{"id":"https://openalex.org/W4387749865","doi":"https://doi.org/10.14309/01.ajg.0000955928.07627.21","title":"S1572 Racial Differences in Primary Sclerosing Cholangitis Risk Factors and Outcomes: A Nationwide Study Leveraging a New ICD-10 Code","display_name":"S1572 Racial Differences in Primary Sclerosing Cholangitis Risk Factors and Outcomes: A Nationwide Study Leveraging a New ICD-10 Code","publication_year":2023,"publication_date":"2023-10-01","ids":{"openalex":"https://openalex.org/W4387749865","doi":"https://doi.org/10.14309/01.ajg.0000955928.07627.21"},"language":"en","primary_location":{"id":"doi:10.14309/01.ajg.0000955928.07627.21","doi":"https://doi.org/10.14309/01.ajg.0000955928.07627.21","is_oa":false,"landing_page_url":"http://dx.doi.org/10.14309/01.ajg.0000955928.07627.21","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027672649","display_name":"Melinda Wang","orcid":"https://orcid.org/0000-0002-1305-8362","observed_orcids":["https://orcid.org/0000-0002-1305-8362"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Melinda Wang","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA;","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057697144","display_name":"Alyssa Hartsell Harris","orcid":"https://orcid.org/0000-0003-2788-5817","observed_orcids":["https://orcid.org/0000-0003-2788-5817"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alyssa Harris","raw_affiliation_strings":["Vizient, Inc., Chicago, IL;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vizient, Inc., Chicago, IL;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053281851","display_name":"Sharad Indur Wadhwani","orcid":"https://orcid.org/0000-0001-5565-6670","observed_orcids":["https://orcid.org/0000-0001-5565-6670"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharad Wadhwani","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA;","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076488821","display_name":"Jennifer C. Lai","orcid":"https://orcid.org/0000-0003-2092-6380","observed_orcids":["https://orcid.org/0000-0003-2092-6380"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer C. Lai","raw_affiliation_strings":["University of California San Francisco, San Francisco, CA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco, San Francisco, CA;","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014281393","display_name":"Jessica B. Rubin","orcid":"https://orcid.org/0000-0003-2105-1256","observed_orcids":["https://orcid.org/0000-0003-2105-1256"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica B. Rubin","raw_affiliation_strings":["University of California San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027672649"],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":"10S","first_page":"S1188","last_page":"S1188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-sclerosing-cholangitis","display_name":"primary sclerosing cholangitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/racial-disparities","display_name":"racial disparities","score":0.9929999709129333},{"id":"https://openalex.org/keywords/black-patients","display_name":"Black patients","score":0.9449999928474426},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.7160000205039978},{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/autoimmune-hepatitis","display_name":"autoimmune hepatitis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.6650000214576721},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.8999999761581421},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":0.9710000157356262},{"id":"https://openalex.org/keywords/health-care-utilization","display_name":"health care utilization","score":0.6880000233650208},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.6069999933242798},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.3409999907016754},{"id":"https://openalex.org/keywords/cholangitis","display_name":"cholangitis","score":0.492000013589859},{"id":"https://openalex.org/keywords/nationwide-inpatient-sample","display_name":"National Inpatient Sample","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.951960027217865},{"id":"https://openalex.org/C2780615123","wikidata":"https://www.wikidata.org/wiki/Q1058608","display_name":"Primary sclerosing cholangitis","level":3,"score":0.7610535621643066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5414396524429321},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5217110514640808},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5171225070953369},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.4430360496044159},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2586456537246704}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/01.ajg.0000955928.07627.21","doi":"https://doi.org/10.14309/01.ajg.0000955928.07627.21","is_oa":false,"landing_page_url":"http://dx.doi.org/10.14309/01.ajg.0000955928.07627.21","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/10","score":0.7692000269889832,"display_name":"Reduced inequalities"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4408326905","https://openalex.org/W3211113232","https://openalex.org/W2921055347","https://openalex.org/W2765525877","https://openalex.org/W4295650854","https://openalex.org/W2083500480","https://openalex.org/W3177823776","https://openalex.org/W4386734742","https://openalex.org/W4387749733","https://openalex.org/W3211166568"],"abstract_inverted_index":{"Introduction:":[0],"The":[1],"natural":[2],"history,":[3],"management,":[4],"and":[5,81,96,120,128,142,156,173,191,259,275,290,302,318,337,342],"outcomes":[6],"of":[7,31,44,58,72,253,262,305,320],"primary":[8,226],"sclerosing":[9],"cholangitis":[10,122],"(PSC)":[11],"have":[12,38,192,208,222],"traditionally":[13],"been":[14,40],"studied":[15],"predominantly":[16],"in":[17,68,322,332],"White":[18,138,178,216,343],"males,":[19],"as":[20,135],"this":[21,333],"is":[22,326],"the":[23,85],"most":[24],"common":[25],"affected":[26],"demographic.":[27],"Larger":[28],"retrospective":[29],"studies":[30],"PSC":[32,55,117,179,182,282,321],"patients,":[33,180,217],"among":[34],"more":[35,185,219,244,285,292,300],"diverse":[36],"populations,":[37],"previously":[39],"limited":[41],"by":[42],"lack":[43],"a":[45,53,110,193],"PSC-specific":[46,111],"diagnosis":[47,317],"code.":[48],"We":[49,77,125,161],"aimed":[50],"to":[51,64,99,151,187,207,215,221,287,328],"leverage":[52],"new":[54],"International":[56],"Classification":[57],"Diseases-":[59],"10th":[60],"Edition":[61],"(ICD-10)":[62],"code":[63,113,118,123],"characterize":[65],"racial":[66],"differences":[67],"nationwide":[69],"contemporary":[70],"cohort":[71],"patients":[73,102,132,164,183,203,280,344],"with":[74,103,109,154,165,177,225,243,281,345],"PSC.":[75,346],"Methods:":[76],"used":[78,150],"deidentified":[79],"clinical":[80,129,155],"administrative":[82],"data":[83],"from":[84],"Vizient\u00ae":[86],"Clinical":[87,338],"Data":[88],"Base":[89],"(":[90],">1000":[91],"US":[92],"hospital":[93,251],"academic,":[94],"affiliated,":[95],"community":[97],"hospitals)":[98],"identify":[100],"adult":[101],"\u22652":[104],"inpatient":[105],"or":[106,115,229],"outpatient":[107],"encounters":[108],"ICD-10":[112],"(K83.01)":[114],"1":[116],"(10/1/18-1/1/22)":[119],"\u22651":[121],"(10/1/15-10/1/18).":[124],"compared":[126,214],"demographic":[127],"characteristics":[130],"between":[131,340],"who":[133],"self-identified":[134],"Black":[136,181,202,238,279,323,341],"versus":[137],"race":[139,153,239],"using":[140],"Chi-squared":[141],"Wilcoxon":[143],"rank":[144],"sum":[145],"analysis.":[146],"Multivariable":[147],"regression":[148],"was":[149,240],"associate":[152],"healthcare":[157,330],"utilization":[158],"outcomes.":[159],"Results:":[160],"identified":[162],"9,428":[163],"PSC:":[166],"79%":[167],"White,":[168],"13%":[169],"Black,":[170],"2%":[171],"Asian,":[172],"6%":[174],"Other.":[175],"Compared":[176],"were":[184,204,283],"likely":[186,206,220,286],"be":[188,288],"female,":[189,289],"younger,":[190,284],"higher":[194],"Charlson":[195],"Comorbidity":[196],"Index":[197],"(P<":[198,232],"0.001)":[199],"(Figure":[200],"1).":[201],"less":[205],"concurrent":[209],"inflammatory":[210],"bowel":[211],"disease":[212,276],"(IBD)":[213],"but":[218],"overlap":[223],"syndromes":[224],"biliary":[227],"cirrhosis":[228],"autoimmune":[230],"hepatitis":[231],"0.001).":[233],"On":[234],"multivariable":[235],"logistic":[236],"regression,":[237],"significantly":[241],"associated":[242],"hospitalizations":[245,301],"(aCoef":[246],"0.26,":[247],"95%CI":[248,257,266],"0.11-0.41),":[249],"longer":[250,303],"length":[252,304],"stay":[254,306],"(aIRR":[255],"1.15,":[256],"1.06-1.25)":[258],"similar":[260],"rates":[261],"transplantation":[263],"(aOR":[264],"0.90,":[265],"0.75-1.08,":[267],"P=0.25),":[268],"even":[269],"after":[270],"adjustment":[271,295],"for":[272,296],"other":[273],"demographics":[274],"severity.":[277],"Conclusion:":[278],"had":[291,299],"comorbidities.":[293],"Despite":[294],"comorbidities,":[297],"they":[298],"when":[307],"hospitalized.":[308],"These":[309],"findings":[310],"suggest":[311],"that":[312],"additional":[313],"research":[314],"on":[315],"optimal":[316],"management":[319],"populations":[324],"specifically":[325],"necessary":[327],"reduce":[329],"disparities":[331],"disease.Figure":[334],"1.:":[335],"Demographic":[336],"Differences":[339]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2023-10-19T00:00:00"}