{"id":"https://openalex.org/W4387677080","doi":"https://doi.org/10.24966/srdt-2060/100107","title":"Development of Membrane-Like Pre-Stem Cells after Released from Tube-Shaped Niches","display_name":"Development of Membrane-Like Pre-Stem Cells after Released from Tube-Shaped Niches","publication_year":2023,"publication_date":"2023-10-16","ids":{"openalex":"https://openalex.org/W4387677080","doi":"https://doi.org/10.24966/srdt-2060/100107"},"language":"en","primary_location":{"id":"doi:10.24966/srdt-2060/100107","doi":"https://doi.org/10.24966/srdt-2060/100107","is_oa":true,"landing_page_url":"https://doi.org/10.24966/srdt-2060/100107","pdf_url":null,"source":{"id":"https://openalex.org/S4210213864","display_name":"Stem Cells Research Development & Therapy","issn_l":"2381-2060","issn":["2381-2060"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Stem Cells Research, Development & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.24966/srdt-2060/100107","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026057588","display_name":"Wuyi Kong","orcid":"https://orcid.org/0000-0002-8180-8292","observed_orcids":["https://orcid.org/0000-0002-8180-8292"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Wuyi Kong","raw_affiliation_strings":["Beijing Khasar Medical Technology Co., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Khasar Medical Technology Co., Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"XiuJuan Han","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"XiuJuan Han","raw_affiliation_strings":["Beijing Khasar Medical Technology Co., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Khasar Medical Technology Co., Beijing, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"XiaoPing Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"XiaoPing Zhu","raw_affiliation_strings":["Beijing Khasar Medical Technology Co., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Khasar Medical Technology Co., Beijing, China","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Hong Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hong Wang","raw_affiliation_strings":["Beijing Khasar Medical Technology Co., Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Khasar Medical Technology Co., Beijing, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5026057588"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25253046,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"1","first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/membrane-like-structures","display_name":"membrane-like structures","score":0.6610000133514404},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9599999785423279},{"id":"https://openalex.org/keywords/stem-cell-lineage","display_name":"stem cell lineage","score":0.5329999923706055},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.7269999980926514},{"id":"https://openalex.org/keywords/stem-cell-niche","display_name":"stem cell niche","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.8140352964401245},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7032777070999146},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6381665468215942},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.6232118606567383},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.5799664258956909},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5001745223999023},{"id":"https://openalex.org/C164794517","wikidata":"https://www.wikidata.org/wiki/Q16729831","display_name":"Stem cell niche","level":4,"score":0.4522193372249603},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.2225324511528015},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07934114336967468}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.24966/srdt-2060/100107","doi":"https://doi.org/10.24966/srdt-2060/100107","is_oa":true,"landing_page_url":"https://doi.org/10.24966/srdt-2060/100107","pdf_url":null,"source":{"id":"https://openalex.org/S4210213864","display_name":"Stem Cells Research Development & Therapy","issn_l":"2381-2060","issn":["2381-2060"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Stem Cells Research, Development & Therapy","raw_type":"journal-article"},{"id":"doi:10.1101/2023.03.04.531096","doi":"https://doi.org/10.1101/2023.03.04.531096","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.03.04.531096","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/03/05/2023.03.04.531096.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.24966/srdt-2060/100107","doi":"https://doi.org/10.24966/srdt-2060/100107","is_oa":true,"landing_page_url":"https://doi.org/10.24966/srdt-2060/100107","pdf_url":null,"source":{"id":"https://openalex.org/S4210213864","display_name":"Stem Cells Research Development & Therapy","issn_l":"2381-2060","issn":["2381-2060"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Stem Cells Research, Development & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387677080.pdf","grobid_xml":"https://content.openalex.org/works/W4387677080.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1593177553","https://openalex.org/W1965281877","https://openalex.org/W1965458767","https://openalex.org/W1978683461","https://openalex.org/W1982860140","https://openalex.org/W1983217510","https://openalex.org/W2011174877","https://openalex.org/W2035402593","https://openalex.org/W2036795046","https://openalex.org/W2041357218","https://openalex.org/W2059134148","https://openalex.org/W2137790111","https://openalex.org/W2138287192","https://openalex.org/W2149053153","https://openalex.org/W2154699417","https://openalex.org/W2398299059","https://openalex.org/W2593420126","https://openalex.org/W2804088280","https://openalex.org/W2804581735","https://openalex.org/W2977917337","https://openalex.org/W4319265433"],"related_works":["https://openalex.org/W4319265433","https://openalex.org/W2588976301","https://openalex.org/W2204712795","https://openalex.org/W2977917337","https://openalex.org/W3137776518","https://openalex.org/W2020830179","https://openalex.org/W2013538305","https://openalex.org/W2027685579","https://openalex.org/W1718270855","https://openalex.org/W1990050585"],"abstract_inverted_index":{"Abstract":[0],"We":[1],"previously":[2],"identified":[3],"three":[4],"distinct":[5,134],"pre-stem":[6,54],"cell":[7,93,148,176,183],"lineages":[8,184],"that":[9,64,114,132,157],"further":[10],"develop":[11],"into":[12,73],"blood":[13],"CD34-positive":[14],"stem":[15,19,23,30,92,116,147,159,175,182,189],"cells,":[16],"and":[17,71,84,120,185],"mesenchymal":[18],"cells.":[20,77,190],"The":[21,78,126],"pre-CD34-positive":[22],"cells":[24,31,117,160],"are":[25,32,118,161],"spore-like,":[26],"while":[27],"the":[28,47,86,138,142,171,179,186],"pre-mesenchymal":[29],"fusiform-shaped.":[33],"All":[34],"of":[35,57,68,88,103,144,174,181,188],"them":[36,58],"originate":[37],"or":[38,44],"released":[39,129],"from":[40,66],"tube-shaped":[41,124,127],"tissue":[42],"structures,":[43],"niches.":[45],"In":[46],"current":[48],"study,":[49],"we":[50],"present":[51],"two":[52],"membrane-like":[53,75,80],"progenitors.":[55,94],"One":[56,95],"had":[59,82],"red":[60],"thin":[61,74],"membrane":[62,97],"structures":[63,128],"were":[65],"disconnection":[67],"bamboo-like":[69],"tissues":[70],"developed":[72],"multi-nucleated":[76],"other":[79],"structure":[81],"geometric-shape":[83],"was":[85],"place":[87],"developing":[89],"numerous":[90],"c-kit-positive":[91],"geometric-shaped":[96],"could":[98],"produce":[99],"dozens":[100],"to":[101],"hundreds":[102],"progenitors":[104],"in":[105,122],"a":[106,164],"synchronized":[107],"pattern.":[108,152,166],"Our":[109,167],"findings":[110,168],"provide":[111],"more":[112],"evidence":[113],"postnatal":[115,158],"unipotent":[119],"self-renewed":[121],"sealed":[123],"structures.":[125],"their":[130],"inclusions":[131],"have":[133],"morphological":[135],"differences":[136],"among":[137],"cellular":[139],"lineages.":[140],"Thus,":[141],"self-renewal":[143,187],"each":[145],"lineage-distinct":[146],"has":[149],"its":[150],"unique":[151],"Further,":[153],"our":[154],"data":[155],"suggests":[156],"renewed":[162],"via":[163],"recurrent":[165],"again":[169],"challenged":[170],"old":[172],"concepts":[173],"niche":[177],"components,":[178],"origins":[180]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-17T00:00:00"}