{"id":"https://openalex.org/W4387753147","doi":"https://doi.org/10.57256/2949-0715-2023-3-116-117","title":"CIRCULATION MICRORNA AS A POSSIBLE PREDICTOR OF ANTHRACYCLINE-INDUCED CARDIOTOXICITY","display_name":"CIRCULATION MICRORNA AS A POSSIBLE PREDICTOR OF ANTHRACYCLINE-INDUCED CARDIOTOXICITY","publication_year":2023,"publication_date":"2023-09-10","ids":{"openalex":"https://openalex.org/W4387753147","doi":"https://doi.org/10.57256/2949-0715-2023-3-116-117"},"language":"en","primary_location":{"id":"doi:10.57256/2949-0715-2023-3-116-117","doi":"https://doi.org/10.57256/2949-0715-2023-3-116-117","is_oa":true,"landing_page_url":"http://dx.doi.org/10.57256/2949-0715-2023-3-116-117","pdf_url":"https://www.bmjour.ru/jour/article/download/139/96","source":{"id":"https://openalex.org/S4387285614","display_name":"Baikal Medical Journal","issn_l":"2949-0715","issn":["2949-0715"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Baikal Medical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.bmjour.ru/jour/article/download/139/96","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Federal State Budgetary Scientific Institution \"","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Federal State Budgetary Scientific Institution \"","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029764642","display_name":"Maria Vladimirovna Khutornaya","orcid":"https://orcid.org/0000-0002-9714-4080","observed_orcids":["https://orcid.org/0000-0002-9714-4080"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Vladimirovna Khutornaya","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9714-4080","affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":", Kemerovo Russian Federation","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":", Kemerovo Russian Federation","raw_affiliation_strings":["\u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u043e\u0435 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0435 \u0431\u044e\u0434\u0436\u0435\u0442\u043d\u043e\u0435 \u043d\u0430\u0443\u0447\u043d\u043e\u0435 \u0443\u0447\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435 \u00ab\u041d\u0430\u0443\u0447\u043d\u043e-\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u0441\u043a\u0438\u0439 \u0438\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u044b\u0445 \u043f\u0440\u043e\u0431\u043b\u0435\u043c \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439\u00bb,  \u041a\u0435\u043c\u0435\u0440\u043e\u0432\u043e"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u043e\u0435 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0435 \u0431\u044e\u0434\u0436\u0435\u0442\u043d\u043e\u0435 \u043d\u0430\u0443\u0447\u043d\u043e\u0435 \u0443\u0447\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435 \u00ab\u041d\u0430\u0443\u0447\u043d\u043e-\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u0441\u043a\u0438\u0439 \u0438\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u044b\u0445 \u043f\u0440\u043e\u0431\u043b\u0435\u043c \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439\u00bb,  \u041a\u0435\u043c\u0435\u0440\u043e\u0432\u043e","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030990869","display_name":"\u0410. V. Sinitskaya","orcid":"https://orcid.org/0000-0002-4467-8732","observed_orcids":["https://orcid.org/0000-0002-4467-8732"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Victorovna Sinitskaya","raw_affiliation_strings":["\u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u043e\u0435 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0435 \u0431\u044e\u0434\u0436\u0435\u0442\u043d\u043e\u0435 \u043d\u0430\u0443\u0447\u043d\u043e\u0435 \u0443\u0447\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435 \u00ab\u041d\u0430\u0443\u0447\u043d\u043e-\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u0441\u043a\u0438\u0439 \u0438\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u044b\u0445 \u043f\u0440\u043e\u0431\u043b\u0435\u043c \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439\u00bb, \u041a\u0435\u043c\u0435\u0440\u043e\u0432\u043e"],"raw_orcid":"https://orcid.org/0000-0002-4467-8732","affiliations":[{"raw_affiliation_string":"\u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u043e\u0435 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0435 \u0431\u044e\u0434\u0436\u0435\u0442\u043d\u043e\u0435 \u043d\u0430\u0443\u0447\u043d\u043e\u0435 \u0443\u0447\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435 \u00ab\u041d\u0430\u0443\u0447\u043d\u043e-\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u0441\u043a\u0438\u0439 \u0438\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u044b\u0445 \u043f\u0440\u043e\u0431\u043b\u0435\u043c \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439\u00bb, \u041a\u0435\u043c\u0435\u0440\u043e\u0432\u043e","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023530884","display_name":"Anna Victorovna Shcheglova","orcid":"https://orcid.org/0000-0002-4108-164X","observed_orcids":["https://orcid.org/0000-0002-4108-164X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Victorovna Shcheglova","raw_affiliation_strings":["\u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u043e\u0435 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0435 \u0431\u044e\u0434\u0436\u0435\u0442\u043d\u043e\u0435 \u043d\u0430\u0443\u0447\u043d\u043e\u0435 \u0443\u0447\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435 \u00ab\u041d\u0430\u0443\u0447\u043d\u043e-\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u0441\u043a\u0438\u0439 \u0438\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u044b\u0445 \u043f\u0440\u043e\u0431\u043b\u0435\u043c \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439\u00bb, \u041a\u0435\u043c\u0435\u0440\u043e\u0432\u043e"],"raw_orcid":"https://orcid.org/0000-0002-4108-164X","affiliations":[{"raw_affiliation_string":"\u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u043e\u0435 \u0433\u043e\u0441\u0443\u0434\u0430\u0440\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0435 \u0431\u044e\u0434\u0436\u0435\u0442\u043d\u043e\u0435 \u043d\u0430\u0443\u0447\u043d\u043e\u0435 \u0443\u0447\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435 \u00ab\u041d\u0430\u0443\u0447\u043d\u043e-\u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u0441\u043a\u0438\u0439 \u0438\u043d\u0441\u0442\u0438\u0442\u0443\u0442 \u043a\u043e\u043c\u043f\u043b\u0435\u043a\u0441\u043d\u044b\u0445 \u043f\u0440\u043e\u0431\u043b\u0435\u043c \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u044b\u0445 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439\u00bb, \u041a\u0435\u043c\u0435\u0440\u043e\u0432\u043e","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117511352","display_name":"Alexei Nikolaevich Sumin","orcid":"https://orcid.org/0000-0002-0963-4793","observed_orcids":["https://orcid.org/0000-0002-0963-4793"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexei Nikolaevich Sumin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0963-4793","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112443471","display_name":"Anastasia Valerievna Ponasenko","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anastasia Valerievna Ponasenko","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7388-356X","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":"3","first_page":"116","last_page":"117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-micrornas","display_name":"circulating microRNAs","score":0.9760000109672546},{"id":"https://openalex.org/keywords/anthracycline-induced-cardiotoxicity","display_name":"anthracycline cardiotoxicity","score":0.9710000157356262},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.996999979019165},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/chemotherapy-induced-cardiotoxicity","display_name":"chemotherapy-induced cardiotoxicity","score":0.7300000190734863},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5929999947547913},{"id":"https://openalex.org/keywords/plasma","display_name":"plasma","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.8192497491836548},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8176369667053223},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.7669413089752197},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.6206375360488892},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6021111607551575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5203670859336853},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5036107897758484},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49592098593711853},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4790800213813782},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.43959933519363403},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3921720087528229},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37145543098449707},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34500226378440857},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32998520135879517},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26338064670562744},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10917547345161438}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.57256/2949-0715-2023-3-116-117","doi":"https://doi.org/10.57256/2949-0715-2023-3-116-117","is_oa":true,"landing_page_url":"http://dx.doi.org/10.57256/2949-0715-2023-3-116-117","pdf_url":"https://www.bmjour.ru/jour/article/download/139/96","source":{"id":"https://openalex.org/S4387285614","display_name":"Baikal Medical Journal","issn_l":"2949-0715","issn":["2949-0715"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Baikal Medical Journal","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:fa9e67cd7ee6421bbf7bd22cef9cd914","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fa9e67cd7ee6421bbf7bd22cef9cd914","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0411\u0430\u0439\u043a\u0430\u043b\u044c\u0441\u043a\u0438\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b, Vol 2, Iss 3, Pp 116-117 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.57256/2949-0715-2023-3-116-117","doi":"https://doi.org/10.57256/2949-0715-2023-3-116-117","is_oa":true,"landing_page_url":"http://dx.doi.org/10.57256/2949-0715-2023-3-116-117","pdf_url":"https://www.bmjour.ru/jour/article/download/139/96","source":{"id":"https://openalex.org/S4387285614","display_name":"Baikal Medical Journal","issn_l":"2949-0715","issn":["2949-0715"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Baikal Medical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387753147.pdf","grobid_xml":"https://content.openalex.org/works/W4387753147.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2904437762","https://openalex.org/W3021348168","https://openalex.org/W4388661294","https://openalex.org/W3085372053","https://openalex.org/W4388817026","https://openalex.org/W6979979933","https://openalex.org/W4303579108","https://openalex.org/W2564929202","https://openalex.org/W2943012593","https://openalex.org/W2604367546"],"abstract_inverted_index":{"Introduction.":[0],"Doxorubicin":[1],"is":[2,40,98,362],"an":[3,20],"anthracycline":[4,57,284],"antibiotic":[5],"widely":[6],"used":[7,182,232],"in":[8,35,92,124,126,271,289,356],"the":[9,26,41,50,61,84,113,117,164,172,210,235,244,260,272,281,290,293,318,330,340,354,366],"treatment":[10,167],"of":[11,28,53,56,90,112,119,121,144,166,174,196,220,275,283,292,320,332,343,350,353,360],"malignant":[12],"neoplasms.":[13],"Anthracyclines":[14],"have":[15,19],"been":[16,68],"shown":[17],"to":[18,70,233,364],"undesirable":[21],"side":[22],"effect":[23],"associated":[24,346],"with":[25,128,140,157,347],"development":[27],"cardiotoxic":[29,54,348],"effects.":[30],"Today,":[31],"a":[32,141,202,269,357],"promising":[33],"direction":[34],"fundamental":[36],"and":[37,79,95,100,108,135,168,305],"practical":[38],"medicine":[39],"search":[42],"for":[43,49,60,183],"highly":[44,46],"sensitive,":[45],"specific":[47],"markers":[48],"early":[51],"diagnosis":[52,143],"effects":[55,349],"antibiotics.":[58],"Thus,":[59],"last":[62],"five":[63],"years,":[64],"special":[65],"attention":[66],"has":[67],"paid":[69],"circulating":[71,122,221,276,295],"miRNAs,":[72],"which":[73,321,328],"are":[74],"small":[75],"sequences":[76],"(19-25":[77],"nucleotides)":[78],"regulate":[80],"gene":[81,335],"expression":[82,120,239,273,291,319,336,355],"at":[83,159],"post-transcriptional":[85],"level.":[86],"An":[87],"important":[88],"role":[89],"microRNAs":[91,315],"many":[93],"physiological":[94],"pathological":[96,344],"processes":[97,345],"noted,":[99],"therefore":[101],"they":[102],"can":[103],"be":[104],"considered":[105],"as":[106,251],"diagnostic":[107],"therapeutic":[109],"targets.":[110],"Purpose":[111],"study:":[114],"To":[115],"assess":[116],"level":[118,219,240,274],"miRNAs":[123,222,277,296],"dynamics":[125],"patients":[127,361],"breast":[129,145],"cancer":[130],"receiving":[131],"anthracyclines":[132,333],"therapy.":[133,285,351],"Materials":[134],"methods.":[136],"In":[137],"15":[138],"women":[139],"verified":[142],"cancer,":[146],"whose":[147],"therapy":[148],"included":[149],"anthracyclines,":[150],"venous":[151],"blood":[152],"was":[153,181,199,231,241,256,297],"taken":[154],"into":[155],"vacutainers":[156],"K3EDTA":[158],"two":[160],"time":[161],"points:":[162],"before":[163],"start":[165,173,282],"6":[169,278,323],"months":[170,279,324],"after":[171,179,280,325],"chemotherapy.":[175],"The":[176,194,218,237,247,266],"resulting":[177],"plasma,":[178],"centrifugation,":[180],"microRNA":[184,212],"isolation":[185],"using":[186,209,243,259],"commercial":[187],"kits":[188],"from":[189],"Qiagen":[190],"(cat.":[191,215],"no.":[192,216],"217184).":[193],"amount":[195],"isolated":[197],"miRNA":[198],"measured":[200],"on":[201,334,339],"Qubit":[203],"4":[204],"instrument":[205],"(Thermofisher":[206],"Scientific,":[207],"USA)":[208],"Qubit\u2122":[211],"Assay":[213],"Kits":[214],"Q32881).":[217],"(hsa-mir-1-3p,":[223],"hsa-mir-200a-3p,":[224,300],"hsa-mir-21-3p,":[225],"hsa-mir-133b,":[226,301],"hsa-mir-429,":[227],"hsa-mir":[228],"-30a-3p).":[229],"hsa-mir-486-5p":[230],"normalize":[234],"results.":[236],"relative":[238],"calculated":[242],"\u0394\u0421t":[245],"method.":[246],"results":[248,367],"were":[249,311,316],"expressed":[250],"fold":[252],"change.":[253],"Statistical":[254],"processing":[255],"carried":[257],"out":[258],"program":[261],"\"GraphPad":[262],"Prism":[263],"8\".":[264],"Results.":[265],"study":[267],"showed":[268],"change":[270],"A":[286],"significant":[287,309],"decrease":[288],"following":[294],"revealed:":[298],"hsa-mir-1-3p,":[299],"hsa-mir-30a-3p.":[302],"For":[303],"hsa-mir-21-3p":[304],"hsa-mir-429":[306],"no":[307],"statistically":[308],"differences":[310],"obtained.":[312,368],"Conclusions.":[313],"Four":[314],"identified,":[317],"decreases":[322],"doxorubicin":[326],"administration,":[327],"indicates":[329],"influence":[331],"and,":[337],"possibly,":[338],"epigenetic":[341],"regulation":[342],"Validation":[352],"larger":[358],"sample":[359],"required":[363],"confirm":[365]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2023-10-19T00:00:00"}