{"id":"https://openalex.org/W4387740485","doi":"https://doi.org/10.3389/fmed.2023.1247851","title":"Exploring the underlying mechanisms of Ashitaba in the management of non-alcoholic fatty liver disease by integrating the analysis of transcriptomics and metabolomics","display_name":"Exploring the underlying mechanisms of Ashitaba in the management of non-alcoholic fatty liver disease by integrating the analysis of transcriptomics and metabolomics","publication_year":2023,"publication_date":"2023-10-18","ids":{"openalex":"https://openalex.org/W4387740485","doi":"https://doi.org/10.3389/fmed.2023.1247851","pmid":"https://pubmed.ncbi.nlm.nih.gov/37920601","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10618682"},"language":"en","primary_location":{"id":"doi:10.3389/fmed.2023.1247851","doi":"https://doi.org/10.3389/fmed.2023.1247851","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2023.1247851","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2023.1247851/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fmed.2023.1247851/pdf?isPublishedV2=False","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101932028","display_name":"Huan Yang","orcid":"https://orcid.org/0000-0002-3106-490X","observed_orcids":["https://orcid.org/0000-0002-3106-490X"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210107879","display_name":"Tongren Hospital","ror":"https://ror.org/01r8rcr36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107879"]},{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Yang","raw_affiliation_strings":["Changning Administration Center of Public Hospital and Community Healthcare Center, Shanghai, China","Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China","Department of Internal Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changning Administration Center of Public Hospital and Community Healthcare Center, Shanghai, China","institution_ids":[]},{"raw_affiliation_string":"Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210124971"]},{"raw_affiliation_string":"Department of Internal Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210107879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101835224","display_name":"Yun\u2010Shan Li","orcid":"https://orcid.org/0000-0001-9534-5922","observed_orcids":["https://orcid.org/0000-0001-9534-5922"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunshan Li","raw_affiliation_strings":["Department of Endocrinology, Seven People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Seven People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210098460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100300120","display_name":"Weihong Xu","orcid":"https://orcid.org/0009-0006-0248-3116","observed_orcids":["https://orcid.org/0009-0006-0248-3116"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210107879","display_name":"Tongren Hospital","ror":"https://ror.org/01r8rcr36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107879"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weihong Xu","raw_affiliation_strings":["Department of Clinical Laboratory, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210107879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100430643","display_name":"Wenjuan Liu","orcid":"https://orcid.org/0000-0003-2947-4093","observed_orcids":["https://orcid.org/0000-0003-2947-4093"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210107879","display_name":"Tongren Hospital","ror":"https://ror.org/01r8rcr36","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107879"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjuan Liu","raw_affiliation_strings":["Department of Internal Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210107879"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100704298","display_name":"Ying Xie","orcid":"https://orcid.org/0000-0002-0735-7198","observed_orcids":["https://orcid.org/0000-0002-0735-7198"]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Xie","raw_affiliation_strings":["Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China","institution_ids":["https://openalex.org/I4210124971"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100704298"],"corresponding_institution_ids":["https://openalex.org/I4210124971"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":null,"first_page":"1247851","last_page":"1247851"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ashitaba","display_name":"ashitaba","score":0.9909999966621399},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":1.0},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.7519999742507935},{"id":"https://openalex.org/keywords/differential-metabolites","display_name":"differential metabolites","score":0.9409999847412109},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6990000009536743},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.7409999966621399},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.7400000095367432},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.8833640813827515},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6624405980110168},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.6400109529495239},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.6312933564186096},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6240745186805725},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5881015658378601},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.48341166973114014},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4356898069381714},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43120288848876953},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4187277853488922},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.35385656356811523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3522666394710541},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22393909096717834},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14500749111175537},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10987433791160583},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fmed.2023.1247851","doi":"https://doi.org/10.3389/fmed.2023.1247851","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2023.1247851","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2023.1247851/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10618682","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10618682","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10618682/pdf/fmed-10-1247851.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Med (Lausanne)","raw_type":"Text"},{"id":"pmid:37920601","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37920601","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:cfa3ed47a3a44bcca3a7244fa6941ba3","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/cfa3ed47a3a44bcca3a7244fa6941ba3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Medicine, Vol 10 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmed.2023.1247851","doi":"https://doi.org/10.3389/fmed.2023.1247851","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmed.2023.1247851","pdf_url":"https://www.frontiersin.org/articles/10.3389/fmed.2023.1247851/pdf?isPublishedV2=False","source":{"id":"https://openalex.org/S2597052008","display_name":"Frontiers in Medicine","issn_l":"2296-858X","issn":["2296-858X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387740485.pdf","grobid_xml":"https://content.openalex.org/works/W4387740485.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W2011271002","https://openalex.org/W2015213149","https://openalex.org/W2022674575","https://openalex.org/W2061662539","https://openalex.org/W2074310845","https://openalex.org/W2077434210","https://openalex.org/W2086035902","https://openalex.org/W2090890378","https://openalex.org/W2115133645","https://openalex.org/W2128904152","https://openalex.org/W2146924462","https://openalex.org/W2162382402","https://openalex.org/W2179438025","https://openalex.org/W2310848991","https://openalex.org/W2474637882","https://openalex.org/W2483891712","https://openalex.org/W2519479884","https://openalex.org/W2802665223","https://openalex.org/W2810423511","https://openalex.org/W2888859009","https://openalex.org/W2896130110","https://openalex.org/W2909128627","https://openalex.org/W2935068751","https://openalex.org/W2947257201","https://openalex.org/W2980944208","https://openalex.org/W3004978237","https://openalex.org/W3006306205","https://openalex.org/W3012883032","https://openalex.org/W3020200374","https://openalex.org/W3090707925","https://openalex.org/W3110600404","https://openalex.org/W3154897461","https://openalex.org/W3160407865","https://openalex.org/W3172197894","https://openalex.org/W3181456162","https://openalex.org/W3190185780","https://openalex.org/W4220729842","https://openalex.org/W4282838589","https://openalex.org/W4293222079","https://openalex.org/W4311455437","https://openalex.org/W4315700891"],"related_works":["https://openalex.org/W4395079118","https://openalex.org/W7204994922","https://openalex.org/W4237353898","https://openalex.org/W4394999900","https://openalex.org/W3135570891","https://openalex.org/W3199449193","https://openalex.org/W7118168817","https://openalex.org/W4407319370","https://openalex.org/W2523163592","https://openalex.org/W7167673829"],"abstract_inverted_index":{"Ashitaba":[0,34,43,76,117],"seems":[1],"to":[2,16,28],"improve":[3],"glucose":[4],"intolerance":[5],"and":[6,10,65,79,92,123],"decrease":[7],"triglyceride":[8],"(TG)":[9],"total":[11],"cholesterol":[12],"(TC),":[13],"which":[14],"contribute":[15],"the":[17,31,40,51,66,103,113,119],"development":[18],"of":[19,33,42,116,121],"non-alcoholic":[20],"fatty":[21],"liver":[22,80],"disease":[23],"(NAFLD).":[24],"However,":[25],"it":[26],"remains":[27],"be":[29,125],"explored":[30,70],"mechanism":[32,68],"in":[35,82,118,127],"managing":[36],"NAFLD.":[37,131],"We":[38],"determined":[39],"impact":[41,115],"on":[44],"NAFLD,":[45],"particularly":[46],"its":[47],"underlying":[48,67],"mechanisms":[49],"at":[50],"bioinformatic":[52],"level.":[53],"The":[54],"established":[55],"NAFLD":[56,83,101,122],"mouse":[57],"model":[58],"was":[59,69],"treated":[60],"with":[61,74],"or":[62],"without":[63],"Ashitaba,":[64],"using":[71],"transcriptomics":[72],"paired":[73],"metabolomics.":[75],"reduced":[77],"obesity":[78],"steatosis":[81],"mice.":[84],"It":[85],"identified":[86],"429":[87],"differentially":[88],"expressed":[89],"genes":[90],"(DEGs)":[91],"verified":[93],"45":[94],"differential":[95],"metabolites,":[96],"especially":[97],"those":[98],"that":[99],"alleviate":[100],"via":[102],"FXR":[104],"signaling":[105],"pathway.":[106],"Our":[107],"data":[108],"may":[109,124],"provide":[110],"insight":[111],"into":[112],"therapeutic":[114],"management":[120],"useful":[126],"clinical":[128],"interventions":[129],"for":[130]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-10-19T00:00:00"}