponding_institution_ids":["https://openalex.org/I103990859","https://openalex.org/I107341208"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.6231,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.72338415,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"11","issue":null,"first_page":"1273641","last_page":"1273641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10673","display_name":"Gestational Diabetes Research and Management","score":0.5541999936103821,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10673","display_name":"Gestational Diabetes Research and Management","score":0.5541999936103821,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.2856000065803528,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.08420000225305557,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maternal-diabetes","display_name":"maternal diabetes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/gestational-diabetes-mellitus","display_name":"gestational diabetes mellitus","score":0.6499999761581421},{"id":"https://openalex.org/keywords/visceral-yolk-sac","display_name":"visceral yolk sac","score":0.8090000152587891},{"id":"https://openalex.org/keywords/embryo","display_name":"embryo","score":0.859000027179718},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7990000247955322},{"id":"https://openalex.org/keywords/nod-mice","display_name":"NOD mice","score":0.7680000066757202},{"id":"https://openalex.org/keywords/gastrulation","display_name":"gastrulation","score":0.6759999990463257},{"id":"https://openalex.org/keywords/developmental-stages","display_name":"developmental stages","score":0.6320000290870667},{"id":"https://openalex.org/keywords/gene-expression-variation","display_name":"gene expression variation","score":0.718999981880188},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nad-metabolism","display_name":"NAD+ metabolism","score":0.996999979019165},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/congenital-malformations","display_name":"congenital malformations","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C2777043721","wikidata":"https://www.wikidata.org/wiki/Q369887","display_name":"Yolk sac","level":3,"score":0.8647825717926025},{"id":"https://openalex.org/C32253518","wikidata":"https://www.wikidata.org/wiki/Q5158447","display_name":"Conceptus","level":4,"score":0.8286083340644836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7693663835525513},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.7365497946739197},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6795978546142578},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5562223196029663},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4517960548400879},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.448598712682724},{"id":"https://openalex.org/C112672928","wikidata":"https://www.wikidata.org/wiki/Q239526","display_name":"Offspring","level":3,"score":0.44706398248672485},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.4284493923187256},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4179459810256958},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.41392382979393005},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.39550280570983887},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.364485502243042},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3507583737373352},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3419354557991028},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.3299862742424011},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.19886380434036255},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.142852783203125}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fcell.2023.1273641","doi":"https://doi.org/10.3389/fcell.2023.1273641","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2023.1273641","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10620973","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10620973","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10620973/pdf/fcell-11-1273641.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmid:37928898","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37928898","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:590f5b01b7f4419f9f16556222d82597","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/590f5b01b7f4419f9f16556222d82597","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 11 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2023.1273641","doi":"https://doi.org/10.3389/fcell.2023.1273641","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2023.1273641","pdf_url":null,"source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3481342876","display_name":"Epigenetic Mechanisms in Diabetic Embryopathy","funder_award_id":"R01HD086604","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G4347996888","display_name":"Mentoring Obesity and Diabetes Research in Louisiana","funder_award_id":"P20GM103528","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6306356698","display_name":"Mentoring Obesity and Diabetes Research in Louisiana","funder_award_id":"P30GM118430","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7642468726","display_name":"Diabetic Pregnancies and Gastrulation","funder_award_id":"R01HD085017","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8529898702","display_name":"Molecular Basis for Individual Susceptibility to Neural Tube Defects","funder_award_id":"R01HD087283","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G9000866203","display_name":"Metabolic Basis of Disease - Phase 2","funder_award_id":"P20GM135002","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000905746","display_name":"Pennington/Louisiana NORC","funder_award_id":"P30DK072476","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W11821529","https://openalex.org/W95153881","https://openalex.org/W1494389740","https://openalex.org/W1514624682","https://openalex.org/W1564187542","https://openalex.org/W1825629489","https://openalex.org/W1885149309","https://openalex.org/W1903300978","https://openalex.org/W1968657995","https://openalex.org/W1979187096","https://openalex.org/W1994633217","https://openalex.org/W2002174700","https://openalex.org/W2004493999","https://openalex.org/W2004868572","https://openalex.org/W2019623985","https://openalex.org/W2024044660","https://openalex.org/W2025470930","https://openalex.org/W2034163116","https://openalex.org/W2037950435","https://openalex.org/W2038735055","https://openalex.org/W2047039177","https://openalex.org/W2047117139","https://openalex.org/W2072982367","https://openalex.org/W2073961895","https://openalex.org/W2082038431","https://openalex.org/W2099275774","https://openalex.org/W2110635302","https://openalex.org/W2121674642","https://openalex.org/W2133184958","https://openalex.org/W2146565101","https://openalex.org/W2146849272","https://openalex.org/W2146871627","https://openalex.org/W2151213561","https://openalex.org/W2153562609","https://openalex.org/W2153947402","https://openalex.org/W2159004116","https://openalex.org/W2168302228","https://openalex.org/W2169456326","https://openalex.org/W2172122906","https://openalex.org/W2177778412","https://openalex.org/W2179438025","https://openalex.org/W2304764269","https://openalex.org/W2602373238","https://openalex.org/W2610767031","https://openalex.org/W2619530120","https://openalex.org/W2732652816","https://openalex.org/W2740957747","https://openalex.org/W2809260382","https://openalex.org/W2901569771","https://openalex.org/W3004313594","https://openalex.org/W3102357733","https://openalex.org/W3164692211","https://openalex.org/W3177586536","https://openalex.org/W3211555657","https://openalex.org/W3215682729","https://openalex.org/W4220799363","https://openalex.org/W4223636686","https://openalex.org/W4254687493","https://openalex.org/W4296120346","https://openalex.org/W4297101926","https://openalex.org/W4308999704","https://openalex.org/W4312588581","https://openalex.org/W4319083915","https://openalex.org/W4322617674","https://openalex.org/W4322745137"],"related_works":["https://openalex.org/W4252576598","https://openalex.org/W2159004116","https://openalex.org/W165354504","https://openalex.org/W2146565101","https://openalex.org/W2175312664","https://openalex.org/W320872639","https://openalex.org/W2463291386","https://openalex.org/W398206232","https://openalex.org/W4249792372","https://openalex.org/W7097113962"],"abstract_inverted_index":{"Introduction:":[0],"Maternal":[1],"diabetes":[2,205,245],"during":[3,206],"pregnancy":[4],"is":[5],"well":[6],"known":[7],"to":[8,57,103,132,169,203,213],"be":[9,305],"associated":[10],"with":[11,111,254],"a":[12,144,173,214,296],"higher":[13],"risk":[14],"for":[15,24,176],"structural":[16],"birth":[17],"defects":[18],"in":[19,33,40,118,151,156,181,186,194,211,219,238,267,287,323],"the":[20,34,47,62,85,141,152,157,159,163,182,220,261,268,324],"offspring.":[21],"Recent":[22],"searches":[23],"underlying":[25],"mechanisms":[26,234],"have":[27],"largely":[28],"focused":[29],"on":[30,74,99,246],"aberrant":[31],"processes":[32],"embryo":[35],"itself,":[36],"although":[37],"prior":[38],"research":[39,55],"rodent":[41],"models":[42],"implicated":[43,286],"dysfunction":[44],"also":[45],"of":[46,53,76,125,140,147,165,230,243,248,263,270,299,312,327],"visceral":[48],"yolk":[49,78,153,222,227],"sac.":[50],"The":[51,91,241],"objective":[52],"our":[54],"was":[56,93],"investigate":[58],"both":[59],"tissues":[60],"within":[61],"conceptus":[63],"simultaneously.":[64],"Methods:":[65],"We":[66],"conducted":[67],"unbiased":[68],"transcriptome":[69],"profiling":[70],"by":[71,106,130,137,307],"RNA":[72],"sequencing":[73],"pairs":[75],"individual":[77],"sacs":[79],"and":[80,135,197,278,292,303],"their":[81],"cognate":[82],"embryos,":[83],"using":[84],"non-obese":[86],"diabetic":[87,189,288,316],"(NOD)":[88],"mouse":[89],"model.":[90],"analysis":[92],"performed":[94],"at":[95],"gestational":[96],"day":[97],"8.5":[98],"morphologically":[100],"normal":[101],"specimen":[102],"circumvent":[104],"confounding":[105],"defective":[107],"development.":[108],"Results:":[109],"Even":[110],"large":[112],"sample":[113],"numbers":[114],"(n":[115],"=":[116],"33":[117],"each":[119],"group),":[120],"we":[121],"observed":[122],"considerable":[123],"variability":[124],"gene":[126,166],"expression,":[127],"primarily":[128],"driven":[129],"exposure":[131,160],"maternal":[133,204,244],"diabetes,":[134],"secondarily":[136],"developmental":[138,170,255,265],"stage":[139],"embryo.":[142],"Only":[143],"moderate":[145],"number":[146],"genes":[148,192,250],"changed":[149],"expression":[150,167,247],"sac,":[154],"while":[155],"embryo,":[158],"distinctly":[161],"influenced":[162],"relationship":[164],"levels":[168],"progression,":[171],"revealing":[172],"possible":[174],"role":[175],"altered":[177],"cell":[178],"cycle":[179],"regulation":[180],"response.":[183],"Also":[184],"affected":[185],"embryos":[187,212],"under":[188],"conditions":[190],"were":[191],"involved":[193],"cholesterol":[195,276,293],"biosynthesis":[196,277],"NAD":[198,279,291],"metabolism":[199,280],"pathways.":[200],"Discussion:":[201],"Exposure":[202],"gastrulation":[207],"changes":[208],"transcriptomic":[209,271],"profiles":[210],"substantially":[215],"greater":[216],"effect":[217],"than":[218],"corresponding":[221],"sacs,":[223],"indicating":[224],"that":[225,251,310],"despite":[226],"sac":[228],"being":[229],"embryonic":[231],"origin,":[232],"different":[233],"control":[235],"transcriptional":[236],"activity":[237],"these":[239],"tissues.":[240],"effects":[242],"many":[249],"are":[252],"correlated":[253],"progression":[256],"(i.e.":[257],"somite":[258],"stage)":[259],"highlight":[260],"importance":[262],"considering":[264],"maturity":[266],"interpretation":[269],"data.":[272],"Our":[273],"analyses":[274],"identified":[275],"as":[281],"novel":[282],"pathways":[283],"not":[284],"previously":[285],"pregnancies.":[289],"Both":[290],"availability":[294],"affect":[295],"wide":[297],"variety":[298],"cellular":[300],"signaling":[301],"processes,":[302],"can":[304],"modulated":[306],"diet,":[308],"implying":[309],"prevention":[311],"adverse":[313],"outcomes":[314],"from":[315],"pregnancies":[317],"may":[318],"require":[319],"broad":[320],"interventions,":[321],"particularly":[322],"early":[325],"stages":[326],"pregnancy.":[328]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-10-20T00:00:00"}