{"id":"https://openalex.org/W4387747459","doi":"https://doi.org/10.1016/j.cmet.2023.09.013","title":"Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived \u03b2-like cells","display_name":"Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived \u03b2-like cells","publication_year":2023,"publication_date":"2023-10-18","ids":{"openalex":"https://openalex.org/W4387747459","doi":"https://doi.org/10.1016/j.cmet.2023.09.013","pmid":"https://pubmed.ncbi.nlm.nih.gov/37214922","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10197532"},"language":"en","primary_location":{"id":"doi:10.1016/j.cmet.2023.09.013","doi":"https://doi.org/10.1016/j.cmet.2023.09.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmet.2023.09.013","pdf_url":null,"source":{"id":"https://openalex.org/S177533077","display_name":"Cell Metabolism","issn_l":"1550-4131","issn":["1550-4131","1932-7420"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.cmet.2023.09.013","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029049813","display_name":"Dongxiang Xue","orcid":"https://orcid.org/0000-0001-9654-6347","observed_orcids":["https://orcid.org/0000-0001-9654-6347"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dongxiang Xue","raw_affiliation_strings":["Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005974205","display_name":"Narisu Narisu","orcid":"https://orcid.org/0000-0002-8483-1156","observed_orcids":["https://orcid.org/0000-0002-8483-1156"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Narisu Narisu","raw_affiliation_strings":["Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003514525","display_name":"D. Leland Taylor","orcid":"https://orcid.org/0000-0001-6498-6970","observed_orcids":["https://orcid.org/0000-0001-6498-6970"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Leland Taylor","raw_affiliation_strings":["Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Meili Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meili Zhang","raw_affiliation_strings":["Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059181649","display_name":"Caleb M. Grenko","orcid":"https://orcid.org/0000-0002-3926-5503","observed_orcids":["https://orcid.org/0000-0002-3926-5503"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caleb Grenko","raw_affiliation_strings":["Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052952485","display_name":"Henry J. Taylor","orcid":"https://orcid.org/0000-0003-2088-5240","observed_orcids":["https://orcid.org/0000-0003-2088-5240"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["GB","US"],"is_corresponding":false,"raw_author_name":"Henry J. Taylor","raw_affiliation_strings":["Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN Cambridge, UK","Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN Cambridge, UK","Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN Cambridge, UK","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I241749","https://openalex.org/I4210090236"]},{"raw_affiliation_string":"Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023681507","display_name":"Tingfen Yan","orcid":"https://orcid.org/0000-0003-4062-2886","observed_orcids":["https://orcid.org/0000-0003-4062-2886"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tingfen Yan","raw_affiliation_strings":["Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023251236","display_name":"Xuming Tang","orcid":"https://orcid.org/0000-0003-1978-4856","observed_orcids":["https://orcid.org/0000-0003-1978-4856"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuming Tang","raw_affiliation_strings":["Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024945091","display_name":"Neelam Sinha","orcid":"https://orcid.org/0000-0001-6496-224X","observed_orcids":["https://orcid.org/0000-0001-6496-224X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neelam Sinha","raw_affiliation_strings":["Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029498896","display_name":"Jiajun Zhu","orcid":"https://orcid.org/0000-0003-2357-267X","observed_orcids":["https://orcid.org/0000-0003-2357-267X"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiajun Zhu","raw_affiliation_strings":["Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011708667","display_name":"J. Jeya Vandana","orcid":"https://orcid.org/0000-0002-1026-569X","observed_orcids":["https://orcid.org/0000-0002-1026-569X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4210100942","display_name":"Tri-Institutional PhD Program in Chemical Biology","ror":"https://ror.org/016twdg30","country_code":"US","type":"education","lineage":["https://openalex.org/I4210100942"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Jeya Vandana","raw_affiliation_strings":["Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Tri-Institutional PhD Program in Chemical Biology, Weill Cornell Medicine, The Rockefeller University, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","Tri-Institutional PhD Program in Chemical Biology, Weill Cornell Medicine, The Rockefeller University, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Tri-Institutional PhD Program in Chemical Biology, Weill Cornell Medicine, The Rockefeller University, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I4210100942","https://openalex.org/I4387153466","https://openalex.org/I83399316"]},{"raw_affiliation_string":"Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Tri-Institutional PhD Program in Chemical Biology, Weill Cornell Medicine, The Rockefeller University, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I4210100942","https://openalex.org/I4387153466","https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068645871","display_name":"Angie Chi Nok Chong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angie Chi Nok Chong","raw_affiliation_strings":["Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100652518","display_name":"Angela Lee","orcid":"https://orcid.org/0009-0001-3730-6391","observed_orcids":["https://orcid.org/0009-0001-3730-6391"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Lee","raw_affiliation_strings":["Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061361435","display_name":"Erin C. Mansell","orcid":"https://orcid.org/0009-0007-9588-8338","observed_orcids":["https://orcid.org/0009-0007-9588-8338"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erin C. Mansell","raw_affiliation_strings":["Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065107846","display_name":"Amy J. Swift","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy J. Swift","raw_affiliation_strings":["Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028962673","display_name":"Michael R. Erdos","orcid":"https://orcid.org/0000-0002-6603-1833","observed_orcids":["https://orcid.org/0000-0002-6603-1833"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Erdos","raw_affiliation_strings":["Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021036874","display_name":"Aaron Zhong","orcid":"https://orcid.org/0000-0002-2468-0923","observed_orcids":["https://orcid.org/0000-0002-2468-0923"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron Zhong","raw_affiliation_strings":["Stem Cell Research Facility, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Research Facility, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080052482","display_name":"Lori L. Bonnycastle","orcid":"https://orcid.org/0000-0003-0663-3944","observed_orcids":["https://orcid.org/0000-0003-0663-3944"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lori L. Bonnycastle","raw_affiliation_strings":["Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055295478","display_name":"Ting Zhou","orcid":"https://orcid.org/0000-0003-1423-1507","observed_orcids":["https://orcid.org/0000-0003-1423-1507"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ting Zhou","raw_affiliation_strings":["Stem Cell Research Facility, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell Research Facility, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024015568","display_name":"Shuibing Chen","orcid":"https://orcid.org/0000-0002-6294-5187","observed_orcids":["https://orcid.org/0000-0002-6294-5187"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Shuibing Chen","raw_affiliation_strings":["Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA. Electronic address: shc2034@med.cornell.edu","Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA; Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA. Electronic address: shc2034@med.cornell.edu","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Center for Genomic Health, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Surgery, Weill Cornell Medicine, 1300 York Avenue, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068242165","display_name":"Francis S. Collins","orcid":"https://orcid.org/0000-0002-1023-7410","observed_orcids":["https://orcid.org/0000-0002-1023-7410"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis S. Collins","raw_affiliation_strings":["Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: francis.collins@nih.gov"],"raw_orcid":"https://orcid.org/0000-0002-1023-7410","affiliations":[{"raw_affiliation_string":"Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: francis.collins@nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5024015568"],"corresponding_institution_ids":["https://openalex.org/I4387153466"],"apc_list":{"value":9080,"currency":"USD","value_usd":9080},"apc_paid":{"value":9080,"currency":"USD","value_usd":9080},"fwci":9.0009,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.98754995,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"35","issue":"11","first_page":"1897","last_page":"1914.e11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9789999723434448},{"id":"https://openalex.org/keywords/beta-cell-differentiation","display_name":"beta cell differentiation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/beta-cell-survival","display_name":"beta-cell survival","score":0.8619999885559082},{"id":"https://openalex.org/keywords/chromatin-accessibility","display_name":"chromatin accessibility","score":0.8460000157356262},{"id":"https://openalex.org/keywords/hnf4a","display_name":"HNF4\u03b1","score":0.9549999833106995},{"id":"https://openalex.org/keywords/faim2","display_name":"FAIM2","score":0.9240000247955322},{"id":"https://openalex.org/keywords/causal-variants","display_name":"causal variants","score":0.4970000088214874},{"id":"https://openalex.org/keywords/insulin-production","display_name":"insulin production","score":0.6399999856948853},{"id":"https://openalex.org/keywords/lipotoxicity","display_name":"lipotoxicity","score":0.9449999928474426},{"id":"https://openalex.org/keywords/allele-specific-expression","display_name":"allele-specific expression","score":0.7699999809265137},{"id":"https://openalex.org/keywords/genetic-association-signals","display_name":"genetic association signals","score":0.6269999742507935},{"id":"https://openalex.org/keywords/cp","display_name":"CP","score":0.375},{"id":"https://openalex.org/keywords/rnase1","display_name":"RNASE1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gsta2","display_name":"GSTA2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dhrs2","display_name":"DHRS2","score":1.0}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7726608514785767},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.7277902960777283},{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.6642053723335266},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.624765157699585},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6122868061065674},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5332619547843933},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.485561341047287},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.474227637052536},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.45990726351737976},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.45643699169158936},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4544553756713867},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2616933584213257},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26035016775131226},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.13054311275482178},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.12229639291763306},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.11360308527946472},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.07914811372756958},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.06536468863487244}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.cmet.2023.09.013","doi":"https://doi.org/10.1016/j.cmet.2023.09.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmet.2023.09.013","pdf_url":null,"source":{"id":"https://openalex.org/S177533077","display_name":"Cell Metabolism","issn_l":"1550-4131","issn":["1550-4131","1932-7420"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Metabolism","raw_type":"journal-article"},{"id":"doi:10.1101/2023.05.07.539774","doi":"https://doi.org/10.1101/2023.05.07.539774","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.05.07.539774","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/05/08/2023.05.07.539774.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:37214922","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37214922","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:37858332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37858332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10841752","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10841752","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10841752/pdf/nihms-1936895.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Metab","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:10197532","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10197532","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.cmet.2023.09.013","doi":"https://doi.org/10.1016/j.cmet.2023.09.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmet.2023.09.013","pdf_url":null,"source":{"id":"https://openalex.org/S177533077","display_name":"Cell Metabolism","issn_l":"1550-4131","issn":["1550-4131","1932-7420"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1735126682","display_name":"A High Content Chemical Screen to Identify the Drug Candidates Promoting Human Beta Cell Proliferation","funder_award_id":"R01DK124463","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2206842409","display_name":"Determining the Intrinsic and Environmental Signal Contributing to Early T1D Progression","funder_award_id":"U01DK127777","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2377245570","display_name":"Genetic analysis of type II diabetes in Finnish population","funder_award_id":"Z01HG000024","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G2395596693","display_name":"A High Throughput Screening to Identify Compounds Rescuing Human Pancreatic Beta Cell Function in Diabetic Conditions","funder_award_id":"R01DK116075","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5483479204","display_name":"Metallothionein 1E as a Central Regulator of Human Pancreatic Beta Cell Function and Survival","funder_award_id":"R01DK119667","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G835524498","display_name":"A hPSC-based multiplex platform to interrogate diabetogenic interactions of T2D-associated genes in human pancreatic beta cells","funder_award_id":"9-22-PDFPM-06","funder_id":"https://openalex.org/F4320306089","funder_display_name":"American Diabetes Association"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000884876","display_name":"Genetic analysis of type II diabetes","funder_award_id":"ZIAHG000024","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"}],"funders":[{"id":"https://openalex.org/F4320306089","display_name":"American Diabetes Association","ror":"https://ror.org/04f6cgz95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332513","display_name":"Weill Cornell Medical College","ror":"https://ror.org/02r109517"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387747459.pdf","grobid_xml":"https://content.openalex.org/works/W4387747459.grobid-xml"},"referenced_works_count":142,"referenced_works":["https://openalex.org/W1555797395","https://openalex.org/W1770544781","https://openalex.org/W1967093093","https://openalex.org/W1977709885","https://openalex.org/W1984068087","https://openalex.org/W1990410261","https://openalex.org/W1997086295","https://openalex.org/W2008145349","https://openalex.org/W2009090927","https://openalex.org/W2009121012","https://openalex.org/W2010457001","https://openalex.org/W2012170675","https://openalex.org/W2030632688","https://openalex.org/W2032472678","https://openalex.org/W2033169664","https://openalex.org/W2057755448","https://openalex.org/W2057844770","https://openalex.org/W2064136116","https://openalex.org/W2066133953","https://openalex.org/W2078591745","https://openalex.org/W2079407198","https://openalex.org/W2081595122","https://openalex.org/W2086211531","https://openalex.org/W2096939168","https://openalex.org/W2098266516","https://openalex.org/W2099328768","https://openalex.org/W2102619694","https://openalex.org/W2103199835","https://openalex.org/W2103441770","https://openalex.org/W2104549677","https://openalex.org/W2105992210","https://openalex.org/W2107208863","https://openalex.org/W2108234281","https://openalex.org/W2110065044","https://openalex.org/W2111399322","https://openalex.org/W2119706813","https://openalex.org/W2120041117","https://openalex.org/W2123679877","https://openalex.org/W2134199796","https://openalex.org/W2136558851","https://openalex.org/W2139123778","https://openalex.org/W2140952049","https://openalex.org/W2142410561","https://openalex.org/W2146324678","https://openalex.org/W2147881017","https://openalex.org/W2153725473","https://openalex.org/W2155666770","https://openalex.org/W2155992983","https://openalex.org/W2156661861","https://openalex.org/W2169456326","https://openalex.org/W2171808845","https://openalex.org/W2179438025","https://openalex.org/W2185664099","https://openalex.org/W2221356560","https://openalex.org/W2259938310","https://openalex.org/W2461793432","https://openalex.org/W2507528796","https://openalex.org/W2510973425","https://openalex.org/W2532473654","https://openalex.org/W2553250439","https://openalex.org/W2587217886","https://openalex.org/W2587633981","https://openalex.org/W2588309716","https://openalex.org/W2605010669","https://openalex.org/W2617439544","https://openalex.org/W2619236098","https://openalex.org/W2734033274","https://openalex.org/W2750416916","https://openalex.org/W2767273194","https://openalex.org/W2781215248","https://openalex.org/W2789317488","https://openalex.org/W2800145886","https://openalex.org/W2827733148","https://openalex.org/W2837512072","https://openalex.org/W2890555481","https://openalex.org/W2894662039","https://openalex.org/W2908475038","https://openalex.org/W2909545741","https://openalex.org/W2924370097","https://openalex.org/W2945877977","https://openalex.org/W2946912605","https://openalex.org/W2951370351","https://openalex.org/W2972869264","https://openalex.org/W2982741813","https://openalex.org/W2990944400","https://openalex.org/W2995527778","https://openalex.org/W2996385620","https://openalex.org/W2998770519","https://openalex.org/W3008468772","https://openalex.org/W3009825875","https://openalex.org/W3010221330","https://openalex.org/W3025013266","https://openalex.org/W3029464556","https://openalex.org/W3035152464","https://openalex.org/W3035892631","https://openalex.org/W3047282727","https://openalex.org/W3081655479","https://openalex.org/W3083922191","https://openalex.org/W3087646378","https://openalex.org/W3091552000","https://openalex.org/W3099179344","https://openalex.org/W3099862724","https://openalex.org/W3109862518","https://openalex.org/W3120241853","https://openalex.org/W3129715829","https://openalex.org/W3131055609","https://openalex.org/W3135043484","https://openalex.org/W3135584324","https://openalex.org/W3158147818","https://openalex.org/W3162091499","https://openalex.org/W3163706616","https://openalex.org/W3163978851","https://openalex.org/W3164662861","https://openalex.org/W3165164478","https://openalex.org/W3183498213","https://openalex.org/W3183533311","https://openalex.org/W3208002743","https://openalex.org/W4210969862","https://openalex.org/W4214586565","https://openalex.org/W4214913889","https://openalex.org/W4220750436","https://openalex.org/W4233620411","https://openalex.org/W4280552086","https://openalex.org/W4285588672","https://openalex.org/W4292183737","https://openalex.org/W4294783762","https://openalex.org/W4297009368","https://openalex.org/W4300865099","https://openalex.org/W4302773960","https://openalex.org/W4309999671","https://openalex.org/W4312094292","https://openalex.org/W4318777291","https://openalex.org/W4324308101","https://openalex.org/W4360610848","https://openalex.org/W4384198172","https://openalex.org/W6652739570","https://openalex.org/W6664980191","https://openalex.org/W6677855403","https://openalex.org/W6785161123","https://openalex.org/W6849464079","https://openalex.org/W6906671302","https://openalex.org/W7021104737"],"related_works":["https://openalex.org/W4381377398","https://openalex.org/W2509347789","https://openalex.org/W2998770519","https://openalex.org/W7154479016","https://openalex.org/W2294396673","https://openalex.org/W3008468772","https://openalex.org/W4378211951","https://openalex.org/W2604554238","https://openalex.org/W4313527524","https://openalex.org/W7116479005"],"abstract_inverted_index":{"Genetic":[0],"studies":[1],"have":[2],"identified":[3,76,91,135],"numerous":[4],"loci":[5,18],"associated":[6,34,99,109],"with":[7,35,100,110],"type":[8],"2":[9],"diabetes":[10],"(T2D),":[11],"but":[12],"the":[13,40,82,87,131],"functional":[14,139],"roles":[15],"of":[16,42,69,143],"many":[17],"remain":[19],"unexplored.":[20],"Here,":[21],"we":[22,117],"engineered":[23],"isogenic":[24],"knockout":[25,44,66],"human":[26],"embryonic":[27],"stem":[28],"cell":[29,47,112],"lines":[30],"for":[31],"20":[32],"genes":[33,93,105],"T2D":[36],"risk.":[37],"We":[38,52],"examined":[39],"impacts":[41],"each":[43,65,142],"on":[45,60],"\u03b2":[46,61,111],"differentiation,":[48],"functions,":[49],"and":[50,56,97,103,107,134],"survival.":[51],"generated":[53],"gene":[54],"expression":[55],"chromatin":[57],"accessibility":[58],"profiles":[59],"cells":[62],"derived":[63],"from":[64],"line.":[67],"Analyses":[68],"T2D-association":[70,84,145],"signals":[71],"overlapping":[72],"HNF4A-dependent":[73],"ATAC":[74],"peaks":[75],"a":[77,136],"likely":[78,138],"causal":[79],"variant":[80,140],"at":[81,127,141],"FAIM2":[83],"signal.":[85],"Additionally,":[86],"integrative":[88],"association":[89],"analyses":[90],"four":[92],"(CP,":[94],"RNASE1,":[95],"PCSK1N,":[96],"GSTA2)":[98],"insulin":[101],"production,":[102],"two":[104],"(TAGLN3":[106],"DHRS2)":[108],"sensitivity":[113],"to":[114,123],"lipotoxicity.":[115],"Finally,":[116],"leveraged":[118],"deep":[119],"ATAC-seq":[120],"read":[121],"coverage":[122],"assess":[124],"allele-specific":[125],"imbalance":[126],"variants":[128],"heterozygous":[129],"in":[130],"parental":[132],"line":[133],"single":[137],"23":[144],"signals.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":23},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-10-19T00:00:00"}
