{"id":"https://openalex.org/W4387728708","doi":"https://doi.org/10.1080/10408444.2023.2258925","title":"A review of pulmonary neutrophilia and insights into the key role of neutrophils in particle-induced pathogenesis in the lung from animal studies of lunar dusts and other poorly soluble dust particles","display_name":"A review of pulmonary neutrophilia and insights into the key role of neutrophils in particle-induced pathogenesis in the lung from animal studies of lunar dusts and other poorly soluble dust particles","publication_year":2023,"publication_date":"2023-09-14","ids":{"openalex":"https://openalex.org/W4387728708","doi":"https://doi.org/10.1080/10408444.2023.2258925","pmid":"https://pubmed.ncbi.nlm.nih.gov/37850621","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10872584"},"language":"en","primary_location":{"id":"doi:10.1080/10408444.2023.2258925","doi":"https://doi.org/10.1080/10408444.2023.2258925","is_oa":true,"landing_page_url":"https://doi.org/10.1080/10408444.2023.2258925","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/10408444.2023.2258925?needAccess=true","source":{"id":"https://openalex.org/S78069630","display_name":"Critical Reviews in Toxicology","issn_l":"0045-6446","issn":["0045-6446","1040-8444","1547-6898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Toxicology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/10408444.2023.2258925?needAccess=true","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102055773","display_name":"Chiu\u2010Wing Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153156064","display_name":"KBR (United States)","ror":"https://ror.org/01g1xae87","country_code":"US","type":"company","lineage":["https://openalex.org/I153156064"]},{"id":"https://openalex.org/I4210124779","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80","country_code":"US","type":"government","lineage":["https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Chiu-wing Lam","raw_affiliation_strings":["Biomedical & Environmental Research Department, KBR Toxicology & Environmental Chemistry, Houston, TX, USA","Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA","Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, TX, USA","Biomedical & Environmental Research Department, KBR Toxicology & Environmental Chemistry, Houston, TX, USA; Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA; Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical & Environmental Research Department, KBR Toxicology & Environmental Chemistry, Houston, TX, USA","institution_ids":["https://openalex.org/I153156064"]},{"raw_affiliation_string":"Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA","institution_ids":["https://openalex.org/I4210149382"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, TX, USA","institution_ids":[]},{"raw_affiliation_string":"Biomedical & Environmental Research Department, KBR Toxicology & Environmental Chemistry, Houston, TX, USA; Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA; Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, TX, USA","institution_ids":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108678933","display_name":"Vincent Castranova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vincent Castranova","raw_affiliation_strings":["Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA","institution_ids":["https://openalex.org/I198423848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041802127","display_name":"Kevin E. Driscoll","orcid":"https://orcid.org/0000-0002-4544-9122","observed_orcids":["https://orcid.org/0000-0002-4544-9122"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Driscoll","raw_affiliation_strings":["Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044206554","display_name":"David B. Warheit","orcid":"https://orcid.org/0000-0002-9780-4704","observed_orcids":["https://orcid.org/0000-0002-9780-4704"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Warheit","raw_affiliation_strings":["Warheit Scientific LLC, Wilmington, DE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warheit Scientific LLC, Wilmington, DE, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013762039","display_name":"Valerie Ryder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valerie Ryder","raw_affiliation_strings":["Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA","institution_ids":["https://openalex.org/I4210149382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100449362","display_name":"Ye Zhang","orcid":"https://orcid.org/0009-0000-4883-8097","observed_orcids":["https://orcid.org/0009-0000-4883-8097","https://orcid.org/0000-0001-5430-1608","https://orcid.org/0000-0002-3494-7206"]},"institutions":[{"id":"https://openalex.org/I2799863703","display_name":"Kennedy Space Center","ror":"https://ror.org/03kjpzv42","country_code":"US","type":"facility","lineage":["https://openalex.org/I2799863703","https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I4210124779","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80","country_code":"US","type":"government","lineage":["https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ye Zhang","raw_affiliation_strings":["Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA","Utilization and Life Sciences Office, Kennedy Space Center, Merritt Island, FL, USA","Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA.; Utilization and Life Sciences Office, Kennedy Space Center, Merritt Island, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA","institution_ids":["https://openalex.org/I4210149382"]},{"raw_affiliation_string":"Utilization and Life Sciences Office, Kennedy Space Center, Merritt Island, FL, USA","institution_ids":["https://openalex.org/I2799863703"]},{"raw_affiliation_string":"Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA.; Utilization and Life Sciences Office, Kennedy Space Center, Merritt Island, FL, USA","institution_ids":["https://openalex.org/I2799863703","https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012166862","display_name":"Patti C. Zeidler-Erdely","orcid":"https://orcid.org/0000-0003-1180-3223","observed_orcids":["https://orcid.org/0000-0003-1180-3223"]},"institutions":[{"id":"https://openalex.org/I198423848","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934","https://openalex.org/I198423848"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patti Zeidler-Erdely","raw_affiliation_strings":["Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA","institution_ids":["https://openalex.org/I198423848"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050221150","display_name":"Robert Lee Hunter","orcid":"https://orcid.org/0000-0002-2105-8856","observed_orcids":["https://orcid.org/0000-0002-2105-8856"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Hunter","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, Houston, TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029614648","display_name":"Robert R. Scully","orcid":"https://orcid.org/0000-0001-6023-7737","observed_orcids":["https://orcid.org/0000-0001-6023-7737"]},"institutions":[{"id":"https://openalex.org/I153156064","display_name":"KBR (United States)","ror":"https://ror.org/01g1xae87","country_code":"US","type":"company","lineage":["https://openalex.org/I153156064"]},{"id":"https://openalex.org/I4210124779","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80","country_code":"US","type":"government","lineage":["https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Scully","raw_affiliation_strings":["Biomedical & Environmental Research Department, KBR Toxicology & Environmental Chemistry, Houston, TX, USA","Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA","Biomedical & Environmental Research Department, KBR Toxicology & Environmental Chemistry, Houston, TX, USA.; Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical & Environmental Research Department, KBR Toxicology & Environmental Chemistry, Houston, TX, USA","institution_ids":["https://openalex.org/I153156064"]},{"raw_affiliation_string":"Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA","institution_ids":["https://openalex.org/I4210149382"]},{"raw_affiliation_string":"Biomedical & Environmental Research Department, KBR Toxicology & Environmental Chemistry, Houston, TX, USA.; Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA","institution_ids":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002041799","display_name":"William T. Wallace","orcid":"https://orcid.org/0000-0002-4246-2428","observed_orcids":["https://orcid.org/0000-0002-4246-2428"]},"institutions":[{"id":"https://openalex.org/I153156064","display_name":"KBR (United States)","ror":"https://ror.org/01g1xae87","country_code":"US","type":"company","lineage":["https://openalex.org/I153156064"]},{"id":"https://openalex.org/I4210124779","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80","country_code":"US","type":"government","lineage":["https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Wallace","raw_affiliation_strings":["Biomedical & Environmental Research Department, KBR Toxicology & Environmental Chemistry, Houston, TX, USA","Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA","Biomedical & Environmental Research Department, KBR Toxicology & Environmental Chemistry, Houston, TX, USA.; Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical & Environmental Research Department, KBR Toxicology & Environmental Chemistry, Houston, TX, USA","institution_ids":["https://openalex.org/I153156064"]},{"raw_affiliation_string":"Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA","institution_ids":["https://openalex.org/I4210149382"]},{"raw_affiliation_string":"Biomedical & Environmental Research Department, KBR Toxicology & Environmental Chemistry, Houston, TX, USA.; Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA","institution_ids":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081850797","display_name":"John T. James","orcid":"https://orcid.org/0000-0001-8098-8992","observed_orcids":["https://orcid.org/0000-0001-8098-8992"]},"institutions":[{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John James","raw_affiliation_strings":["Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA","institution_ids":["https://openalex.org/I4210149382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045172445","display_name":"Brian E. Crucian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Crucian","raw_affiliation_strings":["Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA","institution_ids":["https://openalex.org/I4210149382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056614821","display_name":"Mayra Nelman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153156064","display_name":"KBR (United States)","ror":"https://ror.org/01g1xae87","country_code":"US","type":"company","lineage":["https://openalex.org/I153156064"]},{"id":"https://openalex.org/I4210124779","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80","country_code":"US","type":"government","lineage":["https://openalex.org/I4210124779"]},{"id":"https://openalex.org/I4210149382","display_name":"Johnson Space Center","ror":"https://ror.org/04xx4z452","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mayra Nelman","raw_affiliation_strings":["Biomedical & Environmental Research Department, KBR Toxicology & Environmental Chemistry, Houston, TX, USA","Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA","Biomedical & Environmental Research Department, KBR Toxicology & Environmental Chemistry, Houston, TX, USA.; Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical & Environmental Research Department, KBR Toxicology & Environmental Chemistry, Houston, TX, USA","institution_ids":["https://openalex.org/I153156064"]},{"raw_affiliation_string":"Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA","institution_ids":["https://openalex.org/I4210149382"]},{"raw_affiliation_string":"Biomedical & Environmental Research Department, KBR Toxicology & Environmental Chemistry, Houston, TX, USA.; Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX, USA","institution_ids":["https://openalex.org/I4210124779","https://openalex.org/I4210149382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045232280","display_name":"Richard McCluskey","orcid":"https://orcid.org/0000-0003-0508-9617","observed_orcids":["https://orcid.org/0000-0003-0508-9617"]},"institutions":[{"id":"https://openalex.org/I2800246717","display_name":"Civil Aerospace Medical Institute","ror":"https://ror.org/043e04s74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282462722","https://openalex.org/I1342895125","https://openalex.org/I2800246717"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard McCluskey","raw_affiliation_strings":["FAA Civil Aerospace Medical Institute, Oklahoma City, OK, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FAA Civil Aerospace Medical Institute, Oklahoma City, OK, USA","institution_ids":["https://openalex.org/I2800246717"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112777674","display_name":"Donald E. Gardner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald Gardner","raw_affiliation_strings":["Inhalation Toxicology Associates, Savannah, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inhalation Toxicology Associates, Savannah, GA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046473814","display_name":"Roger A. Renne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roger Renne","raw_affiliation_strings":["Roger Renne ToxPath Consulting Inc., Sumner, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Roger Renne ToxPath Consulting Inc., Sumner, WA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108566137","display_name":"Roger O. McClellan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roger McClellan","raw_affiliation_strings":["Toxicology and Human Health Risk Analysis, Albuquerque, NM, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxicology and Human Health Risk Analysis, Albuquerque, NM, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5102055773","https://openalex.org/A5108678933"],"corresponding_institution_ids":["https://openalex.org/I153156064","https://openalex.org/I198423848","https://openalex.org/I4210124779","https://openalex.org/I4210149382"],"apc_list":null,"apc_paid":null,"fwci":0.3096,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.30558659,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"53","issue":"8","first_page":"441","last_page":"479"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.4262999892234802,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.4262999892234802,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.24819999933242798,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.11810000240802765,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-neutrophilia","display_name":"pulmonary neutrophilia","score":0.8500000238418579},{"id":"https://openalex.org/keywords/alveolar-neutrophils","display_name":"alveolar neutrophils","score":0.9539999961853027},{"id":"https://openalex.org/keywords/lunar-dust","display_name":"lunar dust","score":0.8510000109672546},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7689999938011169},{"id":"https://openalex.org/keywords/intratracheal-instillation","display_name":"intratracheal instillation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/adverse-outcome-pathways","display_name":"adverse outcome pathways","score":0.6959999799728394},{"id":"https://openalex.org/keywords/titanium-dioxide-nanoparticles","display_name":"titanium dioxide nanoparticles","score":0.7080000042915344},{"id":"https://openalex.org/keywords/quartz","display_name":"quartz","score":0.7789999842643738},{"id":"https://openalex.org/keywords/alveolar-epithelial-cells","display_name":"alveolar epithelial cells","score":0.8349999785423279},{"id":"https://openalex.org/keywords/particle-clearance","display_name":"particle clearance","score":0.4350000023841858},{"id":"https://openalex.org/keywords/particle-size-effects","display_name":"particle size effects","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7697024345397949},{"id":"https://openalex.org/C2781047374","wikidata":"https://www.wikidata.org/wiki/Q2100012","display_name":"Pulmonary toxicity","level":3,"score":0.6935907006263733},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6671550869941711},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6177670955657959},{"id":"https://openalex.org/C2779777708","wikidata":"https://www.wikidata.org/wiki/Q6033622","display_name":"Inhalation exposure","level":3,"score":0.5767964124679565},{"id":"https://openalex.org/C2777590204","wikidata":"https://www.wikidata.org/wiki/Q125223","display_name":"Oxygen toxicity","level":3,"score":0.5414389371871948},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.47076845169067383},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.44382452964782715},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42679375410079956},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41950860619544983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35341688990592957},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0988692045211792},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09181764721870422}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004391","descriptor_name":"Dust","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008171","descriptor_name":"Lung Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014025","descriptor_name":"Titanium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/10408444.2023.2258925","doi":"https://doi.org/10.1080/10408444.2023.2258925","is_oa":true,"landing_page_url":"https://doi.org/10.1080/10408444.2023.2258925","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/10408444.2023.2258925?needAccess=true","source":{"id":"https://openalex.org/S78069630","display_name":"Critical Reviews in Toxicology","issn_l":"0045-6446","issn":["0045-6446","1040-8444","1547-6898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Toxicology","raw_type":"journal-article"},{"id":"pmid:37850621","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37850621","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10872584","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10872584","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10872584/pdf/nihms-1941713.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Crit Rev Toxicol","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.library.tmc.edu:uthgsbs_docs-6739","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.library.tmc.edu/uthgsbs_docs/5880","pdf_url":"https://digitalcommons.library.tmc.edu/cgi/viewcontent.cgi?article=6739&context=uthgsbs_docs","source":{"id":"https://openalex.org/S4377196655","display_name":"Digital Commons-TMC (Texas Medical Center)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1337852284","host_organization_name":"Texas Medical Center","host_organization_lineage":["https://openalex.org/I1337852284"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty, Staff and Student Publications","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1080/10408444.2023.2258925","doi":"https://doi.org/10.1080/10408444.2023.2258925","is_oa":true,"landing_page_url":"https://doi.org/10.1080/10408444.2023.2258925","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/10408444.2023.2258925?needAccess=true","source":{"id":"https://openalex.org/S78069630","display_name":"Critical Reviews in Toxicology","issn_l":"0045-6446","issn":["0045-6446","1040-8444","1547-6898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3933523533","display_name":null,"funder_award_id":"NAS9-0.2078","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"},{"id":"https://openalex.org/G7543494365","display_name":null,"funder_award_id":"CC999999","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"},{"id":"https://openalex.org/F4320313675","display_name":"University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337382","display_name":"National Institute for Occupational Safety and Health","ror":"https://ror.org/0502a2655"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387728708.pdf","grobid_xml":"https://content.openalex.org/works/W4387728708.grobid-xml"},"referenced_works_count":155,"referenced_works":["https://openalex.org/W54501125","https://openalex.org/W81369347","https://openalex.org/W94556339","https://openalex.org/W121781868","https://openalex.org/W217840663","https://openalex.org/W241105931","https://openalex.org/W424760417","https://openalex.org/W1489035612","https://openalex.org/W1507093655","https://openalex.org/W1524236374","https://openalex.org/W1529565383","https://openalex.org/W1541750678","https://openalex.org/W1584581818","https://openalex.org/W1587489068","https://openalex.org/W1597240697","https://openalex.org/W1832818975","https://openalex.org/W1896499883","https://openalex.org/W1915510216","https://openalex.org/W1964830741","https://openalex.org/W1966678873","https://openalex.org/W1967026835","https://openalex.org/W1969030685","https://openalex.org/W1970482393","https://openalex.org/W1971422062","https://openalex.org/W1973340131","https://openalex.org/W1974678821","https://openalex.org/W1976646654","https://openalex.org/W1979424160","https://openalex.org/W1985501344","https://openalex.org/W1988781537","https://openalex.org/W1988888066","https://openalex.org/W1989644479","https://openalex.org/W1992646030","https://openalex.org/W1992999268","https://openalex.org/W1998012803","https://openalex.org/W1998593680","https://openalex.org/W2014674765","https://openalex.org/W2015291003","https://openalex.org/W2016904560","https://openalex.org/W2018569462","https://openalex.org/W2020718028","https://openalex.org/W2028026130","https://openalex.org/W2037558943","https://openalex.org/W2041752231","https://openalex.org/W2043787490","https://openalex.org/W2044353844","https://openalex.org/W2044708698","https://openalex.org/W2046209354","https://openalex.org/W2047056154","https://openalex.org/W2047377621","https://openalex.org/W2047882502","https://openalex.org/W2050191889","https://openalex.org/W2051857895","https://openalex.org/W2055547672","https://openalex.org/W2057119680","https://openalex.org/W2061345139","https://openalex.org/W2062279417","https://openalex.org/W2063130535","https://openalex.org/W2063857972","https://openalex.org/W2063892429","https://openalex.org/W2070304486","https://openalex.org/W2071889146","https://openalex.org/W2072629257","https://openalex.org/W2075051672","https://openalex.org/W2076826263","https://openalex.org/W2077699069","https://openalex.org/W2078344429","https://openalex.org/W2079887533","https://openalex.org/W2085053431","https://openalex.org/W2088090527","https://openalex.org/W2090897026","https://openalex.org/W2091557419","https://openalex.org/W2091852951","https://openalex.org/W2095138166","https://openalex.org/W2095285770","https://openalex.org/W2098100151","https://openalex.org/W2100633554","https://openalex.org/W2101245680","https://openalex.org/W2101799341","https://openalex.org/W2109351861","https://openalex.org/W2110087431","https://openalex.org/W2110953827","https://openalex.org/W2111979438","https://openalex.org/W2113637303","https://openalex.org/W2115124025","https://openalex.org/W2116344867","https://openalex.org/W2116761653","https://openalex.org/W2117880839","https://openalex.org/W2119073032","https://openalex.org/W2122021233","https://openalex.org/W2122806458","https://openalex.org/W2123537216","https://openalex.org/W2123884323","https://openalex.org/W2126614953","https://openalex.org/W2131513398","https://openalex.org/W2133390600","https://openalex.org/W2133817540","https://openalex.org/W2134896722","https://openalex.org/W2148562253","https://openalex.org/W2148747550","https://openalex.org/W2149947206","https://openalex.org/W2155118487","https://openalex.org/W2155323443","https://openalex.org/W2155607291","https://openalex.org/W2156242978","https://openalex.org/W2157531458","https://openalex.org/W2158653042","https://openalex.org/W2162621124","https://openalex.org/W2163577514","https://openalex.org/W2165803245","https://openalex.org/W2165892104","https://openalex.org/W2166534990","https://openalex.org/W2166604768","https://openalex.org/W2169055218","https://openalex.org/W2169783846","https://openalex.org/W2171895895","https://openalex.org/W2172385488","https://openalex.org/W2318698569","https://openalex.org/W2323434063","https://openalex.org/W2329412070","https://openalex.org/W2336592170","https://openalex.org/W2412701043","https://openalex.org/W2503510138","https://openalex.org/W2531071129","https://openalex.org/W2562289849","https://openalex.org/W2577093491","https://openalex.org/W2593762970","https://openalex.org/W2616028603","https://openalex.org/W2740895138","https://openalex.org/W2759230352","https://openalex.org/W2783448862","https://openalex.org/W2800312102","https://openalex.org/W2906021714","https://openalex.org/W2916703791","https://openalex.org/W2924792532","https://openalex.org/W2935666746","https://openalex.org/W2981816476","https://openalex.org/W3011931592","https://openalex.org/W3104394245","https://openalex.org/W3133341784","https://openalex.org/W4206756949","https://openalex.org/W4206925177","https://openalex.org/W4220842577","https://openalex.org/W4230927719","https://openalex.org/W4246918661","https://openalex.org/W4249073143","https://openalex.org/W4249201578","https://openalex.org/W4288080841","https://openalex.org/W4292631508","https://openalex.org/W4300503711","https://openalex.org/W4309542861","https://openalex.org/W4311191676","https://openalex.org/W4360976476","https://openalex.org/W6663147013","https://openalex.org/W7147225371"],"related_works":["https://openalex.org/W7053315824","https://openalex.org/W4220842577","https://openalex.org/W7058151479","https://openalex.org/W4413289967","https://openalex.org/W1570795554","https://openalex.org/W2591880296","https://openalex.org/W7014330213","https://openalex.org/W2091852951","https://openalex.org/W7033712999","https://openalex.org/W3171205797"],"abstract_inverted_index":{"The":[0,173,188,479],"mechanisms":[1],"of":[2,21,46,61,86,105,133,146,206,230,238,256,339,348,362,383,418,467,492],"particle-induced":[3,199,484],"pathogenesis":[4,255,430],"in":[5,16,43,103,126,148,156,198,203,253,267,329,413,439],"the":[6,17,38,41,44,55,59,123,127,137,143,157,204,227,239,254,276,285,289,336,359,454],"lung":[7,18,205,222,246,257,314,425,429,458,485],"remain":[8],"poorly":[9,270],"understood.":[10],"Neutrophilic":[11],"inflammation":[12],"and":[13,78,107,113,161,177,185,201,245,259,311,325,350,374,406,463,498],"oxidative":[14,28,420],"stress":[15,29,421],"are":[19,131,450],"hallmarks":[20],"toxicity.":[22,426],"Some":[23],"investigators":[24],"have":[25,293,322],"postulated":[26],"that":[27,76,116,151,164,191,224,280,378,422],"from":[30,84,95,154,162,275,303],"particle":[31,243,468],"surface":[32,81,356],"reactive":[33],"oxygen":[34],"species":[35,265],"(psROS)":[36],"on":[37,142,210,226,242,444],"dust":[39,63,287,343,396,433,496],"produces":[40],"toxicopathology":[42],"lungs":[45,331],"dust-exposed":[47,207],"animals.":[48,208],"This":[49,427],"postulate":[50,392],"was":[51],"tested":[52],"concurrently":[53],"with":[54,91,181,461,476],"studies":[56,85],"to":[57,68,72,122,167,269,284,308,319,335,372,386,409,424,495],"elucidate":[58],"toxicity":[60,109,125,139,202,469],"lunar":[62,80,98],"(LD),":[64],"which":[65,100,365,403],"is":[66],"believed":[67],"contain":[69],"psROS":[70,117],"due":[71],"high-speed":[73],"micrometeoroid":[74],"bombardment":[75],"fractured":[77],"pulverized":[79],"regolith.":[82],"Results":[83],"rats":[87,155,163,292,317,333,440],"intratracheally":[88],"instilled":[89],"(ITI)":[90],"three":[92],"LDs":[93],"(prepared":[94],"an":[96,215],"Apollo-14":[97],"regolith),":[99],"differed":[101],"14-fold":[102],"levels":[104],"psROS,":[106],"two":[108],"reference":[110],"dusts":[111,449],"(TiO2":[112],"quartz)":[114],"indicated":[115],"had":[118],"no":[119],"significant":[120],"contribution":[121],"dusts\u2019":[124],"lung.":[128],"Reported":[129],"here":[130],"results":[132,189],"further":[134,248],"investigations":[135],"by":[136],"LD":[138,169],"study":[140,160],"team":[141],"toxicological":[144],"role":[145,197,229],"oxidants":[147,174,411],"alveolar":[149,192,231,295,368],"neutrophils":[150,176,179,193,296,310,324,384,405],"were":[152,165],"harvested":[153],"5-dust":[158],"ITI":[159],"exposed":[166,318,334],"airborne":[168],"for":[170,220,483,489],"4":[171],"weeks.":[172],"per":[175],"all":[178],"increased":[180],"dose,":[182],"exposure":[183,244,434],"time":[184],"dust\u2019s":[186],"cytotoxicity.":[187],"suggest":[190],"play":[194],"a":[195,250,345,351,380,414,445,471,477],"critical":[196,236],"injury":[200],"Based":[209],"these":[211],"results,":[212],"we":[213,391],"propose":[214],"adverse":[216],"outcome":[217],"pathway":[218],"(AOP)":[219],"particle-associated":[221],"disease":[223,247,258,486],"centers":[225],"crucial":[228],"neutrophil-derived":[232],"oxidant":[233],"species.":[234],"A":[235],"review":[237],"toxicology":[240,277],"literature":[241,278],"supports":[249],"neutrophil-centric":[251],"mechanism":[252],"may":[260],"explain":[261],"previously":[262],"reported":[263],"animal":[264],"differences":[266],"responses":[268],"soluble":[271],"particles.":[272],"Key":[273],"findings":[274],"indicate":[279],"(1)":[281],"after":[282],"exposures":[283,494],"same":[286,290,337,360],"at":[288],"amount,":[291],"more":[294,301,323,326,367,376,387,436,451],"than":[297,332,358,441,453],"hamsters;":[298,442],"hamsters":[299],"clear":[300],"particles":[302,349,497],"their":[304,330],"lungs,":[305],"consequently":[306],"contributing":[307],"fewer":[309],"less":[312],"severe":[313,327,388,437],"lesions;":[315],"(2)":[316],"nano-sized":[320,342,448],"TiO2":[321],"lesions":[328,438,459],"mass-concentration":[338],"micron-sized":[340,363,455],"TiO2;":[341],"has":[344,487],"greater":[346,381],"number":[347,382],"larger":[352],"total":[353],"particle\u2013cell":[354],"contact":[355],"area":[357],"mass":[361],"dust,":[364],"triggers":[366],"epithelial":[369],"cells":[370],"(AECs)":[371],"synthesize":[373],"release":[375,401],"cytokines":[377],"recruit":[379,404],"leading":[385],"lesions.":[389],"Thus,":[390],"that,":[393],"during":[394],"chronic":[395],"exposure,":[397],"particle-inflicted":[398],"AECs":[399],"persistently":[400],"cytokines,":[402],"activate":[407],"them":[408],"produce":[410],"resulting":[412],"prolonged":[415],"continuous":[416],"source":[417],"endogenous":[419],"leads":[423],"neutrophil-driven":[428],"explains":[431],"why":[432,457,464],"induces":[435],"why,":[443],"mass-dose":[446],"basis,":[447],"toxic":[452],"dusts;":[456],"progress":[460],"time;":[462],"dose\u2013response":[465],"curves":[466],"exhibit":[470],"hockey":[472],"stick":[473],"like":[474],"shape":[475],"threshold.":[478],"neutrophil":[480],"centric":[481],"AOP":[482],"implications":[488],"risk":[490],"assessment":[491],"human":[493],"environmental":[499],"particulate":[500],"matter.":[501]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-10-19T00:00:00"}
