{"id":"https://openalex.org/W4387735487","doi":"https://doi.org/10.17918/00001267","title":"Functional studies of a dopamine transporter allosteric modulator and its effect on cocaine-induced behavior","display_name":"Functional studies of a dopamine transporter allosteric modulator and its effect on cocaine-induced behavior","publication_year":2020,"publication_date":"2020-08-01","ids":{"openalex":"https://openalex.org/W4387735487","doi":"https://doi.org/10.17918/00001267"},"language":"en","primary_location":{"id":"doi:10.17918/00001267","doi":"https://doi.org/10.17918/00001267","is_oa":true,"landing_page_url":"https://doi.org/10.17918/00001267","pdf_url":null,"source":null,"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drexel University","raw_type":"dissertation"},"volume":null,"type":"dissertation","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.17918/00001267","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yibin Xu","orcid":"https://orcid.org/0000-0001-8720-5938","observed_orcids":["https://orcid.org/0000-0001-8720-5938"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yibin Xu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8720-5938","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032233275","display_name":"Ole Valente Mortensen","orcid":"https://orcid.org/0000-0002-3487-8239","observed_orcids":["https://orcid.org/0000-0002-3487-8239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ole V. Mortensen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3487-8239","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088164724","display_name":"Joanne R. Mathiasen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanne R. Mathiasen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-transporter","display_name":"dopamine transporter","score":0.8989999890327454},{"id":"https://openalex.org/keywords/allosteric-modulators","display_name":"allosteric modulators","score":0.9710000157356262},{"id":"https://openalex.org/keywords/cocaine-dependence","display_name":"cocaine dependence","score":0.6940000057220459},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.6970000267028809},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.7929999828338623},{"id":"https://openalex.org/keywords/drug-binding-mechanism","display_name":"drug binding mechanism","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.8452446460723877},{"id":"https://openalex.org/C2776038425","wikidata":"https://www.wikidata.org/wiki/Q2649417","display_name":"Allosteric modulator","level":4,"score":0.8051257133483887},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6717851758003235},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.6622893810272217},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5973881483078003},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5322192907333374},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42860960960388184},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3983212113380432},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37944239377975464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24751129746437073},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17431017756462097},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13094350695610046},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.08348679542541504},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06761854887008667}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.17918/00001267","doi":"https://doi.org/10.17918/00001267","is_oa":true,"landing_page_url":"https://doi.org/10.17918/00001267","pdf_url":null,"source":null,"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drexel University","raw_type":"dissertation"},{"id":"pmh:oai:alma.01DRXU_INST:11324274160004721","doi":null,"is_oa":true,"landing_page_url":"https://researchdiscovery.drexel.edu/esploro/outputs/graduate/Functional-studies-of-a-dopamine-transporter/991014695136004721","pdf_url":null,"source":{"id":"https://openalex.org/S7407064447","display_name":"iDEA - Drexel University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Masters Thesis"}],"best_oa_location":{"id":"doi:10.17918/00001267","doi":"https://doi.org/10.17918/00001267","is_oa":true,"landing_page_url":"https://doi.org/10.17918/00001267","pdf_url":null,"source":null,"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drexel University","raw_type":"dissertation"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.47999998927116394,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4206052538","https://openalex.org/W4414988326","https://openalex.org/W4377029215","https://openalex.org/W4408959002","https://openalex.org/W4206642948","https://openalex.org/W4225412323","https://openalex.org/W2952344173","https://openalex.org/W4200342966","https://openalex.org/W2133447074","https://openalex.org/W4401636424"],"abstract_inverted_index":{"Cocaine":[0],"is":[1,49],"one":[2],"of":[3,30,94,104,130,152,191,234,285],"the":[4,19,31,36,40,57,64,99,120,139,150,192,215,221,232,235,256,261,282],"oldest,":[5],"strongest,":[6],"and":[7,59,74,180],"most":[8,93],"dangerous":[9],"psychostimulants":[10],"isolated":[11],"from":[12],"natural":[13],"products.":[14],"It":[15],"works":[16],"by":[17,63,155],"blocking":[18],"dopamine":[20,28,42],"transporter":[21,123],"(DAT),":[22],"a":[23,115,135,188,225],"transmembrane":[24],"protein":[25],"that":[26,53,137,162,231,272],"pumps":[27],"out":[29],"synaptic":[32],"cleft":[33],"back":[34],"into":[35,255],"cytosol,":[37],"thereby":[38],"raising":[39],"extracellular":[41],"level":[43],"resulting":[44],"in":[45,56,68,119,143,157,158,178,239],"euphoria.":[46],"Although":[47],"cocaine":[48,79,90,156,170],"an":[50,127,176,242],"ancient":[51],"drug":[52],"became":[54],"popular":[55],"1880s":[58],"officially":[60],"was":[61],"banned":[62],"United":[65],"States":[66],"government":[67],"1922,":[69],"there":[70],"are":[71],"no":[72],"Food":[73],"Drug":[75],"Administration-approved":[76],"therapies":[77],"for":[78,89,168],"addiction.":[80,171],"Numerous":[81],"attempts":[82],"have":[83,133,165],"been":[84],"made":[85],"to":[86,98,228,247],"find":[87,126],"treatments":[88],"abuse.":[91],"However,":[92,172],"them":[95],"failed":[96],"due":[97],"potential":[100],"abuse":[101],"liability,":[102],"lack":[103],"efficacy,":[105],"or":[106,277],"severe":[107],"side":[108],"effects.":[109],"Our":[110],"lab":[111],"has":[112,175],"previously":[113],"identified":[114],"novel":[116],"allosteric":[117,128,141,216],"site":[118],"human":[121,144],"serotonin":[122],"(hSERT).":[124],"To":[125,186],"modulator":[129],"DAT,":[131],"we":[132,196],"developed":[134],"compound-KM822":[136],"target":[138],"same":[140],"domain":[142],"DAT.":[145],"KM822":[146,174,193,199,252,286],"pretreatment":[147],"can":[148],"increase":[149],"IC50":[151],"DAT":[153,245],"inhibition":[154],"vitro":[159],"studies,":[160],"indicating":[161,271],"it":[163,273],"might":[164],"therapeutic":[166,283],"effects":[167],"treating":[169],"whether":[173],"effect":[177,284],"vivo":[179],"its":[181],"binding":[182,194,217],"mechanism":[183],"remains":[184],"unclear.":[185],"obtain":[187],"better":[189],"understanding":[190],"mechanism,":[195],"tested":[197],"several":[198],"analogs.":[200],"Analogs":[201],"with":[202,244],"different":[203,208,211],"chemical":[204,236],"moiety":[205,237],"substitution":[206,238],"showed":[207],"potency":[209],"towards":[210],"amino":[212],"acids":[213],"forming":[214],"site.":[218],"Among":[219],"all":[220],"analogs,":[222],"NP-1-152":[223,240],"displayed":[224],"pharmacology":[226],"similar":[227,246],"KM822,":[229],"suggesting":[230],"combination":[233],"created":[241],"interaction":[243],"KM822.":[248],"In":[249],"Long-Evans":[250],"rats,":[251],"microinjected":[253],"directly":[254],"nucleus":[257],"accumbens":[258],"didn't":[259],"affect":[260],"regular":[262],"locomotion":[263],"activity":[264],"on":[265,281,287],"rats":[266],"during":[267],"their":[268],"active":[269],"cycle,":[270],"doesn't":[274],"cause":[275],"hyperlocomotion":[276],"sedation.":[278],"Preliminary":[279],"data":[280],"cocaine-induced":[288],"behavior":[289],"will":[290],"also":[291],"be":[292],"presented.":[293]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2023-10-19T00:00:00"}