{"id":"https://openalex.org/W4387701445","doi":"https://doi.org/10.1038/s41467-023-42227-0","title":"O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations","display_name":"O-GlcNAcylation regulates neurofilament-light assembly and function and is perturbed by Charcot-Marie-Tooth disease mutations","publication_year":2023,"publication_date":"2023-10-17","ids":{"openalex":"https://openalex.org/W4387701445","doi":"https://doi.org/10.1038/s41467-023-42227-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/36865196","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9980138"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-023-42227-0","doi":"https://doi.org/10.1038/s41467-023-42227-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-42227-0","pdf_url":"https://www.nature.com/articles/s41467-023-42227-0.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-023-42227-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023584756","display_name":"Duc T. Huynh","orcid":"https://orcid.org/0000-0002-4832-8369","observed_orcids":["https://orcid.org/0000-0002-4832-8369"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duc T. Huynh","raw_affiliation_strings":["Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA"],"raw_orcid":"https://orcid.org/0000-0002-4832-8369","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059827125","display_name":"Kalina N. Tsolova","orcid":"https://orcid.org/0000-0003-4537-6303","observed_orcids":["https://orcid.org/0000-0003-4537-6303"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalina N. Tsolova","raw_affiliation_strings":["Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053884492","display_name":"Abigail J. Watson","orcid":"https://orcid.org/0000-0002-4663-9091","observed_orcids":["https://orcid.org/0000-0002-4663-9091"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abigail J. Watson","raw_affiliation_strings":["Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA"],"raw_orcid":"https://orcid.org/0000-0002-4663-9091","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078064224","display_name":"Sai Kwan Khal","orcid":"https://orcid.org/0000-0002-2433-713X","observed_orcids":["https://orcid.org/0000-0002-2433-713X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sai Kwan Khal","raw_affiliation_strings":["Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA"],"raw_orcid":"https://orcid.org/0000-0002-2433-713X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jordan R. Green","orcid":"https://orcid.org/0000-0002-4325-8576","observed_orcids":["https://orcid.org/0000-0002-4325-8576"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan R. Green","raw_affiliation_strings":["Department of Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA"],"raw_orcid":"https://orcid.org/0000-0002-4325-8576","affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100446351","display_name":"Di Li","orcid":"https://orcid.org/0000-0001-7414-4646","observed_orcids":["https://orcid.org/0000-0001-7414-4646"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Di Li","raw_affiliation_strings":["Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA"],"raw_orcid":"https://orcid.org/0000-0001-7414-4646","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103813557","display_name":"Jimin Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jimin Hu","raw_affiliation_strings":["Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I170897317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054443109","display_name":"Erik J. Soderblom","orcid":"https://orcid.org/0000-0002-6765-1786","observed_orcids":["https://orcid.org/0000-0002-6765-1786"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erik J. Soderblom","raw_affiliation_strings":["Proteomics and Metabolomics Shared Resource, Duke University School of Medicine, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics and Metabolomics Shared Resource, Duke University School of Medicine, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066099267","display_name":"Jen\u2010Tsan Chi","orcid":"https://orcid.org/0000-0003-3433-903X","observed_orcids":["https://orcid.org/0000-0003-3433-903X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jen-Tsan Chi","raw_affiliation_strings":["Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, 27710, USA"],"raw_orcid":"https://orcid.org/0000-0003-3433-903X","affiliations":[{"raw_affiliation_string":"Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033015769","display_name":"Chantell S. Evans","orcid":"https://orcid.org/0000-0001-9401-8604","observed_orcids":["https://orcid.org/0000-0001-9401-8604"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chantell S. Evans","raw_affiliation_strings":["Department of Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055915667","display_name":"Michael Boyce","orcid":"https://orcid.org/0000-0002-2729-4876","observed_orcids":["https://orcid.org/0000-0002-2729-4876"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael Boyce","raw_affiliation_strings":["Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA. michael.boyce@duke.edu","Department of Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA. michael.boyce@duke.edu","Department of Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA"],"raw_orcid":"https://orcid.org/0000-0002-2729-4876","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA. michael.boyce@duke.edu","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA. michael.boyce@duke.edu","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055915667"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"],"apc_list":{"value":6290,"currency":"USD","value_usd":6290},"apc_paid":{"value":6290,"currency":"USD","value_usd":6290},"fwci":1.7657,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.84920402,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"14","issue":"1","first_page":"6558","last_page":"6558"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12331","display_name":"Hereditary Neurological Disorders","score":0.8877000212669373,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.04820000007748604,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.03500000014901161,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/o-glcnacylation","display_name":"O-GlcNAcylation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/neurofilament-light-chain","display_name":"neurofilament light chain","score":0.9150000214576721},{"id":"https://openalex.org/keywords/neurofilament-assembly","display_name":"neurofilament assembly","score":0.9769999980926514},{"id":"https://openalex.org/keywords/charcot-marie-tooth-disease","display_name":"Charcot-Marie-Tooth disease","score":0.9639999866485596},{"id":"https://openalex.org/keywords/alpha-internexin","display_name":"alpha-internexin","score":0.7609999775886536},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.9210000038146973},{"id":"https://openalex.org/keywords/organelle-trafficking","display_name":"organelle trafficking","score":0.8159999847412109},{"id":"https://openalex.org/keywords/neuronal-cytoskeleton","display_name":"neuronal cytoskeleton","score":0.7960000038146973},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.722000002861023},{"id":"https://openalex.org/keywords/site-specific-glycosylation","display_name":"site-specific glycosylation","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6588222980499268},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6542212963104248},{"id":"https://openalex.org/C157207234","wikidata":"https://www.wikidata.org/wiki/Q962115","display_name":"Neurofilament","level":3,"score":0.6054097414016724},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5211639404296875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5030097365379333},{"id":"https://openalex.org/C2777313579","wikidata":"https://www.wikidata.org/wiki/Q898365","display_name":"Glycosylation","level":2,"score":0.48728644847869873},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4623132646083832},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.4519370496273041},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3224663734436035},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2414642572402954},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.11788389086723328},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10678514838218689},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.08374789357185364},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0}],"mesh":[],"locations_count":8,"locations":[{"id":"doi:10.1038/s41467-023-42227-0","doi":"https://doi.org/10.1038/s41467-023-42227-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-42227-0","pdf_url":"https://www.nature.com/articles/s41467-023-42227-0.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"doi:10.1101/2023.02.22.529563","doi":"https://doi.org/10.1101/2023.02.22.529563","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.02.22.529563","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/02/22/2023.02.22.529563.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10582078","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10582078","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10582078/pdf/41467_2023_Article_42227.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmid:36865196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36865196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:37848414","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37848414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9980138","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9980138","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42227-0","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-023-42227-0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:bc888ee5fb374fb2a241843afc353ebd","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/bc888ee5fb374fb2a241843afc353ebd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41467-023-42227-0","doi":"https://doi.org/10.1038/s41467-023-42227-0","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-023-42227-0","pdf_url":"https://www.nature.com/articles/s41467-023-42227-0.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4597471990","display_name":"San Diego Leading the Advancement of Underrepresented Neuroscientists for Change (LAUNCH) Program","funder_award_id":"R25NS117367","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5417759059","display_name":"Super-resolution Imaging via Multiple Modalities with the Zeiss Elyra 7","funder_award_id":"1s10od028703-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5813868237","display_name":"Metabolic regulation of KLHL proteins through O-glycosylation","funder_award_id":"R01NS111588","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000867366","display_name":"Cell and Molecular Biology Training Program","funder_award_id":"T32GM142605","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000905560","display_name":"Cell signaling through O-GlcNAc reader proteins","funder_award_id":"R01GM118847","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000906862","display_name":"Duke/UNC Alzheimer's Disease Research Center","funder_award_id":"P30AG072958","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320307195","display_name":"Ruth K. Broad Biomedical Research Foundation","ror":"https://ror.org/00py81415"},{"id":"https://openalex.org/F4320314494","display_name":"Hope Foundation","ror":"https://ror.org/05wf1w785"},{"id":"https://openalex.org/F4320331874","display_name":"Lord Mayor\u2019s Charitable Foundation","ror":"https://ror.org/04n7vs332"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387701445.pdf","grobid_xml":"https://content.openalex.org/works/W4387701445.grobid-xml"},"referenced_works_count":120,"referenced_works":["https://openalex.org/W1482444677","https://openalex.org/W1577662346","https://openalex.org/W1851307228","https://openalex.org/W1908742724","https://openalex.org/W1963562020","https://openalex.org/W1965355119","https://openalex.org/W1969373668","https://openalex.org/W1974082464","https://openalex.org/W1974694294","https://openalex.org/W1982045496","https://openalex.org/W1993052072","https://openalex.org/W1995784041","https://openalex.org/W1998906741","https://openalex.org/W2003301707","https://openalex.org/W2006296741","https://openalex.org/W2008679290","https://openalex.org/W2010089695","https://openalex.org/W2015357656","https://openalex.org/W2015667893","https://openalex.org/W2016755398","https://openalex.org/W2018038526","https://openalex.org/W2020441525","https://openalex.org/W2037511210","https://openalex.org/W2039205487","https://openalex.org/W2040714286","https://openalex.org/W2044444144","https://openalex.org/W2047096855","https://openalex.org/W2050775180","https://openalex.org/W2052162377","https://openalex.org/W2060744329","https://openalex.org/W2061237420","https://openalex.org/W2071883627","https://openalex.org/W2073614451","https://openalex.org/W2080199849","https://openalex.org/W2080425738","https://openalex.org/W2080845877","https://openalex.org/W2087548571","https://openalex.org/W2088336867","https://openalex.org/W2090078115","https://openalex.org/W2095039458","https://openalex.org/W2098254794","https://openalex.org/W2102272153","https://openalex.org/W2104496885","https://openalex.org/W2112319631","https://openalex.org/W2119333160","https://openalex.org/W2120036668","https://openalex.org/W2123072024","https://openalex.org/W2128727185","https://openalex.org/W2134044586","https://openalex.org/W2140409722","https://openalex.org/W2142213435","https://openalex.org/W2142353117","https://openalex.org/W2142953616","https://openalex.org/W2147529256","https://openalex.org/W2149004697","https://openalex.org/W2150168938","https://openalex.org/W2152874099","https://openalex.org/W2155360303","https://openalex.org/W2157927241","https://openalex.org/W2164029759","https://openalex.org/W2164744009","https://openalex.org/W2168386087","https://openalex.org/W2170127671","https://openalex.org/W2203095742","https://openalex.org/W2298220340","https://openalex.org/W2304181148","https://openalex.org/W2317688815","https://openalex.org/W2468142323","https://openalex.org/W2548027654","https://openalex.org/W2551863723","https://openalex.org/W2604210857","https://openalex.org/W2679424403","https://openalex.org/W2731442884","https://openalex.org/W2747147211","https://openalex.org/W2766860412","https://openalex.org/W2790898940","https://openalex.org/W2795838254","https://openalex.org/W2804509508","https://openalex.org/W2886584234","https://openalex.org/W2888395668","https://openalex.org/W2889223700","https://openalex.org/W2912342283","https://openalex.org/W2921722000","https://openalex.org/W2940091552","https://openalex.org/W2965229043","https://openalex.org/W2978053134","https://openalex.org/W2991446358","https://openalex.org/W2996913710","https://openalex.org/W2999206621","https://openalex.org/W3001807065","https://openalex.org/W3011502837","https://openalex.org/W3024239323","https://openalex.org/W3031176037","https://openalex.org/W3037835371","https://openalex.org/W3103359991","https://openalex.org/W3111946640","https://openalex.org/W3112102705","https://openalex.org/W3132472946","https://openalex.org/W3161205307","https://openalex.org/W3173088412","https://openalex.org/W3173088678","https://openalex.org/W3185646118","https://openalex.org/W3186240525","https://openalex.org/W3202535675","https://openalex.org/W3203514014","https://openalex.org/W3208691473","https://openalex.org/W4200495988","https://openalex.org/W4205210323","https://openalex.org/W4206732962","https://openalex.org/W4213133109","https://openalex.org/W4221137705","https://openalex.org/W4281653479","https://openalex.org/W4283730706","https://openalex.org/W4288424534","https://openalex.org/W4292294909","https://openalex.org/W4293783081","https://openalex.org/W4306920759","https://openalex.org/W4307502324","https://openalex.org/W4309196689","https://openalex.org/W4377966987"],"related_works":["https://openalex.org/W2123072024","https://openalex.org/W2898713735","https://openalex.org/W2090203936","https://openalex.org/W1992259548","https://openalex.org/W2161498474","https://openalex.org/W2155360303","https://openalex.org/W1577662346","https://openalex.org/W4389866396","https://openalex.org/W2322025626","https://openalex.org/W2978053134"],"abstract_inverted_index":{"The":[0],"neurofilament":[1],"(NF)":[2],"cytoskeleton":[3],"is":[4,17,25,44,53,113],"critical":[5],"for":[6,19,115],"neuronal":[7],"morphology":[8],"and":[9,24,37,74,90,131,148,161,163,171],"function.":[10],"In":[11],"particular,":[12],"the":[13,38,92,133],"neurofilament-light":[14],"(NF-L)":[15],"subunit":[16],"required":[18,114],"NF":[20,41,79,93,105,138,150,165],"assembly":[21,42,80,139,160],"in":[22,27,55,84,119],"vivo":[23],"mutated":[26],"subtypes":[28],"of":[29,40,65,104,135],"Charcot-Marie-Tooth":[30],"(CMT)":[31],"disease.":[32],"NFs":[33],"are":[34],"highly":[35],"dynamic,":[36],"regulation":[39],"state":[43],"incompletely":[45],"understood.":[46],"Here,":[47],"we":[48],"demonstrate":[49,154],"that":[50,76,97,110,155],"human":[51],"NF-L":[52,71,82,111,125,159],"modified":[54],"a":[56,62,101,142],"nutrient-sensitive":[57],"manner":[58],"by":[59],"O-linked-\u03b2-N-acetylglucosamine":[60],"(O-GlcNAc),":[61],"ubiquitous":[63],"form":[64],"intracellular":[66],"glycosylation.":[67],"We":[68,107],"identify":[69],"five":[70],"O-GlcNAc":[72,98,129],"sites":[73],"show":[75,109],"they":[77],"regulate":[78],"state.":[81],"engages":[83],"O-GlcNAc-mediated":[85],"protein-protein":[86],"interactions":[87],"with":[88,91],"itself":[89],"component":[94],"\u03b1-internexin,":[95],"implying":[96],"may":[99,167],"be":[100],"general":[102],"regulator":[103],"architecture.":[106],"further":[108],"O-GlcNAcylation":[112,136,147,166],"normal":[116],"organelle":[117],"trafficking":[118],"primary":[120],"neurons.":[121],"Finally,":[122],"several":[123],"CMT-causative":[124],"mutants":[126],"exhibit":[127],"perturbed":[128],"levels":[130],"resist":[132],"effects":[134],"on":[137],"state,":[140],"suggesting":[141],"potential":[143],"link":[144],"between":[145],"dysregulated":[146],"pathological":[149],"aggregation.":[151],"Our":[152],"results":[153],"site-specific":[156],"glycosylation":[157],"regulates":[158],"function,":[162],"aberrant":[164],"contribute":[168],"to":[169],"CMT":[170],"other":[172],"neurodegenerative":[173],"disorders.":[174]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-18T00:00:00"}