{"id":"https://openalex.org/W4387764702","doi":"https://doi.org/10.1161/hypertensionaha.123.21264","title":"Hypertension Trends and White Matter Brain Injury in the Offspring Framingham Heart Study Cohort","display_name":"Hypertension Trends and White Matter Brain Injury in the Offspring Framingham Heart Study Cohort","publication_year":2023,"publication_date":"2023-10-19","ids":{"openalex":"https://openalex.org/W4387764702","doi":"https://doi.org/10.1161/hypertensionaha.123.21264","pmid":"https://pubmed.ncbi.nlm.nih.gov/37855140","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10896002"},"language":"en","primary_location":{"id":"doi:10.1161/hypertensionaha.123.21264","doi":"https://doi.org/10.1161/hypertensionaha.123.21264","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.123.21264","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.123.21264","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.123.21264","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009620953","display_name":"Rodica Elena Petrea","orcid":"https://orcid.org/0000-0001-6214-3566","observed_orcids":["https://orcid.org/0000-0001-6214-3566"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rodica E. Petrea","raw_affiliation_strings":["Department of Medicine, Section of Preventive Medicine and Epidemiology (R.P.), Boston University School of Medicine, Boston, MA","NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","Rodica E. Petrea https://orcid.org/0000-0001-6214-3566 Department of Medicine, Section of Preventive Medicine and Epidemiology (R.P.), Boston University School of Medicine, Boston, MA. NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)"],"raw_orcid":"https://orcid.org/0000-0001-6214-3566","affiliations":[{"raw_affiliation_string":"Department of Medicine, Section of Preventive Medicine and Epidemiology (R.P.), Boston University School of Medicine, Boston, MA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Rodica E. Petrea https://orcid.org/0000-0001-6214-3566 Department of Medicine, Section of Preventive Medicine and Epidemiology (R.P.), Boston University School of Medicine, Boston, MA. NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041188544","display_name":"Adlin Pinheiro","orcid":"https://orcid.org/0000-0002-4241-9198","observed_orcids":["https://orcid.org/0000-0002-4241-9198"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adlin Pinheiro","raw_affiliation_strings":["Department of Biostatistics, Boston University School of Public Health, Boston, MA (A.P., S.D., A.S.B.)","NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","Adlin Pinheiro https://orcid.org/0000-0002-4241-9198 NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA (A.P., S.D., A.S.B.)"],"raw_orcid":"https://orcid.org/0000-0002-4241-9198","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Boston University School of Public Health, Boston, MA (A.P., S.D., A.S.B.)","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Adlin Pinheiro https://orcid.org/0000-0002-4241-9198 NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA (A.P., S.D., A.S.B.)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067354038","display_name":"Serkalem Demissie","orcid":"https://orcid.org/0000-0002-8009-0987","observed_orcids":["https://orcid.org/0000-0002-8009-0987"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Serkalem Demissie","raw_affiliation_strings":["Department of Biostatistics, Boston University School of Public Health, Boston, MA (A.P., S.D., A.S.B.)","NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","Serkalem Demissie NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA (A.P., S.D., A.S.B.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Boston University School of Public Health, Boston, MA (A.P., S.D., A.S.B.)","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Serkalem Demissie NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA (A.P., S.D., A.S.B.)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058168933","display_name":"Oluchi Stella Ekenze","orcid":"https://orcid.org/0000-0002-2510-8427","observed_orcids":["https://orcid.org/0000-0002-2510-8427"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oluchi Ekenze","raw_affiliation_strings":["Graduate Medical Sciences (O.E.), Boston University School of Medicine, Boston, MA","NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","Oluchi Ekenze https://orcid.org/0000-0002-2510-8427 Graduate Medical Sciences (O.E.), Boston University School of Medicine, Boston, MA. NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)"],"raw_orcid":"https://orcid.org/0000-0002-2510-8427","affiliations":[{"raw_affiliation_string":"Graduate Medical Sciences (O.E.), Boston University School of Medicine, Boston, MA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Oluchi Ekenze https://orcid.org/0000-0002-2510-8427 Graduate Medical Sciences (O.E.), Boston University School of Medicine, Boston, MA. NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045747754","display_name":"Hugo Javier Aparicio","orcid":"https://orcid.org/0000-0001-8584-1455","observed_orcids":["https://orcid.org/0000-0001-8584-1455"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hugo J. Aparicio","raw_affiliation_strings":["Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.)","NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","Hugo J. Aparicio NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.). Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.)","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Hugo J. Aparicio NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.). Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107424087","display_name":"Claudia Liliana Satiz\u00e1bal","orcid":"https://orcid.org/0000-0002-1115-4430","observed_orcids":["https://orcid.org/0000-0002-1115-4430"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia L. Satizabal","raw_affiliation_strings":["Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.)","Glenn Biggs Institute for Alzheimer\u2019s and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX (C.L.S., S.S.)","NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","Claudia L. Satizabal https://orcid.org/0000-0002-1115-4430 NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.). Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.). Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX (C.L.S., S.S.)"],"raw_orcid":"https://orcid.org/0000-0002-1115-4430","affiliations":[{"raw_affiliation_string":"Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.)","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Glenn Biggs Institute for Alzheimer\u2019s and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX (C.L.S., S.S.)","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Claudia L. Satizabal https://orcid.org/0000-0002-1115-4430 NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.). Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.). Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX (C.L.S., S.S.)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056482680","display_name":"Pauline Maillard","orcid":"https://orcid.org/0000-0003-3516-6345","observed_orcids":["https://orcid.org/0000-0003-3516-6345"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pauline Maillard","raw_affiliation_strings":["Alzheimer\u2019s Disease Center and Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis School of Medicine, Sacramento, CA (P.M., C.D.)","Pauline Maillard https://orcid.org/0000-0003-3516-6345 Alzheimer's Disease Center and Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis School of Medicine, Sacramento, CA (P.M., C.D.)"],"raw_orcid":"https://orcid.org/0000-0003-3516-6345","affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Center and Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis School of Medicine, Sacramento, CA (P.M., C.D.)","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Pauline Maillard https://orcid.org/0000-0003-3516-6345 Alzheimer's Disease Center and Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis School of Medicine, Sacramento, CA (P.M., C.D.)","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071825455","display_name":"Charles S DeCarli","orcid":"https://orcid.org/0000-0003-1914-2693","observed_orcids":["https://orcid.org/0000-0003-1914-2693"]},"institutions":[{"id":"https://openalex.org/I4210160527","display_name":"University of California Davis Medical Center","ror":"https://ror.org/05t6gpm70","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160527","https://openalex.org/I4210160856"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles DeCarli","raw_affiliation_strings":["Alzheimer\u2019s Disease Center and Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis School of Medicine, Sacramento, CA (P.M., C.D.)","Charles DeCarli https://orcid.org/0000-0003-1914-2693 Alzheimer's Disease Center and Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis School of Medicine, Sacramento, CA (P.M., C.D.)"],"raw_orcid":"https://orcid.org/0000-0003-1914-2693","affiliations":[{"raw_affiliation_string":"Alzheimer\u2019s Disease Center and Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis School of Medicine, Sacramento, CA (P.M., C.D.)","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Charles DeCarli https://orcid.org/0000-0003-1914-2693 Alzheimer's Disease Center and Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for Neuroscience, University of California at Davis School of Medicine, Sacramento, CA (P.M., C.D.)","institution_ids":["https://openalex.org/I4210160527","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063754448","display_name":"Alexa Beiser","orcid":"https://orcid.org/0000-0001-8551-7778","observed_orcids":["https://orcid.org/0000-0001-8551-7778"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexa S. Beiser","raw_affiliation_strings":["Department of Biostatistics, Boston University School of Public Health, Boston, MA (A.P., S.D., A.S.B.)","Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.)","NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","Alexa S. Beiser https://orcid.org/0000-0001-8551-7778 NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA (A.P., S.D., A.S.B.). Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.)"],"raw_orcid":"https://orcid.org/0000-0001-8551-7778","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Boston University School of Public Health, Boston, MA (A.P., S.D., A.S.B.)","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.)","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Alexa S. Beiser https://orcid.org/0000-0001-8551-7778 NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.). Department of Biostatistics, Boston University School of Public Health, Boston, MA (A.P., S.D., A.S.B.). Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011863508","display_name":"Sudha S. Seshadri","orcid":"https://orcid.org/0000-0001-6135-2622","observed_orcids":["https://orcid.org/0000-0001-6135-2622"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudha Seshadri","raw_affiliation_strings":["Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.)","Glenn Biggs Institute for Alzheimer\u2019s and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX (C.L.S., S.S.)","NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","Sudha Seshadri https://orcid.org/0000-0001-6135-2622 NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.). Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.). Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX (C.L.S., S.S.)"],"raw_orcid":"https://orcid.org/0000-0001-6135-2622","affiliations":[{"raw_affiliation_string":"Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.)","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Glenn Biggs Institute for Alzheimer\u2019s and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX (C.L.S., S.S.)","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Sudha Seshadri https://orcid.org/0000-0001-6135-2622 NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.). Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.). Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX (C.L.S., S.S.)","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062198189","display_name":"Vasileios\u2010Arsenios Lioutas","orcid":"https://orcid.org/0000-0002-8521-0036","observed_orcids":["https://orcid.org/0000-0002-8521-0036"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vasileios-Arsenios Lioutas","raw_affiliation_strings":["Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (V.-A.L.)","NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","Vasileios-Arsenios Lioutas https://orcid.org/0000-0002-8521-0036 NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.). Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (V.-A.L.)"],"raw_orcid":"https://orcid.org/0000-0002-8521-0036","affiliations":[{"raw_affiliation_string":"Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (V.-A.L.)","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]},{"raw_affiliation_string":"NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","institution_ids":["https://openalex.org/I4210123017"]},{"raw_affiliation_string":"Vasileios-Arsenios Lioutas https://orcid.org/0000-0002-8521-0036 NHLBI's Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.). Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (V.-A.L.)","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984","https://openalex.org/I4210123017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040070345","display_name":"Jose Rafael Romero","orcid":"https://orcid.org/0000-0002-1101-2950","observed_orcids":["https://orcid.org/0000-0002-1101-2950"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I4210123017","display_name":"Framingham Heart Study","ror":"https://ror.org/031grv205","country_code":"US","type":"facility","lineage":["https://openalex.org/I111088046","https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489","https://openalex.org/I4210123017"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jose Rafael Romero","raw_affiliation_strings":["Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.)","NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)"],"raw_orcid":"https://orcid.org/0000-0002-1101-2950","affiliations":[{"raw_affiliation_string":"Department of Neurology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA (H.J.A., C.L.S., A.S.B., S.S., J.R.R.)","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"NHLBI\u2019s Framingham Heart Study, Framingham, MA (R.P., A.P., S.D., O.E., H.J.A., C.L.S., A.S.B., S.S., V.-A.L., J.R.R.)","institution_ids":["https://openalex.org/I4210123017"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5040070345"],"corresponding_institution_ids":["https://openalex.org/I111088046","https://openalex.org/I4210123017"],"apc_list":null,"apc_paid":null,"fwci":3.4246,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.93426703,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"81","issue":"1","first_page":"87","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.8101000189781189,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.8101000189781189,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.07039999961853027,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.03739999979734421,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/white-matter-hyperintensities","display_name":"white matter hyperintensities","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cerebral-small-vessel-disease","display_name":"cerebral small vessel disease","score":0.8119999766349792},{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.7269999980926514},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"fractional anisotropy","score":0.7459999918937683},{"id":"https://openalex.org/keywords/mean-diffusivity","display_name":"mean diffusivity","score":0.8740000128746033},{"id":"https://openalex.org/keywords/white-matter-microstructure","display_name":"white matter microstructure","score":0.6620000004768372},{"id":"https://openalex.org/keywords/stroke-risk","display_name":"stroke risk","score":0.5870000123977661},{"id":"https://openalex.org/keywords/framingham-offspring-cohort","display_name":"Framingham Offspring cohort","score":0.8930000066757202},{"id":"https://openalex.org/keywords/age-effect-modification","display_name":"age effect modification","score":0.5630000233650208},{"id":"https://openalex.org/keywords/community-dwelling-adults","display_name":"community-dwelling adults","score":0.7139999866485596},{"id":"https://openalex.org/keywords/diffusion-tensor-imaging","display_name":"diffusion tensor imaging","score":0.5419999957084656},{"id":"https://openalex.org/keywords/flair","display_name":"FLAIR","score":0.8679999709129333}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7425335049629211},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6032876968383789},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5931092500686646},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.5403253436088562},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5262578725814819},{"id":"https://openalex.org/C146638467","wikidata":"https://www.wikidata.org/wiki/Q10529587","display_name":"Hyperintensity","level":3,"score":0.5161508321762085},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5058462619781494},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.5033738017082214},{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.4981234073638916},{"id":"https://openalex.org/C111815664","wikidata":"https://www.wikidata.org/wiki/Q1440693","display_name":"Framingham Heart Study","level":4,"score":0.494851291179657},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4391652047634125},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.2888583540916443},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11109694838523865},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1161/hypertensionaha.123.21264","doi":"https://doi.org/10.1161/hypertensionaha.123.21264","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.123.21264","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.123.21264","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmid:37855140","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37855140","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10896002","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10896002","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10896002/pdf/nihms-1937456.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Hypertension","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1161/hypertensionaha.123.21264","doi":"https://doi.org/10.1161/hypertensionaha.123.21264","is_oa":true,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.123.21264","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/HYPERTENSIONAHA.123.21264","source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1035741774","display_name":null,"funder_award_id":"HL-076784","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1345365365","display_name":"UC Davis Alzheimer's Disease Core Center","funder_award_id":"P30AG010129","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1735617348","display_name":null,"funder_award_id":"75N92019D00031","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2356649271","display_name":"Therapeutic target discovery in ADSP data via comprehensive whole-genome analysis incorporating ethnic diversity and systems approaches","funder_award_id":"U01AG058589","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G250621538","display_name":null,"funder_award_id":"N01\u2010HC25195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2629239991","display_name":"Ventricular Matrix Remodeling:  Correlates and Prognosis","funder_award_id":"R01HL067288","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2767432091","display_name":"Risk Factors, Genetics and Cognition in Cerebral Microbleeds: Framingham Study","funder_award_id":"K23AG038444","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G278200998","display_name":null,"funder_award_id":"HHSN268201500001I","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3665864103","display_name":"Aldosterone in Vascular Remodeling and Dysfunction","funder_award_id":"K24HL004334","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4551567088","display_name":"Aging and Inflammation: Longitudinal Markers and Genetics in the Framingham Study","funder_award_id":"R01AG028321","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4976486911","display_name":null,"funder_award_id":"75N92019D00031","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5044472271","display_name":"Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham Cohorts","funder_award_id":"R01AG054076","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5164707915","display_name":null,"funder_award_id":"N01-HC-025195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5393029853","display_name":"Longitudinal Risk Factor Changes and Early Recognition of Cerebral Small Vessel Disease","funder_award_id":"R21NS135268","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5492443930","display_name":"Preclinical AD: Correlates of Amyloid, Tau PET and fcMRI in Framingham Gen 3 Young Adults","funder_award_id":"R01AG049607","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5510283005","display_name":"Cerebral Microbleeds in Young Adults: risk factors, biomarkers and genetics","funder_award_id":"R03AG048180","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5659906136","display_name":"MRI, Cognitive, Genetic and Biomarker Precursors of AD & Dementia in Young Adults","funder_award_id":"R01AG033040","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6151559349","display_name":"Framingham: Inflammation, Genes & Cardiovascular Disease","funder_award_id":"R01HL076784","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G641917991","display_name":"The Framingham Heart Study","funder_award_id":"n01hc25195-41-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G659106026","display_name":"Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequences","funder_award_id":"R01AG059725","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7264467602","display_name":null,"funder_award_id":"NS017950","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8326557007","display_name":null,"funder_award_id":"AG010129","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8566141481","display_name":null,"funder_award_id":"HL67288","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G87479581","display_name":"Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)","funder_award_id":"RF1AG059421","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8779974883","display_name":"Epidemiology of Dementia in the Framingham Study","funder_award_id":"R01AG008122","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8962124162","display_name":null,"funder_award_id":"AG028321","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000108235","display_name":null,"funder_award_id":"AG010129","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000124674","display_name":null,"funder_award_id":"N01-HC 25195","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000885563","display_name":"UC Davis Alzheimer's Disease Research Center","funder_award_id":"P30AG072972","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000906853","display_name":"Precursors of Stroke Incidence and Prognosis","funder_award_id":"R01NS017950","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000907742","display_name":"Multidisciplinary Training Program in Cardiovascular Epidemiology","funder_award_id":"T32HL125232","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000918208","display_name":"South Texas Alzheimer's Disease Center","funder_award_id":"P30AG066546","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387764702.pdf","grobid_xml":"https://content.openalex.org/works/W4387764702.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1968232933","https://openalex.org/W1971548649","https://openalex.org/W1986159654","https://openalex.org/W1997783106","https://openalex.org/W2004006028","https://openalex.org/W2008273493","https://openalex.org/W2050683965","https://openalex.org/W2083711255","https://openalex.org/W2104901197","https://openalex.org/W2105381419","https://openalex.org/W2109334713","https://openalex.org/W2117841533","https://openalex.org/W2126416892","https://openalex.org/W2130766313","https://openalex.org/W2132752715","https://openalex.org/W2140621953","https://openalex.org/W2162069510","https://openalex.org/W2166711387","https://openalex.org/W2295537556","https://openalex.org/W2517883070","https://openalex.org/W2610653416","https://openalex.org/W2612583120","https://openalex.org/W2614900780","https://openalex.org/W2768267412","https://openalex.org/W2932221873","https://openalex.org/W2940420923","https://openalex.org/W2967318538","https://openalex.org/W3011633284","https://openalex.org/W3046420290","https://openalex.org/W3161563824","https://openalex.org/W3163515123","https://openalex.org/W4280531076"],"related_works":["https://openalex.org/W1934592423","https://openalex.org/W4408089881","https://openalex.org/W2811381117","https://openalex.org/W2790890121","https://openalex.org/W3112719226","https://openalex.org/W2056885504","https://openalex.org/W2092665786","https://openalex.org/W2130766313","https://openalex.org/W2767355593","https://openalex.org/W2140075426"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hypertension":[1],"is":[2,10,225],"the":[3,20,35,128,133,167,183,239],"most":[4],"potent":[5],"stroke":[6],"risk":[7],"factor":[8],"and":[9,26,48,53,72,87,92,108,123,149,182,192,219,230,246,251],"also":[11],"related":[12],"to":[13,65,74,231],"cerebral":[14,27],"small":[15],"vessel":[16],"disease.":[17],"We":[18,113],"studied":[19],"relation":[21],"between":[22],"mid-to-late-life":[23],"hypertension":[24,67,223],"trends":[25,68,201],"white":[28,75,205,236],"matter":[29,76,98,206,237],"injury":[30,77],"in":[31],"community-dwelling":[32],"individuals":[33],"from":[34],"FHS":[36,41],"(Framingham":[37],"Heart":[38],"Study).":[39],"METHODS:":[40],"Offspring":[42],"cohort":[43],"participants":[44,116],"with":[45,138,228,254],"available":[46],"mid-life":[47,122],"late-life":[49],"blood":[50,103,248],"pressure":[51,104,249],"measurements":[52],"brain":[54],"magnetic":[55],"resonance":[56],"imaging":[57,82],"were":[58,63],"included.":[59],"Multiple":[60],"regression":[61],"analyses":[62],"used":[64],"relate":[66],"(normotension-normotension":[69],"[reference],":[70],"normotension-hypertension,":[71],"hypertension-hypertension)":[73],"metrics":[78],"on":[79],"diffusion":[80],"tensor":[81],"(free":[83],"water,":[84],"fractional":[85],"anisotropy,":[86],"peak":[88,150],"skeletonized":[89,151],"mean":[90,152],"diffusivity)":[91],"Fluid":[93],"Attenuated":[94],"Inversion":[95],"Recovery":[96],"(white":[97],"hyperintensity":[99,207],"volume)":[100],"by":[101,215],"different":[102],"cutoffs":[105,250],"(130/80,":[106],"140/90,":[107],"150/90":[109],"mm":[110,130,164],"Hg).":[111],"RESULTS:":[112],"included":[114],"1018":[115],"(mean":[117],"age":[118],"47.3\u00b17.4":[119],"years":[120],"at":[121,125,243],"73.2\u00b17.3":[124],"late-life).":[126],"At":[127,161],"140/90":[129],"Hg":[131,165],"cutoff,":[132,166],"hypertension-hypertension":[134,168,193],"trend":[135,169],"was":[136],"associated":[137,227,253],"higher":[139,172],"free":[140,173],"water":[141,174],"(\u03b2,":[142,154,175,185,194],"0.16":[143,176],"[95%":[144,156,177,187,196],"CI,":[145,157,178,188,197],"0.03\u20130.30];":[146],"P":[147,159,180,190,199],"=0.021)":[148],"diffusivity":[153],"0.15":[155],"0.01\u20130.29];":[158],"=0.033).":[160],"a":[162,232],"130/80":[163],"had":[170,202],"significantly":[171,203,226],"0.01\u20130.30];":[179],"=0.035);":[181],"normotension-hypertension":[184],"0.24":[186],"0.03\u20130.44];":[189],"=0.027)":[191],"0.22":[195],"0.04\u20130.41];":[198],"=0.022)":[200],"increased":[204],"volume.":[208],"Exploratory":[209],"stratified":[210],"analysis":[211],"showed":[212],"effect":[213],"modifications":[214],"APOE":[216],"\u025b4":[217],"allele":[218],"age.":[220],"CONCLUSIONS:":[221],"Mid-to-late-life":[222],"exposure":[224],"microstructural":[229],"lesser":[233],"extent,":[234],"visible":[235],"injury;":[238],"effects":[240],"are":[241,252],"observed":[242],"both":[244],"conventional":[245],"lower":[247],"longer":[255],"duration":[256],"of":[257],"hypertension.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-20T00:00:00"}