{"id":"https://openalex.org/W4387747478","doi":"https://doi.org/10.1016/j.tox.2023.153642","title":"Increasing confidence in new approach methodologies for inhalation risk assessment with multiple end point assays using 5-day repeated exposure to 1,3-dichloropropene","display_name":"Increasing confidence in new approach methodologies for inhalation risk assessment with multiple end point assays using 5-day repeated exposure to 1,3-dichloropropene","publication_year":2023,"publication_date":"2023-10-18","ids":{"openalex":"https://openalex.org/W4387747478","doi":"https://doi.org/10.1016/j.tox.2023.153642","pmid":"https://pubmed.ncbi.nlm.nih.gov/37863466"},"language":"en","primary_location":{"id":"doi:10.1016/j.tox.2023.153642","doi":"https://doi.org/10.1016/j.tox.2023.153642","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tox.2023.153642","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050507713","display_name":"Iru Paudel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iru Paudel","raw_affiliation_strings":["ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC 27709, USA","institution_ids":["https://openalex.org/I4210153043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018336750","display_name":"A. Rasim Barutcu","orcid":"https://orcid.org/0000-0002-4838-8695","observed_orcids":["https://orcid.org/0000-0002-4838-8695"]},"institutions":[{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Rasim Barutcu","raw_affiliation_strings":["ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC 27709, USA","institution_ids":["https://openalex.org/I4210153043"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Raymond Samuel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond Samuel","raw_affiliation_strings":["ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC 27709, USA","institution_ids":["https://openalex.org/I4210153043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003647626","display_name":"Marjory Moreau","orcid":"https://orcid.org/0009-0001-3701-2377","observed_orcids":["https://orcid.org/0009-0001-3701-2377"]},"institutions":[{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marjory Moreau","raw_affiliation_strings":["ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC 27709, USA","institution_ids":["https://openalex.org/I4210153043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088953228","display_name":"Scott D. Slattery","orcid":"https://orcid.org/0000-0003-3250-2622","observed_orcids":["https://orcid.org/0000-0003-3250-2622"]},"institutions":[{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott D. Slattery","raw_affiliation_strings":["ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC 27709, USA","institution_ids":["https://openalex.org/I4210153043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108861861","display_name":"Jamie Scaglione","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jamie Scaglione","raw_affiliation_strings":["ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC 27709, USA","institution_ids":["https://openalex.org/I4210153043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037354929","display_name":"Leslie Recio","orcid":"https://orcid.org/0000-0003-4392-6412","observed_orcids":["https://orcid.org/0000-0003-4392-6412"]},"institutions":[{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leslie Recio","raw_affiliation_strings":["ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC 27709, USA. Electronic address: lRecio@scitovation.com","ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC 27709, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC 27709, USA. Electronic address: lRecio@scitovation.com","institution_ids":["https://openalex.org/I4210153043"]},{"raw_affiliation_string":"ScitoVation, LLC, 6 Davis Drive, Suite 146, Durham, NC 27709, USA","institution_ids":["https://openalex.org/I4210153043"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037354929"],"corresponding_institution_ids":["https://openalex.org/I4210153043"],"apc_list":{"value":3520,"currency":"USD","value_usd":3520},"apc_paid":null,"fwci":1.8266,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.84247208,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"499","issue":null,"first_page":"153642","last_page":"153642"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.04430000111460686,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/1-3-dichloropropene","display_name":"1,3-dichloropropene","score":0.9990000128746033},{"id":"https://openalex.org/keywords/inhalation-toxicity","display_name":"inhalation toxicity","score":0.7620000243186951},{"id":"https://openalex.org/keywords/new-approach-methodologies","display_name":"new approach methodologies","score":0.7739999890327454},{"id":"https://openalex.org/keywords/nasal-epithelium","display_name":"nasal epithelium","score":0.7929999828338623},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.7120000123977661},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.9850000143051147},{"id":"https://openalex.org/keywords/repeated-exposure","display_name":"repeated exposure","score":0.7170000076293945},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7570000290870667},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.7059999704360962},{"id":"https://openalex.org/keywords/respiratory-toxicology","display_name":"respiratory toxicology","score":0.5799999833106995},{"id":"https://openalex.org/keywords/alternatives-to-animal-testing","display_name":"alternatives to animal testing","score":0.6940000057220459},{"id":"https://openalex.org/keywords/fumigants","display_name":"fumigants","score":0.5270000100135803},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.4790000021457672},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.7331108450889587},{"id":"https://openalex.org/C2779777708","wikidata":"https://www.wikidata.org/wiki/Q6033622","display_name":"Inhalation exposure","level":3,"score":0.6675835847854614},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6144895553588867},{"id":"https://openalex.org/C87568996","wikidata":"https://www.wikidata.org/wiki/Q1428754","display_name":"Respiratory epithelium","level":3,"score":0.5812972784042358},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5202361345291138},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.47017377614974976},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.46590739488601685},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.4555947780609131},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4283272624015808},{"id":"https://openalex.org/C2779644171","wikidata":"https://www.wikidata.org/wiki/Q13400765","display_name":"Respiratory tract","level":3,"score":0.42680472135543823},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41404831409454346},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3700897693634033},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.36624258756637573},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3402111530303955},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3252812623977661},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3173833191394806},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2936837375164032},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2390596866607666},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.21196603775024414},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.17686325311660767},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.138159841299057},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13528525829315186},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0928632915019989},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06789982318878174}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000498","descriptor_name":"Allyl Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000498","descriptor_name":"Allyl Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006843","descriptor_name":"Hydrocarbons, Chlorinated","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D010575","descriptor_name":"Pesticides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019570","descriptor_name":"Inhalation Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D023381","descriptor_name":"Endpoint Determination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.tox.2023.153642","doi":"https://doi.org/10.1016/j.tox.2023.153642","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tox.2023.153642","pdf_url":null,"source":{"id":"https://openalex.org/S128555845","display_name":"Toxicology","issn_l":"0300-483X","issn":["0300-483X","1879-3185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"journal-article"},{"id":"pmid:37863466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37863466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310101","display_name":"American Chemistry Council","ror":"https://ror.org/03rzy3090"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W113181641","https://openalex.org/W1536463113","https://openalex.org/W1965186311","https://openalex.org/W1967864391","https://openalex.org/W1969502320","https://openalex.org/W1985345381","https://openalex.org/W2011336276","https://openalex.org/W2028562794","https://openalex.org/W2036540361","https://openalex.org/W2043077366","https://openalex.org/W2047917390","https://openalex.org/W2055158365","https://openalex.org/W2060173239","https://openalex.org/W2086367222","https://openalex.org/W2092850402","https://openalex.org/W2154555351","https://openalex.org/W2160699408","https://openalex.org/W2169176267","https://openalex.org/W2179438025","https://openalex.org/W2236421686","https://openalex.org/W2598901972","https://openalex.org/W2803120436","https://openalex.org/W2926822733","https://openalex.org/W3128292968","https://openalex.org/W3175605523","https://openalex.org/W4223926026","https://openalex.org/W4294307752","https://openalex.org/W4297989244","https://openalex.org/W6604619156"],"related_works":["https://openalex.org/W4401135551","https://openalex.org/W4297989244","https://openalex.org/W4415766831","https://openalex.org/W1967864391","https://openalex.org/W4386480335","https://openalex.org/W4402533001","https://openalex.org/W36865997","https://openalex.org/W4241484311","https://openalex.org/W4406435522","https://openalex.org/W2494460182"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-10-19T00:00:00"}