{"id":"https://openalex.org/W4387673455","doi":"https://doi.org/10.3390/mi14101936","title":"Protein-Based Anchoring Methods for Nucleic Acid Detection in Lateral Flow Format Assays","display_name":"Protein-Based Anchoring Methods for Nucleic Acid Detection in Lateral Flow Format Assays","publication_year":2023,"publication_date":"2023-10-16","ids":{"openalex":"https://openalex.org/W4387673455","doi":"https://doi.org/10.3390/mi14101936","pmid":"https://pubmed.ncbi.nlm.nih.gov/37893373","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10608873"},"language":"en","primary_location":{"id":"doi:10.3390/mi14101936","doi":"https://doi.org/10.3390/mi14101936","is_oa":true,"landing_page_url":"https://doi.org/10.3390/mi14101936","pdf_url":"https://www.mdpi.com/2072-666X/14/10/1936/pdf?version=1697449419","source":{"id":"https://openalex.org/S96702057","display_name":"Micromachines","issn_l":"2072-666X","issn":["2072-666X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Micromachines","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-666X/14/10/1936/pdf?version=1697449419","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093070812","display_name":"Kira Hallerbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kira Hallerbach","raw_affiliation_strings":["School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062587671","display_name":"Khadijeh Khederlou","orcid":"https://orcid.org/0000-0001-7832-4820","observed_orcids":["https://orcid.org/0000-0001-7832-4820"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khadijeh Khederlou","raw_affiliation_strings":["School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016687807","display_name":"Lael Wentland","orcid":"https://orcid.org/0000-0003-4155-8812","observed_orcids":["https://orcid.org/0000-0003-4155-8812"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lael Wentland","raw_affiliation_strings":["School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093070813","display_name":"Lana Senten","orcid":"https://orcid.org/0009-0005-0320-0774","observed_orcids":["https://orcid.org/0009-0005-0320-0774"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lana Senten","raw_affiliation_strings":["School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA","institution_ids":["https://openalex.org/I131249849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048265180","display_name":"Steven T. Brentano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324840837","display_name":"Hewlett-Packard (United States)","ror":"https://ror.org/059rn9488","country_code":"US","type":"company","lineage":["https://openalex.org/I1324840837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Brentano","raw_affiliation_strings":["HP Inc., Palo Alto, CA 94304, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HP Inc., Palo Alto, CA 94304, USA","institution_ids":["https://openalex.org/I1324840837"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brian Keefe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324840837","display_name":"Hewlett-Packard (United States)","ror":"https://ror.org/059rn9488","country_code":"US","type":"company","lineage":["https://openalex.org/I1324840837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Keefe","raw_affiliation_strings":["HP Inc., San Diego, CA 92127, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HP Inc., San Diego, CA 92127, USA","institution_ids":["https://openalex.org/I1324840837"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044609990","display_name":"Elain S. Fu","orcid":"https://orcid.org/0000-0001-7675-1677","observed_orcids":["https://orcid.org/0000-0001-7675-1677"]},"institutions":[{"id":"https://openalex.org/I131249849","display_name":"Oregon State University","ror":"https://ror.org/00ysfqy60","country_code":"US","type":"education","lineage":["https://openalex.org/I131249849"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elain Fu","raw_affiliation_strings":["School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA","institution_ids":["https://openalex.org/I131249849"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044609990"],"corresponding_institution_ids":["https://openalex.org/I131249849"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2224},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2224},"fwci":0.4731,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.52500927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"14","issue":"10","first_page":"1936","last_page":"1936"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11393","display_name":"Biosensors and Analytical Detection","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lateral-flow-assay","display_name":"lateral flow assay","score":0.9739999771118164},{"id":"https://openalex.org/keywords/nucleic-acid-detection","display_name":"nucleic acid detection","score":0.9739999771118164},{"id":"https://openalex.org/keywords/biotin-streptavidin","display_name":"biotin-streptavidin","score":0.8659999966621399},{"id":"https://openalex.org/keywords/nitrocellulose","display_name":"nitrocellulose","score":0.8169999718666077},{"id":"https://openalex.org/keywords/sandwich-immunoassay","display_name":"sandwich immunoassay","score":0.8809999823570251},{"id":"https://openalex.org/keywords/nanoparticle-labels","display_name":"nanoparticle labels","score":0.6269999742507935},{"id":"https://openalex.org/keywords/sars-cov-2-detection","display_name":"COVID-19 detection","score":0.8330000042915344},{"id":"https://openalex.org/keywords/point-of-care-testing","display_name":"point-of-care testing","score":0.9399999976158142},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.9228880405426025},{"id":"https://openalex.org/C204628709","wikidata":"https://www.wikidata.org/wiki/Q864854","display_name":"Biotinylation","level":2,"score":0.6384615302085876},{"id":"https://openalex.org/C2778954975","wikidata":"https://www.wikidata.org/wiki/Q143874","display_name":"Nitrocellulose","level":3,"score":0.6232136487960815},{"id":"https://openalex.org/C2910367586","wikidata":"https://www.wikidata.org/wiki/Q348667","display_name":"Nucleic acid detection","level":3,"score":0.5164352059364319},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4911003112792969},{"id":"https://openalex.org/C2776190903","wikidata":"https://www.wikidata.org/wiki/Q421817","display_name":"Streptavidin","level":3,"score":0.4728389382362366},{"id":"https://openalex.org/C126307556","wikidata":"https://www.wikidata.org/wiki/Q4227909","display_name":"Nucleic acid quantitation","level":3,"score":0.4689981937408447},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4586091637611389},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3722470998764038},{"id":"https://openalex.org/C2778204606","wikidata":"https://www.wikidata.org/wiki/Q181354","display_name":"Biotin","level":2,"score":0.2993677854537964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23368966579437256},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/mi14101936","doi":"https://doi.org/10.3390/mi14101936","is_oa":true,"landing_page_url":"https://doi.org/10.3390/mi14101936","pdf_url":"https://www.mdpi.com/2072-666X/14/10/1936/pdf?version=1697449419","source":{"id":"https://openalex.org/S96702057","display_name":"Micromachines","issn_l":"2072-666X","issn":["2072-666X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Micromachines","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10608873","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10608873","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10608873/pdf/micromachines-14-01936.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Micromachines (Basel)","raw_type":"Text"},{"id":"pmid:37893373","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37893373","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Micromachines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:6556830892fa4dd7893a6d3a438c2483","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6556830892fa4dd7893a6d3a438c2483","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Micromachines, Vol 14, Iss 10, p 1936 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/mi14101936","doi":"https://doi.org/10.3390/mi14101936","is_oa":true,"landing_page_url":"https://doi.org/10.3390/mi14101936","pdf_url":"https://www.mdpi.com/2072-666X/14/10/1936/pdf?version=1697449419","source":{"id":"https://openalex.org/S96702057","display_name":"Micromachines","issn_l":"2072-666X","issn":["2072-666X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Micromachines","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387673455.pdf","grobid_xml":"https://content.openalex.org/works/W4387673455.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W610126998","https://openalex.org/W1688235817","https://openalex.org/W1997504861","https://openalex.org/W2035983939","https://openalex.org/W2044949573","https://openalex.org/W2054016136","https://openalex.org/W2071274456","https://openalex.org/W2093973166","https://openalex.org/W2166313817","https://openalex.org/W2176989526","https://openalex.org/W2482442996","https://openalex.org/W2756684348","https://openalex.org/W2772742155","https://openalex.org/W2796219516","https://openalex.org/W2805020710","https://openalex.org/W3001195213","https://openalex.org/W3038720126","https://openalex.org/W3088809894","https://openalex.org/W3125495819","https://openalex.org/W3133737854","https://openalex.org/W3210830652"],"related_works":["https://openalex.org/W4308477292","https://openalex.org/W2626059441","https://openalex.org/W2090098499","https://openalex.org/W4294752372","https://openalex.org/W2102908307","https://openalex.org/W4406236448","https://openalex.org/W4280501700","https://openalex.org/W2166083322","https://openalex.org/W3210830652","https://openalex.org/W4404147980"],"abstract_inverted_index":{"The":[0],"use":[1,96,141,216],"of":[2,70,85,97,145,164,167,198,209,235,242],"lateral":[3,107,229],"flow":[4,108,230],"assays":[5],"to":[6,26,34,47,52,63,76,105,118,221],"detect":[7],"nucleic":[8,38,60,72,87,121,128,146,173,179,190,200,224],"acid":[9,39,61,73,122,129,147,174,180,191,201,225],"targets":[10],"has":[11],"many":[12],"applications":[13,208],"including":[14,94],"point-of-care":[15],"diagnostics,":[16],"environmental":[17],"monitoring,":[18],"and":[19,50,110,176],"food":[20],"safety.":[21],"A":[22,67],"sandwich":[23],"format,":[24],"similar":[25],"that":[27,101,111],"in":[28,142,188,227],"protein":[29,99,133,169,210],"immunoassays,":[30],"is":[31,75],"often":[32],"used":[33],"capture":[35,79,84,123,199,219],"the":[36,82,95,106,114,143,162,165,168,185,196,233],"target":[37,86,127,189],"sequence":[40],"with":[41],"an":[42],"immobilized":[43],"complementary":[44,58],"strand":[45],"anchored":[46],"a":[48,57,64,203,228,236,240],"substrate,":[49],"then":[51],"visualize":[53],"this":[54,150],"event":[55],"using":[56,206],"label":[59],"bound":[62],"nanoparticle":[65],"label.":[66],"critical":[68],"component":[69],"high-sensitivity":[71,223],"detection":[74,226],"utilize":[77,113],"high-density":[78,218],"surfaces":[80,220],"for":[81,125,140,159],"effective":[83],"acid.":[88],"Multiple":[89],"methods":[90],"have":[91,135],"been":[92,137],"reported,":[93],"streptavidin-based":[98],"anchors":[100,134,156],"can":[102,112],"be":[103],"adsorbed":[104],"substrate":[109,205],"high-affinity":[115],"streptavidin-biotin":[116],"linkage":[117],"bind":[119],"biotinylated":[120],"sequences":[124],"subsequent":[126],"binding.":[130],"However,":[131],"these":[132],"not":[136],"systematically":[138],"characterized":[139],"context":[144,234],"detection.":[148],"In":[149],"work,":[151],"we":[152,183,215],"characterize":[153],"several":[154],"protein-based":[155],"on":[157,202],"nitrocellulose":[158,204],"(i)":[160],"capturing":[161,172],"robustness":[163],"attachment":[166],"anchor,":[170],"(ii)":[171],"density,":[175],"(iii)":[177],"targeting":[178],"capture.":[181],"Further,":[182],"demonstrate":[184,222],"signal":[186],"gains":[187],"hybridization":[192],"made":[193],"by":[194],"increasing":[195],"density":[197],"multiple":[207],"loading":[211],"onto":[212],"nitrocellulose.":[213],"Finally,":[214],"our":[217],"assay":[231],"(in":[232],"SARS-CoV-2":[237],"sequence),":[238],"achieving":[239],"LOD":[241],"approximately":[243],"0.2":[244],"nM.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-10-17T00:00:00"}
