{"id":"https://openalex.org/W4387660980","doi":"https://doi.org/10.1128/jvi.01279-23","title":"Protection of the receptor binding domain (RBD) dimer against SARS-CoV-2 and its variants","display_name":"Protection of the receptor binding domain (RBD) dimer against SARS-CoV-2 and its variants","publication_year":2023,"publication_date":"2023-10-16","ids":{"openalex":"https://openalex.org/W4387660980","doi":"https://doi.org/10.1128/jvi.01279-23","pmid":"https://pubmed.ncbi.nlm.nih.gov/37843372","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10688353"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.01279-23","doi":"https://doi.org/10.1128/jvi.01279-23","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.01279-23","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1128/jvi.01279-23","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019443348","display_name":"Yan Ling Wu","orcid":"https://orcid.org/0000-0002-0928-6127","observed_orcids":["https://orcid.org/0000-0002-0928-6127"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106882","display_name":"Wuhan Institute of Virology","ror":"https://ror.org/01jxjav08","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Wu","raw_affiliation_strings":["State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China"],"raw_orcid":"https://orcid.org/0000-0002-0928-6127","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415987","display_name":"Jian R. Shi","orcid":"https://orcid.org/0000-0003-3810-5302","observed_orcids":["https://orcid.org/0000-0003-3810-5302"]},"institutions":[{"id":"https://openalex.org/I4210151591","display_name":"Wuhan YZY Biopharma (China)","ror":"https://ror.org/03wcqja14","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210151591"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Shi","raw_affiliation_strings":["Wuhan YZY Biopharma Co., Ltd. , Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan YZY Biopharma Co., Ltd. , Wuhan, China","institution_ids":["https://openalex.org/I4210151591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112598087","display_name":"Xiaoxue He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106882","display_name":"Wuhan Institute of Virology","ror":"https://ror.org/01jxjav08","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxue He","raw_affiliation_strings":["State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102003456","display_name":"Jia Lu","orcid":"https://orcid.org/0000-0001-5084-818X","observed_orcids":["https://orcid.org/0000-0001-5084-818X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106882","display_name":"Wuhan Institute of Virology","ror":"https://ror.org/01jxjav08","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Lu","raw_affiliation_strings":["State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","University of the Chinese Academy of Sciences , Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]},{"raw_affiliation_string":"University of the Chinese Academy of Sciences , Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111612841","display_name":"Xiao Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106882","display_name":"Wuhan Institute of Virology","ror":"https://ror.org/01jxjav08","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Gao","raw_affiliation_strings":["State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","University of the Chinese Academy of Sciences , Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]},{"raw_affiliation_string":"University of the Chinese Academy of Sciences , Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040398883","display_name":"Xuerui Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106882","display_name":"Wuhan Institute of Virology","ror":"https://ror.org/01jxjav08","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuerui Zhu","raw_affiliation_strings":["State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025138580","display_name":"Xinlan Chen","orcid":"https://orcid.org/0000-0001-9294-425X","observed_orcids":["https://orcid.org/0000-0001-9294-425X","https://orcid.org/0009-0003-8971-0307"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106882","display_name":"Wuhan Institute of Virology","ror":"https://ror.org/01jxjav08","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinlan Chen","raw_affiliation_strings":["State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","University of the Chinese Academy of Sciences , Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]},{"raw_affiliation_string":"University of the Chinese Academy of Sciences , Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100353080","display_name":"Man Zhang","orcid":"https://orcid.org/0000-0003-0202-4172","observed_orcids":["https://orcid.org/0000-0003-0202-4172"]},"institutions":[{"id":"https://openalex.org/I4210151591","display_name":"Wuhan YZY Biopharma (China)","ror":"https://ror.org/03wcqja14","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210151591"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Man Zhang","raw_affiliation_strings":["Wuhan YZY Biopharma Co., Ltd. , Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan YZY Biopharma Co., Ltd. , Wuhan, China","institution_ids":["https://openalex.org/I4210151591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039268328","display_name":"Lijuan Fang","orcid":"https://orcid.org/0000-0002-5765-0210","observed_orcids":["https://orcid.org/0000-0002-5765-0210"]},"institutions":[{"id":"https://openalex.org/I4210151591","display_name":"Wuhan YZY Biopharma (China)","ror":"https://ror.org/03wcqja14","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210151591"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijuan Fang","raw_affiliation_strings":["Wuhan YZY Biopharma Co., Ltd. , Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan YZY Biopharma Co., Ltd. , Wuhan, China","institution_ids":["https://openalex.org/I4210151591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345489","display_name":"Jing Zhang","orcid":"https://orcid.org/0000-0003-2966-9149","observed_orcids":["https://orcid.org/0000-0003-2966-9149","https://orcid.org/0000-0002-2407-5352"]},"institutions":[{"id":"https://openalex.org/I4210151591","display_name":"Wuhan YZY Biopharma (China)","ror":"https://ror.org/03wcqja14","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210151591"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Zhang","raw_affiliation_strings":["Wuhan YZY Biopharma Co., Ltd. , Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wuhan YZY Biopharma Co., Ltd. , Wuhan, China","institution_ids":["https://openalex.org/I4210151591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101632783","display_name":"Zhiming Yuan","orcid":"https://orcid.org/0000-0002-3234-9616","observed_orcids":["https://orcid.org/0000-0002-3234-9616"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106882","display_name":"Wuhan Institute of Virology","ror":"https://ror.org/01jxjav08","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiming Yuan","raw_affiliation_strings":["Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","University of the Chinese Academy of Sciences , Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"raw_affiliation_string":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]},{"raw_affiliation_string":"University of the Chinese Academy of Sciences , Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029228548","display_name":"Gengfu Xiao","orcid":"https://orcid.org/0000-0001-9401-235X","observed_orcids":["https://orcid.org/0000-0001-9401-235X","https://orcid.org/0000-0001-9403-2246"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106882","display_name":"Wuhan Institute of Virology","ror":"https://ror.org/01jxjav08","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gengfu Xiao","raw_affiliation_strings":["Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","University of the Chinese Academy of Sciences , Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"raw_affiliation_string":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]},{"raw_affiliation_string":"University of the Chinese Academy of Sciences , Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044000598","display_name":"Pengfei Zhou","orcid":"https://orcid.org/0000-0001-6335-7769","observed_orcids":["https://orcid.org/0000-0001-6335-7769"]},"institutions":[{"id":"https://openalex.org/I4210151591","display_name":"Wuhan YZY Biopharma (China)","ror":"https://ror.org/03wcqja14","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210151591"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pengfei Zhou","raw_affiliation_strings":["Wuhan YZY Biopharma Co., Ltd. , Wuhan, China"],"raw_orcid":"https://orcid.org/0000-0001-6335-7769","affiliations":[{"raw_affiliation_string":"Wuhan YZY Biopharma Co., Ltd. , Wuhan, China","institution_ids":["https://openalex.org/I4210151591"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038996519","display_name":"Xiaoyan Pan","orcid":"https://orcid.org/0000-0003-0553-5138","observed_orcids":["https://orcid.org/0000-0003-0553-5138"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106882","display_name":"Wuhan Institute of Virology","ror":"https://ror.org/01jxjav08","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391768268","display_name":"State Key Laboratory of Virology","ror":"https://ror.org/05sqd2v93","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I37461747","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoyan Pan","raw_affiliation_strings":["Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","University of the Chinese Academy of Sciences , Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-0553-5138","affiliations":[{"raw_affiliation_string":"Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882"]},{"raw_affiliation_string":"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882","https://openalex.org/I4391768268"]},{"raw_affiliation_string":"University of the Chinese Academy of Sciences , Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5038996519","https://openalex.org/A5044000598"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106882","https://openalex.org/I4210151591","https://openalex.org/I4210165038","https://openalex.org/I4391768268"],"apc_list":null,"apc_paid":null,"fwci":0.963,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.70686116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"97","issue":"11","first_page":"e0127923","last_page":"e0127923"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/receptor-binding-domain","display_name":"receptor binding domain","score":0.7590000033378601},{"id":"https://openalex.org/keywords/recombinant-protein-vaccine","display_name":"recombinant protein vaccine","score":0.9139999747276306},{"id":"https://openalex.org/keywords/omicron-variant","display_name":"Omicron variant","score":0.859000027179718},{"id":"https://openalex.org/keywords/omicron-ba-1","display_name":"Omicron BA.1","score":0.921999990940094},{"id":"https://openalex.org/keywords/delta-variant","display_name":"Delta variant","score":0.875},{"id":"https://openalex.org/keywords/cross-protection","display_name":"cross-protection","score":0.765999972820282},{"id":"https://openalex.org/keywords/booster-vaccination","display_name":"booster vaccination","score":0.7710000276565552},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.5929999947547913},{"id":"https://openalex.org/keywords/spike-protein-mutations","display_name":"spike protein mutations","score":0.781000018119812},{"id":"https://openalex.org/keywords/syrian-hamster-model","display_name":"Syrian hamster model","score":0.6320000290870667}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7318555116653442},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.7302367091178894},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6945394277572632},{"id":"https://openalex.org/C14500911","wikidata":"https://www.wikidata.org/wiki/Q3413375","display_name":"Viral quasispecies","level":4,"score":0.5997763276100159},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4876388609409332},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.4665852189064026},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3778742253780365},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.32638800144195557},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.31312742829322815},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.255246639251709},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23288500308990479},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.16270792484283447},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11115676164627075},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.10744744539260864},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000086663","descriptor_name":"COVID-19 Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/jvi.01279-23","doi":"https://doi.org/10.1128/jvi.01279-23","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.01279-23","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10688353","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10688353","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10688353/pdf/jvi.01279-23.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:37843372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37843372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/jvi.01279-23","doi":"https://doi.org/10.1128/jvi.01279-23","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.01279-23","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322847","display_name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","ror":"https://ror.org/031141b54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387660980.pdf","grobid_xml":"https://content.openalex.org/works/W4387660980.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W2167841507","https://openalex.org/W3003788575","https://openalex.org/W3007151837","https://openalex.org/W3037923073","https://openalex.org/W3040739167","https://openalex.org/W3043991892","https://openalex.org/W3092136311","https://openalex.org/W3093768302","https://openalex.org/W3101992496","https://openalex.org/W3103590655","https://openalex.org/W3107112434","https://openalex.org/W3133591520","https://openalex.org/W3162870890","https://openalex.org/W3164173705","https://openalex.org/W3189381886","https://openalex.org/W3197847129","https://openalex.org/W3201237411","https://openalex.org/W3205004768","https://openalex.org/W3206813437","https://openalex.org/W3216019834","https://openalex.org/W3217661335","https://openalex.org/W4200059944","https://openalex.org/W4200391585","https://openalex.org/W4200585483","https://openalex.org/W4206185298","https://openalex.org/W4206782835","https://openalex.org/W4206906464","https://openalex.org/W4207047906","https://openalex.org/W4210943449","https://openalex.org/W4220850641","https://openalex.org/W4220894677","https://openalex.org/W4223469034","https://openalex.org/W4224308857","https://openalex.org/W4224950176","https://openalex.org/W4225691034","https://openalex.org/W4225982774","https://openalex.org/W4226060569","https://openalex.org/W4280488965","https://openalex.org/W4280623099","https://openalex.org/W4281757199","https://openalex.org/W4291473324","https://openalex.org/W4292649407","https://openalex.org/W4295709321","https://openalex.org/W4309306496","https://openalex.org/W4361268924","https://openalex.org/W4385568795"],"related_works":["https://openalex.org/W4386745901","https://openalex.org/W3197847129","https://openalex.org/W4224950176","https://openalex.org/W7206170876","https://openalex.org/W4322766841","https://openalex.org/W3211931421","https://openalex.org/W7163690225","https://openalex.org/W4386825708","https://openalex.org/W4367309198","https://openalex.org/W4368353566"],"abstract_inverted_index":{"ABSTRACT":[0],"The":[1,97],"severe":[2],"acute":[3,193],"respiratory":[4,165,194],"syndrome":[5,195],"coronavirus":[6,196],"2":[7,197],"(SARS-CoV-2)":[8,198],"recombinant":[9,274,319],"protein":[10,85],"vaccines":[11,141,173,221,245,266,320],"have":[12],"been":[13],"widely":[14],"used":[15,184],"in":[16,41,46,94,134,163,185,213,226,250,294,321],"the":[17,29,55,64,69,107,131,150,160,164,214,218,223,233,241,247,269,310,315,322],"real":[18],"world":[19],"and":[20,48,74,91,158,180,203,207,239,259,284,292,296,306],"shown":[21],"good":[22,92,176,290],"protective":[23],"effects.":[24],"A":[25,114],"vaccine":[26,100,122,128],"prepared":[27,80,142,267],"from":[28,68,111,143,152,268,301],"ancestral":[30,59,98,127],"SARS-CoV-2":[31,60,108,179,305],"receptor-binding":[32,271],"domain":[33,272],"(RBD)":[34,273],"homodimer":[35,172],"was":[36,101],"previously":[37],"made":[38],"a":[39,125,251,282],"candidate":[40,244],"view":[42],"of":[43,58,167,220,243,317],"its":[44,181,307],"effectiveness":[45],"rodents":[47,300],"nonhuman":[49],"primates.":[50],"Here,":[51],"we":[52],"report":[53],"that":[54,265],"RBD":[56,66,99,121,147,171],"homodimers":[57],"as":[61,63],"well":[62],"variant":[65,110],"dimers":[67],"Beta,":[70],"Delta,":[71],"Lambda,":[72],"Omicron,":[73],"Omicron":[75,118,135,145,156,312],"sublineages,":[76],"which":[77,276],"were":[78],"rapidly":[79],"using":[81,281],"our":[82],"universal":[83],"dimeric":[84,120,144,270,318],"platform,":[86,287],"elicit":[87],"both":[88,289],"strong":[89],"immunogenicity":[90,291],"protection":[93,177,293],"vivo":[95,295],".":[96],"verified":[102],"to":[103,229,256],"provide":[104],"cross-protection":[105],"against":[106,178],"Delta":[109],"lethal":[112,153,302],"challenge.":[113],"heterogeneous":[115,188],"booster":[116],"with":[117],"BA.1":[119,136],"based":[123],"on":[124,222],"two-dose":[126],"prime":[129],"reduced":[130,159],"viral":[132,161],"loads":[133],"virus-challenged":[137],"animals.":[138],"In":[139],"addition,":[140],"XBB.1.5":[146],"completely":[148,298],"protected":[149],"mice":[151],"challenge":[154,303],"by":[155,304],"XBB.1.16":[157],"infection":[162],"tract":[166],"Syrian":[168],"hamsters.":[169],"Thus,":[170],"can":[174,277],"confer":[175],"variants":[182,199,249],"when":[183],"homogeneous":[186],"or":[187,225],"boosting":[189],"schemes.":[190],"IMPORTANCE":[191],"Severe":[192],"achieved":[200],"immune":[201],"escape":[202],"became":[204],"less":[205],"virulent":[206],"easily":[208],"transmissible":[209],"through":[210],"rapid":[211],"mutation":[212],"spike":[215],"protein,":[216,275],"thus":[217],"efficacy":[219,242],"market":[224],"development":[227],"continues":[228],"be":[230,278],"challenged.":[231],"Updating":[232],"vaccine,":[234],"exploring":[235],"compromise":[236],"vaccination":[237],"strategies,":[238],"evaluating":[240],"for":[246],"emerging":[248,311],"timely":[252],"manner":[253],"are":[254],"important":[255],"combat":[257],"complex":[258],"volatile":[260],"SARS-CoV-2.":[261],"This":[262],"study":[263],"reports":[264],"quickly":[279],"produced":[280],"mature":[283],"stable":[285],"process":[286],"had":[288],"could":[297],"protect":[299],"variants,":[308],"including":[309],"XBB.1.16,":[313],"highlighting":[314],"value":[316],"post-COVID-19":[323],"era.":[324]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-10-17T00:00:00"}