{"id":"https://openalex.org/W4387744825","doi":"https://doi.org/10.3390/antib12040067","title":"Structure and Dynamics Guiding Design of Antibody Therapeutics and Vaccines","display_name":"Structure and Dynamics Guiding Design of Antibody Therapeutics and Vaccines","publication_year":2023,"publication_date":"2023-10-18","ids":{"openalex":"https://openalex.org/W4387744825","doi":"https://doi.org/10.3390/antib12040067","pmid":"https://pubmed.ncbi.nlm.nih.gov/37873864","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10594513"},"language":"en","primary_location":{"id":"doi:10.3390/antib12040067","doi":"https://doi.org/10.3390/antib12040067","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antib12040067","pdf_url":"https://www.mdpi.com/2073-4468/12/4/67/pdf?version=1697689561","source":{"id":"https://openalex.org/S2739070576","display_name":"Antibodies","issn_l":"2073-4468","issn":["2073-4468"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibodies","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4468/12/4/67/pdf?version=1697689561","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034034027","display_name":"Monica L. Fern\u00e1ndez\u2010Quintero","orcid":"https://orcid.org/0000-0002-6811-6283","observed_orcids":["https://orcid.org/0000-0002-6811-6283"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT","US"],"is_corresponding":true,"raw_author_name":"Monica L. Fern\u00e1ndez-Quintero","raw_affiliation_strings":["Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA","Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria"],"raw_orcid":"https://orcid.org/0000-0002-6811-6283","affiliations":[{"raw_affiliation_string":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016057020","display_name":"Nancy D. Pomarici","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Nancy D. Pomarici","raw_affiliation_strings":["Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110280484","display_name":"Anna-Lena M. Fischer","orcid":"https://orcid.org/0009-0009-3310-5021","observed_orcids":["https://orcid.org/0009-0009-3310-5021"]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Anna-Lena M. Fischer","raw_affiliation_strings":["Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060288685","display_name":"Valentin J. Hoerschinger","orcid":"https://orcid.org/0000-0002-4469-3238","observed_orcids":["https://orcid.org/0000-0002-4469-3238"]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Valentin J. Hoerschinger","raw_affiliation_strings":["Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005950308","display_name":"Katharina B. Kroell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Katharina B. Kroell","raw_affiliation_strings":["Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075949411","display_name":"Jakob R. Riccabona","orcid":"https://orcid.org/0009-0003-6530-2405","observed_orcids":["https://orcid.org/0009-0003-6530-2405"]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Jakob R. Riccabona","raw_affiliation_strings":["Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084001237","display_name":"Anna Sophia Kamenik","orcid":"https://orcid.org/0000-0001-8657-0036","observed_orcids":["https://orcid.org/0000-0001-8657-0036"]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Anna S. Kamenik","raw_affiliation_strings":["Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria"],"raw_orcid":"https://orcid.org/0000-0001-8657-0036","affiliations":[{"raw_affiliation_string":"Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000379524","display_name":"Johannes R. Loeffler","orcid":"https://orcid.org/0000-0002-5724-655X","observed_orcids":["https://orcid.org/0000-0002-5724-655X"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT","US"],"is_corresponding":false,"raw_author_name":"Johannes R. Loeffler","raw_affiliation_strings":["Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA","Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041258142","display_name":"James A. Ferguson","orcid":"https://orcid.org/0000-0003-2891-0850","observed_orcids":["https://orcid.org/0000-0003-2891-0850"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Ferguson","raw_affiliation_strings":["Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062774564","display_name":"Hailee R. Perrett","orcid":"https://orcid.org/0000-0002-1326-1731","observed_orcids":["https://orcid.org/0000-0002-1326-1731"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hailee R. Perrett","raw_affiliation_strings":["Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028405436","display_name":"Klaus Roman Liedl","orcid":"https://orcid.org/0000-0002-0985-2299","observed_orcids":["https://orcid.org/0000-0002-0985-2299"]},"institutions":[{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Klaus R. Liedl","raw_affiliation_strings":["Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria"],"raw_orcid":"https://orcid.org/0000-0002-0985-2299","affiliations":[{"raw_affiliation_string":"Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, Innrain 80/82, A-6020 Innsbruck, Austria","institution_ids":["https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044912285","display_name":"Julianna Han","orcid":"https://orcid.org/0000-0002-3402-2609","observed_orcids":["https://orcid.org/0000-0002-3402-2609"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julianna Han","raw_affiliation_strings":["Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067790213","display_name":"Andrew B. Ward","orcid":"https://orcid.org/0000-0001-7153-3769","observed_orcids":["https://orcid.org/0000-0001-7153-3769"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrew B. Ward","raw_affiliation_strings":["Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA"],"raw_orcid":"https://orcid.org/0000-0001-7153-3769","affiliations":[{"raw_affiliation_string":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034034027","https://openalex.org/A5067790213"],"corresponding_institution_ids":["https://openalex.org/I123431417","https://openalex.org/I190249584"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1779},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1779},"fwci":0.4864,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.47863725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"12","issue":"4","first_page":"67","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.024299999698996544,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibody-structure","display_name":"antibody structure","score":0.8629999756813049},{"id":"https://openalex.org/keywords/antibody-kinetics","display_name":"antibody kinetics","score":0.9570000171661377},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.7590000033378601},{"id":"https://openalex.org/keywords/antibody-engineering","display_name":"antibody engineering","score":0.6700000166893005},{"id":"https://openalex.org/keywords/antigen-recognition","display_name":"antigen recognition","score":0.8510000109672546},{"id":"https://openalex.org/keywords/conformational-ensembles","display_name":"conformational ensembles","score":0.8920000195503235},{"id":"https://openalex.org/keywords/antibody-structure-prediction","display_name":"antibody structure prediction","score":0.6899999976158142},{"id":"https://openalex.org/keywords/therapeutic-antibodies","display_name":"therapeutic antibodies","score":0.640999972820282},{"id":"https://openalex.org/keywords/vaccine-design","display_name":"vaccine design","score":0.9190000295639038},{"id":"https://openalex.org/keywords/effector-function","display_name":"effector function","score":0.8820000290870667}],"concepts":[{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.7066394090652466},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6761560440063477},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.586331307888031},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46225541830062866},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4608592092990875},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4131605625152588},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3345552682876587},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2642256021499634},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18285220861434937},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/antib12040067","doi":"https://doi.org/10.3390/antib12040067","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antib12040067","pdf_url":"https://www.mdpi.com/2073-4468/12/4/67/pdf?version=1697689561","source":{"id":"https://openalex.org/S2739070576","display_name":"Antibodies","issn_l":"2073-4468","issn":["2073-4468"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibodies","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10594513","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10594513","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10594513/pdf/antibodies-12-00067.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibodies (Basel)","raw_type":"Text"},{"id":"pmid:37873864","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37873864","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibodies (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ebfea549dcaf49caafa4ea894542b32c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ebfea549dcaf49caafa4ea894542b32c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Antibodies, Vol 12, Iss 4, p 67 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/antib12040067","doi":"https://doi.org/10.3390/antib12040067","is_oa":true,"landing_page_url":"https://doi.org/10.3390/antib12040067","pdf_url":"https://www.mdpi.com/2073-4468/12/4/67/pdf?version=1697689561","source":{"id":"https://openalex.org/S2739070576","display_name":"Antibodies","issn_l":"2073-4468","issn":["2073-4468"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antibodies","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2583764395","display_name":"The Scripps Research Institute - to establish a Center of Excellence for structure-guided immunogen design for global health-related problems","funder_award_id":"INV-004923","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G3202496206","display_name":null,"funder_award_id":"847476","funder_id":"https://openalex.org/F4320310358","funder_display_name":"Achievement Rewards for College Scientists Foundation"},{"id":"https://openalex.org/G4485173326","display_name":null,"funder_award_id":"INV-004923","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G5143223819","display_name":null,"funder_award_id":"P34518","funder_id":"https://openalex.org/F4320310358","funder_display_name":"Achievement Rewards for College Scientists Foundation"},{"id":"https://openalex.org/G7323625854","display_name":"Antibody Paratope States in Solution","funder_award_id":"P34518","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G7908569301","display_name":null,"funder_award_id":"INV-004923","funder_id":"https://openalex.org/F4320310358","funder_display_name":"Achievement Rewards for College Scientists Foundation"},{"id":"https://openalex.org/G8026256286","display_name":null,"funder_award_id":"P34518","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"},{"id":"https://openalex.org/G8204622549","display_name":null,"funder_award_id":"847476","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G8772107700","display_name":null,"funder_award_id":"847476","funder_id":"https://openalex.org/F4320306137","funder_display_name":"Bill and Melinda Gates Foundation"}],"funders":[{"id":"https://openalex.org/F1100377486","display_name":"European High Performance Computing Joint Undertaking","ror":"https://ror.org/04dvh0v63"},{"id":"https://openalex.org/F4320306137","display_name":"Bill and Melinda Gates Foundation","ror":"https://ror.org/0456r8d26"},{"id":"https://openalex.org/F4320310358","display_name":"Achievement Rewards for College Scientists Foundation","ror":"https://ror.org/054awkm93"},{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387744825.pdf","grobid_xml":"https://content.openalex.org/works/W4387744825.grobid-xml"},"referenced_works_count":237,"referenced_works":["https://openalex.org/W40742011","https://openalex.org/W135654086","https://openalex.org/W216353729","https://openalex.org/W1587235358","https://openalex.org/W1590194625","https://openalex.org/W1591808469","https://openalex.org/W1786216877","https://openalex.org/W1816587284","https://openalex.org/W1891660574","https://openalex.org/W1891993075","https://openalex.org/W1963778872","https://openalex.org/W1966041739","https://openalex.org/W1966140823","https://openalex.org/W1966286047","https://openalex.org/W1974596630","https://openalex.org/W1978470109","https://openalex.org/W1978499958","https://openalex.org/W1980260012","https://openalex.org/W1982679430","https://openalex.org/W1983494459","https://openalex.org/W1983565271","https://openalex.org/W1989208291","https://openalex.org/W1992423971","https://openalex.org/W1992566288","https://openalex.org/W1992612195","https://openalex.org/W1992767687","https://openalex.org/W1992787746","https://openalex.org/W1994957566","https://openalex.org/W1996581857","https://openalex.org/W1996820981","https://openalex.org/W2001483547","https://openalex.org/W2002299335","https://openalex.org/W2002844537","https://openalex.org/W2006648563","https://openalex.org/W2008639498","https://openalex.org/W2008820731","https://openalex.org/W2009573319","https://openalex.org/W2009671611","https://openalex.org/W2013580208","https://openalex.org/W2014050554","https://openalex.org/W2014327275","https://openalex.org/W2019283330","https://openalex.org/W2019486739","https://openalex.org/W2020138245","https://openalex.org/W2020928626","https://openalex.org/W2021256658","https://openalex.org/W2021855052","https://openalex.org/W2025965594","https://openalex.org/W2028450449","https://openalex.org/W2030522563","https://openalex.org/W2030900050","https://openalex.org/W2031209863","https://openalex.org/W2032736431","https://openalex.org/W2033079214","https://openalex.org/W2034015697","https://openalex.org/W2034287217","https://openalex.org/W2035867359","https://openalex.org/W2037007095","https://openalex.org/W2037042031","https://openalex.org/W2039175603","https://openalex.org/W2039618516","https://openalex.org/W2042079029","https://openalex.org/W2045346799","https://openalex.org/W2046596676","https://openalex.org/W2048822589","https://openalex.org/W2050807769","https://openalex.org/W2055839516","https://openalex.org/W2061766263","https://openalex.org/W2063712078","https://openalex.org/W2065303540","https://openalex.org/W2068097958","https://openalex.org/W2069068211","https://openalex.org/W2070086938","https://openalex.org/W2072207242","https://openalex.org/W2072404529","https://openalex.org/W2073948759","https://openalex.org/W2075097399","https://openalex.org/W2082912027","https://openalex.org/W2083028331","https://openalex.org/W2093062941","https://openalex.org/W2093572741","https://openalex.org/W2093744918","https://openalex.org/W2096929343","https://openalex.org/W2099090318","https://openalex.org/W2101346721","https://openalex.org/W2105185829","https://openalex.org/W2105360462","https://openalex.org/W2106306111","https://openalex.org/W2110036226","https://openalex.org/W2111823261","https://openalex.org/W2113118666","https://openalex.org/W2113155348","https://openalex.org/W2114227017","https://openalex.org/W2114698599","https://openalex.org/W2121107218","https://openalex.org/W2123529526","https://openalex.org/W2124266141","https://openalex.org/W2126362472","https://openalex.org/W2129020329","https://openalex.org/W2129739217","https://openalex.org/W2130675979","https://openalex.org/W2134803208","https://openalex.org/W2135305016","https://openalex.org/W2137640292","https://openalex.org/W2140060739","https://openalex.org/W2146048807","https://openalex.org/W2147451568","https://openalex.org/W2148043455","https://openalex.org/W2150884352","https://openalex.org/W2152617913","https://openalex.org/W2154135618","https://openalex.org/W2159599720","https://openalex.org/W2162210398","https://openalex.org/W2166103775","https://openalex.org/W2167686332","https://openalex.org/W2167980959","https://openalex.org/W2169610187","https://openalex.org/W2170276807","https://openalex.org/W2255353486","https://openalex.org/W2259559363","https://openalex.org/W2263209021","https://openalex.org/W2302583067","https://openalex.org/W2316212521","https://openalex.org/W2323929490","https://openalex.org/W2325393979","https://openalex.org/W2325946159","https://openalex.org/W2343608303","https://openalex.org/W2395519819","https://openalex.org/W2409087846","https://openalex.org/W2412035302","https://openalex.org/W2474661075","https://openalex.org/W2513379522","https://openalex.org/W2513769763","https://openalex.org/W2571138221","https://openalex.org/W2571206968","https://openalex.org/W2580666741","https://openalex.org/W2581030149","https://openalex.org/W2583289470","https://openalex.org/W2603247627","https://openalex.org/W2727633585","https://openalex.org/W2734881930","https://openalex.org/W2752678874","https://openalex.org/W2765708508","https://openalex.org/W2773325876","https://openalex.org/W2774559011","https://openalex.org/W2790505494","https://openalex.org/W2866458126","https://openalex.org/W2887011607","https://openalex.org/W2887299058","https://openalex.org/W2887331716","https://openalex.org/W2890955636","https://openalex.org/W2891129333","https://openalex.org/W2893956305","https://openalex.org/W2896148359","https://openalex.org/W2897416090","https://openalex.org/W2910772764","https://openalex.org/W2913172221","https://openalex.org/W2919790473","https://openalex.org/W2945681432","https://openalex.org/W2946638940","https://openalex.org/W2947363422","https://openalex.org/W2948141873","https://openalex.org/W2951936481","https://openalex.org/W2979417923","https://openalex.org/W2980433193","https://openalex.org/W2980681402","https://openalex.org/W2982412239","https://openalex.org/W2991056046","https://openalex.org/W2993866869","https://openalex.org/W2997109716","https://openalex.org/W2999269043","https://openalex.org/W3003832741","https://openalex.org/W3011581239","https://openalex.org/W3012187828","https://openalex.org/W3015284782","https://openalex.org/W3017840536","https://openalex.org/W3018312852","https://openalex.org/W3048109295","https://openalex.org/W3048474896","https://openalex.org/W3048773677","https://openalex.org/W3091589156","https://openalex.org/W3094563030","https://openalex.org/W3098383476","https://openalex.org/W3109079220","https://openalex.org/W3111038302","https://openalex.org/W3133982176","https://openalex.org/W3135330625","https://openalex.org/W3136996287","https://openalex.org/W3137959855","https://openalex.org/W3156060998","https://openalex.org/W3158653486","https://openalex.org/W3165831593","https://openalex.org/W3177828909","https://openalex.org/W3191704104","https://openalex.org/W3196757117","https://openalex.org/W3202105508","https://openalex.org/W3211795435","https://openalex.org/W4200403158","https://openalex.org/W4205628911","https://openalex.org/W4206804999","https://openalex.org/W4210265213","https://openalex.org/W4210520848","https://openalex.org/W4210742194","https://openalex.org/W4213244137","https://openalex.org/W4213304877","https://openalex.org/W4225321559","https://openalex.org/W4226108318","https://openalex.org/W4229020575","https://openalex.org/W4230654908","https://openalex.org/W4233522597","https://openalex.org/W4241512236","https://openalex.org/W4280548401","https://openalex.org/W4280642390","https://openalex.org/W4281619315","https://openalex.org/W4283076480","https://openalex.org/W4283587158","https://openalex.org/W4285386587","https://openalex.org/W4290852328","https://openalex.org/W4291165742","https://openalex.org/W4294176650","https://openalex.org/W4294234222","https://openalex.org/W4297198862","https://openalex.org/W4298008707","https://openalex.org/W4298008750","https://openalex.org/W4308570626","https://openalex.org/W4308583764","https://openalex.org/W4308583995","https://openalex.org/W4310707361","https://openalex.org/W4310875677","https://openalex.org/W4310921804","https://openalex.org/W4320495379","https://openalex.org/W4366998330","https://openalex.org/W4378714914","https://openalex.org/W4382344269","https://openalex.org/W4384575937","https://openalex.org/W4388449445","https://openalex.org/W6781948182"],"related_works":["https://openalex.org/W3165831593","https://openalex.org/W2810332147","https://openalex.org/W7131783646","https://openalex.org/W2183984925","https://openalex.org/W2041498302","https://openalex.org/W4389964467","https://openalex.org/W4239384811","https://openalex.org/W3161140890","https://openalex.org/W3090090102","https://openalex.org/W2419480042"],"abstract_inverted_index":{"Antibodies":[0],"and":[1,71,92,105,118,134,141,150],"other":[2,48],"new":[3],"antibody-like":[4],"formats":[5],"have":[6],"emerged":[7],"as":[8,57],"one":[9],"of":[10,16,43,54,63,88,95,125,148],"the":[11,20,40,52,89,110,122,146],"most":[12],"rapidly":[13],"growing":[14],"classes":[15],"biotherapeutic":[17],"proteins.":[18],"Understanding":[19],"structural":[21,41,91],"features":[22],"that":[23],"drive":[24],"antibody":[25,115,140],"function":[26],"and,":[27],"consequently,":[28],"their":[29,69,77,100],"molecular":[30],"recognition":[31],"is":[32],"critical":[33],"for":[34],"engineering":[35],"antibodies.":[36],"Here,":[37],"we":[38,84,138],"present":[39],"architecture":[42],"conventional":[44],"IgG":[45],"antibodies":[46,56,96],"alongside":[47],"formats.":[49],"We":[50,108],"emphasize":[51],"importance":[53],"considering":[55],"conformational":[58],"ensembles":[59],"in":[60,81,114,145],"solution":[61],"instead":[62],"focusing":[64],"on":[65],"single-static":[66],"structures":[67,129],"because":[68],"functions":[70],"properties":[72],"are":[73],"strongly":[74],"governed":[75],"by":[76,121],"dynamic":[78,93],"nature.":[79],"Thus,":[80],"this":[82],"review,":[83],"provide":[85],"an":[86],"overview":[87],"unique":[90],"characteristics":[94],"with":[97,131],"respect":[98],"to":[99],"antigen":[101],"recognition,":[102],"biophysical":[103],"properties,":[104],"effector":[106],"functions.":[107],"highlight":[109],"numerous":[111],"technical":[112],"advances":[113],"structure":[116,149],"prediction":[117],"design,":[119],"enabled":[120],"vast":[123],"number":[124],"experimentally":[126],"determined":[127],"high-quality":[128],"recorded":[130],"cryo-EM,":[132],"NMR,":[133],"X-ray":[135],"crystallography.":[136],"Lastly,":[137],"assess":[139],"vaccine":[142],"design":[143],"strategies":[144],"context":[147],"dynamics.":[151]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-10-19T00:00:00"}
