{"id":"https://openalex.org/W4387733646","doi":"https://doi.org/10.14309/01.ajg.0000953404.12751.ab","title":"S941 Comparative Efficacy and Safety of Adalimumab vs Vedolizumab in Managing Moderate-to-Severe Crohn's Disease: A Systematic Review and Meta-Analysis","display_name":"S941 Comparative Efficacy and Safety of Adalimumab vs Vedolizumab in Managing Moderate-to-Severe Crohn's Disease: A Systematic Review and Meta-Analysis","publication_year":2023,"publication_date":"2023-10-01","ids":{"openalex":"https://openalex.org/W4387733646","doi":"https://doi.org/10.14309/01.ajg.0000953404.12751.ab"},"language":"en","primary_location":{"id":"doi:10.14309/01.ajg.0000953404.12751.ab","doi":"https://doi.org/10.14309/01.ajg.0000953404.12751.ab","is_oa":false,"landing_page_url":"http://dx.doi.org/10.14309/01.ajg.0000953404.12751.ab","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037622640","display_name":"Nooraldin Merza","orcid":"https://orcid.org/0000-0001-7198-1617","observed_orcids":["https://orcid.org/0000-0001-7198-1617"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nooraldin Merza","raw_affiliation_strings":["University of Toledo, Toledo, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Toledo, Toledo, OH;","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044075173","display_name":"Alsadiq Al\u2010Hillan","orcid":"https://orcid.org/0000-0002-2465-1751","observed_orcids":["https://orcid.org/0000-0002-2465-1751"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alsadiq Al-Hillan","raw_affiliation_strings":["Beaumont Hospital, Corewell Health System, Detroit, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beaumont Hospital, Corewell Health System, Detroit, MI;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049452350","display_name":"Sarmed Mansur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarmed Mansur","raw_affiliation_strings":["University of Toledo, Toledo, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Toledo, Toledo, OH;","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093083153","display_name":"Fatima A. Merza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fatima A. Merza","raw_affiliation_strings":["University of Michigan, Canton, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan, Canton, MI;","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043842535","display_name":"Mohamad Nawras","orcid":"https://orcid.org/0000-0001-8345-8049","observed_orcids":["https://orcid.org/0000-0001-8345-8049"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamad Nawras","raw_affiliation_strings":["University of Toledo College Medicine and Life Sciences, Toledo, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Toledo College Medicine and Life Sciences, Toledo, OH;","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033060576","display_name":"Dushyant Singh Dahiya","orcid":"https://orcid.org/0000-0002-8544-9039","observed_orcids":["https://orcid.org/0000-0002-8544-9039"]},"institutions":[{"id":"https://openalex.org/I146416000","display_name":"University of Kansas","ror":"https://ror.org/001tmjg57","country_code":"US","type":"education","lineage":["https://openalex.org/I146416000"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dushyant Singh Dahiya","raw_affiliation_strings":["University of Kansas School of Medicine, Kansas City, KS;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kansas School of Medicine, Kansas City, KS;","institution_ids":["https://openalex.org/I146416000","https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083744839","display_name":"Safa Boujemaa","orcid":"https://orcid.org/0000-0002-1199-0519","observed_orcids":["https://orcid.org/0000-0002-1199-0519"]},"institutions":[{"id":"https://openalex.org/I4210142087","display_name":"Institut Pasteur de Tunis","ror":"https://ror.org/04pwyer06","country_code":"TN","type":"facility","lineage":["https://openalex.org/I4210142087"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Safa Boujemaa","raw_affiliation_strings":["Institute Pasteur de Tunis, Tunisia, MI;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute Pasteur de Tunis, Tunisia, MI;","institution_ids":["https://openalex.org/I4210142087"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tarek Naguib","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tarek Naguib","raw_affiliation_strings":["Texas Tech University, Amarillo, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Tech University, Amarillo, TX","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015116559","display_name":"Abdallah A. Kobeissy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abdallah A. Kobeissy","raw_affiliation_strings":["University of Toledo, Toledo, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Toledo, Toledo, OH;","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030168910","display_name":"Mona Mamdouh Hassan","orcid":"https://orcid.org/0009-0008-2045-0363","observed_orcids":["https://orcid.org/0009-0008-2045-0363"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mona Hassan","raw_affiliation_strings":["University of Toledo, Toledo, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Toledo, Toledo, OH;","institution_ids":["https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085811848","display_name":"Asm Islam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12315562","display_name":"Texas Tech University","ror":"https://ror.org/0405mnx93","country_code":"US","type":"education","lineage":["https://openalex.org/I12315562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asm Islam","raw_affiliation_strings":["Texas Tech University, Amarillo, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Tech University, Amarillo, TX","institution_ids":["https://openalex.org/I12315562"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067609751","display_name":"Yaseen Alastal","orcid":"https://orcid.org/0000-0002-1308-1132","observed_orcids":["https://orcid.org/0000-0002-1308-1132"]},"institutions":[{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yaseen Alastal","raw_affiliation_strings":["University of Toledo, Toledo, OH;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Toledo, Toledo, OH;","institution_ids":["https://openalex.org/I90871651"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5037622640"],"corresponding_institution_ids":["https://openalex.org/I90871651"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"118","issue":"10S","first_page":"S705","last_page":"S706"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9610000252723694},{"id":"https://openalex.org/keywords/adalimumab","display_name":"adalimumab","score":1.0},{"id":"https://openalex.org/keywords/vedolizumab","display_name":"vedolizumab","score":1.0},{"id":"https://openalex.org/keywords/biological-therapy","display_name":"biologic therapy","score":0.7129999995231628},{"id":"https://openalex.org/keywords/remission-induction","display_name":"remission induction","score":0.906000018119812},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.8600000143051147},{"id":"https://openalex.org/keywords/serious-adverse-events","display_name":"serious adverse events","score":0.6899999976158142},{"id":"https://openalex.org/keywords/treatment-efficacy-comparison","display_name":"treatment efficacy comparison","score":0.6290000081062317},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tnf-alpha-inhibitors","display_name":"TNF-alpha inhibitors","score":0.6299999952316284},{"id":"https://openalex.org/keywords/real-world-evidence","display_name":"real-world evidence","score":0.49000000953674316},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.5559999942779541},{"id":"https://openalex.org/keywords/patient-reported-outcomes","display_name":"patient-reported outcomes","score":0.515999972820282},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.671999990940094}],"concepts":[{"id":"https://openalex.org/C2776207728","wikidata":"https://www.wikidata.org/wiki/Q7918002","display_name":"Vedolizumab","level":4,"score":0.9106061458587646},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8740261197090149},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.6988688111305237},{"id":"https://openalex.org/C2781145037","wikidata":"https://www.wikidata.org/wiki/Q5011772","display_name":"CINAHL","level":3,"score":0.6794273853302002},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.6721106171607971},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.6379601955413818},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.621442437171936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5860271453857422},{"id":"https://openalex.org/C3020774429","wikidata":"https://www.wikidata.org/wiki/Q1201886","display_name":"Web of science","level":3,"score":0.4760206341743469},{"id":"https://openalex.org/C2780132546","wikidata":"https://www.wikidata.org/wiki/Q348260","display_name":"Adalimumab","level":3,"score":0.4626169502735138},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4325111210346222},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3571467995643616},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.35026705265045166},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.21989142894744873},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10975316166877747},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.07186833024024963},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14309/01.ajg.0000953404.12751.ab","doi":"https://doi.org/10.14309/01.ajg.0000953404.12751.ab","is_oa":false,"landing_page_url":"http://dx.doi.org/10.14309/01.ajg.0000953404.12751.ab","pdf_url":null,"source":{"id":"https://openalex.org/S66441642","display_name":"The American Journal of Gastroenterology","issn_l":"0002-9270","issn":["0002-9270","1572-0241"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390350213","https://openalex.org/W4367368248","https://openalex.org/W4387751219","https://openalex.org/W4401325374","https://openalex.org/W4316086203","https://openalex.org/W4417171185","https://openalex.org/W3026683463","https://openalex.org/W4297962909","https://openalex.org/W2424384249","https://openalex.org/W3000034970"],"abstract_inverted_index":{"Introduction:":[0],"Crohn's":[1,329],"disease":[2,330],"(CD)":[3],"continues":[4],"to":[5,24,39,46,98,117,228,255,346],"pose":[6],"a":[7,137,173,186],"substantial":[8],"health":[9,352],"issue,":[10],"perplexing":[11],"patients":[12,285],"and":[13,21,31,63,87,110,143,163,179,201,220,247,298,312,322,326,340,350,363],"healthcare":[14],"professionals":[15],"because":[16],"of":[17,49,76,107,141,147,151,177,183,189,236,263,324,360],"its":[18],"erratic":[19],"progression":[20],"inconsistent":[22],"reaction":[23],"treatment.":[25],"Biological":[26],"drugs":[27],"like":[28],"Adalimumab":[29,325],"(ADA)":[30],"Vedolizumab":[32,327],"(VDZ)":[33],"have":[34],"become":[35],"increasingly":[36],"popular":[37],"due":[38],"their":[40],"potential":[41],"efficacy":[42,321],"in":[43,231,258,316,328,333],"treating":[44],"moderate":[45],"severe":[47],"cases":[48],"the":[50,53,79,229,256,271,320,358],"disease.":[51],"Nonetheless,":[52],"data":[54],"comparing":[55,319],"these":[56],"2":[57,129],"treatments":[58],"can":[59],"often":[60],"be":[61],"diverse":[62],"occasionally":[64],"contradictory.":[65],"Methods:":[66],"A":[67],"systematic":[68,310],"search":[69],"was":[70,172,294],"conducted":[71],"on":[72,366],"PubMed,":[73],"Medline,":[74],"Web":[75],"Science,":[77],"Scopus,":[78],"Cochrane":[80],"Library,":[81],"Embase,":[82],"Google":[83],"Scholar,":[84],"CINAHL,":[85],"Clinicaltrials.gov,":[86],"WHO":[88],"trials":[89],"registry":[90],"(ICTRP)":[91],"from":[92],"database":[93],"inception":[94],"until":[95],"April":[96],"2023":[97],"look":[99],"for":[100,145,181],"potentially":[101],"eligible":[102,108],"articles.":[103],"The":[104,132],"reference":[105],"lists":[106],"studies":[109],"review":[111,311],"articles":[112],"were":[113,125,226,253],"also":[114],"checked":[115],"manually":[116],"identify":[118],"other":[119],"relevant":[120],"publications.":[121],"All":[122],"retrieval":[123],"processes":[124],"performed":[126],"independently":[127],"by":[128],"researchers.":[130],"Results:":[131],"forest":[133],"plot":[134,356],"analysis":[135],"showed":[136,213],"significantly":[138],"beneficial":[139,175],"effect":[140,176],"ADA":[142,152,178,190,215,237,242,264,282,362],"VDZ":[144,154,180,192,221,248,266,297,365],"induction":[146,182],"remission":[148,232],"with":[149,185,234,261],"superiority":[150,188,235,262],"over":[153,191,238,265],"among":[155,193,267,283],"CD":[156,194,268,284],"patients:":[157,195],"OR=":[158,164,196,202],"3,037,":[159],"P":[160,166,198,204,217,223,244,250,287,301],"=":[161,167,199,205,218,224,245,251,288,302],"0,000":[162,200],"2,444,":[165],"0,000,":[168,206],"respectively.":[169,207],"Also,":[170],"there":[171],"significant":[174,292],"response":[184,259],"slight":[187],"2,601,":[197],"2,254,":[203],"Regarding":[208,270],"maintenance":[209],"therapy,":[210],"our":[211],"meta-analysis":[212],"that":[214],"(OR=4,808,":[216],"0,000)":[219,225,246],"(OR=2,014,":[222],"superior":[227,254],"placebo":[230,257,275,299],"rates":[233],"VDZ.":[239],"Similarly,":[240],"both":[241],"(OR=4,330,":[243],"(OR=1,581,":[249],"0,004)":[252],"rates,":[260],"patients.":[269],"serious":[272,278],"adverse":[273,279],"events,":[274],"presented":[276],"more":[277],"events":[280],"than":[281],"(OR=0,514,":[286],"0,000).":[289],"However,":[290],"no":[291],"difference":[293],"detected":[295],"between":[296],"(OR=1,284,":[300],"0,076)":[303],"(Figure":[304],"1).":[305],"Conclusion:":[306],"Systematic":[307],"investigation,":[308],"through":[309],"meta-analysis,":[313],"is":[314],"paramount":[315],"healthcare.":[317],"Specifically,":[318],"safety":[323],"management":[331],"aids":[332],"refining":[334],"treatment":[335],"strategies,":[336],"ensuring":[337],"patient":[338,348],"safety,":[339],"guiding":[341],"future":[342],"research,":[343],"ultimately":[344],"contributing":[345],"better":[347],"care":[349],"improved":[351],"outcomes.Figure":[353],"1.:":[354],"Forest":[355],"showing":[357],"effects":[359],"(A)":[361],"(B)":[364],"CD.":[367]},"counts_by_year":[],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2023-10-19T00:00:00"}