{"id":"https://openalex.org/W4387664616","doi":"https://doi.org/10.1159/000534084","title":"Stereotactic Staged Asymmetric Bilateral Radiofrequency Lesioning for Parkinson\u2019s Disease","display_name":"Stereotactic Staged Asymmetric Bilateral Radiofrequency Lesioning for Parkinson\u2019s Disease","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4387664616","doi":"https://doi.org/10.1159/000534084","pmid":"https://pubmed.ncbi.nlm.nih.gov/37844550","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10711767"},"language":"en","primary_location":{"id":"doi:10.1159/000534084","doi":"https://doi.org/10.1159/000534084","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000534084","pdf_url":null,"source":{"id":"https://openalex.org/S115742856","display_name":"Stereotactic and Functional Neurosurgery","issn_l":"1011-6125","issn":["1011-6125","1423-0372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stereotactic and Functional Neurosurgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1159/000534084","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085105110","display_name":"Kostiantyn R. Kostiuk","orcid":"https://orcid.org/0000-0002-3277-5025","observed_orcids":["https://orcid.org/0000-0002-3277-5025"]},"institutions":[{"id":"https://openalex.org/I4210116814","display_name":"Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine","ror":"https://ror.org/023w5bf45","country_code":"UA","type":"facility","lineage":["https://openalex.org/I4210116814","https://openalex.org/I4210144782"]},{"id":"https://openalex.org/I4210144782","display_name":"National Academy of Medical Sciences of Ukraine","ror":"https://ror.org/042dnf796","country_code":"UA","type":"government","lineage":["https://openalex.org/I4210144782"]}],"countries":["UA"],"is_corresponding":true,"raw_author_name":"Kostiantyn Kostiuk","raw_affiliation_strings":["Department of Functional Neurosurgery and Neuromodulation, SI \"Romodanov Neurosurgery Institute NAMS of Ukraine\", Kyiv, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Functional Neurosurgery and Neuromodulation, SI \"Romodanov Neurosurgery Institute NAMS of Ukraine\", Kyiv, Ukraine","institution_ids":["https://openalex.org/I4210116814","https://openalex.org/I4210144782"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085105110"],"corresponding_institution_ids":["https://openalex.org/I4210116814","https://openalex.org/I4210144782"],"apc_list":null,"apc_paid":null,"fwci":1.9397,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.85461829,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"101","issue":"6","first_page":"359","last_page":"368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stereotactic-lesioning","display_name":"stereotactic lesioning","score":0.8669999837875366},{"id":"https://openalex.org/keywords/radiofrequency-ablation","display_name":"radiofrequency ablation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/thalamotomy","display_name":"thalamotomy","score":0.9089999794960022},{"id":"https://openalex.org/keywords/pallidotomy","display_name":"pallidotomy","score":0.921999990940094},{"id":"https://openalex.org/keywords/tremor","display_name":"tremor","score":0.6190000176429749},{"id":"https://openalex.org/keywords/rigidity","display_name":"rigidity","score":0.9869999885559082},{"id":"https://openalex.org/keywords/hypokinesia","display_name":"hypokinesia","score":0.859000027179718},{"id":"https://openalex.org/keywords/unified-parkinson-s-disease-rating-scale","display_name":"Unified Parkinson's Disease Rating Scale","score":0.8309999704360962},{"id":"https://openalex.org/keywords/levodopa-dose-reduction","display_name":"levodopa dose reduction","score":0.984000027179718},{"id":"https://openalex.org/keywords/surgical-complications","display_name":"surgical complications","score":0.5},{"id":"https://openalex.org/keywords/long-term-outcomes","display_name":"long-term outcomes","score":0.45100000500679016},{"id":"https://openalex.org/keywords/advanced-parkinson-s-disease","display_name":"advanced Parkinson's disease","score":0.621999979019165},{"id":"https://openalex.org/keywords/deep-brain-stimulation-alternative","display_name":"deep brain stimulation alternative","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C2775841352","wikidata":"https://www.wikidata.org/wiki/Q1772023","display_name":"Thalamotomy","level":5,"score":0.8161974549293518},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.813818097114563},{"id":"https://openalex.org/C2781083702","wikidata":"https://www.wikidata.org/wiki/Q3892641","display_name":"Pallidotomy","level":5,"score":0.7718886733055115},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.6609880924224854},{"id":"https://openalex.org/C2777319143","wikidata":"https://www.wikidata.org/wiki/Q2270424","display_name":"Subthalamic nucleus","level":5,"score":0.6435633897781372},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5906477570533752},{"id":"https://openalex.org/C2779634917","wikidata":"https://www.wikidata.org/wiki/Q1931968","display_name":"Stereotactic surgery","level":2,"score":0.5357756614685059},{"id":"https://openalex.org/C2780387249","wikidata":"https://www.wikidata.org/wiki/Q973234","display_name":"Radiosurgery","level":3,"score":0.4986536502838135},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.47718846797943115},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.43406134843826294},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.20433351397514343},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13273823261260986},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007980","descriptor_name":"Levodopa","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020531","descriptor_name":"Subthalamic Nucleus","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1159/000534084","doi":"https://doi.org/10.1159/000534084","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000534084","pdf_url":null,"source":{"id":"https://openalex.org/S115742856","display_name":"Stereotactic and Functional Neurosurgery","issn_l":"1011-6125","issn":["1011-6125","1423-0372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stereotactic and Functional Neurosurgery","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10711767","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10711767","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stereotact Funct Neurosurg","raw_type":"Text"},{"id":"pmid:37844550","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37844550","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stereotactic and functional neurosurgery","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1159/000534084","doi":"https://doi.org/10.1159/000534084","is_oa":true,"landing_page_url":"https://doi.org/10.1159/000534084","pdf_url":null,"source":{"id":"https://openalex.org/S115742856","display_name":"Stereotactic and Functional Neurosurgery","issn_l":"1011-6125","issn":["1011-6125","1423-0372"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stereotactic and Functional Neurosurgery","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1582744819","https://openalex.org/W1971075556","https://openalex.org/W1993936388","https://openalex.org/W2009260926","https://openalex.org/W2027194759","https://openalex.org/W2054020891","https://openalex.org/W2056967381","https://openalex.org/W2062932754","https://openalex.org/W2076835998","https://openalex.org/W2091794045","https://openalex.org/W2106532942","https://openalex.org/W2114075597","https://openalex.org/W2124550832","https://openalex.org/W2125423687","https://openalex.org/W2173431927","https://openalex.org/W2318752784","https://openalex.org/W2505326305","https://openalex.org/W2508131904","https://openalex.org/W2514639617","https://openalex.org/W2546397608","https://openalex.org/W2591639181","https://openalex.org/W2605479150","https://openalex.org/W2606931259","https://openalex.org/W2624182285","https://openalex.org/W2735580835","https://openalex.org/W2783109088","https://openalex.org/W2802507964","https://openalex.org/W2884352095","https://openalex.org/W2889235097","https://openalex.org/W2913846664","https://openalex.org/W2915370500","https://openalex.org/W3197888756"],"related_works":["https://openalex.org/W3030000363","https://openalex.org/W2353593836","https://openalex.org/W2364185640","https://openalex.org/W2090972944","https://openalex.org/W7204107675","https://openalex.org/W2990833338","https://openalex.org/W7166535732","https://openalex.org/W4413960284","https://openalex.org/W4396872031","https://openalex.org/W3126170322"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Parkinson's":[1],"disease":[2,124],"(PD)":[3],"is":[4,355],"one":[5],"of":[6,16,29,33,43,56,65,107,123,222,235,245,364,376],"the":[7,14,27,34,39,108,126,138,150,161,171,174,195,205,214,224,253,259,265,270,274,277,286,292,297,374],"most":[8],"common":[9],"neurodegenerative":[10],"progressive":[11],"disorders.":[12],"Despite":[13],"dominance":[15],"neurostimulation":[17],"technology,":[18],"stereotactic":[19,49,70,333],"lesioning":[20,50,335],"operations":[21,140],"play":[22],"a":[23,52,338],"significant":[24],"role":[25],"in":[26,51,98,114,149,160,258,264,269,291,296,311,343,373],"treatment":[28,375],"PD.":[30],"The":[31,120,134],"aim":[32],"study":[35],"was":[36,96,112,129,141,154,165,303],"to":[37,180,213,219,232,242,285,324],"evaluate":[38],"effectiveness":[40],"and":[41,104,159,237,267,294,340,362],"safety":[42],"staged":[44,83,202,250],"bilateral":[45,85,203,251,332,379],"asymmetric":[46,84,331],"radiofrequency":[47],"(RF)":[48],"highly":[53,344],"selected":[54,345],"group":[55,261],"PD":[57,74,377],"patients.":[58],"MATERIAL":[59],"AND":[60],"METHODS:":[61],"A":[62],"retrospective":[63],"review":[64],"418":[66],"consecutive":[67],"patients":[68,80,101,117,189,346,365],"undergoing":[69],"ablation":[71],"for":[72,366],"advanced":[73,348],"at":[75],"our":[76],"institution":[77],"revealed":[78],"28":[79],"who":[81],"underwent":[82],"ablation.":[86],"In":[87,273],"this":[88],"subset,":[89],"after":[90,194,201,249,327],"initial":[91],"RF":[92,334],"thalamotomy,":[93],"contralateral":[94,105],"pallidotomy":[95],"performed":[97,113],"16":[99],"(57.1%)":[100],"(group":[102,118],"Vim-GPi),":[103],"lesion":[106],"subthalamic":[109],"nucleus":[110],"(STN)":[111],"12":[115],"(32.9%)":[116],"Vim-STN).":[119],"mean":[121,135,206,226],"duration":[122],"before":[125],"first":[127,215,287],"surgery":[128,368],"9.9":[130],"\u00b1":[131,143,156,167,185],"0.8":[132],"years.":[133,169],"interval":[136],"between":[137],"two":[139],"3.5":[142],"0.4":[144,157],"years":[145,182],"(range,":[146],"1-10":[147],"years);":[148],"Vim-GPi":[151,260],"group,":[152,163,276],"it":[153,164],"3.1":[155],"years;":[158],"Vim-STN":[162,275],"4.3":[166],"0.1":[168],"After":[170],"second":[172,196],"operation,":[173,216,288],"long-term":[175],"follow-up":[176],"lasted":[177],"from":[178,210,217,230,240,282],"1":[179,192,317],"8":[181],"(mean":[183],"4.8":[184],"0.5":[186],"years).":[187],"All":[188],"were":[190,309],"evaluated":[191],"year":[193,200,248],"operation.":[197],"RESULTS:":[198],"One":[199,247],"lesioning,":[204,252],"tremor":[207],"score":[208,228,256,280],"improved":[209,229,239,257,281],"baseline,":[211,283],"prior":[212,284],"19.8":[218],"3.8":[220],"(improvement":[221,234,244],"81%),":[223],"overall":[225],"rigidity":[227],"11.0":[231],"3.7":[233],"66%),":[236],"hypokinesia":[238],"14.8":[241],"8.9":[243],"40%).":[246],"total":[254,278],"UPDRS":[255,279],"by":[262,289,305],"47%":[263],"OFF":[266,293],"45.9%":[268],"ON":[271,298],"states.":[272,299],"44.8%":[290],"51.6%":[295],"Overall,":[300],"levodopa":[301],"dose":[302],"reduced":[304],"43.4%.":[306],"Neurological":[307],"complications":[308],"observed":[310],"4":[312],"(14.3%)":[313],"cases;":[314],"among":[315],"them,":[316],"(3.6%)":[318],"patient":[319],"had":[320],"permanent":[321],"events":[322],"related":[323],"local":[325],"ischemia":[326],"pallidotomy.":[328],"CONCLUSION:":[329],"Staged":[330],"can":[336],"be":[337],"safe":[339],"effective":[341],"method":[342],"with":[347,378],"PD,":[349],"particularly":[350],"where":[351],"deep":[352],"brain":[353],"stimulation":[354],"not":[356],"available":[357],"or":[358],"desirable.":[359],"Careful":[360],"identification":[361],"selection":[363],"ablative":[367],"allow":[369],"achieving":[370],"optimal":[371],"results":[372],"symptoms.":[380]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-10-17T00:00:00"}