{"id":"https://openalex.org/W4387660933","doi":"https://doi.org/10.1186/s13046-023-02847-2","title":"LncRNA FTO-IT1 promotes glycolysis and progression of hepatocellular carcinoma through modulating FTO-mediated N6-methyladenosine modification on GLUT1 and PKM2","display_name":"LncRNA FTO-IT1 promotes glycolysis and progression of hepatocellular carcinoma through modulating FTO-mediated N6-methyladenosine modification on GLUT1 and PKM2","publication_year":2023,"publication_date":"2023-10-16","ids":{"openalex":"https://openalex.org/W4387660933","doi":"https://doi.org/10.1186/s13046-023-02847-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/37840133","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10578010"},"language":"en","primary_location":{"id":"doi:10.1186/s13046-023-02847-2","doi":"https://doi.org/10.1186/s13046-023-02847-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-023-02847-2","pdf_url":"https://jeccr.biomedcentral.com/counter/pdf/10.1186/s13046-023-02847-2","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jeccr.biomedcentral.com/counter/pdf/10.1186/s13046-023-02847-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100380496","display_name":"Fan Wang","orcid":"https://orcid.org/0000-0001-9806-5037","observed_orcids":["https://orcid.org/0000-0001-9806-5037"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Wang","raw_affiliation_strings":["Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103957943","display_name":"Yuhang Hu","orcid":"https://orcid.org/0009-0007-0599-2941","observed_orcids":["https://orcid.org/0009-0007-0599-2941"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhang Hu","raw_affiliation_strings":["Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hongda Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongda Wang","raw_affiliation_strings":["Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ping Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Hu","raw_affiliation_strings":["Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102498387","display_name":"Hewei Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hewei Xiong","raw_affiliation_strings":["Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006411450","display_name":"Zhu Zeng","orcid":"https://orcid.org/0009-0004-3520-5783","observed_orcids":["https://orcid.org/0009-0004-3520-5783"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhu Zeng","raw_affiliation_strings":["Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054691132","display_name":"Shengbo Han","orcid":"https://orcid.org/0000-0003-3475-6562","observed_orcids":["https://orcid.org/0000-0003-3475-6562","https://orcid.org/0009-0004-5809-0552"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengbo Han","raw_affiliation_strings":["Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026479645","display_name":"Decai Wang","orcid":"https://orcid.org/0000-0003-3325-1757","observed_orcids":["https://orcid.org/0000-0003-3325-1757"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Decai Wang","raw_affiliation_strings":["Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075878334","display_name":"Jie Wang","orcid":"https://orcid.org/0000-0002-3638-5446","observed_orcids":["https://orcid.org/0000-0002-3638-5446"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Wang","raw_affiliation_strings":["Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071440898","display_name":"Yong Bo Zhao","orcid":"https://orcid.org/0000-0001-5068-2212","observed_orcids":["https://orcid.org/0000-0001-5068-2212"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Zhao","raw_affiliation_strings":["Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091143438","display_name":"Yan Huang","orcid":"https://orcid.org/0000-0002-1789-5088","observed_orcids":["https://orcid.org/0000-0002-1789-5088","https://orcid.org/0009-0000-9130-8833"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Huang","raw_affiliation_strings":["Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028811847","display_name":"Wenfeng Zhuo","orcid":"https://orcid.org/0009-0007-9069-2328","observed_orcids":["https://orcid.org/0009-0007-9069-2328"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenfeng Zhuo","raw_affiliation_strings":["Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101353273","display_name":"Guozheng Lv","orcid":"https://orcid.org/0009-0008-3519-514X","observed_orcids":["https://orcid.org/0009-0008-3519-514X"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guozheng Lv","raw_affiliation_strings":["Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080841434","display_name":"Gang Zhao","orcid":"https://orcid.org/0000-0001-9391-6242","observed_orcids":["https://orcid.org/0000-0001-9391-6242"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Gang Zhao","raw_affiliation_strings":["Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China. gangzhao@hust.edu.cn","Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China. gangzhao@hust.edu.cn","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]},{"raw_affiliation_string":"Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, 1277 Jiefang Avenue, Wuhan, 430022, People's Republic of China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080841434"],"corresponding_institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":8.056,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.98494903,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"42","issue":"1","first_page":"267","last_page":"267"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9589999914169312,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.039000000804662704,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8920000195503235},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.7519999742507935},{"id":"https://openalex.org/keywords/n6-methyladenosine-modification","display_name":"N6-methyladenosine modification","score":0.8679999709129333},{"id":"https://openalex.org/keywords/fto-gene","display_name":"FTO","score":0.7509999871253967},{"id":"https://openalex.org/keywords/glut1","display_name":"GLUT1","score":0.7429999709129333},{"id":"https://openalex.org/keywords/pkm2","display_name":"PKM2","score":1.0},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9490000009536743},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.7419999837875366},{"id":"https://openalex.org/keywords/ythdf2","display_name":"YTHDF2","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5929999947547913},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.5649999976158142},{"id":"https://openalex.org/keywords/tumor-suppressor-lncrna","display_name":"tumor suppressor lncRNA","score":0.5740000009536743},{"id":"https://openalex.org/keywords/glucose-metabolism","display_name":"glucose metabolism","score":0.4099999964237213},{"id":"https://openalex.org/keywords/c-myc-oncogene","display_name":"c-myc oncogene","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.7308353185653687},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6203368306159973},{"id":"https://openalex.org/C10730799","wikidata":"https://www.wikidata.org/wiki/Q18030568","display_name":"PKM2","level":5,"score":0.5364746451377869},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.45314013957977295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43499821424484253},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38076525926589966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2970149517059326},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.1411338448524475},{"id":"https://openalex.org/C2780854706","wikidata":"https://www.wikidata.org/wiki/Q900970","display_name":"Pyruvate kinase","level":4,"score":0.13102394342422485}],"mesh":[{"descriptor_ui":"D000071516","descriptor_name":"Alpha-Ketoglutarate-Dependent Dioxygenase FTO","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000071516","descriptor_name":"Alpha-Ketoglutarate-Dependent Dioxygenase FTO","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000097810","descriptor_name":"Thyroid Hormone-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051272","descriptor_name":"Glucose Transporter Type 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s13046-023-02847-2","doi":"https://doi.org/10.1186/s13046-023-02847-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-023-02847-2","pdf_url":"https://jeccr.biomedcentral.com/counter/pdf/10.1186/s13046-023-02847-2","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10578010","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10578010","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10578010/pdf/13046_2023_Article_2847.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Clin Cancer Res","raw_type":"Text"},{"id":"pmid:37840133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37840133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental & clinical cancer research : CR","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:46458f5c81564693bd36adf7974a761b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/46458f5c81564693bd36adf7974a761b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-20 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13046-023-02847-2","doi":"https://doi.org/10.1186/s13046-023-02847-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13046-023-02847-2","pdf_url":"https://jeccr.biomedcentral.com/counter/pdf/10.1186/s13046-023-02847-2","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental &amp; Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G173095419","display_name":null,"funder_award_id":"82273322","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7421307972","display_name":null,"funder_award_id":"81872030","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7489184984","display_name":null,"funder_award_id":"82072755","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8723381577","display_name":null,"funder_award_id":"82203532","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G874939045","display_name":null,"funder_award_id":"81672406","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321883","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53"},{"id":"https://openalex.org/F4320322449","display_name":"Tongji University","ror":"https://ror.org/03rc6as71"},{"id":"https://openalex.org/F4320336027","display_name":"Tongji Medical College, Huazhong University of Science and Technology","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387660933.pdf","grobid_xml":"https://content.openalex.org/works/W4387660933.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1916486030","https://openalex.org/W1941339056","https://openalex.org/W1991807334","https://openalex.org/W2013793801","https://openalex.org/W2030922603","https://openalex.org/W2065847836","https://openalex.org/W2097259163","https://openalex.org/W2114262960","https://openalex.org/W2117692326","https://openalex.org/W2156527906","https://openalex.org/W2198153867","https://openalex.org/W2395071973","https://openalex.org/W2522153493","https://openalex.org/W2563912688","https://openalex.org/W2600862208","https://openalex.org/W2767348608","https://openalex.org/W2772792536","https://openalex.org/W2793785833","https://openalex.org/W2902817477","https://openalex.org/W2903690648","https://openalex.org/W2915075022","https://openalex.org/W2931058147","https://openalex.org/W2949259826","https://openalex.org/W2953467762","https://openalex.org/W2965299749","https://openalex.org/W2990414953","https://openalex.org/W2993308521","https://openalex.org/W3005053550","https://openalex.org/W3011391389","https://openalex.org/W3034923646","https://openalex.org/W3038789517","https://openalex.org/W3040953736","https://openalex.org/W3042466763","https://openalex.org/W3082599756","https://openalex.org/W3100577837","https://openalex.org/W3102063581","https://openalex.org/W3118401914","https://openalex.org/W3130440943","https://openalex.org/W3137347659","https://openalex.org/W3197263514","https://openalex.org/W3202131445","https://openalex.org/W3205458224","https://openalex.org/W4200441227","https://openalex.org/W4210813406","https://openalex.org/W4213184345","https://openalex.org/W4285489723"],"related_works":["https://openalex.org/W6902385961","https://openalex.org/W6958535221","https://openalex.org/W6958459337","https://openalex.org/W2804830991","https://openalex.org/W4392830674","https://openalex.org/W2736503350","https://openalex.org/W3087328520","https://openalex.org/W2990161111","https://openalex.org/W4409588742","https://openalex.org/W4395453014"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Long":[2],"non-coding":[3],"RNAs":[4],"(LncRNAs)":[5],"have":[6],"been":[7],"extensively":[8],"studied":[9],"to":[10,23,92,140,159,209,218,239,284,310,343],"play":[11],"essential":[12],"roles":[13],"in":[14,42,174,195],"tumor":[15,180],"progression.":[16],"However,":[17],"more":[18],"in-depth":[19],"studies":[20],"are":[21],"waiting":[22],"be":[24,352],"solved":[25],"on":[26,68,147,254],"how":[27],"lncRNAs":[28,41],"regulate":[29],"the":[30,94,142,161,219,267,278,333],"progression":[31,221],"of":[32,40,49,61,96,100,145,163,166,172,189,202,213,222,231,241,256,281,286,295,306,332,339,347],"hepatocellular":[33],"carcinoma":[34],"(HCC).":[35],"Methods":[36],"Different":[37],"expression":[38,280,305],"levels":[39],"HCC":[43,69,101,196,214,223],"cells":[44,70,102],"were":[45,71,90,138],"compared":[46],"by":[47,73,103,119,168,224,234,291,308],"analysis":[48],"Gene":[50],"Expression":[51],"Omnibus":[52],"and":[53,75,85,98,115,124,135,150,197,211,216,263,289,323,345,349],"The":[54,59,105,170],"Cancer":[55],"Genome":[56],"Atlas":[57],"databases.":[58],"effects":[60],"lncRNA":[62],"FTO":[63,190,232,242,250],"Intronic":[64],"Transcript":[65],"1":[66],"(FTO-IT1)":[67],"assessed":[72,160],"gain-":[74],"loss-of-function":[76],"experiments.":[77,127],"Colony":[78],"formation":[79],"assay,":[80,82,130],"Edu":[81],"glucose":[83],"uptake":[84],"lactic":[86],"acid":[87],"production":[88],"assay":[89,156],"performed":[91],"evaluate":[93],"regulation":[95,162],"proliferation":[97,210],"glycolysis":[99,167,212,257,294,344],"FTO-IT1.":[104,324],"binding":[106,111,271,309],"between":[107,321],"protein":[108,237,272],"interleukin":[109],"enhancer":[110],"factor":[112],"2/3":[113],"(ILF2/ILF3)":[114],"FTO-IT1":[116,146,206,228,282,307,350],"was":[117,157,176,192,207,299],"determined":[118],"RNA":[120,125,128,154,270],"pull-down,":[121],"mass":[122,149],"spectroscopy":[123],"immunoprecipitation":[126,155],"stability":[129],"quantitative":[131],"reverse":[132],"transcription":[133],"PCR":[134],"Western":[136],"blot":[137],"employed":[139],"determine":[141],"regulatory":[143],"mechanisms":[144],"fat":[148],"obesity-associated":[151],"(FTO).":[152],"Methylated":[153],"used":[158],"key":[164],"enzymes":[165],"FTO.":[169],"role":[171,331],"FTO-IT1/FTO":[173,334],"vivo":[175],"confirmed":[177],"via":[178],"xenograft":[179],"model.":[181],"Results":[182],"LncRNA":[183],"FTO-IT1,":[184],"an":[185,329],"intronic":[186],"region":[187],"transcript":[188],"gene,":[191],"highly":[193],"expressed":[194],"associated":[198,258],"with":[199,204],"poor":[200],"prognosis":[201],"patients":[203],"HCC.":[205,296,360],"related":[208],"cells,":[215],"contributed":[217,342],"malignant":[220],"promoting":[225],"glycolysis.":[226],"Mechanistically,":[227],"induced":[229],"stabilization":[230],"mRNA":[233,275],"recruiting":[235],"ILF2/ILF3":[236],"complex":[238],"3\u2019UTR":[240],"mRNA.":[243],"As":[244],"a":[245,318,355],"demethylase":[246],"for":[247,359],"N6-methyladenosine":[248,269],"(m6A),":[249],"decreased":[251],"m6A":[252,337],"modification":[253,338],"mRNAs":[255],"genes":[259,341],"including":[260],"GLUT1,":[261,287],"PKM2,":[262,288],"c-Myc":[264,290,302,322],"which":[265,292],"alleviated":[266],"YTH":[268],"2":[273],"(YTHDF2)-mediated":[274],"degradation.":[276],"Therefore,":[277],"upregulated":[279],"leaded":[283],"overexpression":[285],"enhanced":[293],"Meanwhile,":[297],"it":[298],"found":[300],"that":[301],"transcriptional":[303],"regulated":[304],"its":[311],"promoter":[312],"area":[313],"under":[314],"hypo-glucose":[315],"condition,":[316],"forming":[317],"reciprocal":[319],"loop":[320],"Conclusions":[325],"This":[326],"study":[327],"identified":[328],"important":[330],"axis":[335],"mediated":[336],"glycolytic":[340],"tumorigenesis":[346],"HCC,":[348],"might":[351],"served":[353],"as":[354],"new":[356],"therapeutic":[357],"target":[358]},"counts_by_year":[{"year":2026,"cited_by_count":33},{"year":2025,"cited_by_count":35},{"year":2024,"cited_by_count":18}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-10-17T00:00:00"}
