{"id":"https://openalex.org/W4387764520","doi":null,"title":"Precision oncology strategy in cetuximab-resistant ERRFI1-mutant colon cancer: case report of disease progression on afatinib.","display_name":"Precision oncology strategy in cetuximab-resistant ERRFI1-mutant colon cancer: case report of disease progression on afatinib.","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4387764520","pmid":"https://pubmed.ncbi.nlm.nih.gov/37854204","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10579037"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10579037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10579037","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10579037/pdf/ajtr0015-5785.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10579037/pdf/ajtr0015-5785.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040037979","display_name":"Olesya A. Kuznetsova","orcid":"https://orcid.org/0000-0001-7753-3081","observed_orcids":["https://orcid.org/0000-0001-7753-3081"]},"institutions":[{"id":"https://openalex.org/I4210090957","display_name":"Russian Cancer Research Center NN Blokhin","ror":"https://ror.org/00ab9fg88","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210090957"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Olesya Kuznetsova","raw_affiliation_strings":["OncoAtlas LLC 119049 Moscow, Russia","N.N. Blokhin Russian Cancer Research Center 115478 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OncoAtlas LLC 119049 Moscow, Russia","institution_ids":[]},{"raw_affiliation_string":"N.N. Blokhin Russian Cancer Research Center 115478 Moscow, Russia","institution_ids":["https://openalex.org/I4210090957"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074392530","display_name":"Alexandra Lebedeva","orcid":"https://orcid.org/0000-0003-1920-5076","observed_orcids":["https://orcid.org/0000-0003-1920-5076"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Lebedeva","raw_affiliation_strings":["OncoAtlas LLC 119049 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OncoAtlas LLC 119049 Moscow, Russia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038360104","display_name":"Alexandra Kavun","orcid":"https://orcid.org/0000-0003-3861-5281","observed_orcids":["https://orcid.org/0000-0003-3861-5281"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Kavun","raw_affiliation_strings":["OncoAtlas LLC 119049 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OncoAtlas LLC 119049 Moscow, Russia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091823262","display_name":"Ekaterina Belova","orcid":"https://orcid.org/0000-0002-7701-8765","observed_orcids":["https://orcid.org/0000-0002-7701-8765"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Ekaterina Belova","raw_affiliation_strings":["OncoAtlas LLC 119049 Moscow, Russia","Lomonosov Moscow State University 119991 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OncoAtlas LLC 119049 Moscow, Russia","institution_ids":[]},{"raw_affiliation_string":"Lomonosov Moscow State University 119991 Moscow, Russia","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080856237","display_name":"Mikhail Yu. Fedyanin","orcid":"https://orcid.org/0000-0001-5615-7806","observed_orcids":["https://orcid.org/0000-0001-5615-7806"]},"institutions":[{"id":"https://openalex.org/I4210090957","display_name":"Russian Cancer Research Center NN Blokhin","ror":"https://ror.org/00ab9fg88","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210090957"]},{"id":"https://openalex.org/I4210113199","display_name":"National Medical and Surgical Center named after N.I. Pirogov","ror":"https://ror.org/01v2h2d39","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210113199"]},{"id":"https://openalex.org/I4210117042","display_name":"Ministry of Health of the Russian Federation","ror":"https://ror.org/01p8ehb87","country_code":"RU","type":"government","lineage":["https://openalex.org/I4210117042"]},{"id":"https://openalex.org/I4405285160","display_name":"Moscow Multidisciplinary Clinical Center \"Kommunarka\"","ror":"https://ror.org/04wp5yq54","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4405285160"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Mikhail Fedyanin","raw_affiliation_strings":["N.N. Blokhin Russian Cancer Research Center 115478 Moscow, Russia","State Budgetary Institution of Health Care of The City of Moscow \"Moscow Multidisciplinary Clinical Center Kommunarka\" of The Department of Health of The City of Moscow 142770 Moscow, Russia","Federal State Budgetary Institution \"National Medical and Surgical Center Named After N.I. Pirogov\" of The Ministry of Health of The Russian Federation 105203 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"N.N. Blokhin Russian Cancer Research Center 115478 Moscow, Russia","institution_ids":["https://openalex.org/I4210090957"]},{"raw_affiliation_string":"State Budgetary Institution of Health Care of The City of Moscow \"Moscow Multidisciplinary Clinical Center Kommunarka\" of The Department of Health of The City of Moscow 142770 Moscow, Russia","institution_ids":["https://openalex.org/I4405285160"]},{"raw_affiliation_string":"Federal State Budgetary Institution \"National Medical and Surgical Center Named After N.I. Pirogov\" of The Ministry of Health of The Russian Federation 105203 Moscow, Russia","institution_ids":["https://openalex.org/I4210113199","https://openalex.org/I4210117042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040010672","display_name":"Vladislav Mileyko","orcid":"https://orcid.org/0000-0002-0272-1747","observed_orcids":["https://orcid.org/0000-0002-0272-1747"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vladislav Mileyko","raw_affiliation_strings":["OncoAtlas LLC 119049 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OncoAtlas LLC 119049 Moscow, Russia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102017873","display_name":"Maxim V. Ivanov","orcid":"https://orcid.org/0000-0002-9961-0129","observed_orcids":["https://orcid.org/0000-0002-9961-0129"]},"institutions":[{"id":"https://openalex.org/I153845743","display_name":"Moscow Institute of Physics and Technology","ror":"https://ror.org/00v0z9322","country_code":"RU","type":"education","lineage":["https://openalex.org/I153845743"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Maxim Ivanov","raw_affiliation_strings":["OncoAtlas LLC 119049 Moscow, Russia","Moscow Institute of Physics and Technology 141701 Dolgoprudny, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"OncoAtlas LLC 119049 Moscow, Russia","institution_ids":[]},{"raw_affiliation_string":"Moscow Institute of Physics and Technology 141701 Dolgoprudny, Russia","institution_ids":["https://openalex.org/I153845743"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055109644","display_name":"Dmitry Nosov","orcid":"https://orcid.org/0000-0001-8415-5197","observed_orcids":["https://orcid.org/0000-0001-8415-5197"]},"institutions":[{"id":"https://openalex.org/I2800355153","display_name":"Central Clinical Hospital and Polyclinic","ror":"https://ror.org/01wc8dm69","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I2800355153"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitry Nosov","raw_affiliation_strings":["The Central Clinical Hospital of The Administrative Directorate of The President of The Russian Federation 121359 Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Central Clinical Hospital of The Administrative Directorate of The President of The Russian Federation 121359 Moscow, Russia","institution_ids":["https://openalex.org/I2800355153"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19653356,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"9","first_page":"5785","last_page":"5790"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cetuximab-resistance","display_name":"cetuximab resistance","score":0.9089999794960022},{"id":"https://openalex.org/keywords/afatinib","display_name":"afatinib","score":0.9129999876022339},{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.9340000152587891},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.7540000081062317},{"id":"https://openalex.org/keywords/genomic-profiling","display_name":"genomic profiling","score":0.8040000200271606},{"id":"https://openalex.org/keywords/ras-braf-wild-type","display_name":"RAS/BRAF wild-type","score":0.8220000267028809},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.984000027179718},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2780586478","wikidata":"https://www.wikidata.org/wiki/Q4688818","display_name":"Afatinib","level":5,"score":0.9446831941604614},{"id":"https://openalex.org/C2779998722","wikidata":"https://www.wikidata.org/wiki/Q420296","display_name":"Cetuximab","level":4,"score":0.9040663242340088},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8456987142562866},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.8154873251914978},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.7169085144996643},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6691766977310181},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6198286414146423},{"id":"https://openalex.org/C2778332735","wikidata":"https://www.wikidata.org/wiki/Q417775","display_name":"Panitumumab","level":5,"score":0.6017798185348511},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.553568422794342},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5016891956329346},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4568420946598053},{"id":"https://openalex.org/C2777506169","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"EGFR inhibitors","level":4,"score":0.42665913701057434},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.42504698038101196},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34497037529945374},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.3199240565299988},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.3074246644973755},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.21141856908798218}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:10579037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10579037","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10579037/pdf/ajtr0015-5785.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"pmid:37854204","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37854204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Case Reports"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10579037","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10579037","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10579037/pdf/ajtr0015-5785.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387764520.pdf","grobid_xml":"https://content.openalex.org/works/W4387764520.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1983760206","https://openalex.org/W1992099172","https://openalex.org/W2006168411","https://openalex.org/W2025275840","https://openalex.org/W2046151919","https://openalex.org/W2051978340","https://openalex.org/W2095046027","https://openalex.org/W2095775828","https://openalex.org/W2161097769","https://openalex.org/W2674532415","https://openalex.org/W2888034354","https://openalex.org/W2910338182","https://openalex.org/W2922251533","https://openalex.org/W2950245492","https://openalex.org/W3009376277","https://openalex.org/W3080458669","https://openalex.org/W3128646645","https://openalex.org/W3207379781"],"related_works":["https://openalex.org/W2107070608","https://openalex.org/W2460287001","https://openalex.org/W2567158292","https://openalex.org/W2157049259","https://openalex.org/W2908755091","https://openalex.org/W7203796853","https://openalex.org/W2032648482","https://openalex.org/W1979688926","https://openalex.org/W2041507573","https://openalex.org/W2530554506"],"abstract_inverted_index":{"Despite":[0],"the":[1,37,50,66,76,80],"existence":[2],"of":[3,39,52,60,68,82],"effective":[4],"first":[5,77],"and":[6,62],"second":[7],"line":[8],"therapy":[9,47],"options":[10],"for":[11,29],"patients":[12,18,86],"with":[13,45,87],"colorectal":[14,42,91],"cancer,":[15],"heavily":[16],"treated":[17],"have":[19],"limited":[20],"additional":[21],"therapies.":[22],"Genomic":[23],"profiling":[24],"is":[25,75],"a":[26,41,58],"promising":[27],"tool":[28],"guiding":[30],"subsequent":[31],"treatment":[32],"selection.":[33],"Here,":[34],"we":[35],"describe":[36],"results":[38,51],"treating":[40],"cancer":[43],"patient":[44,56],"molecularly-matched":[46],"based":[48],"on":[49,79],"genomic":[53],"profiling.":[54],"The":[55],"received":[57],"combination":[59],"afatinib":[61],"bevacizumab":[63],"due":[64],"to":[65],"presence":[67],"ERRFI1":[69],"variant.":[70],"To":[71],"our":[72],"knowledge,":[73],"this":[74],"report":[78],"effect":[81],"EGFR":[83],"inhibitors":[84],"in":[85],"ERRFI1-altered":[88],"RAS/BRAF":[89],"wild-type":[90],"adenocarcinoma.":[92]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-10-20T00:00:00"}