{"id":"https://openalex.org/W4387765740","doi":"https://doi.org/10.1007/s12032-023-02201-8","title":"Unveiling the genetic and epigenetic landscape of colorectal cancer: new insights into pathogenic pathways","display_name":"Unveiling the genetic and epigenetic landscape of colorectal cancer: new insights into pathogenic pathways","publication_year":2023,"publication_date":"2023-10-19","ids":{"openalex":"https://openalex.org/W4387765740","doi":"https://doi.org/10.1007/s12032-023-02201-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/37855910"},"language":"en","primary_location":{"id":"doi:10.1007/s12032-023-02201-8","doi":"https://doi.org/10.1007/s12032-023-02201-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12032-023-02201-8","pdf_url":null,"source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033970351","display_name":"Humzah I. Postwala","orcid":"https://orcid.org/0000-0001-6494-9002","observed_orcids":["https://orcid.org/0000-0001-6494-9002"]},"institutions":[{"id":"https://openalex.org/I114173286","display_name":"Gujarat University","ror":"https://ror.org/017f2w007","country_code":"IN","type":"education","lineage":["https://openalex.org/I114173286"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Humzah Postwala","raw_affiliation_strings":["Department of Pharmacology and Pharmacy Practice, L. M. College of Pharmacy, Opp. Gujarat University, Ahmedabad, 380009, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmacy Practice, L. M. College of Pharmacy, Opp. Gujarat University, Ahmedabad, 380009, Gujarat, India","institution_ids":["https://openalex.org/I114173286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025949331","display_name":"Yesha S. Shah","orcid":"https://orcid.org/0000-0002-8967-6351","observed_orcids":["https://orcid.org/0000-0002-8967-6351"]},"institutions":[{"id":"https://openalex.org/I114173286","display_name":"Gujarat University","ror":"https://ror.org/017f2w007","country_code":"IN","type":"education","lineage":["https://openalex.org/I114173286"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yesha Shah","raw_affiliation_strings":["Department of Pharmacology and Pharmacy Practice, L. M. College of Pharmacy, Opp. Gujarat University, Ahmedabad, 380009, Gujarat, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmacy Practice, L. M. College of Pharmacy, Opp. Gujarat University, Ahmedabad, 380009, Gujarat, India","institution_ids":["https://openalex.org/I114173286"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037677901","display_name":"Priyajeet S. Parekh","orcid":"https://orcid.org/0009-0002-6284-8771","observed_orcids":["https://orcid.org/0009-0002-6284-8771"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Priyajeet S. Parekh","raw_affiliation_strings":["AV Pharma LLC, 1545 University Blvd N Ste A, Jacksonville, Florida, 32211, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AV Pharma LLC, 1545 University Blvd N Ste A, Jacksonville, Florida, 32211, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001367208","display_name":"Mehul R. Chorawala","orcid":"https://orcid.org/0000-0002-3724-0986","observed_orcids":["https://orcid.org/0000-0002-3724-0986"]},"institutions":[{"id":"https://openalex.org/I114173286","display_name":"Gujarat University","ror":"https://ror.org/017f2w007","country_code":"IN","type":"education","lineage":["https://openalex.org/I114173286"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Mehul R. Chorawala","raw_affiliation_strings":["Department of Pharmacology and Pharmacy Practice, L. M. College of Pharmacy, Opp. Gujarat University, Ahmedabad, 380009, Gujarat, India. mchorawalaresearch@gmail.com","Department of Pharmacology and Pharmacy Practice, L. M. College of Pharmacy, Opp. Gujarat University, Ahmedabad, 380009, Gujarat, India"],"raw_orcid":"https://orcid.org/0000-0002-3724-0986","affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Pharmacy Practice, L. M. College of Pharmacy, Opp. Gujarat University, Ahmedabad, 380009, Gujarat, India. mchorawalaresearch@gmail.com","institution_ids":["https://openalex.org/I114173286"]},{"raw_affiliation_string":"Department of Pharmacology and Pharmacy Practice, L. M. College of Pharmacy, Opp. Gujarat University, Ahmedabad, 380009, Gujarat, India","institution_ids":["https://openalex.org/I114173286"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001367208"],"corresponding_institution_ids":["https://openalex.org/I114173286"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":1.2944,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.81882022,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"40","issue":"11","first_page":"334","last_page":"334"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.6880000233650208,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.2734000086784363,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.024399999529123306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":1.0},{"id":"https://openalex.org/keywords/genetic-alterations","display_name":"genetic alterations","score":0.8709999918937683},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.8870000243186951},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.9980000257492065},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.9829999804496765},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.8679999709129333},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8029999732971191},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5130000114440918},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.5860000252723694},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.9194455146789551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6583561301231384},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.588883101940155},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4789370000362396},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.43755054473876953},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4218613803386688},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4212767481803894},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3768600523471832},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23364588618278503},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20044255256652832}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s12032-023-02201-8","doi":"https://doi.org/10.1007/s12032-023-02201-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12032-023-02201-8","pdf_url":null,"source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},{"id":"pmid:37855910","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37855910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical oncology (Northwood, London, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":222,"referenced_works":["https://openalex.org/W56241122","https://openalex.org/W777727261","https://openalex.org/W1556990476","https://openalex.org/W1639623904","https://openalex.org/W1754904635","https://openalex.org/W1903713003","https://openalex.org/W1926951007","https://openalex.org/W1942560962","https://openalex.org/W1965151932","https://openalex.org/W1967278753","https://openalex.org/W1967856042","https://openalex.org/W1968907488","https://openalex.org/W1974091059","https://openalex.org/W1978929052","https://openalex.org/W1984625204","https://openalex.org/W1993237836","https://openalex.org/W1997209348","https://openalex.org/W2002032142","https://openalex.org/W2004419844","https://openalex.org/W2007691970","https://openalex.org/W2018023891","https://openalex.org/W2027337701","https://openalex.org/W2031681802","https://openalex.org/W2047098641","https://openalex.org/W2058142370","https://openalex.org/W2061623083","https://openalex.org/W2077269515","https://openalex.org/W2094390470","https://openalex.org/W2095249623","https://openalex.org/W2105389498","https://openalex.org/W2111699167","https://openalex.org/W2149303776","https://openalex.org/W2150625137","https://openalex.org/W2155230904","https://openalex.org/W2158796507","https://openalex.org/W2162709127","https://openalex.org/W2164424287","https://openalex.org/W2165083157","https://openalex.org/W2165450197","https://openalex.org/W2346939081","https://openalex.org/W2361876374","https://openalex.org/W2468296498","https://openalex.org/W2493808054","https://openalex.org/W2535173298","https://openalex.org/W2555260204","https://openalex.org/W2576006617","https://openalex.org/W2583744451","https://openalex.org/W2597230258","https://openalex.org/W2597953270","https://openalex.org/W2605230952","https://openalex.org/W2620367356","https://openalex.org/W2677344660","https://openalex.org/W2735767394","https://openalex.org/W2773379569","https://openalex.org/W2779263916","https://openalex.org/W2782103295","https://openalex.org/W2783151045","https://openalex.org/W2795078864","https://openalex.org/W2797121391","https://openalex.org/W2804781394","https://openalex.org/W2885299218","https://openalex.org/W2885659166","https://openalex.org/W2888644986","https://openalex.org/W2890516462","https://openalex.org/W2895357007","https://openalex.org/W2897778033","https://openalex.org/W2903870145","https://openalex.org/W2912626193","https://openalex.org/W2920628741","https://openalex.org/W2920863623","https://openalex.org/W2923057410","https://openalex.org/W2936741942","https://openalex.org/W2937354235","https://openalex.org/W2937507204","https://openalex.org/W2939056166","https://openalex.org/W2942749280","https://openalex.org/W2944548605","https://openalex.org/W2946629069","https://openalex.org/W2951221521","https://openalex.org/W2972355728","https://openalex.org/W2972416174","https://openalex.org/W2972444443","https://openalex.org/W2973017325","https://openalex.org/W2981559425","https://openalex.org/W2982905695","https://openalex.org/W2983881420","https://openalex.org/W2984550196","https://openalex.org/W2985795188","https://openalex.org/W2987132227","https://openalex.org/W2987225757","https://openalex.org/W2987284967","https://openalex.org/W2992809542","https://openalex.org/W2995898384","https://openalex.org/W2997457188","https://openalex.org/W2997492439","https://openalex.org/W2998881619","https://openalex.org/W3005923115","https://openalex.org/W3016485299","https://openalex.org/W3016984311","https://openalex.org/W3024495812","https://openalex.org/W3031126723","https://openalex.org/W3032868570","https://openalex.org/W3035350645","https://openalex.org/W3037463591","https://openalex.org/W3044903507","https://openalex.org/W3047882216","https://openalex.org/W3087730663","https://openalex.org/W3092357984","https://openalex.org/W3093452641","https://openalex.org/W3093927794","https://openalex.org/W3094695908","https://openalex.org/W3094801273","https://openalex.org/W3097409164","https://openalex.org/W3103114756","https://openalex.org/W3106956241","https://openalex.org/W3107176737","https://openalex.org/W3110003772","https://openalex.org/W3114284311","https://openalex.org/W3115880421","https://openalex.org/W3117402266","https://openalex.org/W3117886022","https://openalex.org/W3120591296","https://openalex.org/W3124370821","https://openalex.org/W3127376650","https://openalex.org/W3128200801","https://openalex.org/W3136119724","https://openalex.org/W3137091346","https://openalex.org/W3138415968","https://openalex.org/W3150339341","https://openalex.org/W3153531807","https://openalex.org/W3153990830","https://openalex.org/W3155387234","https://openalex.org/W3158220003","https://openalex.org/W3160873367","https://openalex.org/W3161189560","https://openalex.org/W3163586240","https://openalex.org/W3164791653","https://openalex.org/W3165199846","https://openalex.org/W3167244513","https://openalex.org/W3169321271","https://openalex.org/W3171648992","https://openalex.org/W3175395406","https://openalex.org/W3176165488","https://openalex.org/W3177297957","https://openalex.org/W3179886125","https://openalex.org/W3183476852","https://openalex.org/W3187773944","https://openalex.org/W3193718704","https://openalex.org/W3195514600","https://openalex.org/W3196232603","https://openalex.org/W3199023494","https://openalex.org/W3200117713","https://openalex.org/W3205627802","https://openalex.org/W3207944698","https://openalex.org/W3210186410","https://openalex.org/W3210893762","https://openalex.org/W3214173072","https://openalex.org/W3217235523","https://openalex.org/W4200190958","https://openalex.org/W4200211768","https://openalex.org/W4200307603","https://openalex.org/W4200486799","https://openalex.org/W4206368391","https://openalex.org/W4206908848","https://openalex.org/W4213257519","https://openalex.org/W4214900502","https://openalex.org/W4220677690","https://openalex.org/W4220764901","https://openalex.org/W4220871154","https://openalex.org/W4221041782","https://openalex.org/W4221111564","https://openalex.org/W4224221174","https://openalex.org/W4224880107","https://openalex.org/W4225122437","https://openalex.org/W4225398025","https://openalex.org/W4255913902","https://openalex.org/W4283590904","https://openalex.org/W4284886667","https://openalex.org/W4285010507","https://openalex.org/W4285388129","https://openalex.org/W4289528166","https://openalex.org/W4291168357","https://openalex.org/W4292212542","https://openalex.org/W4293008345","https://openalex.org/W4296129731","https://openalex.org/W4296164037","https://openalex.org/W4308909302","https://openalex.org/W4308952170","https://openalex.org/W4309084269","https://openalex.org/W4309947468","https://openalex.org/W4311247426","https://openalex.org/W4311283346","https://openalex.org/W4316468447","https://openalex.org/W4316662983","https://openalex.org/W4317388020","https://openalex.org/W4317567311","https://openalex.org/W4319444998","https://openalex.org/W4319723584","https://openalex.org/W4319827264","https://openalex.org/W4319982936","https://openalex.org/W4321457518","https://openalex.org/W4321497960","https://openalex.org/W4323920770","https://openalex.org/W4323971780","https://openalex.org/W4328142556","https://openalex.org/W4353089939","https://openalex.org/W4360616209","https://openalex.org/W4362471129","https://openalex.org/W4364380577","https://openalex.org/W4375867606","https://openalex.org/W4376226672","https://openalex.org/W4376274714","https://openalex.org/W4377011375","https://openalex.org/W4377292628","https://openalex.org/W4379209153","https://openalex.org/W4379966180","https://openalex.org/W4381948333","https://openalex.org/W4382701052","https://openalex.org/W4382893349","https://openalex.org/W4386318500","https://openalex.org/W6605699737","https://openalex.org/W6779108555"],"related_works":["https://openalex.org/W1982529507","https://openalex.org/W7160537886","https://openalex.org/W7117979787","https://openalex.org/W2121239890","https://openalex.org/W4290975097","https://openalex.org/W2997492439","https://openalex.org/W4392865173","https://openalex.org/W4391382512","https://openalex.org/W2885659166","https://openalex.org/W2164749542"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-20T00:00:00"}
