{"id":"https://openalex.org/W4387653046","doi":"https://doi.org/10.1016/j.biomaterials.2023.122350","title":"Fusogenic liposomes encapsulating mitochondria as a promising delivery system for osteoarthritis therapy","display_name":"Fusogenic liposomes encapsulating mitochondria as a promising delivery system for osteoarthritis therapy","publication_year":2023,"publication_date":"2023-10-15","ids":{"openalex":"https://openalex.org/W4387653046","doi":"https://doi.org/10.1016/j.biomaterials.2023.122350","pmid":"https://pubmed.ncbi.nlm.nih.gov/37864947"},"language":"en","primary_location":{"id":"doi:10.1016/j.biomaterials.2023.122350","doi":"https://doi.org/10.1016/j.biomaterials.2023.122350","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biomaterials.2023.122350","pdf_url":null,"source":{"id":"https://openalex.org/S163807576","display_name":"Biomaterials","issn_l":"0142-9612","issn":["0142-9612","1878-5905"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/j.biomaterials.2023.122350","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076304730","display_name":"Hye-Ryoung Kim","orcid":"https://orcid.org/0000-0002-8926-2298","observed_orcids":["https://orcid.org/0000-0002-8926-2298"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hye-Ryoung Kim","raw_affiliation_strings":["Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea","Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea. Electronic address: khye4680@naver.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea","institution_ids":["https://openalex.org/I4210148737"]},{"raw_affiliation_string":"Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea. Electronic address: khye4680@naver.com","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086199249","display_name":"Hui Bang Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hui Bang Cho","raw_affiliation_strings":["Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101929014","display_name":"Sujeong Lee","orcid":"https://orcid.org/0000-0003-3231-1949","observed_orcids":["https://orcid.org/0000-0003-3231-1949"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sujeong Lee","raw_affiliation_strings":["Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018592521","display_name":"Ji-In Park","orcid":"https://orcid.org/0000-0003-1563-5669","observed_orcids":["https://orcid.org/0000-0003-1563-5669"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji-In Park","raw_affiliation_strings":["Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103567419","display_name":"Hye Jin Kim","orcid":"https://orcid.org/0000-0001-9111-5572","observed_orcids":["https://orcid.org/0000-0001-9111-5572"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hye Jin Kim","raw_affiliation_strings":["Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea","Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea. Electronic address: khye4680@naver.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea","institution_ids":["https://openalex.org/I4210148737"]},{"raw_affiliation_string":"Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea. Electronic address: khye4680@naver.com","institution_ids":["https://openalex.org/I4210148737"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027084477","display_name":"Keun\u2010Hong Park","orcid":"https://orcid.org/0000-0002-3489-2890","observed_orcids":["https://orcid.org/0000-0002-3489-2890"]},"institutions":[{"id":"https://openalex.org/I4210148737","display_name":"CHA University","ror":"https://ror.org/04yka3j04","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210148737","https://openalex.org/I4405258985"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Keun-Hong Park","raw_affiliation_strings":["Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea. Electronic address: pkh0410@cha.ac.kr","Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-3489-2890","affiliations":[{"raw_affiliation_string":"Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea. Electronic address: pkh0410@cha.ac.kr","institution_ids":["https://openalex.org/I4210148737"]},{"raw_affiliation_string":"Laboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, 335 Pangyo-ro, Sampyeong-Dong, Bundang-gu, Seongnam-si, 13488, Republic of Korea","institution_ids":["https://openalex.org/I4210148737"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027084477","https://openalex.org/A5103567419"],"corresponding_institution_ids":["https://openalex.org/I4210148737"],"apc_list":{"value":4740,"currency":"USD","value_usd":4740},"apc_paid":{"value":4740,"currency":"USD","value_usd":4740},"fwci":13.762,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.99412084,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"302","issue":null,"first_page":"122350","last_page":"122350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.7890999913215637,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.10379999876022339,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.04019999876618385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-transfer","display_name":"mitochondrial transfer","score":0.49900001287460327},{"id":"https://openalex.org/keywords/fusogenic-liposomes","display_name":"fusogenic liposomes","score":0.8610000014305115},{"id":"https://openalex.org/keywords/membrane-fusion","display_name":"membrane fusion","score":0.7739999890327454},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cartilage-regeneration","display_name":"cartilage regeneration","score":0.9430000185966492},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.9850000143051147},{"id":"https://openalex.org/keywords/dotap","display_name":"DOTAP","score":0.6809999942779541},{"id":"https://openalex.org/keywords/liposome-composition","display_name":"liposome composition","score":0.3540000021457672},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mmp-13","display_name":"MMP-13","score":0.7649999856948853},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8399999737739563},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.8870000243186951},{"id":"https://openalex.org/keywords/mitochondrial-delivery","display_name":"mitochondrial delivery","score":0.328000009059906}],"concepts":[{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.6412378549575806},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5268094539642334},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.5219295024871826},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.49233853816986084},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.46844083070755005},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.45911118388175964},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4408632218837738},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4192638397216797},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.4172126054763794},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2593849301338196},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.25790631771087646},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2492428719997406},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21830707788467407},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08552321791648865},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.05724644660949707}],"mesh":[{"descriptor_ui":"D000644","descriptor_name":"Quaternary Ammonium Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005229","descriptor_name":"Fatty Acids, Monounsaturated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biomaterials.2023.122350","doi":"https://doi.org/10.1016/j.biomaterials.2023.122350","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biomaterials.2023.122350","pdf_url":null,"source":{"id":"https://openalex.org/S163807576","display_name":"Biomaterials","issn_l":"0142-9612","issn":["0142-9612","1878-5905"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials","raw_type":"journal-article"},{"id":"pmid:37864947","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37864947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.biomaterials.2023.122350","doi":"https://doi.org/10.1016/j.biomaterials.2023.122350","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.biomaterials.2023.122350","pdf_url":null,"source":{"id":"https://openalex.org/S163807576","display_name":"Biomaterials","issn_l":"0142-9612","issn":["0142-9612","1878-5905"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomaterials","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1982425938","display_name":null,"funder_award_id":"NRF-2020R1A2C3009783","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G2799050504","display_name":null,"funder_award_id":"NRF-2019R1A6A1A03032888","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320326061","display_name":"CHA University","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1535569627","https://openalex.org/W1967720772","https://openalex.org/W1969690844","https://openalex.org/W1988934949","https://openalex.org/W2027676310","https://openalex.org/W2033885016","https://openalex.org/W2051155342","https://openalex.org/W2078910654","https://openalex.org/W2080648518","https://openalex.org/W2097265055","https://openalex.org/W2115601182","https://openalex.org/W2269139557","https://openalex.org/W2498411827","https://openalex.org/W2510495333","https://openalex.org/W2560285613","https://openalex.org/W2604174049","https://openalex.org/W2606272507","https://openalex.org/W2615464488","https://openalex.org/W2620783538","https://openalex.org/W2789018621","https://openalex.org/W2796493184","https://openalex.org/W2805615833","https://openalex.org/W2900022657","https://openalex.org/W2924809867","https://openalex.org/W2948727038","https://openalex.org/W2952074033","https://openalex.org/W2968810602","https://openalex.org/W2998620589","https://openalex.org/W3014919511","https://openalex.org/W3023538751","https://openalex.org/W3039965632","https://openalex.org/W3042170703","https://openalex.org/W3082870108","https://openalex.org/W3106887263","https://openalex.org/W3111228069","https://openalex.org/W3111890329","https://openalex.org/W4200513221","https://openalex.org/W4210254819","https://openalex.org/W4211067786","https://openalex.org/W4280584125","https://openalex.org/W4280621866","https://openalex.org/W4292542165"],"related_works":["https://openalex.org/W1974839200","https://openalex.org/W2303105148","https://openalex.org/W7140304708","https://openalex.org/W181101639","https://openalex.org/W7202116495","https://openalex.org/W904766667","https://openalex.org/W7131133394","https://openalex.org/W4410707555","https://openalex.org/W4391263741","https://openalex.org/W4306909289"],"abstract_inverted_index":{"Many":[0],"attempts":[1],"have":[2],"been":[3],"made":[4],"to":[5,9,20,117,183],"use":[6],"mitochondria":[7],"(MT)":[8],"treat":[10],"human":[11],"diseases;":[12],"however,":[13],"MT":[14,182,196],"are":[15,172],"large,":[16],"making":[17],"them":[18],"difficult":[19],"deliver":[21],"effectively.":[22],"Therefore,":[23],"a":[24,38,42,127,173,192],"transfer":[25,197],"strategy":[26,178],"based":[27],"on":[28],"membrane":[29,71],"fusion":[30,72,94,125],"was":[31,119,126],"established.":[32],"Fusogenic":[33],"mitochondrial":[34],"capsules":[35],"(FMCs)":[36],"comprising":[37],"neutral":[39],"lipid":[40,44,48],"(PE),":[41],"cationic":[43],"(DOTAP),":[45],"an":[46],"aromatic":[47],"(Liss":[49],"Rhod":[50],"PE),":[51],"and":[52,59,63,88,90,93,98,107,121,143,155,163,176,187],"three":[53],"types":[54],"of":[55,67,80,115,139,152,159,181],"liposome":[56],"(FMC0,":[57],"FMC1,":[58],"FMC2),":[60],"were":[61,83,100],"designed":[62],"synthesized.":[64],"The":[65,78],"amount":[66],"DOTAP,":[68],"which":[69],"affects":[70],"efficiency,":[73],"differed":[74],"between":[75,96],"FMC":[76],"preparations.":[77],"characteristics":[79],"these":[81],"FMCs":[82,116,149,171],"analyzed":[84],"by":[85,102,136],"DLS,":[86],"TEM,":[87],"AFM,":[89],"the":[91],"encapsulation":[92],"efficiency":[95],"FMC-MT":[97],"FMC-chondrocytes":[99],"confirmed":[101],"FRET,":[103],"mtDNA":[104],"copy":[105],"number,":[106],"CLSM,":[108],"respectively.":[109],"Compared":[110],"with":[111],"naked":[112],"MT,":[113],"delivery":[114,130,180],"chondrocytes":[118],"faster":[120],"more":[122,128],"efficient.":[123],"Moreover,":[124],"stable":[129],"method":[131],"than":[132],"endocytosis,":[133],"as":[134,191],"evidenced":[135],"reduced":[137,150],"induction":[138],"mitophagy.":[140],"In":[141],"vitro":[142],"in":[144],"vivo":[145],"experiments":[146],"revealed":[147],"that":[148,170],"expression":[151,158],"inflammatory":[153],"cytokines":[154],"MMP13,":[156],"increased":[157],"extracellular":[160],"matrix":[161],"components,":[162],"promoted":[164],"cartilage":[165,185],"regeneration.":[166],"These":[167],"findings":[168],"suggest":[169],"highly":[174],"effective":[175],"promising":[177],"for":[179,195],"promote":[184],"regeneration,":[186],"highlight":[188],"their":[189],"potential":[190],"novel":[193],"platform":[194],"therapy.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":34},{"year":2025,"cited_by_count":31},{"year":2024,"cited_by_count":17}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-10-16T00:00:00"}