{"id":"https://openalex.org/W4387680239","doi":"https://doi.org/10.5137/1019-5149.jtn.45237-23.2","title":"Evaluation of the effect of tenoxicam on neural tube defect using an embryo culture system","display_name":"Evaluation of the effect of tenoxicam on neural tube defect using an embryo culture system","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4387680239","doi":"https://doi.org/10.5137/1019-5149.jtn.45237-23.2","pmid":"https://pubmed.ncbi.nlm.nih.gov/39087289"},"language":"en","primary_location":{"id":"doi:10.5137/1019-5149.jtn.45237-23.2","doi":"https://doi.org/10.5137/1019-5149.jtn.45237-23.2","is_oa":true,"landing_page_url":"http://dx.doi.org/10.5137/1019-5149.jtn.45237-23.2","pdf_url":"https://turkishneurosurgery.org.tr/pdf.php?id=2999","source":{"id":"https://openalex.org/S104231055","display_name":"Turkish Neurosurgery","issn_l":"1019-5149","issn":["1019-5149","2651-5032"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2","tr-dizin"],"host_organization":"https://openalex.org/P4327874767","host_organization_name":"Turkish Neurosurgical Society","host_organization_lineage":["https://openalex.org/P4327874767"],"host_organization_lineage_names":["Turkish Neurosurgical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://turkishneurosurgery.org.tr/pdf.php?id=2999","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087128802","display_name":"Burak Bahad\u0131r","orcid":"https://orcid.org/0000-0003-2456-8170","observed_orcids":["https://orcid.org/0000-0003-2456-8170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Burak Bahadir","raw_affiliation_strings":["Ankara City Hospital, Department of Neurosurgery, Ankara, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ankara City Hospital, Department of Neurosurgery, Ankara, T\u00fcrkiye","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103205056","display_name":"Onur \u00d6zg\u00fcral","orcid":"https://orcid.org/0000-0001-5797-4373","observed_orcids":["https://orcid.org/0000-0001-5797-4373","https://orcid.org/0000-0003-0592-6139"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Onur Ozgural","raw_affiliation_strings":["Ankara University School of Medicine , Department of Neurosurgery , Ankara , T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ankara University School of Medicine , Department of Neurosurgery , Ankara , T\u00fcrkiye","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007034404","display_name":"Orkhan Mammadkhanl\u0131","orcid":"https://orcid.org/0000-0003-3299-4196","observed_orcids":["https://orcid.org/0000-0003-3299-4196"]},"institutions":[{"id":"https://openalex.org/I12387023","display_name":"Trakya University","ror":"https://ror.org/00xa0xn82","country_code":"TR","type":"education","lineage":["https://openalex.org/I12387023"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Orkhan Mammadkhanli","raw_affiliation_strings":["Trakya University , School of Medicine , Department of Neurosurgery , Edirne , T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Trakya University , School of Medicine , Department of Neurosurgery , Edirne , T\u00fcrkiye","institution_ids":["https://openalex.org/I12387023"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009804644","display_name":"Eray Serhat Aktan","orcid":"https://orcid.org/0000-0001-8970-9582","observed_orcids":["https://orcid.org/0000-0001-8970-9582"]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Eray Serhat Aktan","raw_affiliation_strings":["Ankara University School of Medicine , Department of Neurosurgery , Ankara , T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ankara University School of Medicine , Department of Neurosurgery , Ankara , T\u00fcrkiye","institution_ids":["https://openalex.org/I149218525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035914711","display_name":"Derya \u00d6ZDEM\u0130R TA\u015e","orcid":"https://orcid.org/0000-0001-6968-6379","observed_orcids":["https://orcid.org/0000-0001-6968-6379"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Derya Ozdemir Tas","raw_affiliation_strings":["Ankara City Hospital , Center for Assisted Reproduction , Ankara , T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ankara City Hospital , Center for Assisted Reproduction , Ankara , T\u00fcrkiye","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eda Aslanbaba Bahadir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eda Aslanbaba Bahadir","raw_affiliation_strings":["Ankara Golbasi \u015eehit Ahmet \u00d6zsoy State Hospital , Department of Neurology , Ankara , T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ankara Golbasi \u015eehit Ahmet \u00d6zsoy State Hospital , Department of Neurology , Ankara , T\u00fcrkiye","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Mustafa Agahan Unlu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149218525","display_name":"Ankara University","ror":"https://ror.org/01wntqw50","country_code":"TR","type":"education","lineage":["https://openalex.org/I149218525"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa Agahan Unlu","raw_affiliation_strings":["Ankara University School of Medicine , Department of Neurosurgery , Ankara , T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ankara University School of Medicine , Department of Neurosurgery , Ankara , T\u00fcrkiye","institution_ids":["https://openalex.org/I149218525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5457,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.5934063,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"34","issue":"5","first_page":"827","last_page":"832"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.7651000022888184,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11833","display_name":"Spinal Dysraphism and Malformations","score":0.10679999738931656,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11964","display_name":"Pregnancy and Medication Impact","score":0.07180000096559525,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tenoxicam","display_name":"tenoxicam","score":1.0},{"id":"https://openalex.org/keywords/neural-tube-defects","display_name":"neural tube defects","score":0.9860000014305115},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chicken-embryo-culture","display_name":"chicken embryo culture","score":0.6970000267028809},{"id":"https://openalex.org/keywords/neural-tube-closure","display_name":"neural tube closure","score":0.8360000252723694},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.8220000267028809},{"id":"https://openalex.org/keywords/congenital-malformations","display_name":"congenital malformations","score":0.8019999861717224}],"concepts":[{"id":"https://openalex.org/C2778432687","wikidata":"https://www.wikidata.org/wiki/Q45050","display_name":"Tenoxicam","level":4,"score":0.9646823406219482},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9410638809204102},{"id":"https://openalex.org/C2780594696","wikidata":"https://www.wikidata.org/wiki/Q1127402","display_name":"Neural tube","level":3,"score":0.6667042970657349},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.5943514704704285},{"id":"https://openalex.org/C2777551473","wikidata":"https://www.wikidata.org/wiki/Q2093072","display_name":"Tube (container)","level":2,"score":0.4868106544017792},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1316210925579071},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12911087274551392},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.06305867433547974},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.05578702688217163},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C2778139025","wikidata":"https://www.wikidata.org/wiki/Q408676","display_name":"Piroxicam","level":3,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009436","descriptor_name":"Neural Tube Defects","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009436","descriptor_name":"Neural Tube Defects","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D010894","descriptor_name":"Piroxicam","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054259","descriptor_name":"Neural Tube","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D054259","descriptor_name":"Neural Tube","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.5137/1019-5149.jtn.45237-23.2","doi":"https://doi.org/10.5137/1019-5149.jtn.45237-23.2","is_oa":true,"landing_page_url":"http://dx.doi.org/10.5137/1019-5149.jtn.45237-23.2","pdf_url":"https://turkishneurosurgery.org.tr/pdf.php?id=2999","source":{"id":"https://openalex.org/S104231055","display_name":"Turkish Neurosurgery","issn_l":"1019-5149","issn":["1019-5149","2651-5032"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2","tr-dizin"],"host_organization":"https://openalex.org/P4327874767","host_organization_name":"Turkish Neurosurgical Society","host_organization_lineage":["https://openalex.org/P4327874767"],"host_organization_lineage_names":["Turkish Neurosurgical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Neurosurgery","raw_type":"journal-article"},{"id":"pmid:39087289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/39087289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish neurosurgery","raw_type":"Journal Article"},{"id":"pmh:oai:acikerisim.trakya.edu.tr:20.500.14551/28953","doi":null,"is_oa":false,"landing_page_url":"https://search.trdizin.gov.tr/tr/yayin/detay/1351723","pdf_url":null,"source":{"id":"https://openalex.org/S4306401406","display_name":"Trakya University's Institutional Open Access System (Trakya University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I12387023","host_organization_name":"Trakya University","host_organization_lineage":["https://openalex.org/I12387023"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.5137/1019-5149.jtn.45237-23.2","doi":"https://doi.org/10.5137/1019-5149.jtn.45237-23.2","is_oa":true,"landing_page_url":"http://dx.doi.org/10.5137/1019-5149.jtn.45237-23.2","pdf_url":"https://turkishneurosurgery.org.tr/pdf.php?id=2999","source":{"id":"https://openalex.org/S104231055","display_name":"Turkish Neurosurgery","issn_l":"1019-5149","issn":["1019-5149","2651-5032"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2","tr-dizin"],"host_organization":"https://openalex.org/P4327874767","host_organization_name":"Turkish Neurosurgical Society","host_organization_lineage":["https://openalex.org/P4327874767"],"host_organization_lineage_names":["Turkish Neurosurgical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Neurosurgery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309936","display_name":"Ankara Universitesi","ror":"https://ror.org/01wntqw50"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387680239.pdf","grobid_xml":"https://content.openalex.org/works/W4387680239.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W192310367","https://openalex.org/W1480874656","https://openalex.org/W1951862796","https://openalex.org/W1979848006","https://openalex.org/W2011807665","https://openalex.org/W2019607388","https://openalex.org/W2022537145","https://openalex.org/W2091567133","https://openalex.org/W2093923036","https://openalex.org/W2105667622","https://openalex.org/W2116776716","https://openalex.org/W2146350496","https://openalex.org/W2791559304","https://openalex.org/W2802864672","https://openalex.org/W2889724122","https://openalex.org/W3011250703","https://openalex.org/W3084036816","https://openalex.org/W3216346182","https://openalex.org/W4313857364","https://openalex.org/W4323535448"],"related_works":["https://openalex.org/W4390117672","https://openalex.org/W2186337486","https://openalex.org/W2065845101","https://openalex.org/W4413523912","https://openalex.org/W2889724122","https://openalex.org/W2418881234","https://openalex.org/W3011581881","https://openalex.org/W2362834459","https://openalex.org/W2790541582","https://openalex.org/W4416786352"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"evaluate":[2],"tenoxicam's":[3],"effects":[4,226],"on":[5,64],"embryonic":[6,222],"neural":[7,21,124],"tube":[8,22,125],"formation":[9],"to":[10,20,216,228],"identify":[11],"potential":[12],"teratogenicity":[13],"and":[14,71,110,158,181,187,189,224,230,233],"determine":[15,217],"the":[16,47,102,107,111,170,190,218,221,235],"underlying":[17,220],"mechanisms":[18,219],"leading":[19],"defects":[23,203],"(NTDs).":[24],"MATERIAL":[25],"AND":[26],"METHODS:":[27],"This":[28],"study":[29],"was":[30,76,127],"conducted":[31],"at":[32,106],"our":[33],"University's":[34],"Neuro-embryology":[35],"Laboratory.":[36],"A":[37],"total":[38],"of":[39,53,119,136,146,155,166,172,174,237],"100":[40],"fertile":[41],"chicken":[42,121,206],"eggs":[43,88,103],"were":[44,58,81,89,104,113,177],"opened":[45,105],"using":[46],"windowing":[48],"method":[49],"after":[50,95],"24":[51,93,164],"hours":[52,94],"incubation.":[54],"The":[55,78,87],"embryo":[56,175],"models":[57],"divided":[59],"into":[60],"four":[61],"groups":[62,80],"based":[63],"tenoxicam":[65,79,198],"dosage:":[66],"0.01,":[67],"0.02,":[68],"0.10":[69],"\u03bcg,":[70],"control":[72,191],"group":[73,117],"(0.9%":[74],"SF":[75],"administered).":[77],"administered":[82],"20":[83,144],"\u03bcL":[84],"volume":[85],"sub-blastodermally.":[86],"incubated":[90],"for":[91],"another":[92],"being":[96],"covered":[97],"with":[98,133,143,152,163],"sterile":[99],"draping.":[100],"All":[101],"48th":[108],"hour,":[109],"embryos":[112,207],"evaluated.":[114],"RESULTS:":[115],"Each":[116],"consisted":[118],"25":[120,137,147,156,167],"embryos.":[122,168],"Normal":[123],"development":[126,176,236],"observed":[128,196],"in":[129,183,204,208],"Group":[130,139,149,159],"1":[131],"(0.01\u03bcg)":[132],"23":[134],"out":[135,145,154,165],"embryos,":[138,148,157],"2":[140],"(0.02":[141],"\u03bcg)":[142],"3":[150,188],"(0.10\u03bcg)":[151],"16":[153],"4":[160],"(control":[161],"group)":[162],"Additionally,":[169],"rates":[171],"absence":[173],"8%,":[178,179],"12%,":[180],"4%":[182],"Groups":[184],"1,":[185],"2,":[186],"group,":[192],"respectively.":[193],"CONCLUSION:":[194],"We":[195],"that":[197],"use":[199],"caused":[200],"midline":[201],"closure":[202],"early":[205],"a":[209],"dose-dependent":[210],"manner.":[211],"Further":[212],"studies":[213],"are":[214],"required":[215],"damage":[223],"teratogenic":[225],"due":[227],"genetic":[229],"environmental":[231],"factors":[232],"minimize":[234],"congenital":[238],"defects.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-17T00:00:00"}
