{"id":"https://openalex.org/W4387738533","doi":"https://doi.org/10.1016/s1569-1993(23)01504-7","title":"582 Cholesterol levels increase on elexacaftor-tezacaftor-ivacaftor therapy but remain within acceptable ranges","display_name":"582 Cholesterol levels increase on elexacaftor-tezacaftor-ivacaftor therapy but remain within acceptable ranges","publication_year":2023,"publication_date":"2023-10-01","ids":{"openalex":"https://openalex.org/W4387738533","doi":"https://doi.org/10.1016/s1569-1993(23)01504-7"},"language":"en","primary_location":{"id":"doi:10.1016/s1569-1993(23)01504-7","doi":"https://doi.org/10.1016/s1569-1993(23)01504-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1569-1993(23)01504-7","pdf_url":"https://doi.org/10.1016/s1569-1993(23)01504-7","source":{"id":"https://openalex.org/S147774598","display_name":"Journal of Cystic Fibrosis","issn_l":"1569-1993","issn":["1569-1993","1873-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cystic Fibrosis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/s1569-1993(23)01504-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054444782","display_name":"R. Boyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"R. Boyle","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, the Johns Hopkins University Baltimore, MD;","School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, the Johns Hopkins University Baltimore, MD;","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia;","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2802977208","display_name":"Royal Hobart Hospital","ror":"https://ror.org/031382m70","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802977208"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"J. Xia","raw_affiliation_strings":["School of Nursing, the Johns Hopkins University, Baltimore, MD;","Tasmanian Pediatric Cystic Fibrosis Service, Women's and Children's Services, Royal Hobart Hospital, Hobart, Tasmania, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, the Johns Hopkins University, Baltimore, MD;","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Tasmanian Pediatric Cystic Fibrosis Service, Women's and Children's Services, Royal Hobart Hospital, Hobart, Tasmania, Australia;","institution_ids":["https://openalex.org/I2802977208"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. Patel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"S. Patel","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, the Johns Hopkins University Baltimore, MD;","School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, the Johns Hopkins University Baltimore, MD;","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia;","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":null,"display_name":"K. Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2802977208","display_name":"Royal Hobart Hospital","ror":"https://ror.org/031382m70","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802977208"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"K. Ho","raw_affiliation_strings":["School of Nursing, the Johns Hopkins University, Baltimore, MD;","Tasmanian Pediatric Cystic Fibrosis Service, Women's and Children's Services, Royal Hobart Hospital, Hobart, Tasmania, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, the Johns Hopkins University, Baltimore, MD;","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Tasmanian Pediatric Cystic Fibrosis Service, Women's and Children's Services, Royal Hobart Hospital, Hobart, Tasmania, Australia;","institution_ids":["https://openalex.org/I2802977208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101740814","display_name":"Di Lu","orcid":"https://orcid.org/0000-0003-1040-7763","observed_orcids":["https://orcid.org/0000-0003-1040-7763"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2802977208","display_name":"Royal Hobart Hospital","ror":"https://ror.org/031382m70","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802977208"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"D. Lu","raw_affiliation_strings":["School of Nursing, the Johns Hopkins University, Baltimore, MD;","Tasmanian Pediatric Cystic Fibrosis Service, Women's and Children's Services, Royal Hobart Hospital, Hobart, Tasmania, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, the Johns Hopkins University, Baltimore, MD;","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Tasmanian Pediatric Cystic Fibrosis Service, Women's and Children's Services, Royal Hobart Hospital, Hobart, Tasmania, Australia;","institution_ids":["https://openalex.org/I2802977208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077856299","display_name":"N. Lechtzin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129801699","display_name":"University of Tasmania","ror":"https://ror.org/01nfmeh72","country_code":"AU","type":"education","lineage":["https://openalex.org/I129801699"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210150714","display_name":"Johns Hopkins Hospital","ror":"https://ror.org/05cb1k848","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436","https://openalex.org/I4210150714"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"N. Lechtzin","raw_affiliation_strings":["Department of Medicine-Pulmonary, Johns Hopkins Hospital, Baltimore, MD;","School of Medicine, University of Tasmania, Hobart, Tasmania, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine-Pulmonary, Johns Hopkins Hospital, Baltimore, MD;","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I4210150714"]},{"raw_affiliation_string":"School of Medicine, University of Tasmania, Hobart, Tasmania, Australia","institution_ids":["https://openalex.org/I129801699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012232604","display_name":"Christian A. Merlo","orcid":"https://orcid.org/0000-0002-9283-3928","observed_orcids":["https://orcid.org/0000-0002-9283-3928"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"C. Merlo","raw_affiliation_strings":["Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, the Johns Hopkins University Baltimore, MD;","School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, the Johns Hopkins University Baltimore, MD;","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia;","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040817775","display_name":"Sarah Allgood","orcid":"https://orcid.org/0000-0003-0259-6613","observed_orcids":["https://orcid.org/0000-0003-0259-6613"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2802977208","display_name":"Royal Hobart Hospital","ror":"https://ror.org/031382m70","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2802977208"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"S. Allgood","raw_affiliation_strings":["School of Nursing, the Johns Hopkins University, Baltimore, MD;","Tasmanian Pediatric Cystic Fibrosis Service, Women's and Children's Services, Royal Hobart Hospital, Hobart, Tasmania, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Nursing, the Johns Hopkins University, Baltimore, MD;","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Tasmanian Pediatric Cystic Fibrosis Service, Women's and Children's Services, Royal Hobart Hospital, Hobart, Tasmania, Australia;","institution_ids":["https://openalex.org/I2802977208"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004213410","display_name":"Natalie E. West","orcid":"https://orcid.org/0000-0002-0025-2422","observed_orcids":["https://orcid.org/0000-0002-0025-2422"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. West","raw_affiliation_strings":["Department of Medicine, the Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, the Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4070,"currency":"USD","value_usd":4070},"apc_paid":null,"fwci":0.1832,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.53305331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"22","issue":null,"first_page":"S310","last_page":"S310"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.9003999829292297,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.042899999767541885,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/elexacaftor-tezacaftor-ivacaftor","display_name":"elexacaftor/tezacaftor/ivacaftor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cftr-modulator-therapy","display_name":"CFTR modulator therapy","score":0.871999979019165},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.9120000004768372},{"id":"https://openalex.org/keywords/serum-lipids","display_name":"serum lipids","score":0.7120000123977661},{"id":"https://openalex.org/keywords/total-cholesterol","display_name":"total cholesterol","score":0.8510000109672546},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.8360000252723694},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.9629999995231628},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.996999979019165},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.9549999833106995},{"id":"https://openalex.org/keywords/adult-cystic-fibrosis","display_name":"adults with cystic fibrosis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/f508del-mutation","display_name":"F508del mutation","score":0.6690000295639038},{"id":"https://openalex.org/keywords/pancreatic-insufficiency","display_name":"pancreatic insufficiency","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C2776502428","wikidata":"https://www.wikidata.org/wiki/Q6095693","display_name":"Ivacaftor","level":4,"score":0.9950908422470093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8821761608123779},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.7813678979873657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3259429931640625},{"id":"https://openalex.org/C2778428886","wikidata":"https://www.wikidata.org/wiki/Q420470","display_name":"Cystic fibrosis transmembrane conductance regulator","level":3,"score":0.05788347125053406}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s1569-1993(23)01504-7","doi":"https://doi.org/10.1016/s1569-1993(23)01504-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1569-1993(23)01504-7","pdf_url":"https://doi.org/10.1016/s1569-1993(23)01504-7","source":{"id":"https://openalex.org/S147774598","display_name":"Journal of Cystic Fibrosis","issn_l":"1569-1993","issn":["1569-1993","1873-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cystic Fibrosis","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/s1569-1993(23)01504-7","doi":"https://doi.org/10.1016/s1569-1993(23)01504-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s1569-1993(23)01504-7","pdf_url":"https://doi.org/10.1016/s1569-1993(23)01504-7","source":{"id":"https://openalex.org/S147774598","display_name":"Journal of Cystic Fibrosis","issn_l":"1569-1993","issn":["1569-1993","1873-5010"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cystic Fibrosis","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387738533.pdf","grobid_xml":"https://content.openalex.org/works/W4387738533.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2891378911"],"related_works":["https://openalex.org/W4387738550","https://openalex.org/W4387738543","https://openalex.org/W4390176330","https://openalex.org/W4409158362","https://openalex.org/W4300716584","https://openalex.org/W4300716694","https://openalex.org/W4389857138","https://openalex.org/W4404104292","https://openalex.org/W4399425728","https://openalex.org/W7139957997"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-10-19T00:00:00"}